PL3043803T3 - Kompozycje nukleotydowe i nukleozydowe oraz ich zastosowanie - Google Patents
Kompozycje nukleotydowe i nukleozydowe oraz ich zastosowanieInfo
- Publication number
- PL3043803T3 PL3043803T3 PL14844012.6T PL14844012T PL3043803T3 PL 3043803 T3 PL3043803 T3 PL 3043803T3 PL 14844012 T PL14844012 T PL 14844012T PL 3043803 T3 PL3043803 T3 PL 3043803T3
- Authority
- PL
- Poland
- Prior art keywords
- nucleotide
- nucleoside compositions
- nucleoside
- compositions
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361876473P | 2013-09-11 | 2013-09-11 | |
| US201461923317P | 2014-01-03 | 2014-01-03 | |
| US201461986577P | 2014-04-30 | 2014-04-30 | |
| PCT/US2014/054930 WO2015038596A1 (en) | 2013-09-11 | 2014-09-10 | Nucleotide and nucleoside compositions and uses related thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3043803T3 true PL3043803T3 (pl) | 2022-11-07 |
Family
ID=52666219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14844012.6T PL3043803T3 (pl) | 2013-09-11 | 2014-09-10 | Kompozycje nukleotydowe i nukleozydowe oraz ich zastosowanie |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US10149859B2 (pl) |
| EP (2) | EP3043803B1 (pl) |
| JP (4) | JP6762873B2 (pl) |
| DK (1) | DK3043803T3 (pl) |
| ES (1) | ES2927955T3 (pl) |
| HR (1) | HRP20220911T1 (pl) |
| LT (1) | LT3043803T (pl) |
| PL (1) | PL3043803T3 (pl) |
| SI (1) | SI3043803T1 (pl) |
| TW (1) | TW201542581A (pl) |
| UY (1) | UY35732A (pl) |
| WO (1) | WO2015038596A1 (pl) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013174962A1 (en) | 2012-05-25 | 2013-11-28 | Janssen R&D Ireland | Uracyl spirooxetane nucleosides |
| ES2725491T3 (es) | 2012-11-16 | 2019-09-24 | Univ College Cardiff Consultants Ltd | Mezcla de RP/SP gemcitabina-[fenil-(benciloxi-L-alaninil)]-fosfato |
| EP3043803B1 (en) | 2013-09-11 | 2022-04-27 | Emory University | Nucleotide and nucleoside compositions and their uses |
| AU2015280234B2 (en) * | 2014-06-24 | 2021-04-01 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| CN117379452A (zh) | 2014-06-24 | 2024-01-12 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸和其类似物 |
| RS60968B1 (sr) | 2014-06-25 | 2020-11-30 | NuCana plc | Prolekovi gemcitabina |
| SG10202009020VA (en) | 2014-11-28 | 2020-10-29 | NuCana plc | New 2' and/or 5' amino-acid ester phosphoramidate 3'-deoxy adenosine derivatives as anti-cancer compounds |
| SG10202013032YA (en) * | 2014-12-15 | 2021-02-25 | Univ Emory | Phosphoramidates for the treatment of hepatitis b virus |
| SG10202105371YA (en) | 2014-12-26 | 2021-07-29 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| GEAP202215528A (en) | 2015-03-06 | 2022-11-10 | Atea Pharmaceuticals Inc | B-D-2'-DEOXY-2'a-FLUORO-2'-B-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT |
| EP3344642A1 (en) | 2015-09-02 | 2018-07-11 | AbbVie Inc. | Anti-viral tetrahydrofurane derivatives |
| CN106674297A (zh) * | 2015-11-11 | 2017-05-17 | 中国科学院生态环境研究中心 | 具有抗癌活性的新型krn7000类似物及合成方法 |
| WO2017155923A1 (en) * | 2016-03-07 | 2017-09-14 | Emory University | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
| GB201609601D0 (en) | 2016-06-01 | 2016-07-13 | Nucana Biomed Ltd | Phosphoramidate compounds |
| RU2752172C2 (ru) | 2016-08-31 | 2021-07-23 | Фуджифилм Корпорэйшн | Противоопухолевый агент, усилитель противоопухолевого действия и противоопухолевый набор |
| BR112019004297A2 (pt) | 2016-09-07 | 2019-05-28 | Atea Pharmaceuticals Inc | método, uso de uma quantidade eficaz de um composto, composto, e, composição farmacêutica. |
| JP7016170B2 (ja) * | 2016-12-16 | 2022-02-04 | 国立大学法人東海国立大学機構 | ヌクレオシド誘導体及びその利用 |
| SG11201906163TA (en) | 2017-02-01 | 2019-08-27 | Atea Pharmaceuticals Inc | Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus |
| GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
| US10688112B2 (en) | 2017-07-13 | 2020-06-23 | Emory University | Lipid disulfide prodrugs and uses related thereto |
| JP7173467B2 (ja) | 2017-10-31 | 2022-11-16 | ヤマサ醤油株式会社 | ヌクレオシド誘導体及びその利用 |
| GB201720279D0 (en) | 2017-12-05 | 2018-01-17 | Nucana Biomed Ltd | Anticancer compounds |
| FI3706762T3 (fi) | 2017-12-07 | 2024-12-13 | Univ Emory | N4-hydroksisytidiini ja johdannaisia sekä niihin liittyviä virusten vastaisia käyttötapoja |
| MX2020006864A (es) * | 2017-12-27 | 2020-11-11 | Univ Emory | Modalidades combinadas para inhibidores de nucleosidos y/o nadph oxidasa (nox) como agentes antivirales especificos de mieloides. |
| CN111836823B (zh) * | 2018-03-09 | 2023-06-30 | 国立研究开发法人科学技术振兴机构 | β修饰磷酸化合物前体、β修饰磷酸化合物、反应阻碍剂和包含这些化合物的医药品以及反应阻碍方法 |
| EP3773753A4 (en) | 2018-04-10 | 2021-12-22 | ATEA Pharmaceuticals, Inc. | TREATMENT OF PATIENTS INFECTED WITH THE HEPATITIS C VIRUS WITH CIRRHOSIS |
| CN110655546B (zh) * | 2018-12-18 | 2023-05-16 | 安徽贝克制药股份有限公司 | 索非布韦衍生物及其制备方法和应用 |
| CN109503688A (zh) * | 2018-12-21 | 2019-03-22 | 佛山科学技术学院 | 具有抑制病毒复制活性的核苷磷酸长链酯类似物、制备方法及其药物用途 |
| JP7233660B2 (ja) * | 2019-04-05 | 2023-03-07 | 株式会社日本触媒 | 架橋型人工ヌクレオシドの製造 |
| CN110204584B (zh) * | 2019-06-17 | 2022-09-09 | 大连大学 | 一种4-s-2’,3’,5’-o-三乙酰基尿苷合成方法 |
| CN110105416B (zh) * | 2019-06-17 | 2022-07-12 | 大连大学 | 一种4-S-5-Br-2’,3’,5’-O-三乙酰基尿苷合成方法 |
| EP4017499A4 (en) | 2019-08-22 | 2024-01-10 | Emory University | Nucleoside prodrugs and uses related thereto |
| DK4069691T3 (da) | 2019-12-06 | 2024-10-28 | Vertex Pharma | Substituerede tetrahydrofuraner som modulatorer af natriumkanaler |
| TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| EP4106876B1 (en) | 2020-02-18 | 2025-09-17 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| KR102145197B1 (ko) * | 2020-03-10 | 2020-08-18 | 부광약품 주식회사 | 코로나바이러스를 치료하기 위한 l-뉴클레오사이드의 용도 |
| AR121620A1 (es) | 2020-03-20 | 2022-06-22 | Gilead Sciences Inc | Profármacos de nucleósidos 4-c-sustituidos-2-halo-2-deoxiadenosina y métodos de preparación y uso de los mismos |
| WO2022081823A1 (en) * | 2020-10-14 | 2022-04-21 | Temple University -Of The Commonwealth System Of Higher Education | Pharmacologic approach for suppression of coronaviruses |
| CN112778356B (zh) * | 2020-12-26 | 2022-07-01 | 山东日兴新材料股份有限公司 | 一种三(三溴新戊基)磷酸酯阻燃剂的一锅法合成工艺 |
| CN112661802B (zh) * | 2021-01-25 | 2022-05-13 | 阿里生物新材料(常州)有限公司 | 一种3′-甲氧基鸟苷的合成方法 |
| TW202241454A (zh) | 2021-02-01 | 2022-11-01 | 日商第一三共股份有限公司 | 抗體-免疫賦活化劑共軛物之新穎製造方法 |
| KR102923359B1 (ko) | 2021-04-16 | 2026-02-05 | 길리애드 사이언시즈, 인코포레이티드 | 아미드를 사용한 카르바뉴클레오시드를 제조하는 방법 |
| CN112979733B (zh) * | 2021-04-25 | 2021-09-10 | 南京颐媛生物医学研究院有限公司 | 抗乙肝病毒的化合物及其制备方法和应用 |
| EP4333859A4 (en) * | 2021-05-05 | 2025-03-26 | Emory University | THERAPEUTIC COMPOSITIONS CONTAINING NUCLEOTIDES AND NUCLEOSIDES, COMBINATIONS AND USES THEREOF |
| MA64853B1 (fr) | 2021-06-04 | 2025-11-28 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques |
| JP2024525164A (ja) | 2021-06-17 | 2024-07-10 | アテア ファーマシューティカルズ, インコーポレイテッド | 有利な抗hcv併用療法 |
| CN113278041B (zh) * | 2021-07-16 | 2021-10-19 | 南京颐媛生物医学研究院有限公司 | 一种核苷磷酸酯及其合成方法与抗肝炎病毒的制药应用 |
| EP4387977A1 (en) | 2021-08-18 | 2024-06-26 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| CN113501853B (zh) * | 2021-09-13 | 2021-12-07 | 南京颐媛生物医学研究院有限公司 | 4-硫代尿嘧啶脱氧核苷磷酸酯及其抗病毒药物用途 |
| CN113735927B (zh) * | 2021-10-18 | 2024-06-28 | 厦门蔚扬药业有限公司 | 一种核苷酸类似物及其制备方法和用途 |
| WO2023086557A1 (en) * | 2021-11-11 | 2023-05-19 | Emory University | Nucleosides for the treatment of dna virus infections |
| US11541071B1 (en) | 2021-12-16 | 2023-01-03 | Ascletis BioScience Co., Ltd | Nucleoside derivatives and methods of use thereof |
| CN118591377A (zh) * | 2022-01-26 | 2024-09-03 | 加利福尼亚大学董事会 | 抗病毒前药、中效和长效制剂和方法 |
| CN116554249B (zh) * | 2022-01-28 | 2025-03-18 | 北京恩泰伟医药科技有限公司 | 抗病毒化合物及其用途 |
| JP2025509635A (ja) | 2022-03-15 | 2025-04-11 | ローム・セラピューティクス・インコーポレイテッド | 疾患を治療するための化合物及び方法 |
| WO2023178228A1 (en) * | 2022-03-16 | 2023-09-21 | Pharmalectin, Inc. | Lectin-binding carbohydrates for treating viral infections |
| EP4248949B1 (en) | 2022-03-21 | 2024-08-28 | R.G.C.C. Holdings AG | Liposomal compositions |
| JP7679129B2 (ja) * | 2022-07-12 | 2025-05-19 | 南京工▲業▼大学 | コルジセピンの誘導体化による抗腫瘍効果を有する化合物 |
| WO2024137577A1 (en) * | 2022-12-19 | 2024-06-27 | Ohio State Innovation Foundation | Multiparametric integrated molecular detection of viral antigens and viral nucleic acids |
| WO2024167952A1 (en) * | 2023-02-08 | 2024-08-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Oxidatively cleavable organophosphate drugs |
| WO2024249234A1 (en) * | 2023-05-26 | 2024-12-05 | Altesa BioSciences, Inc. | Method of treating hepatitis c virus in patients |
| WO2025058573A1 (en) * | 2023-09-15 | 2025-03-20 | National Science And Technology Development Agency | Cordycepin derivatives or a pharmaceutically acceptable salt thereof as pan-antiviral agents |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3404144A (en) * | 1965-12-23 | 1968-10-01 | Research Corp | 1-beta-d-arabinofuranosyl-5-fluorocytosine compounds |
| DE2041735A1 (de) * | 1970-08-22 | 1972-02-24 | Merck Patent Gmbh | Thio-pyrimidin-derivate |
| US3975374A (en) * | 1970-12-21 | 1976-08-17 | The Upjohn Company | Process for preparing 2-thiouracil nucleosides |
| JPS4947379A (pl) * | 1972-09-12 | 1974-05-08 | ||
| PL107865B1 (pl) | 1977-04-27 | 1980-03-31 | Polska Akademia Nauk Instytut | Method of obtaining styrene oxide sposob otrzymywania tlenku styrenu |
| US6448392B1 (en) | 1985-03-06 | 2002-09-10 | Chimerix, Inc. | Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use |
| US4954485A (en) * | 1987-10-20 | 1990-09-04 | Sanyo-Kokusaku Pulp Co., Ltd. | 2',3'-dideoxy-4-thio-uridine derivatives, process for their preparation and antivirus agents using them |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| DK0831852T3 (da) | 1995-06-07 | 2007-03-19 | Univ Emory | Nukleosider med anti-hepatitis B-virusaktivitet |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| JPH107694A (ja) * | 1996-06-21 | 1998-01-13 | Toagosei Co Ltd | 3’−アミノ−2−チオピリミジンヌクレオシド |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6610835B1 (en) | 1998-02-12 | 2003-08-26 | Emory University | Sphingolipid derivatives and their methods of use |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US6461422B1 (en) * | 2000-01-27 | 2002-10-08 | Chartpak, Inc. | Pressure sensitive ink jet media for digital printing |
| MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| JP5230052B2 (ja) | 2000-05-26 | 2013-07-10 | イデニクス(ケイマン)リミテツド | フラビウイルスおよびペスチウイルス治療のための方法および組成物 |
| US20030008841A1 (en) * | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| EP1346724A4 (en) | 2000-12-26 | 2004-11-17 | Mitsubishi Pharma Corp | AGENT FOR TREATING HEPATITIS C |
| US20040006002A1 (en) * | 2001-09-28 | 2004-01-08 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
| WO2003026589A2 (en) | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
| PL197669B1 (pl) * | 2002-02-28 | 2008-04-30 | Pan Inst Biochemii I Biofizyki | Nowe analogi 2',3'-dideoksy-3'-fluorotymidyny o aktywności przeciwko wirusom (54) ludzkiego niedoboru immunologicznego HIV-1 i HIV-2, sposób ich wytwarzania oraz zawierające je środki farmaceutyczne |
| US20040063658A1 (en) | 2002-05-06 | 2004-04-01 | Roberts Christopher Don | Nucleoside derivatives for treating hepatitis C virus infection |
| TW200500375A (en) | 2002-06-28 | 2005-01-01 | Idenix Cayman Ltd | Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae |
| US20040035547A1 (en) | 2002-08-20 | 2004-02-26 | 3M Innovative Properties Company | Metal matrix composites, and methods for making the same |
| US7902203B2 (en) | 2002-11-01 | 2011-03-08 | Abbott Laboratories, Inc. | Anti-infective agents |
| WO2005020885A2 (en) | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
| WO2006121820A1 (en) * | 2005-05-05 | 2006-11-16 | Valeant Research & Development | Phosphoramidate prodrugs for treatment of viral infection |
| RU2441869C2 (ru) | 2005-12-21 | 2012-02-10 | Эбботт Лэборетриз | Противовирусные соединения |
| HUP0600042A3 (en) | 2006-01-19 | 2012-12-28 | Debreceni Egyetem | New medical use of thiolated pyrimidine-mononucleotides and -nucleosides |
| US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| CN105693626A (zh) | 2007-09-17 | 2016-06-22 | 艾伯维巴哈马有限公司 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| CN102746239B (zh) | 2007-09-17 | 2016-02-10 | 艾伯维巴哈马有限公司 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| CN102264737A (zh) | 2008-12-23 | 2011-11-30 | 雅培制药有限公司 | 抗病毒化合物 |
| RU2552533C2 (ru) | 2009-03-25 | 2015-06-10 | Эббви Инк. | Противовирусные соединения и их применения |
| CN105924386A (zh) | 2009-03-25 | 2016-09-07 | Abbvie 公司 | 抗病毒化合物和其用途 |
| RU2541571C2 (ru) | 2009-04-15 | 2015-02-20 | Эббви Инк. | Противовирусные соединения |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| UA118080C2 (uk) | 2009-06-11 | 2018-11-26 | Еббві Айрленд Анлімітед Компані | Противірусні сполуки |
| US8232246B2 (en) | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
| AU2011224558B2 (en) | 2010-03-10 | 2014-02-27 | Abbvie Ireland Unlimited Company | Solid compositions |
| US8691775B2 (en) * | 2010-04-19 | 2014-04-08 | Back Bay Scientific, Llc | Use of drugs that activate P2Y receptors to enhance synaptogenesis |
| EP2576564A4 (en) | 2010-06-07 | 2014-01-22 | Abbvie Inc | MACROCYCLIC HEPATITIS C SERIN PROTEASE INHIBITORS |
| EP3056486B1 (en) | 2010-07-16 | 2018-07-11 | AbbVie Ireland Unlimited Company | Process for preparing intermediates for antiviral compounds |
| EA025341B1 (ru) | 2010-09-22 | 2016-12-30 | Алиос Биофарма, Инк. | Замещенные аналоги нуклеотидов |
| TWI451439B (zh) | 2010-12-10 | 2014-09-01 | Phison Electronics Corp | 記憶體儲存裝置、其記憶體控制器與資料寫入方法 |
| CN103384664A (zh) | 2010-12-16 | 2013-11-06 | Abbvie公司 | 抗病毒化合物 |
| EP2651885A1 (en) | 2010-12-16 | 2013-10-23 | Abbvie Inc. | Anti-viral compounds |
| CN103649079B (zh) | 2010-12-22 | 2016-11-16 | Abbvie公司 | 丙型肝炎抑制剂及其用途 |
| US8951964B2 (en) | 2010-12-30 | 2015-02-10 | Abbvie Inc. | Phenanthridine macrocyclic hepatitis C serine protease inhibitors |
| EP3384938A1 (en) | 2011-09-12 | 2018-10-10 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3043803B1 (en) * | 2013-09-11 | 2022-04-27 | Emory University | Nucleotide and nucleoside compositions and their uses |
| SG10202013032YA (en) * | 2014-12-15 | 2021-02-25 | Univ Emory | Phosphoramidates for the treatment of hepatitis b virus |
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- 2014-09-10 EP EP14844012.6A patent/EP3043803B1/en active Active
- 2014-09-10 PL PL14844012.6T patent/PL3043803T3/pl unknown
- 2014-09-10 DK DK14844012.6T patent/DK3043803T3/da active
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- 2014-09-10 US US14/917,681 patent/US10149859B2/en active Active
- 2014-09-10 TW TW103131136A patent/TW201542581A/zh unknown
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- 2014-09-10 HR HRP20220911TT patent/HRP20220911T1/hr unknown
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- 2014-09-10 WO PCT/US2014/054930 patent/WO2015038596A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3043803B1 (en) | 2022-04-27 |
| US20160220595A1 (en) | 2016-08-04 |
| TW201542581A (zh) | 2015-11-16 |
| US20190298750A1 (en) | 2019-10-03 |
| LT3043803T (lt) | 2022-08-10 |
| JP7045411B2 (ja) | 2022-03-31 |
| US20240173345A1 (en) | 2024-05-30 |
| US20220296626A1 (en) | 2022-09-22 |
| HRP20220911T1 (hr) | 2022-10-28 |
| JP2024123107A (ja) | 2024-09-10 |
| US11857560B2 (en) | 2024-01-02 |
| JP2016530313A (ja) | 2016-09-29 |
| EP3043803A4 (en) | 2017-03-29 |
| WO2015038596A1 (en) | 2015-03-19 |
| DK3043803T3 (da) | 2022-08-01 |
| US20260053838A1 (en) | 2026-02-26 |
| JP2020143073A (ja) | 2020-09-10 |
| UY35732A (es) | 2015-06-30 |
| SI3043803T1 (sl) | 2022-09-30 |
| JP7508501B2 (ja) | 2024-07-01 |
| US10149859B2 (en) | 2018-12-11 |
| EP3043803A1 (en) | 2016-07-20 |
| ES2927955T3 (es) | 2022-11-14 |
| US12414961B2 (en) | 2025-09-16 |
| JP6762873B2 (ja) | 2020-09-30 |
| JP2022081641A (ja) | 2022-05-31 |
| EP4094767A1 (en) | 2022-11-30 |
| US11166973B2 (en) | 2021-11-09 |
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