YU35603A - Derivati benzodiazepina kao modulatori gaba a receptora - Google Patents
Derivati benzodiazepina kao modulatori gaba a receptoraInfo
- Publication number
- YU35603A YU35603A YU35603A YUP35603A YU35603A YU 35603 A YU35603 A YU 35603A YU 35603 A YU35603 A YU 35603A YU P35603 A YUP35603 A YU P35603A YU 35603 A YU35603 A YU 35603A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- lower alkyl
- halogen
- gaba
- hydrogen
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na jedinjenja formule (I) u kojoj R1 oznacava vodonik, halogen, nizi alkil, nizi alkoksi, hidroksi, cijan, trifluorometil, trifluorometoksi ili nizi alkiltio, R2 oznacava -C(O)O-nizi alkil, izoksazol, 1,2,4-oksadiazol-3-il ili 1,2,4-oksadiazol-5-il, koji prstenovi mogu biti supstituisani nizim alkilom, trifluormetilom ili cikloalkilom, R3 oznacava vodonik, nizi alkil, -(CH2)n-cikloalkil, -(CH2)n-halogen, -(CH2)n-piridin-4-il ili -(CH2)n-fenil, pri cemu fenil- prsten moze biti supstituisan sa jednim ili dva supstituenta koji su odabrani iz grupe koja se sastoji od nize alkoksi-grupe, halogena, -SO2CH3, fenila, -OCF3, nitro-grupe, -CF3, -NR2 ili oznacava -(CH2)n-indolil, koji je opciono supstituisan nizim alkilom ili nizom alkoksi-grupom, ili oznacava pirolidinil-5-okso, -C(O)-NR2, -(CH2)n-OH, -(CH2)n-NR2 ili -(CH2)n-benzo[1,3]dioksol, R oznacava vodonik ili nizi alkil i n je 0, 1, 2 ili 3, i na njihove farmaceutski prihvatljive kiselinske adicione soli uz izuzetak sledecih jedinjenja: etil-9H-imidazol[1,5-a][1,2,4]triazolo[3,4-d][1,4]enzodiazepin-10-karboksilata, 10-(3-ciklopropil-1,2,4-oksadiazol-5-il)-9H-imidazo[1,5-a][1,2,4]triazolo[4,3-d][1,4]benzodiazepina, etil-3-fluor-9H-imidazol[1,5-a][1,2,4]triazolo[3,4-d][1,4]benzodiazepin-10-karboksilata, 10-(3-ciklopropil-1,2,4-oksadiazol-5-il)-3-fluor-9H-imidazo[1,5-a][1,2,4]triazolo[3,4-d][1,4]benzodiazepina, etil-3-hlor-9H-imidazol[1,5-a][1,2,4]triazolo[3,4-d][1,4]benzodiazepin-10-karboksilata i 3-hlor-10-(3-ciklopriopil-1,2,4-oksadiazol-5-il)-9Himidazo[1,5-a][1,2,4]triazolo[3,4-d][1,4]benzodiazepina. Ova jedinjenja imaju dobar afinitet prema GABA α5 receptoru i ona su otuda korisna za lecenje bolesti koje su u vezi sa ovim receptorom.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00124332 | 2000-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU35603A true YU35603A (sh) | 2006-05-25 |
Family
ID=8170315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU35603A YU35603A (sh) | 2000-11-16 | 2001-11-08 | Derivati benzodiazepina kao modulatori gaba a receptora |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US6743789B2 (sh) |
| EP (1) | EP1337535B1 (sh) |
| JP (1) | JP4088151B2 (sh) |
| KR (1) | KR100504300B1 (sh) |
| CN (1) | CN1191255C (sh) |
| AR (1) | AR031345A1 (sh) |
| AT (1) | ATE268776T1 (sh) |
| AU (2) | AU2002217007B2 (sh) |
| BG (1) | BG107817A (sh) |
| BR (1) | BR0115393A (sh) |
| CA (1) | CA2427576C (sh) |
| CZ (1) | CZ295256B6 (sh) |
| DE (1) | DE60103776T2 (sh) |
| DK (1) | DK1337535T3 (sh) |
| EC (1) | ECSP034607A (sh) |
| ES (1) | ES2220831T3 (sh) |
| GC (1) | GC0000375A (sh) |
| GT (1) | GT200100230A (sh) |
| HK (1) | HK1062442A1 (sh) |
| HR (1) | HRP20030360A2 (sh) |
| HU (1) | HUP0303281A3 (sh) |
| IL (1) | IL155813A0 (sh) |
| JO (1) | JO2359B1 (sh) |
| MA (1) | MA26962A1 (sh) |
| MX (1) | MXPA03004251A (sh) |
| MY (1) | MY141675A (sh) |
| NO (1) | NO324706B1 (sh) |
| NZ (1) | NZ525413A (sh) |
| PA (1) | PA8532401A1 (sh) |
| PE (1) | PE20020583A1 (sh) |
| PL (1) | PL362925A1 (sh) |
| PT (1) | PT1337535E (sh) |
| RU (1) | RU2278865C2 (sh) |
| SI (1) | SI1337535T1 (sh) |
| SK (1) | SK7232003A3 (sh) |
| TR (1) | TR200402073T4 (sh) |
| TW (1) | TWI239333B (sh) |
| UY (1) | UY27026A1 (sh) |
| WO (1) | WO2002040487A2 (sh) |
| YU (1) | YU35603A (sh) |
| ZA (1) | ZA200303435B (sh) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6686352B2 (en) * | 2001-05-18 | 2004-02-03 | Hoffmann-La Roche Inc. | Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives |
| WO2004113321A1 (ja) * | 2003-06-19 | 2004-12-29 | Daiichi Pharmaceutical Co., Ltd. | 選択的なアミノ置換基導入法 |
| PL1691811T3 (pl) | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
| CA2577060A1 (en) | 2004-08-13 | 2006-02-23 | Amgen Inc. | Substituted benzofused heterocycles |
| CN101039678B (zh) | 2004-10-12 | 2011-06-15 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗认知障碍的咪唑并[1,5-a]三唑并[1,5-d]苯并二氮杂䓬衍生物 |
| CN101084220B (zh) * | 2004-10-20 | 2010-12-15 | 弗·哈夫曼-拉罗切有限公司 | 卤素取代的苯并二氮杂*衍生物 |
| RU2007112940A (ru) | 2004-10-20 | 2008-11-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные имидазобензодиазепина |
| ES2307230T3 (es) | 2004-12-14 | 2008-11-16 | F. Hoffmann-La Roche Ag | Imidazo-benzodiacepinas tetraciclicas como moduladores de los receptores gaba. |
| US8510055B2 (en) | 2005-08-03 | 2013-08-13 | The Johns Hopkins University | Methods for characterizing and treating cognitive impairment in aging and disease |
| WO2007019312A2 (en) * | 2005-08-03 | 2007-02-15 | The Johns Hopkins University | Methods for characterizing and treating cognitive impairment in aging and disease |
| ATE477255T1 (de) * | 2005-10-11 | 2010-08-15 | Hoffmann La Roche | Imidazobenzdiazepinderivate |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| WO2009139916A1 (en) * | 2008-05-16 | 2009-11-19 | Synta Pharmaceuticals Corp. | Tricyclic triazole compounds that modulate hsp90 activity |
| AU2009317386B2 (en) * | 2008-11-18 | 2013-07-25 | F. Hoffmann-La Roche Ag | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
| ES2431279T3 (es) * | 2008-11-28 | 2013-11-25 | F. Hoffmann-La Roche Ag | Arilciclohexiléteres de dihidro-tetraazabenzoazulenos para uso como antagonistas del receptor V1A de la vasopresina |
| CU20090172A6 (es) | 2009-10-09 | 2011-10-05 | Facultad De Quimica Universidad De La Habana | Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular |
| AU2011328993B2 (en) | 2010-11-15 | 2017-03-02 | Agenebio, Inc. | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| WO2014047413A1 (en) * | 2012-09-21 | 2014-03-27 | Uwm Research Foundation, Inc. | Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
| JP6883988B2 (ja) * | 2013-12-20 | 2021-06-09 | エージンバイオ， インコーポレイテッド | ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法 |
| EA036844B1 (ru) | 2015-06-19 | 2020-12-28 | Эйджинбайо, Инк. | Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения |
| US10059718B2 (en) | 2016-01-04 | 2018-08-28 | Tabomedex Biosciences, LLC | Fused quadracyclic compounds, compositions and uses thereof |
| US10973479B2 (en) | 2016-05-16 | 2021-04-13 | Canon Medical Systems Corporation | X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system |
| BR112019012821A2 (pt) | 2016-12-19 | 2019-11-26 | Agenebio Inc | derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo |
| US20180170941A1 (en) * | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| KR102512548B1 (ko) | 2017-12-22 | 2023-03-22 | 삼성디스플레이 주식회사 | 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물 |
| JP7514534B2 (ja) * | 2018-06-19 | 2024-07-11 | エージンバイオ， インコーポレイテッド | 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法 |
| KR102151969B1 (ko) * | 2019-12-11 | 2020-09-04 | 주식회사 지투비 | 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창 |
| CN112979658B (zh) * | 2021-02-22 | 2022-05-31 | 南湖实验室 | 一种氟马西尼的制备方法 |
| US20240132513A1 (en) | 2022-08-19 | 2024-04-25 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK174086D0 (da) | 1986-04-16 | 1986-04-16 | Ferrosan As | Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme |
| TW201311B (sh) | 1991-06-17 | 1993-03-01 | Hoffmann La Roche |
-
2001
- 2001-11-07 TW TW090127658A patent/TWI239333B/zh not_active IP Right Cessation
- 2001-11-08 DK DK01996541T patent/DK1337535T3/da active
- 2001-11-08 YU YU35603A patent/YU35603A/sh unknown
- 2001-11-08 SI SI200130125T patent/SI1337535T1/xx unknown
- 2001-11-08 BR BR0115393-5A patent/BR0115393A/pt not_active IP Right Cessation
- 2001-11-08 AU AU2002217007A patent/AU2002217007B2/en not_active Ceased
- 2001-11-08 EP EP01996541A patent/EP1337535B1/en not_active Expired - Lifetime
- 2001-11-08 PT PT01996541T patent/PT1337535E/pt unknown
- 2001-11-08 MX MXPA03004251A patent/MXPA03004251A/es active IP Right Grant
- 2001-11-08 TR TR2004/02073T patent/TR200402073T4/xx unknown
- 2001-11-08 DE DE60103776T patent/DE60103776T2/de not_active Expired - Lifetime
- 2001-11-08 US US10/007,883 patent/US6743789B2/en not_active Expired - Fee Related
- 2001-11-08 SK SK723-2003A patent/SK7232003A3/sk unknown
- 2001-11-08 JP JP2002543495A patent/JP4088151B2/ja not_active Expired - Fee Related
- 2001-11-08 AU AU1700702A patent/AU1700702A/xx active Pending
- 2001-11-08 NZ NZ525413A patent/NZ525413A/en unknown
- 2001-11-08 HU HU0303281A patent/HUP0303281A3/hu unknown
- 2001-11-08 AT AT01996541T patent/ATE268776T1/de not_active IP Right Cessation
- 2001-11-08 PL PL01362925A patent/PL362925A1/xx not_active Application Discontinuation
- 2001-11-08 RU RU2003116895/04A patent/RU2278865C2/ru not_active IP Right Cessation
- 2001-11-08 CA CA002427576A patent/CA2427576C/en not_active Expired - Fee Related
- 2001-11-08 ES ES01996541T patent/ES2220831T3/es not_active Expired - Lifetime
- 2001-11-08 IL IL15581301A patent/IL155813A0/xx unknown
- 2001-11-08 KR KR10-2003-7006609A patent/KR100504300B1/ko not_active IP Right Cessation
- 2001-11-08 CN CNB018189415A patent/CN1191255C/zh not_active Expired - Fee Related
- 2001-11-08 WO PCT/EP2001/012887 patent/WO2002040487A2/en active IP Right Grant
- 2001-11-08 CZ CZ20031597A patent/CZ295256B6/cs not_active IP Right Cessation
- 2001-11-12 JO JO2001183A patent/JO2359B1/en active
- 2001-11-13 GC GCP20011724 patent/GC0000375A/en active
- 2001-11-14 PE PE2001001135A patent/PE20020583A1/es not_active Application Discontinuation
- 2001-11-15 UY UY27026A patent/UY27026A1/es not_active Application Discontinuation
- 2001-11-15 GT GT200100230A patent/GT200100230A/es unknown
- 2001-11-15 MY MYPI20015253A patent/MY141675A/en unknown
- 2001-11-15 PA PA20018532401A patent/PA8532401A1/es unknown
- 2001-11-15 AR ARP010105323A patent/AR031345A1/es not_active Application Discontinuation
-
2003
- 2003-05-05 ZA ZA200303435A patent/ZA200303435B/en unknown
- 2003-05-07 HR HR20030360A patent/HRP20030360A2/hr not_active Application Discontinuation
- 2003-05-15 NO NO20032208A patent/NO324706B1/no unknown
- 2003-05-15 EC EC2003004607A patent/ECSP034607A/es unknown
- 2003-05-16 BG BG107817A patent/BG107817A/bg unknown
- 2003-05-16 MA MA27163A patent/MA26962A1/fr unknown
-
2004
- 2004-07-21 HK HK04105348A patent/HK1062442A1/xx not_active IP Right Cessation
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