JP2018529671A5 - - Google Patents

Info

Publication number

JP2018529671A5

JP2018529671A5 JP2018511491A JP2018511491A JP2018529671A5 JP 2018529671 A5 JP2018529671 A5 JP 2018529671A5 JP 2018511491 A JP2018511491 A JP 2018511491A JP 2018511491 A JP2018511491 A JP 2018511491A JP 2018529671 A5 JP2018529671 A5 JP 2018529671A5

Authority

JP

Japan

Prior art keywords

compound

salt

pharmaceutically acceptable

phosphoryl

dioxo

Prior art date

2016-09-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000003839 salts Chemical class 0.000 claims 27
• 150000001875 compounds Chemical class 0.000 claims 26
• -1 (phenoxy) phosphoryl Chemical group 0.000 claims 13
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
• XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 4
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 241000711549 Hepacivirus C Species 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims 2
• 125000000336 imidazol-5-yl group Chemical group [H]N1C([H])=NC([H])=C1[*] 0.000 claims 2
• KJDMHQIHCXUXAM-PHHLIPDPSA-N ethyl 2-[[[(2R,3R,4R,5R)-4-bromo-4-chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]-2-methylpropanoate Chemical compound Br[C@@]1([C@@H]([C@H](O[C@H]1N1C(NC(C=C1)=O)=O)CO[P@](=O)(OC1=CC=CC=C1)NC(C(=O)OCC)(C)C)O)Cl KJDMHQIHCXUXAM-PHHLIPDPSA-N 0.000 claims 1
• KJDMHQIHCXUXAM-YTBGVTTRSA-N ethyl 2-[[[(2R,3R,4R,5R)-4-bromo-4-chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]-2-methylpropanoate Chemical compound Br[C@@]1([C@@H]([C@H](O[C@H]1N1C(NC(C=C1)=O)=O)CO[P@@](=O)(OC1=CC=CC=C1)NC(C(=O)OCC)(C)C)O)Cl KJDMHQIHCXUXAM-YTBGVTTRSA-N 0.000 claims 1
• IVBQJSWAIJZGDV-IHCGESCNSA-N ethyl 2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]-2-methylpropanoate Chemical compound O=C1N(C=CC(N1)=O)[C@H]1[C@]([C@@H]([C@H](O1)COP(=O)(OC1=CC=CC=C1)NC(C(=O)OCC)(C)C)O)(C)F IVBQJSWAIJZGDV-IHCGESCNSA-N 0.000 claims 1
• OEFWWTWBGKIMOJ-KXINHHJESA-N ethyl 2-[[[(2R,3R,4S,5R)-4-bromo-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]-2-methylpropanoate Chemical compound Br[C@]1([C@@H]([C@H](O[C@H]1N1C(NC(C=C1)=O)=O)CO[P@@](=O)(OC1=CC=CC=C1)NC(C(=O)OCC)(C)C)O)F OEFWWTWBGKIMOJ-KXINHHJESA-N 0.000 claims 1
• OEFWWTWBGKIMOJ-LVGFUXGXSA-N ethyl 2-[[[(2R,3R,4S,5R)-4-bromo-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]-2-methylpropanoate Chemical compound Br[C@]1([C@@H]([C@H](O[C@H]1N1C(NC(C=C1)=O)=O)CO[P@](=O)(OC1=CC=CC=C1)NC(C(=O)OCC)(C)C)O)F OEFWWTWBGKIMOJ-LVGFUXGXSA-N 0.000 claims 1
• 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
• 0 C[C@@](C(*[C@]1(*)COP)N(C=CC(N2)=O)C2=O)[C@@]1(*)*(C)=* Chemical compound C[C@@](C(*[C@]1(*)COP)N(C=CC(N2)=O)C2=O)[C@@]1(*)*(C)=* 0.000 description 2
• GFADCAXVBCLJGH-YUNKPMOVSA-N CC(C)C(OC[C@H](C)N[P@](C)(Oc1ccccc1)=O)=O Chemical compound CC(C)C(OC[C@H](C)N[P@](C)(Oc1ccccc1)=O)=O GFADCAXVBCLJGH-YUNKPMOVSA-N 0.000 description 1
• CDWPKRNDHQACEI-JRTLGTJJSA-N CCP(N[C@@H](C)C(OC(C)C)=O)(Oc1cccc(C)c1)=O Chemical compound CCP(N[C@@H](C)C(OC(C)C)=O)(Oc1cccc(C)c1)=O CDWPKRNDHQACEI-JRTLGTJJSA-N 0.000 description 1