WO2003105770A3 - Carbocyclic nucleoside analogs as rna-antivirals - Google Patents

Carbocyclic nucleoside analogs as rna-antivirals Download PDF

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Publication number
WO2003105770A3
WO2003105770A3 PCT/US2003/018841 US0318841W WO03105770A3 WO 2003105770 A3 WO2003105770 A3 WO 2003105770A3 US 0318841 W US0318841 W US 0318841W WO 03105770 A3 WO03105770 A3 WO 03105770A3
Authority
WO
WIPO (PCT)
Prior art keywords
rna
inhibitors
dependent rna
carbocyclic nucleoside
infection
Prior art date
Application number
PCT/US2003/018841
Other languages
French (fr)
Other versions
WO2003105770A2 (en
Inventor
Balkrishen Bhat
Neelima Bhat
Prasad Dande
Anne B Eldrup
David B Olsen
Malcolm Maccoss
Original Assignee
Merck & Co Inc
Isis Pharmaceuticals Inc
Balkrishen Bhat
Neelima Bhat
Prasad Dande
Anne B Eldrup
David B Olsen
Malcolm Maccoss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Isis Pharmaceuticals Inc, Balkrishen Bhat, Neelima Bhat, Prasad Dande, Anne B Eldrup, David B Olsen, Malcolm Maccoss filed Critical Merck & Co Inc
Priority to AU2003251524A priority Critical patent/AU2003251524A1/en
Priority to EP03760371A priority patent/EP1515971A2/en
Priority to CA002488842A priority patent/CA2488842A1/en
Priority to JP2004512678A priority patent/JP2005533777A/en
Publication of WO2003105770A2 publication Critical patent/WO2003105770A2/en
Publication of WO2003105770A3 publication Critical patent/WO2003105770A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention provides carbocyclic nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such carbocyclic nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the carbocyclic nucleoside compounds of the present invention
PCT/US2003/018841 2002-06-17 2003-06-14 Carbocyclic nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase WO2003105770A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003251524A AU2003251524A1 (en) 2002-06-17 2003-06-14 Carbocyclic nucleoside analogs as RNA-antivirals
EP03760371A EP1515971A2 (en) 2002-06-17 2003-06-14 Carbocyclic nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
CA002488842A CA2488842A1 (en) 2002-06-17 2003-06-14 Carbocyclic nucleoside analogs as rna-antivirals
JP2004512678A JP2005533777A (en) 2002-06-17 2003-06-14 Carbocyclic nucleoside analogs as RNA antiviral agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60/389,161 2002-06-01
US38916102P 2002-06-17 2002-06-17

Publications (2)

Publication Number Publication Date
WO2003105770A2 WO2003105770A2 (en) 2003-12-24
WO2003105770A3 true WO2003105770A3 (en) 2004-10-07

Family

ID=29736594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/018841 WO2003105770A2 (en) 2002-06-17 2003-06-14 Carbocyclic nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase

Country Status (5)

Country Link
EP (1) EP1515971A2 (en)
JP (1) JP2005533777A (en)
AU (1) AU2003251524A1 (en)
CA (1) CA2488842A1 (en)
WO (1) WO2003105770A2 (en)

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US8957046B2 (en) 2007-03-30 2015-02-17 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9393256B2 (en) 2011-09-16 2016-07-19 Gilead Pharmasset Llc Methods for treating HCV
US9549941B2 (en) 2011-11-29 2017-01-24 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus

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TWI576352B (en) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 Nucleoside phosphoramidates
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CN102438989B (en) 2009-06-22 2015-05-27 霍夫曼-拉罗奇有限公司 Novel oxazolone and pyrrolidinone-substituted arylamides
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CA2795054A1 (en) 2010-04-01 2011-10-06 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
TW201329096A (en) 2011-09-12 2013-07-16 Idenix Pharmaceuticals Inc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
TW201331221A (en) 2011-10-14 2013-08-01 Idenix Pharmaceuticals Inc Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
CA2873315A1 (en) 2012-05-22 2013-11-28 Idenix Pharamaceuticals, Inc. D-amino acid compounds for liver disease
WO2013177195A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphate prodrugs for hcv infection
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HUE029038T2 (en) 2012-05-25 2017-01-30 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
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Cited By (8)

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US8957046B2 (en) 2007-03-30 2015-02-17 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
US9585906B2 (en) 2007-03-30 2017-03-07 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US9394331B2 (en) 2010-11-30 2016-07-19 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9393256B2 (en) 2011-09-16 2016-07-19 Gilead Pharmasset Llc Methods for treating HCV
US9549941B2 (en) 2011-11-29 2017-01-24 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus

Also Published As

Publication number Publication date
WO2003105770A2 (en) 2003-12-24
EP1515971A2 (en) 2005-03-23
JP2005533777A (en) 2005-11-10
AU2003251524A1 (en) 2003-12-31
CA2488842A1 (en) 2003-12-24

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