CN108350016B - 抗病毒四氢呋喃衍生物 - Google Patents

抗病毒四氢呋喃衍生物 Download PDF

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Publication number
CN108350016B
CN108350016B CN201680063114.8A CN201680063114A CN108350016B CN 108350016 B CN108350016 B CN 108350016B CN 201680063114 A CN201680063114 A CN 201680063114A CN 108350016 B CN108350016 B CN 108350016B
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China
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compound
weeks
hcv
formula
invention features
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Expired - Fee Related
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CN201680063114.8A
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English (en)
Chinese (zh)
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CN108350016A (zh
Inventor
J.周
H-J.J.陈
D.A.德盖伊
J.哈唐
N.伊德
V.卡尔索
A.C.克吕格尔
顾宜音
李彤梅
J.T.兰多尔夫
R.瓦纳
E.沃伊特
G.T.哈尔沃森
C.C.马文
B.S.布朗
S.R.马丁内斯
A.什雷萨
H.R.海曼
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AbbVie Inc
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AbbVie Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201680063114.8A 2015-09-02 2016-09-01 抗病毒四氢呋喃衍生物 Expired - Fee Related CN108350016B (zh)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US201562213378P 2015-09-02 2015-09-02
US62/213378 2015-09-02
US201562242136P 2015-10-15 2015-10-15
US62/242136 2015-10-15
US201562253426P 2015-11-10 2015-11-10
US62/253426 2015-11-10
US201662294449P 2016-02-12 2016-02-12
US62/294449 2016-02-12
US201662296801P 2016-02-18 2016-02-18
US62/296801 2016-02-18
US201662321538P 2016-04-12 2016-04-12
US62/321538 2016-04-12
US201662327087P 2016-04-25 2016-04-25
US62/327087 2016-04-25
US201662351038P 2016-06-16 2016-06-16
US62/351038 2016-06-16
US201662363640P 2016-07-18 2016-07-18
US62/363640 2016-07-18
US201662375029P 2016-08-15 2016-08-15
US62/375029 2016-08-15
PCT/US2016/049873 WO2017040766A1 (en) 2015-09-02 2016-09-01 Anti-viral tetrahydrofurane derivatives

Publications (2)

Publication Number Publication Date
CN108350016A CN108350016A (zh) 2018-07-31
CN108350016B true CN108350016B (zh) 2021-07-27

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US (2) US9676797B2 (enExample)
EP (1) EP3344642A1 (enExample)
JP (1) JP6743135B2 (enExample)
CN (1) CN108350016B (enExample)
CA (1) CA2997170A1 (enExample)
MX (1) MX2018002707A (enExample)
WO (1) WO2017040766A1 (enExample)

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EP3344642A1 (en) * 2015-09-02 2018-07-11 AbbVie Inc. Anti-viral tetrahydrofurane derivatives
WO2018093717A1 (en) * 2016-11-17 2018-05-24 Abbvie Inc. Compositions and methods for treating hcv infection
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
EP3752511A4 (en) 2018-01-10 2021-12-29 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
CN109762040A (zh) * 2019-01-14 2019-05-17 歌礼生物制药(杭州)有限公司 一种核苷类ns5b聚合酶抑制剂的制备方法
EP3999519A4 (en) 2019-07-17 2023-08-16 Nucorion Pharmaceuticals, Inc. CYCLIC DEOXYRIBONUCLEOTIDE COMPOUNDS
WO2021216427A1 (en) 2020-04-21 2021-10-28 Ligand Pharmaceuticals, Inc. Nucleotide prodrug compounds
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors

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JP2018529671A (ja) 2018-10-11
US20180022763A1 (en) 2018-01-25
EP3344642A1 (en) 2018-07-11
JP6743135B2 (ja) 2020-08-19
US20170057981A1 (en) 2017-03-02
US9676797B2 (en) 2017-06-13
CN108350016A (zh) 2018-07-31
WO2017040766A1 (en) 2017-03-09
US10053474B2 (en) 2018-08-21
MX2018002707A (es) 2018-08-01
CA2997170A1 (en) 2017-03-09

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