JP2015529652A5 - - Google Patents
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- Publication number
- JP2015529652A5 JP2015529652A5 JP2015524600A JP2015524600A JP2015529652A5 JP 2015529652 A5 JP2015529652 A5 JP 2015529652A5 JP 2015524600 A JP2015524600 A JP 2015524600A JP 2015524600 A JP2015524600 A JP 2015524600A JP 2015529652 A5 JP2015529652 A5 JP 2015529652A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- aryl
- deuterium
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCC(**1)=C(*2**(C)CCC(C)CCC3**CC2)C3=C1C(C)C(C)C Chemical compound CCC(**1)=C(*2**(C)CCC(C)CCC3**CC2)C3=C1C(C)C(C)C 0.000 description 5
- YIINKKNBXUALQJ-CPPUAGTESA-N CC(C)[C@@H](C(N(CCC1)C1c1ncc(-c(c2c3C4NC2CC(C)C4)ccc3-c(cc2)ccc2-c(cc2)cc3c2nc(C(CCC2)N2C([C@H](C(C)C)NC(OC)=O)=O)[nH]3)[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)C1c1ncc(-c(c2c3C4NC2CC(C)C4)ccc3-c(cc2)ccc2-c(cc2)cc3c2nc(C(CCC2)N2C([C@H](C(C)C)NC(OC)=O)=O)[nH]3)[nH]1)=O)NC(OC)=O YIINKKNBXUALQJ-CPPUAGTESA-N 0.000 description 1
- LQKWQBFFAXGZOK-WPZYDENFSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1ncc(-c(cc2)c(C(C3)N4C3(C)CC43)c3c2-c(cc2)ccc2-c2cnc([C@H](CC3(C4)OCCO3)N4C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1ncc(-c(cc2)c(C(C3)N4C3(C)CC43)c3c2-c(cc2)ccc2-c2cnc([C@H](CC3(C4)OCCO3)N4C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O LQKWQBFFAXGZOK-WPZYDENFSA-N 0.000 description 1
- JWJIPZPFNNVDPQ-BSDZSUBPSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1ncc(-c(cc2)cc(cc3)c2cc3-c(cc2)c(C3N(C4C5)C5(C)C3)c4c2-c2cnc([C@H](CCC3)N3C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1ncc(-c(cc2)cc(cc3)c2cc3-c(cc2)c(C3N(C4C5)C5(C)C3)c4c2-c2cnc([C@H](CCC3)N3C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O JWJIPZPFNNVDPQ-BSDZSUBPSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210273491 | 2012-08-03 | ||
| CN201210273491.8 | 2012-08-03 | ||
| CN201310116933 | 2013-04-03 | ||
| CN201310116933.2 | 2013-04-03 | ||
| PCT/CN2013/000915 WO2014019344A1 (en) | 2012-08-03 | 2013-08-05 | Bridged ring compounds as hepatitis c virus (hcv) inhibitors and pharmaceutical applications thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015529652A JP2015529652A (ja) | 2015-10-08 |
| JP2015529652A5 true JP2015529652A5 (enExample) | 2016-09-23 |
Family
ID=50027184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524600A Pending JP2015529652A (ja) | 2012-08-03 | 2013-08-05 | Ｃ型肝炎阻害剤である架橋環化合物及びその医薬品への応用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9309231B2 (enExample) |
| EP (1) | EP2880030B1 (enExample) |
| JP (1) | JP2015529652A (enExample) |
| KR (1) | KR20150039200A (enExample) |
| CN (1) | CN103570693B (enExample) |
| AU (1) | AU2013299246B2 (enExample) |
| BR (1) | BR112015000420A2 (enExample) |
| CA (1) | CA2872118A1 (enExample) |
| MX (1) | MX2015001571A (enExample) |
| MY (1) | MY187617A (enExample) |
| RU (1) | RU2015107043A (enExample) |
| SG (1) | SG11201406824XA (enExample) |
| TW (1) | TWI610916B (enExample) |
| WO (1) | WO2014019344A1 (enExample) |
| ZA (1) | ZA201407779B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201412709A (zh) * | 2012-09-28 | 2014-04-01 | Sunshine Lake Pharma Co Ltd | 作為丙型肝炎抑制劑的螺環化合物及其在藥物中的應用 |
| EA025560B1 (ru) | 2012-10-19 | 2017-01-30 | Бристол-Майерс Сквибб Компани | Ингибиторы вируса гепатита с |
| US9334279B2 (en) | 2012-11-02 | 2016-05-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2914613B1 (en) | 2012-11-02 | 2017-11-22 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9409943B2 (en) | 2012-11-05 | 2016-08-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP6342922B2 (ja) | 2013-03-07 | 2018-06-13 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｃ型肝炎ウイルス阻害剤 |
| WO2015077572A1 (en) | 2013-11-22 | 2015-05-28 | CL BioSciences LLC | Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis |
| WO2015110048A1 (en) * | 2014-01-23 | 2015-07-30 | Sunshine Lake Pharma Co., Ltd. | Bridged ring compounds as hepatitis c virus inhibitors, pharmaceutical compositions and uses thereof |
| CN107954997A (zh) * | 2014-02-21 | 2018-04-24 | 常州寅盛药业有限公司 | 作为丙肝病毒抑制剂的联环化合物 |
| CN105384792B (zh) * | 2014-08-23 | 2020-12-22 | 广东东阳光药业有限公司 | 作为丙型肝炎抑制剂的化合物及其在药物中的应用 |
| US9675632B2 (en) | 2014-08-26 | 2017-06-13 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| CN105693700B (zh) * | 2014-12-16 | 2019-01-04 | 广东东阳光药业有限公司 | 作为丙型肝炎抑制剂的桥环化合物及其制备方法 |
| WO2016141890A1 (en) * | 2015-03-12 | 2016-09-15 | Sunshine Lake Pharma Co., Ltd. | Compounds as hepatitis c virus inhibitors and pharmaceutical uses thereof |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| WO2017037616A1 (en) | 2015-08-31 | 2017-03-09 | Lupin Limited | Arylalkylamine compounds as calcium sensing receptor modulators |
| RU2019130048A (ru) * | 2017-03-02 | 2021-04-02 | Вокхардт Лимитед | Антибактериальные соединения |
| EP3706740A4 (en) * | 2017-11-06 | 2021-07-28 | Suzhou Pengxu Pharmatech Co., Ltd. | METHOD FOR MANUFACTURING ACALABRUTINIB |
| US11634389B2 (en) | 2018-11-28 | 2023-04-25 | The Regents Of The University Of Michigan | Succinate dehydrogenase inhibitors and methods of making and using the same |
| WO2020234103A1 (en) | 2019-05-21 | 2020-11-26 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
| CN111118073B (zh) * | 2019-12-27 | 2022-02-15 | 宜昌东阳光生化制药有限公司 | 酶法合成依米他韦中间体的方法 |
| WO2021138315A1 (en) * | 2020-01-03 | 2021-07-08 | Blue Oak Pharmaceuticals, Inc. | Compounds and compositions for treating cns disorders |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| GB202013383D0 (en) * | 2020-08-26 | 2020-10-07 | Givaudan Sa | Process |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3019259A (en) * | 1959-11-02 | 1962-01-30 | Dow Chemical Co | 1, 4-dihydro-1, 4-methanonaphthalene-5, 8-diamine |
| US3268581A (en) * | 1964-05-08 | 1966-08-23 | Dow Chemical Co | Anthraquinone dialkanesulfonimide |
| US3493616A (en) * | 1967-02-27 | 1970-02-03 | Universal Oil Prod Co | Hydroxy and/or hydrocarbyloxy and amino-alkano-tetrahydronaphthalenes |
| US3835104A (en) * | 1968-09-05 | 1974-09-10 | Snam Progetti | Curable,amorphous,olefinic terpolymers from alphamono olefins and polyenes |
| US4009200A (en) * | 1973-02-02 | 1977-02-22 | Uniroyal, Inc. | Hexahalo-1,4-dihydro-1,4-methano-napth-5,8-ylene acetates |
| JPS60152435A (ja) * | 1984-01-20 | 1985-08-10 | Dainippon Ink & Chem Inc | ２，３−ジアセチルノルボルナジエンとその製造法 |
| US7291689B1 (en) * | 2006-05-01 | 2007-11-06 | Seoul National University Industry Foundation | Thermally stable low dielectric norbornene polymers with improved solubility and adhesion property |
| US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8303944B2 (en) | 2006-08-11 | 2012-11-06 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7704992B2 (en) | 2008-02-13 | 2010-04-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2750577A1 (en) | 2008-12-03 | 2010-06-10 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| WO2010065674A1 (en) | 2008-12-03 | 2010-06-10 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| EP2393359A4 (en) * | 2009-02-09 | 2012-10-03 | Enanta Pharm Inc | COMPOUND DIBENZIMIDAZOLE DERIVATIVES |
| US8314135B2 (en) | 2009-02-09 | 2012-11-20 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole antivirals |
| US8637561B2 (en) | 2009-02-17 | 2014-01-28 | Enanta Pharmaceuticals, Inc. | Linked diimidazole derivatives |
| RU2544010C2 (ru) * | 2009-02-27 | 2015-03-10 | Энанта Фармасьютикалс, Инк. | Ингибиторы вируса гепатита с |
| US8709999B2 (en) | 2009-03-27 | 2014-04-29 | Presidio Pharmaceuticals, Inc. | Substituted bicyclic HCV inhibitors |
| SG174883A1 (en) | 2009-03-27 | 2011-11-28 | Presidio Pharmaceuticals Inc | Fused ring inhibitors of hepatitis c |
| DK2410844T3 (en) | 2009-03-27 | 2016-07-04 | Merck Sharp & Dohme | Inhibitors of hepatitis C virus replication |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2430015B1 (en) | 2009-05-12 | 2015-06-17 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds useful for the treatment of viral diseases |
| HUE030465T2 (hu) * | 2009-05-13 | 2017-05-29 | Antivirális vegyületek | |
| AU2010250789B2 (en) | 2009-05-18 | 2015-05-14 | Actelion Pharmaceuticals Ltd | Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists |
| EP2435421A1 (en) * | 2009-05-29 | 2012-04-04 | Schering Corporation | Antiviral compounds composed of three aligned aryl moieties to treat diseases such as hepatitis c |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US8221737B2 (en) * | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| WO2011004276A1 (en) | 2009-07-06 | 2011-01-13 | Pfizer Limited | Hepatitis c virus inhibitors |
| AU2010274001A1 (en) | 2009-07-16 | 2012-02-23 | Vertex Pharmaceuticals Incorporated | Benzimidazole analogues for the treatment or prevention of Flavivirus infections |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| EP2503881B1 (en) | 2009-11-25 | 2015-05-13 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
| MX2012006877A (es) | 2009-12-18 | 2012-08-31 | Idenix Pharmaceuticals Inc | Inhibidores de virus de hepatitis c de arileno o heteroarileno 5, 5 - fusionado. |
| AU2010341537A1 (en) | 2009-12-22 | 2012-08-09 | Merck Sharp & Dohme Corp. | Fused Tricyclic Compounds and methods of use thereof for the treatment of viral diseases |
| MX2012007420A (es) | 2009-12-24 | 2012-07-23 | Vertex Pharma | Analogos para el tratamiento o prevencion de infecciones de flavivirus. |
| AU2011232348A1 (en) | 2010-03-24 | 2012-10-11 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of Flavivirus infections |
| CN102869657A (zh) | 2010-03-24 | 2013-01-09 | 沃泰克斯药物股份有限公司 | 用于治疗或预防黄病毒感染的类似物 |
| US20110312996A1 (en) | 2010-05-17 | 2011-12-22 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| WO2011149856A1 (en) | 2010-05-24 | 2011-12-01 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| AR081848A1 (es) | 2010-06-09 | 2012-10-24 | Presidio Pharmaceuticals Inc | Inhibidores de la proteina ns5a del vhc |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| WO2012003642A1 (en) | 2010-07-09 | 2012-01-12 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds and use thereof for treating viral diseases |
| CN103180310B (zh) | 2010-07-26 | 2015-11-25 | 爱尔兰詹森科学公司 | 作为hcv抑制剂的杂二环衍生物 |
| AU2011286276A1 (en) | 2010-07-26 | 2013-01-24 | Merck Sharp & Dohme Corp. | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
| RS55186B1 (sr) * | 2010-07-29 | 2017-01-31 | Astellas Pharma Inc | Kondenzovana jedinjenja piridina kao ligandi cb2 kanabinoidnog receptora |
| US20120195857A1 (en) | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| AR082619A1 (es) | 2010-08-13 | 2012-12-19 | Hoffmann La Roche | Inhibidores del virus de la hepatitis c |
| WO2012041227A1 (en) | 2010-09-29 | 2012-04-05 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds for treating hepatitis c viral infection |
| WO2012050918A2 (en) | 2010-09-29 | 2012-04-19 | Presidio Pharmaceutical, Inc. | Tricyclic fused ring inhibitors of hepatitis c |
| JP2013540122A (ja) | 2010-09-29 | 2013-10-31 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合四環式化合物誘導体およびウィルス疾患治療のためのそれの使用方法 |
| WO2012040923A1 (en) | 2010-09-29 | 2012-04-05 | Merck Sharp & Dohme Corp. | Tetracyclic indole derivatives and methods of use thereof for the treatment of viral diseases |
| EP2621931A4 (en) | 2010-09-29 | 2014-03-19 | Merck Sharp & Dohme | TETRAZYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTIONS |
| WO2012040924A1 (en) | 2010-09-29 | 2012-04-05 | Merck Sharp & Dohme Corp. | Fused tetracyclic heterocycle compounds and methods of use thereof for treatment of viral diseases |
| EP2651926A4 (en) | 2010-12-15 | 2014-07-09 | Abbvie Inc | ANTI-VIRAL COMPOUNDS |
| WO2012083048A2 (en) | 2010-12-15 | 2012-06-21 | Abbott Laboratories | Anti-viral compounds |
| WO2012083164A1 (en) | 2010-12-16 | 2012-06-21 | Abbott Laboratories | Anti-viral compounds |
| WO2012122716A1 (en) | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Tetracyclic xanthene derivatives and methods of use thereof for treatment of viral diseases |
| CA2841095A1 (en) * | 2011-07-09 | 2013-01-17 | Sunshine Lake Pharma Co., Ltd. | Spiro compounds as hepatitis c virus inhibitors |
| SG10201606446XA (en) | 2011-08-08 | 2016-09-29 | Lupin Ltd | Antiviral compounds with a fused tricyclic ring |
| US8889726B2 (en) | 2011-08-08 | 2014-11-18 | Glaxosmithkline Llc | Chemica compounds |
-
2013
- 2013-08-02 TW TW102127866A patent/TWI610916B/zh active
- 2013-08-05 MY MYPI2014703257A patent/MY187617A/en unknown
- 2013-08-05 CA CA2872118A patent/CA2872118A1/en not_active Abandoned
- 2013-08-05 SG SG11201406824XA patent/SG11201406824XA/en unknown
- 2013-08-05 KR KR20157002654A patent/KR20150039200A/ko not_active Withdrawn
- 2013-08-05 WO PCT/CN2013/000915 patent/WO2014019344A1/en not_active Ceased
- 2013-08-05 CN CN201310337556.5A patent/CN103570693B/zh active Active
- 2013-08-05 US US14/397,200 patent/US9309231B2/en not_active Expired - Fee Related
- 2013-08-05 MX MX2015001571A patent/MX2015001571A/es unknown
- 2013-08-05 AU AU2013299246A patent/AU2013299246B2/en not_active Ceased
- 2013-08-05 RU RU2015107043A patent/RU2015107043A/ru not_active Application Discontinuation
- 2013-08-05 BR BR112015000420A patent/BR112015000420A2/pt not_active IP Right Cessation
- 2013-08-05 EP EP13824843.0A patent/EP2880030B1/en not_active Not-in-force
- 2013-08-05 JP JP2015524600A patent/JP2015529652A/ja active Pending
-
2014
- 2014-10-24 ZA ZA2014/07779A patent/ZA201407779B/en unknown
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