HRP20141241T1 - Spoj benzamida supstituiran izoksazolinom i sredstvo za suzbijanje štetnih organizama - Google Patents
Spoj benzamida supstituiran izoksazolinom i sredstvo za suzbijanje štetnih organizama Download PDFInfo
- Publication number
- HRP20141241T1 HRP20141241T1 HRP20141241TT HRP20141241T HRP20141241T1 HR P20141241 T1 HRP20141241 T1 HR P20141241T1 HR P20141241T T HRP20141241T T HR P20141241TT HR P20141241 T HRP20141241 T HR P20141241T HR P20141241 T1 HRP20141241 T1 HR P20141241T1
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- Croatia
- Prior art keywords
- alkyl
- phenyl
- substituted
- atom
- haloalkyl
- Prior art date
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- -1 Isoxazoline-substituted benzamide compound Chemical class 0.000 title claims 54
- 230000001473 noxious effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 153
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 137
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 63
- 125000000304 alkynyl group Chemical group 0.000 claims 56
- 125000002947 alkylene group Chemical group 0.000 claims 54
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 53
- 125000003342 alkenyl group Chemical group 0.000 claims 50
- 125000005843 halogen group Chemical group 0.000 claims 47
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 39
- 125000004093 cyano group Chemical group *C#N 0.000 claims 35
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 33
- 230000015572 biosynthetic process Effects 0.000 claims 32
- 125000005347 halocycloalkyl group Chemical group 0.000 claims 32
- 229910052757 nitrogen Inorganic materials 0.000 claims 32
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 27
- 125000004430 oxygen atom Chemical group O* 0.000 claims 25
- 125000004432 carbon atom Chemical group C* 0.000 claims 24
- 125000004434 sulfur atom Chemical group 0.000 claims 23
- RBIIKVXVYVANCQ-CUWPLCDZSA-N (2s,4s,5s)-5-amino-n-(3-amino-2,2-dimethyl-3-oxopropyl)-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-2-propan-2-ylhexanamide Chemical group C1C(C)(C)N(C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)CC(=O)N1C1=CC=CC=C1Cl RBIIKVXVYVANCQ-CUWPLCDZSA-N 0.000 claims 22
- 229910052717 sulfur Inorganic materials 0.000 claims 22
- 125000000262 haloalkenyl group Chemical group 0.000 claims 21
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 20
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 17
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 17
- 101100294104 Caenorhabditis elegans nhr-34 gene Proteins 0.000 claims 17
- 101100240516 Caenorhabditis elegans nhr-10 gene Proteins 0.000 claims 16
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 16
- 229910052799 carbon Inorganic materials 0.000 claims 15
- 125000000232 haloalkynyl group Chemical group 0.000 claims 15
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 14
- 125000004741 (C1-C6) haloalkylsulfonyl group Chemical group 0.000 claims 14
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 14
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 12
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 125000006771 (C1-C6) haloalkylthio group Chemical group 0.000 claims 11
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 11
- RFEJUZJILGIRHQ-XRIOVQLTSA-N 2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C(O)C(O)C(O)=O.OC(=O)C(O)C(O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-XRIOVQLTSA-N 0.000 claims 10
- 101100365011 Arabidopsis thaliana SCL33 gene Proteins 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 10
- 239000013057 ectoparasiticide Substances 0.000 claims 10
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 9
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 9
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 8
- 101100451196 Caenorhabditis elegans hizr-1 gene Proteins 0.000 claims 8
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 7
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 7
- 125000001188 haloalkyl group Chemical group 0.000 claims 7
- 125000003971 isoxazolinyl group Chemical group 0.000 claims 7
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 6
- 125000000464 thioxo group Chemical group S=* 0.000 claims 6
- LFMFPKKYRXFHHZ-UHFFFAOYSA-N R24 Chemical group C1=C(Cl)C(C)=CC=C1NC1=NC(N)=C(C=CC=C2)C2=N1 LFMFPKKYRXFHHZ-UHFFFAOYSA-N 0.000 claims 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 4
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 4
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 4
- 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 claims 4
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 4
- 101150065749 Churc1 gene Proteins 0.000 claims 4
- 102100038239 Protein Churchill Human genes 0.000 claims 4
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000004641 (C1-C12) haloalkyl group Chemical group 0.000 claims 3
- 125000004749 (C1-C6) haloalkylsulfinyl group Chemical group 0.000 claims 3
- RFEBDZANCVHDLP-UHFFFAOYSA-N 3-[(4-cyanophenyl)methylamino]-6-(trifluoromethyl)quinoxaline-2-carboxylic acid Chemical compound OC(=O)C1=NC2=CC=C(C(F)(F)F)C=C2N=C1NCC1=CC=C(C#N)C=C1 RFEBDZANCVHDLP-UHFFFAOYSA-N 0.000 claims 3
- KYMQCBPHCXAPDE-UHFFFAOYSA-N 90594-15-3 Chemical compound N1=C2C=CC=CN2C2=C1C(C)=C(NO)C=N2 KYMQCBPHCXAPDE-UHFFFAOYSA-N 0.000 claims 3
- 101100478290 Arabidopsis thaliana SR30 gene Proteins 0.000 claims 3
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 claims 3
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 3
- 125000004692 haloalkylcarbonyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 2
- 125000004844 (C1-C6) alkoxyimino group Chemical group 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 2
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims 2
- 125000006772 (C1-C6) haloalkylsulfonyloxy group Chemical group 0.000 claims 2
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 claims 2
- 241000258242 Siphonaptera Species 0.000 claims 2
- 101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- NFGODEMQGQNUKK-UHFFFAOYSA-M [6-(diethylamino)-9-(2-octadecoxycarbonylphenyl)xanthen-3-ylidene]-diethylazanium;chloride Chemical group [Cl-].CCCCCCCCCCCCCCCCCCOC(=O)C1=CC=CC=C1C1=C2C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C21 NFGODEMQGQNUKK-UHFFFAOYSA-M 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 125000004685 alkoxythiocarbonyl group Chemical group 0.000 claims 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 2
- 125000005277 alkyl imino group Chemical group 0.000 claims 2
- 125000001118 alkylidene group Chemical group 0.000 claims 2
- JYNZIOFUHBJABQ-UHFFFAOYSA-N allyl-{6-[3-(4-bromo-phenyl)-benzofuran-6-yloxy]-hexyl-}-methyl-amin Chemical group C=1OC2=CC(OCCCCCCN(C)CC=C)=CC=C2C=1C1=CC=C(Br)C=C1 JYNZIOFUHBJABQ-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- SYGWYBOJXOGMRU-UHFFFAOYSA-N chembl233051 Chemical compound C1=CC=C2C3=CC(C(N(CCN(C)C)C4=O)=O)=C5C4=CC=CC5=C3SC2=C1 SYGWYBOJXOGMRU-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims 2
- 125000004995 haloalkylthio group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000006678 phenoxycarbonyl group Chemical group 0.000 claims 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 2
- 125000001863 phosphorothioyl group Chemical group *P(*)(*)=S 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 1
- 125000004750 (C1-C6) alkylaminosulfonyl group Chemical group 0.000 claims 1
- MALIONKMKPITBV-UHFFFAOYSA-N 2-(3-chloro-4-hydroxyphenyl)-n-[2-(4-sulfamoylphenyl)ethyl]acetamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1CCNC(=O)CC1=CC=C(O)C(Cl)=C1 MALIONKMKPITBV-UHFFFAOYSA-N 0.000 claims 1
- 241000238679 Amblyomma Species 0.000 claims 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 claims 1
- 241000282465 Canis Species 0.000 claims 1
- 241001480824 Dermacentor Species 0.000 claims 1
- 241001549209 Echidnophaga gallinacea Species 0.000 claims 1
- 241000282324 Felis Species 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 241001423309 Haemaphysalis campanulata Species 0.000 claims 1
- 241001053172 Haemaphysalis flava Species 0.000 claims 1
- 241000179420 Haemaphysalis longicornis Species 0.000 claims 1
- 241001480847 Ixodes persulcatus Species 0.000 claims 1
- 241000604373 Ovatus Species 0.000 claims 1
- 241000718000 Pulex irritans Species 0.000 claims 1
- 241000238680 Rhipicephalus microplus Species 0.000 claims 1
- 241001481696 Rhipicephalus sanguineus Species 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 241000353223 Xenopsylla cheopis Species 0.000 claims 1
- 230000000895 acaricidal effect Effects 0.000 claims 1
- 239000000642 acaricide Substances 0.000 claims 1
- 239000012872 agrochemical composition Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 238000003287 bathing Methods 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004965 chloroalkyl group Chemical group 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 125000003963 dichloro group Chemical group Cl* 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 238000007598 dipping method Methods 0.000 claims 1
- 238000010410 dusting Methods 0.000 claims 1
- MLBZKOGAMRTSKP-UHFFFAOYSA-N fluralaner Chemical compound C1=C(C(=O)NCC(=O)NCC(F)(F)F)C(C)=CC(C=2CC(ON=2)(C=2C=C(Cl)C=C(Cl)C=2)C(F)(F)F)=C1 MLBZKOGAMRTSKP-UHFFFAOYSA-N 0.000 claims 1
- 108700039708 galantide Proteins 0.000 claims 1
- 125000004993 haloalkoxycarbonyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000002917 insecticide Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 239000007928 intraperitoneal injection Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical group [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 230000000361 pesticidal effect Effects 0.000 claims 1
- 125000003884 phenylalkyl group Chemical group 0.000 claims 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 1
- 238000010079 rubber tapping Methods 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/04—Amoebicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
- C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/02—Monocyclic aromatic halogenated hydrocarbons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/02—Monocyclic aromatic halogenated hydrocarbons
- C07C25/06—Monochloro-benzene
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/02—Monocyclic aromatic halogenated hydrocarbons
- C07C25/08—Dichloro-benzenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/02—Monocyclic aromatic halogenated hydrocarbons
- C07C25/13—Monocyclic aromatic halogenated hydrocarbons containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/24—Halogenated aromatic hydrocarbons with unsaturated side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
- C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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Claims (20)
1. Spoj benzamida supstituiran izoksazolinom, naznačen time, da ima formula (1) ili njegova sol:
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u kojoj su A1, A2 i A3 međusobno neovisno atom ugljika ili atom dušika,
G je benzen-prsten, 6-člani aromatski heterociklički prsten koji sadrži dušik, furan- prsten, tiofen-prsten, ili 5-člani aromatski heterociklički prsten koji sadrži dva ili više heteroatoma odabrana od atoma kiska, atoma sumpora i atoma dušika, W je atom kisika ili atom sumpora,
X je atom halogena, cijano, nitro, azido, -SCN, -SF5, C1-C6alkil, C1-C6alkil po izboru supstituiran s R4, C3-C8cikloalkil, C3-C8cikloalkil po izboru supstituiran s R4, C2-C6alkenil, C2-C6alkenil po izboru supstituiran s R4, C3-C8 cikloalkenil, C3-C8halocikloalkenil, C1-C6 alkinil, C2-C6 alkinil po izboru supstituiran s R4, -OH, -OR5, -OSO2R5, -SH, -S(O)rR5, -N CHOR8, -N=C(R9)OR8, -CHO, -C(O)R9, -C(O)OR9, -C(O)SR9, -C(O)NHR10, -C(O)N(R10)R9, -C(S)OR8, -C(S)SR9, -C(S)NHR10, -C(S)N(R10)R9, -CH=NOR11, -C(R9)=OR11,S(O)2OR9,
-S(O),NHR10, -S(O)2N(R10)R9, -Si(R13)(R14)R12, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49, kada m je 2, 3, 4 ili 5, svaki X može biti isti ili različit jedan od drugoga, nadalje, kada su dva od X susjedna, susjedna dva X mogu tvoriti 5-člani ili 6-člani prsten zajedno s atomima ugljika na koje su ta dva X vezana putem tvorbe sljedećih: -CH2CH2CH2-, -CH2CH2O-, -CH2OCH2-, -OCH2O-, -CH2CH2S-, -CH2SCH2-, -CH2CH2N(R15)-, -CH2N(R15)CH2-,-CH2CH2CH2CH2-, -CH2CH2CH2O-, -CH2CH2OCH2-, -CH2OCH2O-, -OCH2CH2O-, -OCH2CH2S-, -CH2CH=CH-, -OCH=CH-, -SCH=CH-, -N(R15)CH=CH-, -OCH=N-, -SCH=N-, -N(R15)CH=N-, -N(R15)N=CH-, -CH=CHCH=CH-, -OCH2CH=CH-, -N=CHCH=CH-, -N=CHCH=N- ili -N=CHN=CH-, i u tom slučaju, atomi vodika koji su vezani na svaki atom ugljika koji tvori prsten, mogu po izboru biti supstituirani s Z,
nadalje kada su atomi vodika supstituirani s dva ili više od Z u isto vrijeme, tada svaki Z može biti isti ili različit jedan od drugoga,
Y je atom halogena, cijano, nitro, azido, -SCN, -SF5, C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R4, C3-C8 cikloalkil, C3-C8 cikloalkil po izboru supstituiran s R4, -OH, -OR5, -OSO2R5, -SH, -S(O)rR5, -NHR7, -N(R7)R6, -N=CHOR8, -N=C(R9)OR8, -C(O)NHR10, -C(O)N(R10)R9, -C(S)NHR10, -C(S)N(R10)R9, -Si(R13)(R10)R12, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49, kada n je 2, 3 ili 4, svaki Y može biti isti ili različit jedan od drugoga,
nadalje, kada su dva od Y susjedni, susjedna dva Y mogu tvoriti 5-člani ili 6-člani prsten zajedno s atomima ugljika na koje su ta dva Y vezana putem tvorbe sljedećih:
-CH2CH2CH2-, -CH2CH2O-, -CH2OCH2-, -OCH2O-, -CH2CH2S-, -CH2SCH2-, -SCH2S-, -CH2CH2CH2CH2-, -CH2CH2CH2O-, -CH2CH2OCH2-, -CH2OCH2O-, -OCH2CH2O-, -OCH2CH2S-, -SCH2CH2S-, -OCH=N- ili -SCH=N-, i u tom slučaju, atomi vodika koji su vezani 11a svaki atom ugljika koji tvori prsten, mogu biti po izboru supstituirani sa Z,
nadalje, kada su atomi vodika supstituirani s dva ili više od Z u isto vrijeme, svaki Z može biti isti ili različit jedan od drugoga,
R1 i R2 međusobno neovisno su atom vodika, cijano, C1-C12 alkil, C1-C12alkil po izboru supstituiran s R16, C3-C12 cikloalkil, C3-C12cikloalkil po izboru supstituiran s R16, C3-C12alkenil, C3-C12 alkenil po izboru supstituiran s R16, C3-C12 cikloalkenil, C3-C12halocikloalkenil, C3-C12 alkinil, C3-C12 alkinil po izboru supstituiran s R16, -SR9, -S(O)2R9, -SN(R18)R17, -S(O)ZN(R10)R9, -OH, -OR19, -NHR20, -N(R20)R19, -N=CHR19b, -N=C(R19b)R19a, -C(O)R9, -C(O)OR9, -C(O)SR9, -C(O)N(R10)R9, -C(S)OR9, -C(S)SR9, -C(S)N(R10)R9, -C(=NR11)OR9, -C(=NR11)SR9, -C(=NR11)N(R10)R9, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-6 do D-13, D-15 do D-23, D-25 do D-37, D-39, D-40, D-42, D-45 do D-60, E-3 do E-9, E-23 do E-28, E-30, E-31, E-34 ili E-45, ili
R1 i R2 zajedno tvore =C(R2a)R1a, i dalje R1 i R2 zajedno mogu tvoriti 3-člani do 8-člani prsten zajedno s atomom dušika koji ih povezuje putem tvorbe C2-C7 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti po izboru supstituiran s atomom halogena, C1-C6 alkil, C1-C6haloalkil, C1-C6alkoksi-(C1-C6)alkil, C1-C6alkoksi, formil, C1-C6 alkilkarbonil, C1-C6haloalkilkarbonil ili C1-C6alkoksikarbonil,
R1a i R2a međusobno neovisno su C1-C12 alkil, C1-C12haloalkil, C3-C12 cikloalkil, C3-C12 alkenil, C3-C12 haloalkenil, C3-C12 alkinil, C3-C12haloalkinil, -SR9,-OR9, -N(R10)R9, fenil, fenil supstituiran s (Z)p1, ili
R1a i R2a zajedno mogu tvoriti 5-člani ili 6-člani prsten zajedno s atomom ugljika koji ih povezuje putem tvorbe C4 ili C5 alkilen-lanac, ili C4 ili C5 alkenilen-lanac, i u tom slučaju, alkilen-lanac i alkenilen-lanac mogu sadržavati jedan do tri atoma kisika, atoma sumpora ili atoma dušika, i mogu po izboru biti supstituirani s atomom halogena, C1-C6 alkil, C1-C6haloalkil, C1-C6 alkoksi, C1-C6haloalkoksi, C1-C6alkiltio ili C1-C6 haloalkiltio,
R3 je atom halogena, cijano, C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R4, C3-C8 cikloalkil, C3-C8 cikloalkil po izboru supstituiran s R4, C3-C6 alkenil, C2-C6 alkenil po izboru supstituiran s R4, C3-C6 alkinil, C2-C6 alkinil po izboru supstituiran s R4, -QR5, -S(O), R5, -N(R10)R9, -CHO, -C(O)R9, -C(O)OR9, -C(O)SR9, -C(O)NHR10, -C(O)N(R10)R9, -C(S)OR9, -C(S)SR9, -C(S)NHR10, -C(S)N(R10)R9, -CN=NOR11, -C(R9)=NOR11, -Si(R13)(R14)R12,-P(O)(OR21)2, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49, D-1 do D-60 su aromatski heterociklički prsteni sa sljedećim formulama, prema odnosnom redoslijedu:
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Z je atom halogena, cijano, nitro, C1-C6alkil, C1-C6haloalkil, C1-C4alkoksi-C1-C4alkil, C1-C4haloalkoksi-C1-C4 alkil, C1-C4alkiltio-C1-C4 alkil, C1-C4haloalkiltio-C1-C4 alkil, C1-C4alkilsulfinil-C1-C4alkil, C1-C4haloalkilsulflnil-C1-C4alkil, C1-C4alkilsulfonil-C1-C4 alkil, C1-C4 haloalkilsulfonil-C1-C4alkil, C3-C6 cikloalkil, C3-C6halocikloalkil,-OH, C1-C6alkoksi, C1-C6haloalkoksi, C1-C6alkilsulfoniloksi, C1-C6haloalkilsulfoniloksi, C1-C6alkiltio, C1-C6haloalkiltio, C1-C6alkilsulfinil, C1-C6haloalkilsulfmil, C1-C6alkilsulfonil, C1-C6haloalkilsulfonil, -NH2, C1-C6alkilamino, di(C1-C6alkil)amino, C1-C6alkoksikarbonil, C1-C6haloalkoksikarbonil, -C(O)NHO, C1-C6alkilaminokarbonil, di(C1-C6alkil)aminokarbonil, -C(S)NH2, -S(O)2NH2, C1-C6alkilaminosulfonil, di(C1-C6alkil)aminosulfonil, fenil ili fenil po izboru supstituiran s halogen atom, kada p1, p2, p3 ili p4 je cijeli broj 2 ili veći, a svaki Z može biti isti ili različit jedan od drugog,
nadalje, kada su dva Z susjedni, susjedna dva Z mogu tvoriti 5-člani ili 6-člani prsten zajedno s atomima ugljika na koje su vezana dva Z pomoću tvorbe -CH2CH2CH2-, -CH2CH2O-, -CH2OCH2-, -OCH2O-, -CH2CH2S-, -CH2SCH2-, -CH2CH2CH2CH2-, -CH2CH2CH2O-, -CH2CH2OCH2-, -CH2OCH2O-, -OCH2CH2O-, -CH2CH2CH2S-, -OCH2CH2S- ili -CH=CH-CH=CH-, u lom slučaju, atomi vodika koji su vezani na svaki atom ugljika tvore prsten koji može biti po izboru supstituiran s atomom halogena, C1-C4 alkil ili C1-C4haloalkil, te su E-1 do E-49 zasićeni heterociklički prsteni sljedećih formula, prema odnosnom redoslijedu:
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R4 je atom halogena, cijano, C3-C8 cikloalkil, C3-C8 halocikloalkil, -OH, -OR5, -SH, -S(O)rR6, -N(R10)R9, -N(R10)CHO, -N(R10)C(O)R9, -N(R10)C(O)OR9, -N(R10)C(O)SR9, -N(R10)C(S)OR9, -N(R10)C(S)SR9, -N(R10)S(O)2R9, -C(O)OR9, -C(O)N(R10)R9, -Si(R13)(R14)R12, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49,
R5 je C1-C6 alkil, C1-C6 alkil po izbom supstituiran s R24, C3-C8cikloalkil, C3-C8cikloalkil po izboru supstituiran s R24, C2-C6 alkenil, C1-C6 alkenil po izboru supstituiran s R24, C3-C8 cikloalkenil, C3-C8 halocikloalkenil, C3-C6 alkinil, C3-C6 alkinil po izboru supstituiran s R24, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-6 do D-13, D-15 do D-23, D-25 do D-35, D-39, D-40, D-42, D-45 do D-60, E-3 do E-9, E-23 do E-31, E-34 ili E-45,
R6 je C1-C6alkil, C1-C6haloalkil, C3-C6 cikloalkil- C1-C4 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4alkiltio-C1-C4 alkil, feniltio C1-C4 alkil, feniltio C1-C4alkil supstituiran s (Z)p1, cijano C1-C6 alkil, C1-C6 alkoksikarbonil-C1-C4alkil, C1-C6 alkilaminokarbonil-C1-C4 alkil, di(C1-C6 alkil)aminokarbonil-C1-C4 alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C1-C4 alkil supstituiran s bilo kojim od D-1 do D-60, C1-C4 alkil supstituiran s bilo kojim od E-1 do E-49, C3-C6cikloalkil, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, C3-C6haloalkinil, -OH, C1-C6alkilkarboniloksi, C1-C6 alkiltio, C1-C6haloalkiltio, feniltio, feniltio supstituiran s (Z)p1, -SN(R18)R17, -S(O)2R9, -S(O)2N(R10)R9, -CHO, -C(O)R9, -C(O)OR9, -C(O)SR9, -C(O)NHR10, -C(O)N(R10)R9, -C(S)OR9, -C(S)SR9, -C(S)NHR10, -C(S)N(R10)R9, -C(O)C(O)R9, -C(O)C(O)OR9, -P(O)(OR21)2 ili -P(S)(OR21),
R7 je atom vodika, C1-C6alkil, C1-C6haloalkil, C3-C8cikloalkil-C1-C6 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, C3-C8 cikloalkil, C3-C8 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, C3-C6haloalkinil, -CHO, C1-C6alkilkarbonil, C1-C6 haloalkilkarbonil ili C1-C6 alkoksikarbonil, ili
R7 zajedno s R6 mogu tvoriti 3-člani do 7-člani prsten s vezanjem atoma dušika putem tvorbe C2-C6 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti po izboru supstituiran s atomom halogena, C1-C6 alkil ili C1-C6 haloalkil,
R8 je C1-C6 alkil, C1-C6 haloalkil, C3-C6 alkenil, fenil ili fenil supstituiran s (Z)p1,
R9 je C1-C6alkil, C1-C6 haloalkil, C3-C6cikloalkil-C1-C4 alkil, C1-C6alkoksi-C1-C4 alkil, C1-C6haloalkoksi-C1-C4alkil, C1-C6alkiltio-C1-C4alkil, C1-C6 haloalkiltio-C1-C4 alkil, cijano C1-C6alkil, fenil C1-C4alkil, fenil C1-C4alkil supstituiran s (Z)p1, C1-C4alkil supstituiran s bilo kojim od D-1 do D-60, C1-C4 alkil supstituiran s bilo kojim od E-1 do E-49, C3-C8 cikloalkil, C3-C8 halocikloalkil, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, C3-C6haloalkinil, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49,
R10 je atom vodika, C1-C6 alkil, C1-C6haloalkil, C3-C6 cikloalkil-C1-C4 alkil, C1-C6alkoksi-C1-C4alkil, C1-C6alkiltio-C1-C4alkil, cijano C1-C8alkil, C3-C6alkenil ili C3-C6 alkinil,
R10 zajedno s R9 može tvoriti 3-člani do 7-člani prsten s atomom koji ih povezuje putem tvorbe C2-C6 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti po izboru supstituiran s atomom halogena, C1-C6 alkil, C1-C6alkoksi, formil, C1-C6alkilkarbonil ili C1-C6 alkoksikarbonil,
R11 je atom vodika, C1-C6 alkil, C1-C6 haloalkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C3-C6 alkenil, C3-C8haloalkenil, C3-C6 alkinil, C3-C6 haloalkinil, fenil ili fenil koji može biti supstituiran s (Z)p1,
R11 zajedno s R9 može tvoriti 5-člani do 7-člani prsten s atomom koji ih povezuje putem tvorbe C2-C4 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti po izboru supstituiran s atomom halogena ili C1-C6 alkil,
R12 je C1-C6 alkil, C1-C6 haloalkil, fenil ili fenil supstituiran s (Z)p1,
R13 i R14 su međusobno neovisno C1-C6 alkil ili C1-C6 haloalkil,
R15 je atom vodika, C1-C6alkil, C1-C6haloalkil, C1-C6alkoksikarbonil-C1-C4 alkil, C1-C6haloalkoksikarbonil-C1-C4 alkil, fenil C1-C4alkil, fenil C1-C4alkil supstituiran s (Z)p1, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6alkinil, C3-C6haloalkinil, C1-C6alkoksi, C1-C6alkoksikarbonil, C1-C6haloalkoksikarbonil, fenil ili fenil supstituiran s (Z)p1, nadalje, u slučaju kada je Z prisutan na susjednoj poziciji od R13, susjedni R15 i Z mogu tvoriti 6-člani prsten zajedno s atomom koji ih povezuje putem tvorbe sljedećih: -CH2CH2CH2CH2-, -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- ili -CH=CH-CH=N-, i u tom slučaju, atomi vodika koji su vezani na svaki atom ugljika koji tvori prsten, mogu biti supstituirani s atomom halogena, C1-C4alkil ili C1-C4haloalkil,
R16 je atom halogena, cijano, nitro, C3-C8 cikloalkil, C3-C8 halocikloalkil, -OR25, -N(R26)R25, -SH, -S(O)rR21, -SO2NHR29, -SO2N(R29)R28, -CHO, -C(O)R28, -C(O)OH, -C(O)OR28, -C(O)SR28, -C(O)NHR29, -C(O)N(R29)R28, -C(S)NHR29, -C(S)N(R29)R28, -C(O)C(O)OR28, -C(R31)=NOH, -C(R31)=NOR30,-C(=NR31)OR30, -C(=NR31)SR30, -C(=NR31)N(R29)R30, -C(=NOR31)NHR29, -C(=NOR31)N(R29)R30, -Si(R13)(R14)R12, -P(O)(OR21), -P(S)(OR21), -P(fenil)2, -P(O)(fenil)2, fenil ili fenil supstituiran s (Z)p1, a D-1 do D-60, E-1 do E-49 ili M-1 do M-22, M-1 do M-22 su djelomično zasićeni heterociklički prsteni sljedećih formula, prema odnosnom redoslijedu:
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R17 je C1-C12alkil, C1-C12haloalkil, C1-C12alkoksi-C1-C12alkil, cijano C1-C12 alkil, C1-C12alkoksikarbonil-C1-C12alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C3-C12 alkenil, C3-C12 haloalkenil, C3-C12 alkinil, C3-C12haloalkinil, C1-C12alkilkarbonil, C1-C12alkoksikarbonil, -C(O)ON=C(CH3)SCH3, -C(O)ON=C(SCH3)C(O)N(CH3)2, fenil ili fenil supstituiran s (Z)p1,
R18 je C1-C12alkil, C1-C12haloalkil, C1-C12alkoksi-C1-C12alkil, cijano C1-C12alkil, C1-C12alkoksikarbonil-C1-C12alkil, fenil C1-C4alkil, fenil C1-C4alkil supstituiran s(Z)p1, C3-C12 alkenil, C3-C12haloalkenil, C3-C12alkinil, C3-C12haloalkinil, fenil ili fenil supstituiran s (Z)p1, ili
R18 zajedno s R17 može tvoriti 5-člani do 8-člani prsten s atomom dušika koji ih povezuje putem tvorbe C4-C7 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika ili atom sumpora, i može biti po izboru supstituiran s C1-C4 alkil ili C1-C4 alkoksi,
R18 je atom vodika, C1-C6alkil, C1-C6alkil po izboru supstituiran s R16, C3-C8 cikloalkil,C3-C8halocikloalkil, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, C3-C6haloalkinil, -CHO, -C(O)R18, -C(O)OR28, -C(O)SR28, -C(O)NHR29, -C(O)N(R29)R28, -C(S)NHR29, -C(S)N(R29)R28, -S(O)2R28, -S(O)2NHR29, -S(O)2N(R29)R28, -P(O)(OR21)2, -P(S)(OR21)2, fenil, fenil supstituiran s (Z)p1, D-1 do D-13, D-15 do D-25, D-30 do D-37, D-39, D-40, D-42, D-45 do D-60, E-5, E-7, E-9, E-24, E-25, E-27, E-28, E-30 ili E-31,
R18a je C1-C6alkil, C1-C6 haloalkil, C1-C4alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, C1-C4alkilsulfonil-C1-C4alkil, C1-C4alkoksikarbonil-C1-C4alkil, fenil C1-C4alkil, fenil C1-C4 alkil supstituiran s (Ζ)ρ1, C3-C6 cikloalkil, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49,
R18b je atom vodika ili C1-C6 alkil, ili
R18a zajedno s R19b može tvoriti 4-člani do 6-člani prsten s atomom ugljika koji ih povezuje putem tvorbe C3-C5 alkilen-lanca, u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti po izboru supstituiran s C1-C6alkil, formil, C1-C6alkilkarbonil ili C1-C6alkoksikarbonil,
R20 je atom vodika, C1-C6 alkil, C1-C6haloalkil, C1-C4alkoksi-C1-C4 alkil, C1-C4haloalkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, C1-C4 haloalkiltio-C1-C4 alkil, C1-C4alkilsulfonil-C1-C4alkil, C1-C4haloalkilsulfonil-C1-C4alkil, cijano C1-C6alkil, C1-C4alkoksikarbonil-C1-C4alkil, C2-C6 alkenil, C1-C6 haloalkenil, C3-C6 alkinil, C3-C6haloalkinil, -C-HO, -C(O)R9, -C(O)OR9, -C(O)SR5, -C(S)OR9, -C(S)SR9, C1-C6 alkilsulfonil ili C1-C6haloalkilsulfonil,
R21 je C1-C6 alkil ili C1-C6 haloalkil,
R22 je atom halogena, cijano, C1-C6 alkil, C1-C6 haloalkil, hidroksi C1-C6 alkil, C1-C4alkoksi-C1-C4alkil, C1-C4alkoksikarbonil- C1-C4 alkil, C1-C6alkoksi, C1-C6alkiltio, C1-C6 alkilamino, di(C1-C4 alkil)amino, C1-C8 alkoksikarbonil, fenil ili fenil supstituiran s (Z)p1, kada je q1, q2, q3 ili q4 cijeli broj 2 ili veći, svaki R22 može biti isti ili različit jedan od drugoga,
nadalje, u slučaju kada su dva R22 prisutna na istom atomu ugljika, tada dva R22 zajedno mogu tvoriti okso, tiokso, imino, C1-C6 alkilimino, C1-C6 alkoksiimino ili C1-C6 alkiliden,
R23 je atom vodika, C1-C6 alkil, C1-C6 alkil supstituiran s R32, C3-C6 cikloalkil, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, -OH, benziloksi, -CHO, -C(O)R33, -C(O)OR33, -C(O)SR33, -C(O)NHR34, -C(O)N(R34)R33, -C(S)NHR34, -C(S)N(R34)R33, -S(O)2R33, -P(O)(OR21)2, -P(S)(OR21)2, fenil, fenil supstituiran s (Z)p1 ili D-5,
R24 je atom halogena, cijano, C3-C8 cikloalkil, C3-C8halocikloalkil, C1-C6 alkoksi, C1-C6haloalkoksi, C1-C6 alkiltio, C1-C6haloalkiltio, C1-C6alkilsulfonil, C1-C6haloalkilsulfonil, C1-C6 alkilamino, di(C1-C6alkil)amino, -CHO, C1-C6alkilkarbonil, C1-C6haloalkilkarbonil, C1-C6alkoksikarbonil, C1-C6haloalkoksikarbonil, -CH=NOR11, -C(R9)=NOR11, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49,
R25 je atom vodika, C1-C8 alkil, C1-C8 alkil po izboru supstituiran s R32, C3-C8 cikloalkil, C3-C8 cikloalkil po izboru supstituiran s R32, C3-C8 alkenil, C3-C8 alkenil po izboru supstituiran s R32, C3-C8 alkinil, C3-C8 alkinil po izboru supstituiran s R32, -CHO, -C(O)R33, -C(O)OR33, -C(O)SR33, -C(O)NHR34, -C(O)N(R34)R33, -C(O)C(O)R33, -C(O)C(O)OR33, -C(S)R33, -C(S)OR33, -C(S)SR33, -C(S)NHR34, -C(S)N(R34)R33, -S(O)2R33, -S(O)2N(R34)R33, -Si(R13)(R14)R12, -P(O)(OR21)2, -P(S)(OR21)2, fenil, fenil supstituiran s (Z)p1, D-1 do 0-4, D-6 do D-13, D-15 do D-23, D-25 do D-37, D-39, D-40, D-42, D-45 do D-60, E-3 do E-9, E-23 do E-31, E-34 ili E-45,
R28 je atom vodika, C1-C6 alkil, C1-C6 haloalkil, C1-C4 allcoksi- C1-C4 alkil, C1-C4alkiltio-C1-C4alkil, C3-C6cikloalkil, C3-C6alkenil, C3-C6alkinil ili C1-C6 alkoksi, ili
R26 zajedno s R25 može tvoriti 3-člani do 6-člani prsten s atomom dušika koji ih povezuje putem tvorbe C2-C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti supstituiran s atomom halogena, C1-C6 alkil, C1-C6 haloalkil, C1-C6 alkoksi, fenil, fenil supstituiran s (Z)p1, okso ili tiokso,
R27 je C1-C8 alkil, C1-C8 alkil po izboru supstituiran s R32, C3-C8 cikloalkil, C3-C8 cikloalkil po izboru supstituiran s R32 , C3-C8 alkenil, C3-C8 alkenil po izboru supstituiran s R32, C3-C8 alkinil, C3-C8 alkinil po izboru substituiran s R32, -SH, C1-C6 alkiltio, C1-C6haloalkiltio, feniltio, feniltio supstituiran s (Z)p1, -CHO, -C(O)R33, -C(O)OR33, -C(O)SR33, -C(O)NHR34, -C(O)N(R34)R33, -C(O)C(O)R33, -C(O)C(O)0R33, -C(S)R33, -C(S)OR33, -C(S)SR33, -C(S)NHR34, -C(S)N(R34)R33, -P(O)(OR21)2, -P(S)(OR21)2, fenil, fenil supstituiran s (Z)p1, D-18, D-21, D-25, D-30 do D-35, D-47, D-50, D-51, E-3 do E-9, E-23 do E-31, E-34 ili E-45,
R28 je C1-C6alkil, C1-C6 alkil po izboru supstituiran s R32, C3-C8 cikloalkil, C3-C8 cikloalkil po izboru supstituiran s R32, C2-C6alkenil-C3-C8 cikloalkil, C2-C6 haloalkenil-C3-C8 cikloalkil, C2-C8 alkenil, C2-C8 alkenil po izboru supstituiran s R32, C2-C6 alkinil, C2-C6 alkinil po izboru supstituiran s R32, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49,
R29 je atom vodika, C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R32, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, C3-C6 haloalkinil, fenil ili fenil supstituiran s (Z)p1, ili
R29 zajedno s R28 može tvoriti 3-člani do 6-člani prsten s atomom dušika koji ih povezuje putem tvorbe C2-C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti po izboru supstituiran s atomom halogena, C1-C6 alkil, C1-C6 alkoksi, formil, C1-C6alkilkarbonil, C1-C6alkoksikarbonil, fenil ili fenil supstituiran s (Z)p1,
R30 je C1-C8alkil, C1-C8 alkil po izboru supstituiran s R12, C3-C8 cikloalkil, C3-C8 alkenil, C3-C8 alkenil po izboru supstituiran s R32, C3-C8 alkinil, C3-C8 alkinil po izboru supstituiran s R32,
R31 je atom vodika, C1-C6 alkil, C1-C6 haloalkil, C3-C6cikloalkil-C1-C4alkil, C1-C6alkoksi-C1-C4 alkil, C1-C6 haloalkoksi- C1-C4alkil, C1-C6alkiltio-C1-C4alkil, C1-C6haloalkiltio-C1-C4alkil, C1-C6 alkiIsulfonil-C1-C4alkil, C1-C6haloalkilsulfonil-C1-C4 alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C3-C6 cikloalkil, fenil ili fenil supstituiran s (Z)p1, ili
R31 zajedno s R30 može tvoriti 5-člani do 7-člani prsten s atomom koji ih povezuje putem tvorbe C2-C4alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti po izboru supstituiran s atomom halogena ili C1-C6 alkil,
R32 je atom halogena, cijano, nitro, C3-C8cikloalkil, C3-C8 halocikloalkil, -OH, -OR33, -OC(O)R33, -OC(O)OR33, -OC(O)NHR33, -OC(O)N(R34)R33, -OC(S)NHR33, -OC(S)N(R34)R33, -SH, -S(O)rR33, -SC(O)R33, -SC(O)OR33, -SC(O)NHR33, -SC(O)N(R34)R33, -SC(S)NHR33, -SC(S)N(R34)R33, -NHR34, -N(R34)R33, -N(R34)CHO, -N(R34)C(O)R33, -N(R34)C(O)OR33, -N(R34)C(O)NHR33, -N(R34)C(O)N(R34)R33, -N(R34)C(S)NHR33, -N(R34)C(S)N(R34)R33, -CHO, -C(O)R33, -C(O)OR33, -C(O)SR33, -C(O)NHR34, -C(O)N(R34)R33, -C(O)C(O)OR33,-CH=NOR11, -C(R9)=NOR11, -Si(R13)(R14)R13, -P(O)(OR21)2, -P(S)(OR21)2, -P(fenil)2, -P(O)(fenil)2, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49,
R33 je C1-C6alkil, C1-C6haloalkil, C3-C6cikloalkil-C1-C4alkil, C3-C6 halocikloalkil-C1-C4 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 haloalkoksi-C1-C4 alkiL, C1-C4 alkiltio-C1-C4alkil, C1-C4haloalkiltio-C1-C4alkil, C1-C4alkilsulfonil-C1-C4 alkil, C1-C4haIoalkilsufonil-C1-C4 alkil, cijano C1-C6 alkil, C1-C6 alkilkarbonil-C1-C4 alkil, C1-C6 haloalkilkarbonil-C1-C4 alkil, C1-C6 alkoksikarbonil-C1-C4 alkil, di(C1-C6 alkil)aminokarbonil-C1-C4 alkil, tri(C1-C4alkil)silil-C1-C4 alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C1-C4alkil supstituiran s bilo kojim od D-1 do D-60, C1-C4alkil supstituiran s bilo kojim od E-1 do E-49, C3-C6 cikloalkil, C3-C6 halocikloalkil, C2-C6 alkenil-C3-C8 cikloalkil, C2-C6 haloalkenil-C3-C8 cikloalkil, C2-C8 alkenil, C2-C8 haloalkenil, C3-C8cikloalkenil, C3-C8halocikloalkenil, C2-C8 alkinil, C2-C8 haloalkinil, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49,
R34 je atom vodika, C1-C6 alkil, C1-C6 haloalkil, C3-C8 cikloalkil, C3-C6 alkenil, C1-C6 alkinil, C1-C6 alkilkarbonil, C1-C6 haloalkilkarbonil, C1-C6 alkoksikarbonil, C1-C6 haloalkoksikarbonil, fenoksikarbonil, fenoksikarbonil supstituiran s (Z)p1, fenilkarbonil, fenilkarbonil supstituiran s (Z)p1, C1-C6 alkilsulfonil, C1-C6haloalkilsulfonil, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-6 do D-13, D-15 do D-23, D-25 do D-37, D-39, D-40, D-42, D-45 do D-60, E-3 do E-9, E-23 do E-31, E-34 ili E-45, ili
R34 zajedno s R33 može tvoriti 3-člani do 6-člani prsten s atomom dušika koji ih povezuje putem tvorbe C2-C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisik, atom sumpora ili atom dušika, i može biti po izboru supstituiran s atomom halogena, C1-C6alkil, C1-C6alkoksi, formil, C1-C6alkilkarbonil, C1-C6alkoksikarbonil, fenil ili fenil supstituiran s (Z)p1,
m je cijeli broj od 0 do 5,
n je cijeli broj od 0 do 4,
p1 je cijeli broj od 1 do 5,
p2 je cijeli broj od 0 do 4,
p3 je cijeli broj od 0 do 3,
p4 je cijeli broj od 0 do 2,
p5 je cijeli broj od 0 ili 1,
q1 je cijeli broj od 0 do 3,
q2 je cijeli broj od 0 do 5,
q3 je cijeli broj od 0 do 7,
q4 je cijeli broj od 0 do 9,
r je cijeli broj od 0 do 2, i
t je cijeli broj od 0 ili 1.
2. Spoj benzamida supstituiran izoksazolinom ili njegova sol prema zahtjevu 1, naznačen time, da
G je aromatski 6-člani prsten prikazan u bilo kojem od G-1 do G-10 ili aromatski 5-člani prsten prikazan u bilo kojem od sljedećih G-11 do G-25:
[image]
X je atom halogena, cijano, nitro, -SF5, C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R4, C3-C8 cikloalkil, C3-C8 cikloalkil po izboru supstituiran s R4, C2-C6 alkenil, C1-C6 alkenil po izboru supstituiran s R4, C2-C6 alkinil, C2-C6 alkinil po izboru supstituiran s R4, -OH, -OR3, -OSO2R5, -S(O)rR5, -C(O)OR9, -C(O)SR9, -C(O)NHR10, -C(O)N(R10)R9, -C(S)OR9, -C(S)SR9, -C(S)NHR10, -C(S)N(R10)R9, -CH=NOR11, -C(R9)=NQR11, -S(O)2NHR10, -S(O)2N(R10)R9, -Si(R13)(R14)R12, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49, kada m je cijeli broj od 2 ili veći, tada svaki X može biti isti ili različit jedan od drugoga,
nadalje, kada su dva od X susjedni, tada dva susjedna X mogu tvoriti 5-člani ili 6-člani prsten zajedno s atomima ugljika na koje su dva X povezani putem tvorbe sljedećih:
-CH2CH2CH2-, -CH2CH2O-, -CH2OCH2-, -OCH2O-, -CH2CH2S-, -CH2SCH2-, -CH2CH2CH2CH2-, -CH2CH2CH2O-, -CH2CH2OCH2-, -CH2OCH2O-, -OCH2CH2O-, -OCH2CH2S- ili -CH=CHCH=CH-, i u tom slučaju, atomi vodika povezani za svaki atom ugljika koji tvori prsten, mogu biti po izboru supstituirani s atomom halogena, C1-C4 alkil ili C1-C4 haloalkil,
Y je atom halogena, cijano, nitro, C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R4, -OR5, -OSO2R5, -S(O)rR5, -NHR7, -N(R7)R6, -N=CHOR8, -N=C(R9)OR8, -C(O)NHR10, -C(O)N(R10)R9, -C(S)NHR10, -C(S)N(R10)R9, fenil, fenil supstituiran s (Z)p1, D-1 do D-24, D-30 do D-38, D-43 do D-52 ili D-53, kada n je cijeli broj od 2 ili veći, tada svaki Y može biti isti ili različit jedan od drugoga,
nadalje, kada su dva od Y susjedni, tada dva susjedna Y mogu tvoriti 5-člani ili 6-člani prsten zajedno s atomima ugljika na koje su dva Y povezani putem tvorbe sljedećih: -CH2CH2CH2-, -CH2CH2O-, -CH2OCH2-, -OCH2O-, -CH2CH2CH2CH2-, -CH2CH2CH2O-, -CH2CH2OCH2-, -CH2OCH2O-, -OCH2CH2O-, -OCH=N- ili -SCH=N-, i u tom slučaju, atomi vodika povezani na svaki atom ugljika koji tvore prsten, mogu biti po izboru supstituirani s atomom halogena, C1-C4 alkil ili C1-C4 haloalkil,
R1 je C1-C8 alkil, C1-C8 alkil po izboru supstituiran s R16, C3-C8 cikloalkil, C3-C8 halocikloalkil, C3-C8 alkenil, C3-C8 haloalkenil, fenil C3-C6 alkenil, fenil C3-C6 alkenil supstituiran s (Z)p1, C3-C8 alkinil, C3-C8 haloalkinil, fenil C3-C6 alkinil, fenil C3-C6 alkinil supstituiran s (Z)p1, C1-C8 alkoksi, -N(R20)R19,-N=CHR19b,-N=C(R19b)R19a, -C(O)N(R10)R9, -C(S)N(R10)R9, -C(=NR11)OR9, -C(=NR11)SR9, -C(=NR11)N(R10)R9, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-6 do D-13, D-15 do D-23, D-26, D-27, D-29 do D-37, D-39, D-40, D-42, D-45 do D-58, E-4 do E-9, E-23 do E-28, E-30, E-31, E-34 ili E-45,
R2 je atom vodika, C1-C6 alkil, C1-C6 haloalkil, C3-C6 cikloalkil-C1-C4 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 haloalkoksi-C1-C4 alkil, benziloksi C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, C1-C4 haloalkiltio-C1-C4 alkil, C1-C4 alkilsulfonil-C1-C4 alkil, C1-C4 haloalkilsuffonil-C1-C4 alkil, feniltio C1-C4 alkil, feniltio C1-C4 alkil supstituiran s (Z)p1, cijano C1-C6 alkil, nitro C1-C6 alkil, C1-C4 alkilkarbonil-C1-C4 alkil, C1-C4 alkoksikarbonil-C1-C4 alkil, C3-C6 cikloalkil, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, -SR9, -S(O)2R9, -SN(R18)R17, -OH,-OR19,-NHR20,-N(R20)R19, -N=CHR19b, -N=C(R19b)R19a, -C(O)R9, -C(O)OR9, -C(O)SR5, -C(S)OR9, -C(S)SR9, fenil, fenil supstituiran s (Z)p1,
ili R1 i R2 zajedno tvore =C(R2a)R1a, i
nadalje, R1 i R2 zajedno mogu tvoriti 3-člani do 7-člani prsten zajedno s atomom dušika koji ih povezuje putem tvorbe C2 do C6 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti po izboru supstituiran s C1-C6 alkil, formil, C1-C6 alkilkarbonil ili C1-C6 alkoksikarbonil,
R1a i R2a zajedno mogu tvoriti 5-člani ili 6-člani prsten zajedno s atomom ugljika koji ih povezuje putem tvorbe C4 ili C5 alkilen-lanca ili C4 ili C5 alkenilen-lanca, i u tom slučaju, alkilen-lanac i alkenilen-lanac mogu sadržavati jedan do tri atoma kisika, atoma sumpora ili atoma dušika, i mogu biti po izboru supstituirani s atomom halogena ili C1-C6alkil,
R3 je cijano, C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R4, C3-C8 cikloalkil, C3-C8 halocikloalkil, C1-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, C3-C6 haloalkinil, -OR5, -S(O)rR5, -N(R10)R9, -C(O)OR9, -C(O)SR9, -C(O)NHR10, -C(O)N(R10)R9, -C(S)OR9, -C(S)SR9, -C(S)NHR10, -C(S)N(R10)R9, -CH=NOR11, -C(R9)=NOR11, -Si(R13)(R14)R12, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-8 do D-13, D-15 do D-23, D-25 do D-37, D-39, D-40, D-42, D-45 do D-60 ili E-4 do E-7, E-23 do E27 ili E-28,
R4 je atom halogena, cijano, C3-C6 cikloalkil, C3-C6 halocikloalkil, -OH, -OR5, -S(O)rR5, -N(R10)R9, -N(R10)C(O)R9, -N(R10)C(O)OR9, -N(R10)C(O)SR9, -N(R10)C(S)OR9, -N(R10)C(S)SR9, -N(R10)S(O)2R9, -Si(R13)(R14)R12, fenil, fenil supstituiran s (Z)p1, D-1 do D-5, D-8 do D-38, D-41, D-43, D-44, D-47 do D-52 ili D-53,
R5 je C1-C6 alkil, C1-C6 haloalkil, C1-C3 haloalkoksi-C1-C3 haloalkil, C3-C8 cikloalkil, C3-C8 halocikloalkil, C2-C6 alkenil, C2-C6 haloalkenil, C3-C6 alkinil, C3-C6 haloalkinil, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-7, D-9, D-15 do D-23, D-30 do D-35, D-47 do D-53, E-3 do E-9, E-23 do E-27 ili E-28,
R6 je C1-C6 alkil, C1-C6 haloalkil, C3-C6 cikloalkil-C1-C4 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, -S(O)2R9, -CHO, -C(O)R9, -C(O)OR9, -C(O)SR9, -C(S)OR9 ili -C(S)SR9,
R7 je atom vodika, C1-C6 alkil, C1-C6 haloalkil, C3-C6 alkenil ili C3-C6 alkinil,
R8 je C1-C6 alkil,
R9 je C1-C6 alkil, C1-C6 haloalkil, C3-C6 cikloalkil-C1-C4 alkil, C1-C6 alkoksi-C1-C4 alkil, C1-C6 alkiltio-C1-C4 alkil, cijano C1-C6 alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C3-C8 cikloalkil, C3-C8halocikloalkiI, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, C3-C6 haloalkinil, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-6 do D-35, D-38, D-47 do D-54 ili D-55,
R10 je atom vodika ili C1-C6 alkil, ili
R10 zajedno s R9 može tvoriti 5-člani do 7-člani prsten s atomom dušika koji ih povezuje putem tvorbe C4-C6 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati atom kisika ili atom sumpora,
R11 je C1-C6 alkil, C1-C8 haloalkil, fenil C1-C4alkil, fenil C1-C4 alkil supstituiran s (Z)p1, fenil ili fenil supstituiran s (Z)p), ili
R11 zajedno s R9 može tvoriti 5-člani ili 6-člani prsten s atomom koji ih povezuje putem tvorbe C2-C3 alkilen-lanca, i u tom slučaju, alkilen-lanac može biti po izboru supstituiran s C1-C6 alkil,
R12 je C1-C6 alkil, fenil ili fenil supstituiran s (Z)p1,
R13 i R14 su međusobno neovisno C1-C6 alkil,
R15 je C1-C6 alkil, C1-C6 haloalkil, fenil C1-C4 alkil, fenil C1-C4alkil supstituiran s (Z)p1, fenil ili fenil supstituiran s (Z)p1,
R16 je atom halogena, cijano, C3-C6 cikloalkil, C3-C6 halocikloalkil, -OR25, -N(R26)R25, -SH, -S(O)rR27, -SO2NHR29, -SO2N(R29)R2S, -CHO, -C(O)R28, -C(O)OR28, -C(O)NHR29, -C(O)N(R29)R28, -C(O)N(R29)OR28, -C(S)NHR29, -C(S)N(R29)R28, -C(R31)=NOH, -C(R31)=NOR30, -C(=NR31)OR30, -C(=NR31)SR30, -C(=NR31)N(R29)R30, -C(=NOR31)NHR29, -C(=NOR31)N(R29)R30, -Si(R13)(R14)R12, fenil, fenil supstituiran s (Z)p1, D-1 do D-60, E-1 do E-49 ili M-1 do M-22,
R17 je C1-C6 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C6 alkoksikarbonil-C1-C4 alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1 ili C1-C6 alkoksikarbonil,
R18 je C1-C6 alkil, fenil C1-C4 alkil ili fenil C1-C4 alkilsupstituiran s (Z)p1, ili R18 zajedno s R17 može tvoriti 5-člani ili 6-člani prsten s atomom dušika koji ih povezuje putem tvorbe C4-C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika ili atom sumpora, i može biti po izboru supstituiran s metil ili metoksi,
R19 je C1-C6 alkil, C1-C6 alkil po izbom supstituiran s R16, C3-C6 cikloalkil, C3-C6 halocikloalkil, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, -CHO, -C(O)R28, -C(O)OR28, -C(O)NHR29, -C(O)N(R29)R28, -C(S)NHR29, -C(S)N(R29)R28, -S(O)2R28, -S(O)2NHR29, -S(O)2N(R29)R28, fenil, fenil supstituiran s (Z)p1, D-1 do D-13, D-15 do D-25, D-30 do D-37, D-39, D-40, D-42, D-45 do D-60, E-5, E-7, E-9, E-24, E-25, E-27, E-28, E-30 ili E-31,
R19a je C1-C6 alkil, C1-C6 haloalkil, C3-C6 cikloalkil, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-8 do D-10, D-15 do D-23, D-47 do D-55, E-4 do E-7, E-23 do E-27 ili E-28,
R19b je atom vodika ili C1-C6 alkil, ili
R19a zajedno s R19b može tvoriti 5-člani ili 6-člani prsten s atomom ugljika koji ih povezuje putem tvorbe C4 ili C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika ili atom sumpora,
R20 je atom vodika, C1-C6 alkil, C1-C6 haloalkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, cijano C1-C6 alkil, C1-C4 alkoksikarbonil-C1-C4 alkil, C2-C6 alkenil, C3-C6 alkinil, -CHO, -C(O)R9, -C(O)OR9, -C(O)SR9, -C(S)OR9, -C(S)SR9 ili C1-C6 alkilsulfonil,
R22 je atom halogena, cijano, C1-C6 alkil, C1-C6 haloalkil, C1-C6 alkoksi, C1-C6 alkoksikarbonil,-C(O)NH2 ili-C(S)NH2, kada je q1, q2, q3 ili q4 cijeli broj od 2 ili veći, svaki R22 može biti isti ili različit jedan od drugoga,
nadalje, u slučaju kada su dva od R22 prisutni na istom atomu ugljika, dva R22 zajedno mogu tvoriti okso, tiokso, imino, C1-C6 alkilimino, C1-C6 alkoksiimino ili C1-C6 alkiliden,
R23 je atom vodika, C1-C6 alkil, C1-C6 alkil po izbom supstituiran s R32, C3-C6 cikloalkil, C3-C6 alkenil, C3-C6 alkinil, -OH, benziloksi, -CHO, -C(O)R33, -C(O)OR33, -C(O)SR13, -C(O)NHR34, -C(O)N(R34)R33, -S(O)2R33s fenil, fenil supstituiran s (Z)p1 ili D-5,
R25 je atom vodika, C1-C6 alkil, C1-C6 haloalkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, cijano C1-C6 alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C3-C6 alkenil, C3-C6 alkinil, -CHO, -C(O)R33, -C(O)OR33, -C(O)SR33, -C(O)NHR34, -C(O)N(R34)R33, -C(S)R33, -C(S)OR31, -C(S)SR33, -C(S)NHR34, -C(S)N(R34)R33, -S(O)2R33, -S(O)2N(R34)R33, di(C1-C6 alkil)fosforil, di(C1-C6 alkil)tiofosforil, tri(C1-C4 alkil)silil, fenil ili fenil supstituiran s (Z)p1,
R21 je atom vodika, C1-C6 alkil, C3-C6 alkenil, C3-C6 alkinil ili C1-C6 alkoksi, ili
R26 zajedno s R25 može tvoriti 4-člani do 6-člani prsten s atomom dušika koji ih povezuje putem tvorbe C3-C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti supstituiran s C1-C6 alkil, okso ili tiokso,
R27 je C1-C6 alklil, C1-C6 haloalkil, hidroksi C1-C6 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, C1-C4 alkilkarbonil-C1-C4 alkil, C1-C4 alkoksikarbonil-C1-C4 alkil, di(C1-C4 alkil)aminokarbonil-C1-C4 alkil, tri(C1-C4 alkil)silil-C1-C4 alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C3-C6 alkenil, C3-C6 alkinil, C1-C6 alkilkarbonil, C1-C6 alkiltio, feniltio, feniltio supstituiran s (Z)p1, -C(O)NHR34, -C(O)N(R34)R33, -C(S)NHR34, -C(S)N(R34)R33, fenil, fenil supstituiran s (Z)p1, D-21, D-35, D-47 ili D-50,
R28 je C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R32, C3-C6 cikloalkil, C3-C6 halocikloalkil, C1-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, C3-C6 haloalkinil, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49,
R29 je atom vodika, C1-C6 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, cijano C1-C6 alkil, C3-C6 alkenil ili C3-C6 alkinil, ili
R29 zajedno s R28 može tvoriti 3-člani do 6-člani prsten s atomom dušika koji ih povezuje putem tvorbe C2-C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika ili atom sumpora,
R30 je C1-C6 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, C3-C6 cikloalkil-C1-C4 alkil, tri(C1-C6alkil)silil-C1-C4 alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C3-C8 alkenil, C3-C8 haloalkenil, C3-C8 alkinil ili C3-C8 haloalkinil,
R31 je atom vodika, C1-C6 alkil, C1-C6 haloalkil ili C3-C6 cikloalkil, ili
R31 zajedno s R30 može tvoriti 5-člani ili 6-člani prsten s atomom koji ih povezuje putem tvorbe C2-C3 alkilen-lanca, i u tom slučaju, alkilen-lanac može biti po izboru supstituiran s C1-C6 alkil,
R32 je atom halogena, cijano, C3-C8 cikloalkil, C3-C8 halocikloalkil, -OR33, -OC(O)R33, -OC(O)NHR33, -OC(O)N(R34)R33, -S(O)rR33, -SC(O)R33, -SC(O)NHR33, -SC(O)N(R34)R33, -N(R34)CHO, -N(R34)C(O)R33, -N(R34)C(O)OR33, -C(O)OR33, -C(O)NHR34, -C(O)N(R34)R31, fenil, fenil supstituiran s (Z)p1, D-1 do D-60 ili E-1 do E-49,
R33 je C1-C6 alkil, C1-C6 haloalkil, C3-C6 cikloalkil-C1-C4 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 haloalkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, C1-C4 haloalkiltio-C1-C4 alkil, C1-C4 alkiIsulfonil-C1-C4 alkil, C1-C4 haloalkilsulfonil-C1-C4 alkil, cijano C1-C6 alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C3-C6 cikloalkil, C3-C6 halocikloalkil, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-8 do D-13, D-15 do D-18, D-21, D-29 do D-37, D-47 do D-55, E-5, E-7, E-9, E-24, E-25, E-27, E-28, E-30, E-31 ili E-34,
R34 je atom vodika, C1-C6 alkil, C1-C6 haloalkil, C3-C6 alkenil ili C3-C6 alkinil, ili
R34 zajedno s R33 može tvoriti 3-člani do 6-člani prsten s atomom dušika koji ih povezuje putem tvorbe C2-C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika ili atom sumpora.
3. Spoj benzamida supstituiran izoksazolinom ili njegova sol prema zahtjevu 2, naznačen time, da
G je G-1, G-3, G-4, G-13, G-14, G-17, G-18, G-20, G-21 ili G-22,
X je atom halogena, cijano, nitro, -SF5, C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R, C3-C8 cikloalkil, C3-C8 halocikloalkil, C2-C6 alkenil, C9-C6 haloalkenil, C2-C6 alkinil, C2-C6 haloalkinil, -OR5, -OSO2R5, -S(O)rR5, -C(O)OR9, -C(O)SR9, -C(S)OR9, -C(S)SR9, -C(S)NHR10, -C(S)N(R10)R9, -CH=NOR11, -C(R9)=NOR11, -Si(R13)(R14)R12, E-10, E-12, E-18, E-32, E-35 ili E-43, kada m je 2 ili 3, svaki X može biti isti ili različit jedan od drugoga,
nadalje, kada su dva od X susjedni, tada susjedna dva X mogu tvoriti 5-člani ili 6-člani prsten zajedno s atomima ugljika na koje su vezani dva X, putem tvorbe sljedećih: -CF2OCF2-, -OCF2O-, -CF2OCF2O- ili -OCF2CF2O-,
Y je atom halogena, cijano, nitro, C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R4, -OR5, -OSO2R5, -S(O)rR5, -NHR7, -N(R7)R6, -N=C(R9)OR8, -C(O)NH2 ili -C(S)NH2, kada nje 2 ili 3, svaki Y može biti ili različit jedan od drugoga,
R' je C1-C8 alkil, C1-C8 alkil po izboru supstituiran s R16, C3-C8 cikloalkil, C3-C8 halocikloalkil, C3-C8 alkenil, C3-C8 haloalkenil, C3-C8 alkinil, C3-C8 haloalkinil, -N(R20)R19, -C(O)N(R10)R9, -C(S)N(R10)R9, fenil supstituiran s (Z)p1, D-8 do D-13, D-15 do D-18, D-21 do D-23, D-26, D-27, D-29 do D-37, D-39, D-40, D-42, D-45 do D-58, E-5, E-7, E-8, E-9, E-24, E-25, E-27, E-28, E-30, E-31 ili E-34,
R2 je atom vodika, C1-C6 alkil, C1-C6 haloalkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, cijano C1-C6 alkil, C3-C6 cikloalkil, C3-C6 alkenil, C3-C6 alkinil, -OH, C1-C6 alkoksi, C1-C6 alkilkarboniloksi, C1-C6 alkoksikarboniloksi, C1-C6 alkilsulfoniloksi, C1-C6 haloalkiltio, feniltio, feniltio supstituiran s (Z)p1, C1-C6 alkilsulfonil, -SN(R18)R17, -NHR20, -N=CHR19b, -N=C(R19b)R19b, -C(O)R9, -C(O)OR9, -C(O)SR9, -C(S)OR9 ili -C(S)SR9, ili
R2 zajedno s R1 može tvoriti 3-člani do 7-člani prsten s atomom dušika koji ih povezuje putem tvorbe C2-C6 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika ili atom sumpora,
R3 je C1-C6 alkil, C1-C8 haloalkil, C3-C6 cikloalkil-C1-C4 alkil, C3-C6 halocikloalkil-C1-C4 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 haloalkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, C1-C4 alkilsuIfinil-C1-C4 alkil, C1-C4 alkilsulfonil-C1-C4 alkil, C1-C4 haloalkiltio-C1-C4 alkil, C1-C4 haloalkilsulfmil-C1-C4 alkil, C1-C4 haloalkilsulfonil-C1-C4 alkil, cijano C1-C6 alkil, C1-C4 alkoksi-C1-C4 haloalkil, C1-C4 haloallcoksi-C1-C4 haloalkil, C1-C4 alkiltio-C1-C4 haloalkil, C1-C4 alkilsulfinil-C1-C4 haloalkil, C1-C4 alkilsulfonil-C1-C4 haloalkil, C1-C4 haloalkiltio-C1-C4 haloalkil, C1-C4 haloalkilsulfinil-C1-C4 haloalkil, C1-C4 haloalkilsulfonil-C1-C4 haloalkil, cijano C1-C6 haloalkil, C3-C8 cikloalkil, C3-C8 halocikloalkil, E-4 do E-7, E-23 do E-27 ili E-28,
R4 je atom halogena, cijano, -OH, C1-C6 alkoksi, C1-C6 haloalkoksi, C1-C6 alkiltio, C1-C6 haloalkiltio, C1-C6 alkilsulfinil, C1-C6 haloalkilsulfinil, C1-C6 alkilsulfonil, C1-C6 haloalkilsulfonil ili tri(C1-C6 alkil)silil,
R5 je C1-C6 alkil, C1-C6 haloalkil, C1-C3 haloalkoksi-C1-C3 haloalkil, C3-C8 cikloalkil, C3-C8 halocikloalkil, C2-C6 alkenil, C2-C6 haloalkenil, C3-C6 alkinil, C3-C8 haloalkinil, E-4 do E-9, E-23 do E-27 ili E-28,
R6 je C1-C6 alkil, C1-C6 haloalkil, -S(O)2R9, -CHO, -C(O)R9, -C(O)OR9, -C(O)SR9, -C(S)OR9 ili -C(S)SR9,
R7 je atom vodika, C1-C6 alkil ili C1-C6 haloalkil,
R9 je C1-C6 alkil, C1-C6 haloalkil, C3-C6 cikloalkil-C1-C4 alkil, C1-C6 alkoksi-C1-C4 alkil, C1-C6 alkiltio-C1-C4 alkil, cijano C1-C6 alkil, fenil C1-C4 alkil, C3-C8 cikloalkil, C3-C8 halocikloalkil, C3-C6 alkenil ili C3-C6 alkinil,
R10 je atom vodika ili C1-C8 alkil, ili
R10 zajedno s R9 može tvoriti 5-člani ili 6-člani prsten s atomom dušika koji ih povezuje putem tvorbe C4 ili C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika ili atom sumpora,
R11 je C1-C6 alkil ili C1-C6 haloalkil, ili
R11 zajedno s R9 može tvoriti 5-člani ili 6-člani prsten s atomom koji ih povezuje putem tvorbe C2 ili C3 alkilen-lanca, i u tom slučaju, alkilen-lanac može biti po izboru supstituiran s C1-C6 alkil,
R15 je C1-C6 alkil ili C1-C6 haloalkil,
R16 je atom halogena, cijano, C3-C6 cikloalkil, C3-C6 halocikloalkil, -OR25, -N(R26)R25, -S(O)rR27, -SO2NHR29, -SO2N(R29)R28, -CHO, -C(O)R28, -C(O)OR28, -C(O)NHR29, -C(O)N(R29)R28, -C(O)N(R29)OR28, -C(S)NHR29, -C(S)N(R29)R28, -C(R31)=NOH, -C(R31)=NOR30, -C(=NR31)OR30, -C(=NR31)SR31, -C(=NR31)N(R29)R30, -C(=NOR31)NHR29, -C(=N0R31)N(R29)R30, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-8 do D-42, D-47 do D-55, E-4 do E-12, E-14, E-16 do E-19, E-21 do E-23, E-26 do E-35, E-40 do E-45, E-48, M-2, M-3, M-5, M-8 do M-10, M-14, M-15 ili M-l6,
R17 je C1-C6 alkil, C1-C6 alkoksikarbonil-C1-C4 alkil ili C1-C6 alkoksikarbonil,
R18 je C1-C6 alkil ili benzil,
R19je C1-C6 alkil, C1-C6 haloalkil, C3-C6 ciklaolakil-C1-C6 alkil, fenil C1-C6 alkil, fenil C1-C6 alkil supstituiran s (Z)p1, C1-C6 cikloalkil, C3-C6 alkenil, C3-C6haloalkenil, C3-C6 alkinil, -C(O)R28, -C(O)OR28, -C(O)NHR29, -C(O)N(R29)R2S, -C(S)NHR29, -C(S)N(R29)R28, C1-C6alkilsulfonil, C1-C6haloalkilsulfonil, fenilsulfonil, fenilsulfonil supstituiran s (Z)p1, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-18, D-21, D-25, D-30 do D-35, D-47 do D-55 ili D-56,
R19a je C1-C6 alkil,
R19b je atom vodika ili C1-C6 alkil,
R20 je atom vodika, C1-C6 alkil, C1-C4alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, cijano C1-C6 alkil, C3-C6 alkenil, C3-C6alkinil, -CHO, C1-C6 alkilkarbonil, C1-C6haloalkilkarbonil, C1-C6 alkoksikarbonil, C1-C6-haloalkoksikarbonil ili
C1-C6 alkilsulfonil,
R22 je C1-C4 alkil ili C1-C4 haloalkil, ili dva od R22 koji su prisutni na istom atomu ugljika, mogu zajedno tvoriti okso ili tiokso,
R21 je atom vodika, C1-C6 alkil, -CHO, C1-C6alkilkarbonil, C1-C6 haloalkilkarbonil, C1-C6 alkoksikarbonil, C1-C6 alkilsulfonil ili C1-C6 haloalkilsulfonil,
R25 je atom vodika, C1-C6 alkil, C1-C8 haloalkil, -C(O)R33, -C(O)OR33, -C(O)SR33, -C(O)NHR34, -C(O)N(R34)R33, -C(S)R33, -C(S)OR33, -C(S)SR33, -C(S)NHR34, -C(S)N(R34)R33, -S(O)2R33, -S(O)2N(R34)R33, di(C1-C6 alkil)tiofosforil, fenil ili fenil supstituiran s (Z)p1,
R26 je atom vodika ili C1-C6 alkil, ili
R26 zajedno s R23 može tvoriti 4-člani do 6-člani prsten s atomom dušika koji ih povezuje putem tvorbe C3-C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika, atom sumpora ili atom dušika, i može biti supstituiran s C1-C6 alkil, okso ili tiokso,
R27 je C1-C6 alkil, C1-C6 haloalkil, tri(C1-C4alkil)silil-C1-C4alkil, C1-C6 alkiltio, -C(O)NHR34, -C(O)N(R34)R33, -C(S)NHR34, -C(S)N(R34)R33, fenil, fenil supstituiran s (Z)p1, D-47 ili D-50,
R28 je C1-C6alkil, C1-C6 alkil po izboru supstituiran s R32, C3-C6 cikloalkil, C3-C6 halocikloalkil, C3-C6 alkenil, C3-C6haloalkenil, C3-C6 alkinil, C3-C8haloalkinil, fenil ili fenil supstituiran s (Z)p1,
R29 je atom vodika, C1-C6 alkil, C3-C6 alkenil ili C3-C6 alkinil, ili
R29 zajedno s R28 može tvoriti 3-člani do 6-člani prsten s atomom dušika koji ih povezuje putem tvorbe C2-C5 alkilen-lanca, i u tom slučaju, alkilen-lanac može sadržavati jedan atom kisika ili atom sumpora,
R30 je C1-C6alkil, C3-C6 cikloalkil-C1-C4alkil, fenil C1-C4alkil, fenil C1-C4 alkil supstituiran s (Z)p1,
R31 je atom vodika ili C1-C6 alkil, ili
R31 zajedno s R30 može tvoriti 5-člani do 6-člani prsten s atomom koji ih povezuje putem tvorbe C2 ili C3 alkilen-lanca, i u tom slučaju, alkilen-lanac može po izboru biti supstituiran s C1-C6 alkil,
R32 je atom halogena, cijano, C3-C6 cikloalkil, C3-C6 halocikloalkil, C1-C4 alkoksi, C1-C4haloaIkoksi, C1-C4alkiltio, C1-C4 haloalkiltio, C1-C4 alkoksikarbonil, -C(O)NH2, C1-C4 alkilaminokarbonil, di(C1-C4 alkil)aminokarbonil, fenil ili fenil supstituiran s (Z)p1,
R33 je C1-C6alkil, C1-C6 haloalkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, C1-C4alkilsulfonil-C1-C4 alkil, fenil C1-C4 alkil, fenil C1-C4 alkil supstituiran s (Z)p1, C3-C6 cikloalkil, C3-C6 halocikloalkil, C3-C6alkenil, C3-C6 alkinil, fenil ili fenil supstituiran s(Z)p1,
R34 je atom vodika ili C1-C6 alkil,
m je cijeli broj od 1 do 3,
n je cijeli broj od 0 do 2,
q2 je cijeli broj od 0 do 3,
q3 je cijeli broj od 0 do 2, i
q4 je cijeli broj od 0 do 2.
4. Spoj benzamida supstituiran izoksazolinom ili njegova sol prema zahtjevu 3, naznačen time, da
A1 je atom ugljika ili atom dušika,
A i A su atom ugljika,
G je G-1,
X je atom halogena, cijano, nitro, -SF5, C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R4, C3-C8 cikloalkil, C3-C6 halocikloalkil, C2-C8 alkenil, C2-C6 haloalkenil, C2-C6 alkinil, C2-C6 haloalkinil, -OR5, -OSO2R5, -S(O)rR5, ili tri(C1-C6 alkil)silil, kada m je 2 ili 3, svaki X može biti isti ili različit jedan od drugoga,
nadalje, kada su dva od X susjedni, tada dva susjedna X mogu tvoriti 5-člani ili 6-člani prsten zajedno s atomima ugljika na koje su dva X povezana putem tvorbe sljedećih: -CF2OCF2, -OCF2O-, -CF2OCF2O- ili -OCF2CF2O-,
Y je atom halogena, cijano, nitro, C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R4, -OR5, -OSO2R5, -S(O)rR5, -NHR7, -N(R7)R6, C(O)NH2 ili C(S)NH2, kada n je 2 ili 3, svaki Y može biti isti ili različit jedan od drugoga,
R' je C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R16, C3-C8 cikloalkil, C3-C6 halocikloalkil, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, C3-C6 haloalkinil, -N(R20)R19, -C(O)N(R10)R9, -C(S)N(R10)R9, fenil supstituiran s (Z)p1, D-8, D-10, D-11, D-13, D-15, D-17, D-18, D-21 do D-23, D-26, D-27, D-29 do D-37, D-39, D-40, D-42, D-45, D-47, D-48, D-50, D-51, D-53, D-54, D-56, D-58, E-5, E-7 ili E-9,
R2 je atom vodika, C1-C6 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, cijano alkil, C3-C6 cikloalkil, C3-C6 alkenil, C3-C6 alkinil, -OH, C1-C6 alkilkarboniloksi, C1-C6 alkilsulfoniloksi, -NH2, -C(O)R9, -C(O)OR8, -C(O)SR9, -C(S)OR9 ili -C(S)SR9,
R3 je C1-C6 haloalkil, C1-C4 alkoksi-C1-C4haloalkil, C1-C4 haloalkoksi-C1-C4 haloalkil, C1-C4 alkiltio-C1-C4 haloalkil, C1-C4 haloalkiltio-C1-C4 haloalkil, cijano C1-C6 haloalkil ili C3-C8 halocikloalkil,
R4 je atom halogena, cijano,-OH, C1-C6 alkoksi, C1-C6haloalkoksi, C1-C6 alkiltio, C1-C6, haloalkiltio, C1-C6 alkilsulfinil, C1-C6haloalkilsulfinil, C3-C6 alkilsulfonil, C1-C6 haloalkilsulfonil ili tri(C1-C6 alkil)silil,
R5 je C1-C6alkil, C1-C6 haloalkil, C1-C3 haloalkoksi-C1-C3 haloalkil, C3-C8 cikloalkil, C3-C8 halocikloalkil, C2-C6 alkenil, C2-C6 haloalkenil, C3-C6 alkinil ili C5-C6 haloalkinil,
R6 je C3-C6 alkil, C3-C6 haloalkil, -CHO, C3-C6 alkilkarbonil, C1-C6haloalkilkarbonil, C3-C6 cikloalkilkarbonil, C3-C6 halocikloalkilkarbonil, C1-C6alkoksikarbonil, C1-C6 haloalkoksikarbonil, C1-C6 alkiltiokarbonil, C1-C6 alkoksitiokarbonil, C1-C6 alkilditiokarbonil, C1-C6 alkilsulfonil ili C1-C6 haloalkilsulfonil,
R7 je atom vodika ili C1-C6 alkil,
R9 je C1-C6 alkil, C1-C6 haloalkil, C3-C6 cikloalkil-C1-C4 alkil, C1-C6 alkoksi-C1-C4 alkil, C1-C6 alkiltio-C1-C4 alkil, cijano C1-C6 alkil, C3-C8 cikloalkil, C3-C6 alkenil ili C3-C6 alkinil,
R16 je atom halogena, cijano, C3-C6 cikloalkil, C3-C6 halocikloalkil, -OR25, -N(R26)R25, -S(O)rR27, -SO2NHR29, -SO2N(R29)R28, -C(O)R28, -C(O)OR26, -C(O)NHR29, -C(O)N(R29)R28,-C(O)N(R29)OR28, -C(S)NHR29, -C(S)N(R29)R28, -C(R31)=NOH, -C(R31)=NOR30, -C(=NR31)OR30, -C(=NR31)SR30, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-8 do D-38, D-47 do D-55, E-4 do E-12, E-18, E-19, E-32, E-35, E-43, M-2, M-3, M-5, M-8, M-9 ili M-10,
R19 je C1-C6haloalkil, C3-C6 cikloalkil, -C(O)R28, -C(O)OR28, -C(O)NHR29, -C(O)N(R29)R28, -C(S)NHR29, -C(S)N(R29)R28, fenil, fenil supstituiran s (Z)p1, D-3, D-4, D-21, D-47, D-50, D-51, D-53 ili D-54,
R20 je atom vodika, C1-C6 alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4alkiltio-C1-C4 alkil, cijano C1-C6alkil, C3-C6 alkenil, C3-C6 alkinil, -CHO, C1-C6 alkilkarbonil, C1-C6 alkoksikarbonil ili C1-C6 alkilsulfonil,
R25 je C1-C6 alkil, C1-C6 haloalkil, C1-C6 alkilkarbonil, C1-C6 alkoksikarbonil, C1-C6alkilaminokarbonil, di(C1-C6alkil)aminokarbonil ili C1-C6 alkilsulfonil,
R26 je atom vodika ili C1-C6 alkil,
R27 je C1-C6 alkil, C1-C6haloalkil ili tri(C1-C4 alkil)silil-C1-C4 alkil,
R28 je C1-C6 alkil, C1-C6 haloalkil, C3-C6cikloalkil-C1-C4alkil, C1-C4 alkoksi-C1-C4 alkil, C1-C4 alkiltio-C1-C4 alkil, cijano C1-C6 alkil, fenil C1-C4 alkil, fenil C1-C4alkil supstituiran s (Z)p1, C3-C6 cikloalkil, C3-C6 alkenil, C3-C6haloalkenil, C3-C6 alkinil, fenil ili fenil supstituiran s (Z)p1,
R29 je atom vodika, C1-C6 alkil, C3-C6 alkenil ili C3-C6 alkinil,
R30 je C1,-C6 alkil ili C1-C6 cikloalkil-C1-C4 alkil,
R31 je atom vodika ili C1-C6 alkil, ili
R31 zajedno s R30 može tvoriti 5-člani ili 6-člani prsten s atomom koji ih povezuje putem tvorbe C2 ili C3 alkilen-lanca.
5. Spoj benzamida supstituiran izoksazolinom ili njegova sol prema zahtjevu 4, naznačen time, da
X je atom halogena, cijano, nitro, -SF5, C1-C6 alkil, C1-C6 haloalkil, hidroksi-C1-C6 haloalkil, C1-C6 alkoksi-C1-C6 haloalkil, C1-C6 haloalkoksi-C1-C6 haloalkil, C3-C8 halocikloalkil, -OR5, -OSO3R3 ili -S(O)rR3, kada m je 2 ili 3, svaki X može biti isti ili različit jedan od drugoga,
Y je atom halogena, cijano, nitro, C1-C4 alkil, C1-C4 haloalkil, C1-C4 alkoksi, C1-C4 haloalkoksi, C1-C6 alkiltio, C1-C6 haloalkiltio, C1-C6 alkilsulfonil, C1-C8 haloalkilsulfonil, -NHR7 ili -N(R7)R6,
R1 je C1-C6 alkil, C1-C6 alkil po izboru supstituiran s R16, C3-C5 cikloalkil, C3-C6 alkenil, C3-C6 haloalkenil, C3-C6 alkinil, -N(R20)R19, D-8, D-10, D-13, D-15, D-18, D-21, D-34, D-35, D-50 ili D-51,
R2 je atom vodika, C1-C5 alkil, C1-C4 alkoksi-C1-C4 alkil, cijano C1-C6 alkil, C3-C6 alkinil, -C(O)R9 ili -C(O)OR9,
R3 je C1-C6 haloalkil ili C3-C8 halocikloalkil,
R5 je C1-C6 alkil, C1-C6 haloalkil ili C1-C3 haloalkoksi-C1-C3 haloalkil,
R6 je C1-C6 alkil, -CHO, C1-C6 alkilkarbonil, C1-C6 haloalkilkarbonil, C1-C6 alkoksikarbonil, C1-C6 alkiltiokarbonil, C1-C6 alkoksitiokarbonil, C1-C6 alkilditiokarbonil, C1-C6 alkilsulfonil ili C1-C6 haloalkilsulfonil,
R9 je C1-C6 alkil, C1-C6 alkoksi-C1-C6 alkil, C1-C6 alkiltio-C1-C4 alkil, C3-C8 cikloalkil, C3-C6 alkenil ili C3-C6 alkinil,
R16 je atom halogena, cijano, C3-C6 cikloalkil, C3-C6 halocikloalkil, C1-C6 alkoksi, C1-C6 haloalkoksi, C1-C6 alkiltio, C1-C6 haloalkiltio, C1-C6 alkilsulfinil, C1-C6 haloalkiIsulfinil, C1-C6 alkilsulfonil, C1-C6 haloalkilsulfonil, C1-C6 alkilkarbonil, -C(O)OR28, -C(O)NHR29, -C(O)N(R29)R28, -C(S)NH2, -C(R31)=NOH, -C(R31)=NOR30, fenil, fenil supstituiran s (Z)p1, D-1 do D-4, D-8 do D-38, D-47 do D-55, E-4 do E-7, E-10, E-11 ili E-32,
R19 je C1-C6 haloalkil, -C(O)R28, -C(O)OR28, fenil, fenil supstituiran s (Z)p1, D-3, D-4, D-21, D-47, D-50, D-51, D-53 ili D-54,
R20 je atom vodika ili C1-C6 alkil,
R28 je C1-C6 alkil, C1-C6 haloalkil, C3-C6 cikloalkil-C1-C4 alkil, C3-C6 cikloalkil, C3-C6 alkenil ili C3-C6 alkinil,
R29 je atom vodika ili C1-C6 alkil,
R30 je C1-C6 alkil,
R31 je atom vodika ili C1-C6 alkil, i
n je cijeli broj od 0 ili 1.
6. Spoj benzamida supstituiran izoksazolinom ili njegova sol prema zahtjevu 1, naznačen time, da
spoj je 4-[5-(3,5-diklorofenil)-4,5-dihidro-5-(trifluorometil)izoksazol-3-il]-2-metil-N-[2-okso-2-[(2,2,2-trifluoroetil)amino]etil]benzamid predstavljen sljedećom formulom:
[image]
u kojoj
(X)m je 3,5 dikloro,
R3 je CF3,
(Y)n je 2-CH3, i
R1 je CH2C(O)NHCH2CF3.
7. Uporaba spoja 3,5-Bis (supstituirani aril) supstituiranog izoksazolinom formule (2) ili njegove soli:
[image]
u kojoj
A1 je atom ugljika ili atom dušika,
X1 je atom halogena, -SF5, C1-C6 haloalkil, hidroksi-C1-C6 haloalkil, C1-C6alkoksi-C1-C6haloalkil, C1-C6haloalkoksi-C1-C6haloalkil, C3-C8halocikloalkil, C1-C6haloalkoksi, C1-C6haloalkoksi-C1-C3haloalkoksi, C1-C6haloalkiltio, C1-C6 haloalkilsulfinil ili C1-C6 haloalkilsulfonil,
X2 je atom halogena, cijano, nitro, C1-C6alkil, C1-C6 haloalkil, -OR5, -OSO2R ili -S(O),
R5, kada m1 je 2, tada svaki X može biti isti ili različiti jedan od drugoga,
Y je atom halogena, cijano, nitro, C1-C4 alkil, C1-C4 haloalkil, C1-C4 alkoksi, C1-C4 haloalkoksi, C1-C6 alkiltio, C1-C6 haloalkiltio, C1-C6 alkilsulfonil, C1-C6haloalkilsulfonil, -NHR7 ili -N(R7)R8,
R3 je C1-C6 haloalkil ili C3-C8 halocikloalkil,
R5 je C1-C6 alkil ili C1-C6 haloalkil,
R6 je C1-C6alkil, -CHO, C1-C6alkilkarbonil, C1-C6haloalkilkarbonil, C1-C6 alkoksikarbonil, C1-C6 alkiltiokarbonil, C1-C6 alkoksitiokarbonil, C1-C6 alkilditiokarbonil, C1-C6 alkilsulfonil ili C1-C6 haloalkilsuffonil,
R7 je atom vodika ili C1-C6 alkil,
R je atom halogena, cijano, nitro, -NH2, halosulfoniloksi, C1-C6alkilsulfoniloksi, C1-C6haloalkilsuIfoniloksi, fenilsulfoniloksi, fenilsulfoniloksi supstituiran s (Z)p1 ili -C(O)Ra,
Ra je atom halogena, -OH, C1-C6 alkoksi, 1-pirazolil, 1-imidazoil ili 1-triazolil,
Z je atom halogena, C1-C6 alkil ili C1-C6haloalkil, kada p1 je cijeli broj od 2 ili veći, svaki
Z može biti isti ili različit jedan od drugoga,
m1 je cijeli broj od 0 do 2,
n je cijeli broj od 0 ili 1,
p1 je cijeli broj od 1 ili 5, i
r je cijeli broj od 0 do 2;
naznačena time, da služi kao intermedijer u sintezi spoja benzamida formule (1) supstituiranog izoksazolinom, ili njegove soli kao što je definirano u zahtjevu 1.
8. Pesticidni sastav, naznačen time, da sadrži kao djelotvornu tvar jedan ili više spojeva benzamida supstituiranih izoksazolinom ili njegovih soli, prema bilo kojem zahtjevu od 1 do 6.
9. Agrokemijski sastav, naznačen time, da sadrži kao djelotvornu tvar jedan ili više spojeva benzamida supstituiranih izoksazolinom ili njegovih soli prema bilo kojem zahtjevu od 1 do 6.
10. Endoparaziticid ili ektoparaziticid za sisavce ili ptice, naznačen time, da sadrži kao djelotvornu tvar jedan ili više spojeva benzamida supstituiranih izoksazolinom ili njegovih soli prema bilo kojem zahtjevu od 1 do 6.
11. Insekticid ili akaricid, naznačen time, da sadrži kao djelotvornu tvar jedan ili više spojeva benzamida supstituiranih izoksazolinom ili njegovih soli prema bilo kojem zahtjevu od 1 do 6.
12. Endoparaziticid ili ektoparaziticid za sisavce ili ptice prema zahtjevu 10, naznačen time, da je to gotov proizvod odabran od naprave sljedećih oblika: traka, pločica, obruč, ovratnik, ušna markica, zavoj za udove i naljepnica, preko koje se primjenjuje spoj benzamida supstituiran izoksazolinom.
13. Endoparaziticid ili ektoparaziticid za sisavce ili ptice prema zahtjevu 10, naznačen time, da je to proizvod u obliku prikladnom za intramuskularnu, subkutanu, intravenoznu ili intraperitonealnu injekciju.
14. Endoparaziticid ili ektoparaziticid za sisavce ili ptice prema zahtjevu 10, naznačen time, da je to proizvod u obliku prikladnom za transdermalnu primjenu putem umakanja, raspršivanja, kupanja, ispiranja, nalijevanja, tapkanja ili zaprašivanja.
15. Endoparaziticid ili ektoparaziticid za sisavce ili ptice prema zahtjevu 10, naznačen time, da je to proizvod u obliku prikladnom za oralnu primjenu.
16. Endoparaziticid ili ektoparaziticid za sisavce ili ptice prema zahtjevu 10, naznačen time, da je to proizvod u obliku prikladnom za transnazalnu primjenu.
17. Endoparaziticid ili ektoparaziticid za sisavce ili ptice prema zahtjevu 10, naznačen time, da je to proizvod za uporabu u postupku suzbijanja kukaca Siphonaptera.
18. Endoparaziticid ili ektoparaziticid za sisavce ili ptice prema zahtjevu 17, naznačen time, da kukci Siphonaptera su odabrani iz skupine koju čine Ctenocephalidae felis, Ctenocephalidae canis, Echidnophaga gallinacea, Pulex irritans i Xenopsylla cheopis.
19. Endoparaziticid ili ektoparaziticid za sisavce ili ptice prema zahtjevu 10, naznačen time, da je to proizvod za uporabu u postupku suzbijanja Ixodides.
20. Endoparaziticid ili ektoparaziticid za sisavce ili ptice prema zahtjevu 19, naznačen time, da su lxodides odabrani iz skupine koju čine Boophilus microplus, Rhipicephalus sanguineus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata, lxodes ovatus, Ixodes persulcatus, Amblyomma spp. i Dermacentor spp.
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- 2005-03-04 WO PCT/JP2005/004268 patent/WO2005085216A1/ja active Application Filing
- 2005-03-04 RS RS20140693A patent/RS53639B1/en unknown
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