BRPI0914902B8 - Composição farmacêutica para uso no tratamento de mal de parkinson - Google Patents

Composição farmacêutica para uso no tratamento de mal de parkinson

Info

Publication number
BRPI0914902B8
BRPI0914902B8 BRPI0914902A BRPI0914902A BRPI0914902B8 BR PI0914902 B8 BRPI0914902 B8 BR PI0914902B8 BR PI0914902 A BRPI0914902 A BR PI0914902A BR PI0914902 A BRPI0914902 A BR PI0914902A BR PI0914902 B8 BRPI0914902 B8 BR PI0914902B8
Authority
BR
Brazil
Prior art keywords
disease
parkinson
treatment
pharmaceutical composition
immediate release
Prior art date
Application number
BRPI0914902A
Other languages
English (en)
Inventor
Itschak Lamensdorf
Yoram Sela
Original Assignee
Pharma Two B Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41051156&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0914902(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharma Two B Ltd filed Critical Pharma Two B Ltd
Publication of BRPI0914902A2 publication Critical patent/BRPI0914902A2/pt
Publication of BRPI0914902B1 publication Critical patent/BRPI0914902B1/pt
Publication of BRPI0914902B8 publication Critical patent/BRPI0914902B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

composição farmacêutica para uso no tratamento de mal de parkinson. composições farmacêuticas são fornecidas para tratamento de mal de parkinson compreendendo carreador farmaceuticamente aceitável e combinação de dose fixa de dois agentes ativos selecionados a partir de compostos com efeitos neuroprotetores ou sintomáticos, ou ambos, em pacientes com mal de parkinson, em que a razão molar dos dois componentes esta na faixa de 1:1 a 1:100. as composições são formuladas para liberação imediata, liberação controlada, ou liberação tanto controlada quanto imediata.
BRPI0914902A 2008-06-06 2009-06-07 Composição farmacêutica para uso no tratamento de mal de parkinson BRPI0914902B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5932608P 2008-06-06 2008-06-06
US61/059,326 2008-06-06
PCT/IL2009/000567 WO2009147681A1 (en) 2008-06-06 2009-06-07 Pharmaceutical compositions for treatment of parkinson's disease

Publications (3)

Publication Number Publication Date
BRPI0914902A2 BRPI0914902A2 (pt) 2017-06-20
BRPI0914902B1 BRPI0914902B1 (pt) 2022-02-22
BRPI0914902B8 true BRPI0914902B8 (pt) 2022-04-12

Family

ID=41051156

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0914902A BRPI0914902B8 (pt) 2008-06-06 2009-06-07 Composição farmacêutica para uso no tratamento de mal de parkinson

Country Status (22)

Country Link
US (2) US8969417B2 (pt)
EP (1) EP2303330B2 (pt)
JP (1) JP5648216B2 (pt)
KR (1) KR101613749B1 (pt)
CN (1) CN102105169B (pt)
AU (1) AU2009254730B2 (pt)
BR (1) BRPI0914902B8 (pt)
CA (1) CA2726833C (pt)
CL (1) CL2010001358A1 (pt)
CY (1) CY1119865T1 (pt)
DK (1) DK2303330T4 (pt)
ES (1) ES2659394T5 (pt)
HU (1) HUE037974T2 (pt)
LT (1) LT2303330T (pt)
MX (1) MX2010013393A (pt)
NO (1) NO2303330T3 (pt)
NZ (1) NZ590291A (pt)
PL (1) PL2303330T5 (pt)
PT (1) PT2303330T (pt)
RU (1) RU2540470C9 (pt)
WO (1) WO2009147681A1 (pt)
ZA (1) ZA201100034B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9943489B2 (en) 2010-02-03 2018-04-17 Pharmatwob Ltd. Extended release formulations of rasagiline and uses thereof
TW201304822A (zh) * 2010-11-15 2013-02-01 Vectura Ltd 組成物及用途
US9504657B2 (en) * 2012-01-12 2016-11-29 Pharmatwob Ltd. Fixed dose combination therapy of Parkinson's disease
KR102276896B1 (ko) 2012-01-12 2021-07-14 파마 투 비 엘티디 파킨슨병의 고정용량 조합 치료법
WO2013168032A1 (en) * 2012-05-07 2013-11-14 Micro Labs Limited Pharmaceutical compositions comprising rasagiline
KR101320945B1 (ko) * 2012-07-03 2013-10-23 주식회사파마킹 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제
WO2014052935A2 (en) * 2012-09-27 2014-04-03 Teva Pharmaceutical Industries Ltd. Combination of rasagiline and pridopidine for treating neurodegenerative disorders, in particular huntington's disease
CA2917145C (en) 2013-03-15 2023-10-24 Techfields Pharma Co., Ltd. Novel high penetration drugs and their compositions thereof for treatment of parkinson diseases
EP2808023A1 (en) * 2013-05-30 2014-12-03 Université Pierre et Marie Curie (Paris 6) New drug for the treatment and/or prevention of depressive disorders
CN104473942A (zh) * 2014-12-12 2015-04-01 青岛大学 一种抗帕金森氏病的药物组合物
WO2016190766A1 (en) 2015-05-26 2016-12-01 Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa Compositions for use in treating parkinson's disease and related disorders
WO2017070293A1 (en) * 2015-10-20 2017-04-27 Ironwood Pharmaceuticals, Inc. Phosphodiesterase 9 inhibitor and levodopa therapy
US20170143681A1 (en) 2015-11-02 2017-05-25 Apkarian Technologies Llc Methods and compositions for treating pain
US20190343780A1 (en) * 2016-12-22 2019-11-14 Rvx Therapeutics Ltd. Low dose drug combinations for use in preventing and treating neuronal damage
WO2019010491A1 (en) * 2017-07-07 2019-01-10 University Of Pittsburgh-Of The Commonwealth System Of Higher Education COMBINATIONS OF MEDICINES FOR THE PROTECTION AGAINST THE DEATH OF NEURONAL CELLS
JP6596483B2 (ja) * 2017-12-28 2019-10-23 テックフィールズ ファーマ カンパニー リミテッド パ−キンソン病治療用の新規高透過薬物及びその組成物
WO2020084168A1 (en) * 2018-10-26 2020-04-30 Icm (Institut Du Cerveau Et De La Moelle Épinière) Tetracycline compound for treating drug-induced dyskinesia
WO2020214886A1 (en) * 2019-04-17 2020-10-22 Vici Health Sciences LLC Liquid pharmaceutical compositions
EP3946302A4 (en) * 2019-05-09 2023-01-04 Apkarian Technologies LLC METHODS AND COMPOSITIONS FOR PAIN MANAGEMENT
EP4070793A4 (en) 2019-12-06 2023-06-14 Shanghai Pharmaceuticals Holding Co., Ltd. PHARMACEUTICAL COMPOSITION, COMPLEMENTARY KIT AND ITS APPLICATION
WO2022020621A1 (en) 2020-07-24 2022-01-27 XWPharma Ltd. Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative
US12084491B2 (en) 2020-09-10 2024-09-10 Prothena Biosciences Limited Treatment of Parkinson's disease
JP2023544420A (ja) 2020-10-05 2023-10-23 エックスダブリューファーマ リミテッド ガンマ－ヒドロキシ酪酸誘導体の調節放出組成物
CN114762684B (zh) * 2021-01-14 2023-11-21 华益泰康药业股份有限公司 一种治疗帕金森的缓释胶囊及其制备方法
JP2024511991A (ja) 2021-03-19 2024-03-18 エックスダブリューファーマ リミテッド ガンマ－ヒドロキシ酪酸誘導体の組み合わされた放出製剤の薬物動態
KR20240080457A (ko) * 2022-11-30 2024-06-07 주식회사한국파마 신경퇴행성 질환 예방 또는 치료용 필름코팅정제

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3764144D1 (de) * 1986-04-16 1990-09-13 Asta Pharma Ag Synergistische kombination von amantadin und selegilin.
US5190763A (en) * 1990-05-07 1993-03-02 Alza Corporation Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
US5221536A (en) * 1990-05-07 1993-06-22 Alza Corporation Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
DK0828513T3 (da) * 1995-05-26 2004-04-13 Pfizer Kombinationspræparater til behandling af parkinsonisme, indeholdende selektive NMDA-antagonister
DE60124085D1 (de) 2000-04-19 2006-12-07 Lilly Icos Llc Pde-v hemmer zur behandlung von morbus parkinson
US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
FR2857594B1 (fr) * 2003-07-17 2005-09-16 Servier Lab Composition pharmaceutique pour l'administration par voie nasale de piribedil
AU2005215136A1 (en) 2004-02-20 2005-09-01 Novartis Ag DPP-IV inhibitors for treating neurodegeneration and cognitive disorders
WO2007002518A1 (en) 2005-06-23 2007-01-04 Spherics, Inc. Delayed release or extended-delayed release dosage forms of pramipexole
WO2007048034A2 (en) 2005-10-21 2007-04-26 Caritas St. Elizabeth Medical Center Of Boston, Inc. Use of androgens for the treatment of parkinson' s disease
DE602006018529D1 (de) 2005-12-29 2011-01-05 Osmotica Kereskedelmi Es Szolgaltato Kft Mehrschichtige tablette mit dreifacher freisetzungskombination
EA017983B1 (ru) 2006-02-17 2013-04-30 Бедс Фарма Гмбх Беролина Инновейтив Ресёч Энд Девелопмент Сёвисиз Дейтерированные производные катехоламина и лекарственные средства, содержащие указанные соединения
CN101442997B (zh) 2006-04-03 2012-11-14 泰华制药工业有限公司 雷沙吉兰用于治疗多动腿综合征
ES2379117T3 (es) 2006-05-16 2012-04-20 Knopp Neurosciences, Inc. Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas
WO2008008398A2 (en) 2006-07-14 2008-01-17 Shionogi & Co., Ltd. Oxime compounds and the use thereof
TW200820963A (en) 2006-07-28 2008-05-16 Xenoport Inc Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use
US20080090897A1 (en) 2006-08-11 2008-04-17 The Johns Hopkins University Compositions and methods for neuroprotectin
JP2010501566A (ja) 2006-08-21 2010-01-21 プレクサ ファーマシューティカルズ， インコーポレイテッド 中枢神経系障害の治療において使用するための多伝達物質トランスポータ阻害剤
US7622495B2 (en) 2006-10-03 2009-11-24 Neurim Pharmaceuticals (1991) Ltd. Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
NZ575939A (en) 2006-11-01 2011-09-30 Purdue Pharma Lp Phenylpropionamide compounds and the use thereof
EP2150239A1 (en) * 2007-04-24 2010-02-10 Boehringer Ingelheim International GmbH Combination with an extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof

Also Published As

Publication number Publication date
JP2011522035A (ja) 2011-07-28
ES2659394T5 (es) 2021-12-13
RU2540470C9 (ru) 2015-07-20
WO2009147681A1 (en) 2009-12-10
HUE037974T2 (hu) 2018-09-28
CY1119865T1 (el) 2018-06-27
DK2303330T3 (en) 2018-02-26
EP2303330A1 (en) 2011-04-06
DK2303330T4 (da) 2021-09-13
AU2009254730A1 (en) 2009-12-10
CA2726833A1 (en) 2009-12-10
CN102105169A (zh) 2011-06-22
RU2540470C2 (ru) 2015-02-10
CN102105169B (zh) 2014-09-10
NZ590291A (en) 2013-11-29
JP5648216B2 (ja) 2015-01-07
ZA201100034B (en) 2012-04-25
EP2303330B1 (en) 2017-11-15
LT2303330T (lt) 2018-04-10
KR20110031181A (ko) 2011-03-24
BRPI0914902B1 (pt) 2022-02-22
CL2010001358A1 (es) 2011-08-19
PT2303330T (pt) 2018-02-12
MX2010013393A (es) 2011-06-21
PL2303330T5 (pl) 2021-10-25
ES2659394T3 (es) 2018-03-15
US20110230513A1 (en) 2011-09-22
US20150133513A1 (en) 2015-05-14
KR101613749B1 (ko) 2016-04-19
RU2010154716A (ru) 2012-08-10
EP2303330B2 (en) 2021-06-16
CA2726833C (en) 2016-03-22
BRPI0914902A2 (pt) 2017-06-20
US9259418B2 (en) 2016-02-16
AU2009254730B2 (en) 2014-06-26
NO2303330T3 (pt) 2018-04-14
US8969417B2 (en) 2015-03-03
PL2303330T3 (pl) 2018-04-30

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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