CY1119865T1 - Φαρμακευτικες συνθεσεις για την αντιμετωπιση της νοσου του παρκινσον - Google Patents
Φαρμακευτικες συνθεσεις για την αντιμετωπιση της νοσου του παρκινσονInfo
- Publication number
- CY1119865T1 CY1119865T1 CY20181100112T CY181100112T CY1119865T1 CY 1119865 T1 CY1119865 T1 CY 1119865T1 CY 20181100112 T CY20181100112 T CY 20181100112T CY 181100112 T CY181100112 T CY 181100112T CY 1119865 T1 CY1119865 T1 CY 1119865T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- pharmaceutical compositions
- disease
- parkinson
- compounds
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Παρέχονται φαρμακευτικές συνθέσεις για την αντιμετώπιση της νόσου του Πάρκινσον, οι οποίες περιλαμβάνουν έναν φαρμακευτικώς αποδεκτό φορέα και έναν συνδυασμό σταθερής δόσης δύο δραστικών παραγόντων που επιλέγονται από ενώσεις που έχουν είτε νευροπροστατευτικά ή συμπτωματικά αποτελέσματα, ή και τα δύο, σε παρκινσονικούς ασθενείς, όπου η γραμμομοριακή αναλογία των δύο ενώσεων είναι στο εύρος από 1:1 έως 1:100. Οι συνθέσεις μορφοποιούνται για άμεση απελευθέρωση, ελεγχόμενη απελευθέρωση, ή και άμεση και ελεγχόμενη απελευθέρωση.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5932608P | 2008-06-06 | 2008-06-06 | |
PCT/IL2009/000567 WO2009147681A1 (en) | 2008-06-06 | 2009-06-07 | Pharmaceutical compositions for treatment of parkinson's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119865T1 true CY1119865T1 (el) | 2018-06-27 |
Family
ID=41051156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100112T CY1119865T1 (el) | 2008-06-06 | 2018-01-31 | Φαρμακευτικες συνθεσεις για την αντιμετωπιση της νοσου του παρκινσον |
Country Status (22)
Country | Link |
---|---|
US (2) | US8969417B2 (el) |
EP (1) | EP2303330B2 (el) |
JP (1) | JP5648216B2 (el) |
KR (1) | KR101613749B1 (el) |
CN (1) | CN102105169B (el) |
AU (1) | AU2009254730B2 (el) |
BR (1) | BRPI0914902B8 (el) |
CA (1) | CA2726833C (el) |
CL (1) | CL2010001358A1 (el) |
CY (1) | CY1119865T1 (el) |
DK (1) | DK2303330T4 (el) |
ES (1) | ES2659394T5 (el) |
HU (1) | HUE037974T2 (el) |
LT (1) | LT2303330T (el) |
MX (1) | MX2010013393A (el) |
NO (1) | NO2303330T3 (el) |
NZ (1) | NZ590291A (el) |
PL (1) | PL2303330T5 (el) |
PT (1) | PT2303330T (el) |
RU (1) | RU2540470C9 (el) |
WO (1) | WO2009147681A1 (el) |
ZA (1) | ZA201100034B (el) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2011095973A1 (en) | 2010-02-03 | 2011-08-11 | Pharma Two B Ltd. | Extended release formulations of rasagiline and uses thereof |
TW201304822A (zh) * | 2010-11-15 | 2013-02-01 | Vectura Ltd | 組成物及用途 |
US9504657B2 (en) * | 2012-01-12 | 2016-11-29 | Pharmatwob Ltd. | Fixed dose combination therapy of Parkinson's disease |
JP6243351B2 (ja) | 2012-01-12 | 2017-12-06 | ファーマ ツゥ ビー リミテッド | パーキンソン病の固定投与量薬剤組合せ治療 |
WO2013168032A1 (en) * | 2012-05-07 | 2013-11-14 | Micro Labs Limited | Pharmaceutical compositions comprising rasagiline |
KR101320945B1 (ko) * | 2012-07-03 | 2013-10-23 | 주식회사파마킹 | 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제 |
CN104768545A (zh) * | 2012-09-27 | 2015-07-08 | 泰华制药工业有限公司 | 雷沙吉兰和普多比啶组合以治疗神经退化性病症,尤其亨廷顿氏病 |
WO2014139161A1 (en) | 2013-03-15 | 2014-09-18 | Techfields Pharma Co., Ltd. | Novel high penetration drugs and their compositions thereof for treatment of parkinson diseases |
EP2808023A1 (en) * | 2013-05-30 | 2014-12-03 | Université Pierre et Marie Curie (Paris 6) | New drug for the treatment and/or prevention of depressive disorders |
CN104473942A (zh) * | 2014-12-12 | 2015-04-01 | 青岛大学 | 一种抗帕金森氏病的药物组合物 |
EP3302454B1 (en) | 2015-05-26 | 2021-03-10 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA | Compositions for use in treating parkinson's disease and related disorders |
WO2017070293A1 (en) * | 2015-10-20 | 2017-04-27 | Ironwood Pharmaceuticals, Inc. | Phosphodiesterase 9 inhibitor and levodopa therapy |
US20170143681A1 (en) | 2015-11-02 | 2017-05-25 | Apkarian Technologies Llc | Methods and compositions for treating pain |
EP3558378A4 (en) * | 2016-12-22 | 2020-09-16 | Synnerva Ltd. | LOW DOSE COMBINATION OF MEDICINAL PRODUCTS FOR THE PREVENTION AND TREATMENT OF NEURAL DAMAGE |
US11253594B2 (en) * | 2017-07-07 | 2022-02-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Drug combinations for protecting against neuronal cell death |
JP6596483B2 (ja) * | 2017-12-28 | 2019-10-23 | テックフィールズ ファーマ カンパニー リミテッド | パ−キンソン病治療用の新規高透過薬物及びその組成物 |
WO2020084168A1 (en) * | 2018-10-26 | 2020-04-30 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Tetracycline compound for treating drug-induced dyskinesia |
US11701340B2 (en) * | 2019-04-17 | 2023-07-18 | Vici Health Sciences., Llc | Liquid pharmaceutical compositions |
CA3139559A1 (en) * | 2019-05-09 | 2020-11-12 | Apkarian Technologies Llc | Methods and compositions for treating pain |
JP2023504876A (ja) | 2019-12-06 | 2023-02-07 | シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド | 薬物組成物、キット及びその応用 |
US11896573B2 (en) | 2020-07-24 | 2024-02-13 | XWPharma Ltd. | Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative |
EP4211162A1 (en) * | 2020-09-10 | 2023-07-19 | Prothena Biosciences Limited | Treatment of parkinson's disease |
WO2022076466A1 (en) | 2020-10-05 | 2022-04-14 | XWPharma Ltd. | Modified release compositions of a gamma-hydroxybutyric acid derivative |
CN114762684B (zh) * | 2021-01-14 | 2023-11-21 | 华益泰康药业股份有限公司 | 一种治疗帕金森的缓释胶囊及其制备方法 |
WO2022198033A1 (en) | 2021-03-19 | 2022-09-22 | XWPharma Ltd. | Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative |
KR20240080457A (ko) * | 2022-11-30 | 2024-06-07 | 주식회사한국파마 | 신경퇴행성 질환 예방 또는 치료용 필름코팅정제 |
Family Cites Families (22)
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ATE55245T1 (de) | 1986-04-16 | 1990-08-15 | Asta Pharma Ag | Synergistische kombination von amantadin und selegilin. |
US5190763A (en) * | 1990-05-07 | 1993-03-02 | Alza Corporation | Dosage form indicated for the management of abnormal posture, tremor and involuntary movement |
US5221536A (en) | 1990-05-07 | 1993-06-22 | Alza Corporation | Dosage form indicated for the management of abnormal posture, tremor and involuntary movement |
US6258827B1 (en) * | 1995-05-26 | 2001-07-10 | Pfizer Inc. | Combinations for the treatment of parkinsonism containing selective NMDA antagonists |
CN1436080A (zh) | 2000-04-19 | 2003-08-13 | 利利艾科斯有限公司 | 环gmp-特异性磷酸二酯酶抑制剂治疗帕金森氏病的用途 |
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AR044007A1 (es) * | 2003-04-11 | 2005-08-24 | Newron Pharmaceuticals Inc | Metodos para el tratamiento de la enfermedad de parkinson |
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BRPI0507905A (pt) | 2004-02-20 | 2007-07-10 | Novartis Ag | uso de compostos orgánicos |
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EP2040698A4 (en) | 2006-07-14 | 2011-08-10 | Shionogi & Co | OXIM CONNECTIONS AND ITS USE |
US7531572B2 (en) | 2006-07-28 | 2009-05-12 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use |
ATE510538T1 (de) | 2006-08-11 | 2011-06-15 | Univ Johns Hopkins | Zusammensetzungen und verfahren für nervenschutz |
WO2008024371A2 (en) | 2006-08-21 | 2008-02-28 | Prexa Pharmaceuticals, Inc. | Multimediator transporter inhibitors for use in treatment of central nervous system disorders |
US7622495B2 (en) | 2006-10-03 | 2009-11-24 | Neurim Pharmaceuticals (1991) Ltd. | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
KR20120031245A (ko) | 2006-11-01 | 2012-03-30 | 퍼듀 퍼머 엘피 | 페닐프로피온아미드 화합물 및 그의 용도 |
US20100092554A1 (en) † | 2007-04-24 | 2010-04-15 | Boehringer Ingelheim International Gmbh | Combination with an extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof |
-
2009
- 2009-06-07 WO PCT/IL2009/000567 patent/WO2009147681A1/en active Application Filing
- 2009-06-07 PT PT97580252T patent/PT2303330T/pt unknown
- 2009-06-07 RU RU2010154716/15A patent/RU2540470C9/ru active
- 2009-06-07 ES ES09758025T patent/ES2659394T5/es active Active
- 2009-06-07 CA CA2726833A patent/CA2726833C/en active Active
- 2009-06-07 DK DK09758025.2T patent/DK2303330T4/da active
- 2009-06-07 MX MX2010013393A patent/MX2010013393A/es active IP Right Grant
- 2009-06-07 PL PL09758025T patent/PL2303330T5/pl unknown
- 2009-06-07 KR KR1020117000189A patent/KR101613749B1/ko active IP Right Grant
- 2009-06-07 LT LTEP09758025.2T patent/LT2303330T/lt unknown
- 2009-06-07 EP EP09758025.2A patent/EP2303330B2/en active Active
- 2009-06-07 HU HUE09758025A patent/HUE037974T2/hu unknown
- 2009-06-07 BR BRPI0914902A patent/BRPI0914902B8/pt active IP Right Grant
- 2009-06-07 NO NO09758025A patent/NO2303330T3/no unknown
- 2009-06-07 NZ NZ590291A patent/NZ590291A/xx unknown
- 2009-06-07 AU AU2009254730A patent/AU2009254730B2/en active Active
- 2009-06-07 CN CN200980129250.2A patent/CN102105169B/zh active Active
- 2009-06-07 US US12/996,455 patent/US8969417B2/en active Active
- 2009-06-07 JP JP2011512269A patent/JP5648216B2/ja active Active
-
2010
- 2010-12-06 CL CL2010001358A patent/CL2010001358A1/es unknown
-
2011
- 2011-01-03 ZA ZA2011/00034A patent/ZA201100034B/en unknown
-
2015
- 2015-01-22 US US14/602,518 patent/US9259418B2/en active Active - Reinstated
-
2018
- 2018-01-31 CY CY20181100112T patent/CY1119865T1/el unknown
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