JP6743135B2 - 抗ウィルス性テトラヒドロフラン誘導体 - Google Patents

抗ウィルス性テトラヒドロフラン誘導体 Download PDF

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Publication number
JP6743135B2
JP6743135B2 JP2018511491A JP2018511491A JP6743135B2 JP 6743135 B2 JP6743135 B2 JP 6743135B2 JP 2018511491 A JP2018511491 A JP 2018511491A JP 2018511491 A JP2018511491 A JP 2018511491A JP 6743135 B2 JP6743135 B2 JP 6743135B2
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JP
Japan
Prior art keywords
compound
weeks
formula
hcv
another aspect
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Expired - Fee Related
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JP2018511491A
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English (en)
Japanese (ja)
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JP2018529671A5 (enExample
JP2018529671A (ja
Inventor
チャウ，ジャクリーン
チェン，ホイ−ジュイ・ジェイ
デゴイー，デイビッド・エイ
ハートゥング，ジョン
イデ，ネイサン
カルソッド，ビクラム
クリューガー，アラン・シー
クー，イー−イン
リー，トンメイ
ランドルフ，ジョン・ティー
ワグナー，ロルフ
ボイト，エリック
ハルボーセン，ジェフ・ティー
マービン，クリストファー・シー
ブラウン，ブライアン・エス
マルティネス，スティーブン・アール
シュレスタ，アヌルパ
ヘイマン，ハワード・アール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
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AbbVie Inc
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Publication of JP2018529671A publication Critical patent/JP2018529671A/ja
Publication of JP2018529671A5 publication Critical patent/JP2018529671A5/ja
Application granted granted Critical
Publication of JP6743135B2 publication Critical patent/JP6743135B2/ja
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2018511491A 2015-09-02 2016-09-01 抗ウィルス性テトラヒドロフラン誘導体 Expired - Fee Related JP6743135B2 (ja)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US201562213378P 2015-09-02 2015-09-02
US62/213,378 2015-09-02
US201562242136P 2015-10-15 2015-10-15
US62/242,136 2015-10-15
US201562253426P 2015-11-10 2015-11-10
US62/253,426 2015-11-10
US201662294449P 2016-02-12 2016-02-12
US62/294,449 2016-02-12
US201662296801P 2016-02-18 2016-02-18
US62/296,801 2016-02-18
US201662321538P 2016-04-12 2016-04-12
US62/321,538 2016-04-12
US201662327087P 2016-04-25 2016-04-25
US62/327,087 2016-04-25
US201662351038P 2016-06-16 2016-06-16
US62/351,038 2016-06-16
US201662363640P 2016-07-18 2016-07-18
US62/363,640 2016-07-18
US201662375029P 2016-08-15 2016-08-15
US62/375,029 2016-08-15
PCT/US2016/049873 WO2017040766A1 (en) 2015-09-02 2016-09-01 Anti-viral tetrahydrofurane derivatives

Publications (3)

Publication Number Publication Date
JP2018529671A JP2018529671A (ja) 2018-10-11
JP2018529671A5 JP2018529671A5 (enExample) 2019-11-21
JP6743135B2 true JP6743135B2 (ja) 2020-08-19

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JP2018511491A Expired - Fee Related JP6743135B2 (ja) 2015-09-02 2016-09-01 抗ウィルス性テトラヒドロフラン誘導体

Country Status (7)

Country Link
US (2) US9676797B2 (enExample)
EP (1) EP3344642A1 (enExample)
JP (1) JP6743135B2 (enExample)
CN (1) CN108350016B (enExample)
CA (1) CA2997170A1 (enExample)
MX (1) MX2018002707A (enExample)
WO (1) WO2017040766A1 (enExample)

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CN107709344B (zh) * 2015-05-01 2022-07-15 共晶制药股份有限公司 用于治疗黄病毒科病毒和癌症的核苷类似物
JP6743135B2 (ja) * 2015-09-02 2020-08-19 アッヴィ・インコーポレイテッド 抗ウィルス性テトラヒドロフラン誘導体
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CN109762040A (zh) * 2019-01-14 2019-05-17 歌礼生物制药(杭州)有限公司 一种核苷类ns5b聚合酶抑制剂的制备方法
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Also Published As

Publication number Publication date
US20180022763A1 (en) 2018-01-25
US9676797B2 (en) 2017-06-13
CN108350016B (zh) 2021-07-27
CN108350016A (zh) 2018-07-31
MX2018002707A (es) 2018-08-01
CA2997170A1 (en) 2017-03-09
JP2018529671A (ja) 2018-10-11
WO2017040766A1 (en) 2017-03-09
US10053474B2 (en) 2018-08-21
EP3344642A1 (en) 2018-07-11
US20170057981A1 (en) 2017-03-02

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