PA8532401A1 - Derivados de imidazol [1,5-a][1,2,4]triazolo[4,3-d][1,4] benzodiazepina - Google Patents
Derivados de imidazol [1,5-a][1,2,4]triazolo[4,3-d][1,4] benzodiazepinaInfo
- Publication number
- PA8532401A1 PA8532401A1 PA20018532401A PA8532401A PA8532401A1 PA 8532401 A1 PA8532401 A1 PA 8532401A1 PA 20018532401 A PA20018532401 A PA 20018532401A PA 8532401 A PA8532401 A PA 8532401A PA 8532401 A1 PA8532401 A1 PA 8532401A1
- Authority
- PA
- Panama
- Prior art keywords
- benzodiazepina
- triazolo
- imidazo
- ciclopropil
- etil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA PRESENTE INVENCION DESCRIBE LOS COMPUESTOS DE FORMULA Y SUS SALES DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLES, CON LA EXCEPCION DE LOS SIGUIENTES COMPUESTOS: ETIL-9H-IMIDAZO [1, 5-A][1, 2, 4]TRIAZOLO [3, 4-D][1, 4]-BEMZODIAZEPINA-10-CARBOXILATO, 10-(3-CICLOPROPIL-1, 2, 4-OXADIAZOL-5-IL)-9H-IMIDAZO [1, 5-A][1, 2, 4]TRIAZOLO [4, 3-D][1, 4]-BENZODIAZEPINA, ETIL 3-FLUORO-9H-IMIDAZO [1, 5-A][1, 2, 4]TRIAZOLO [4, 3-D][1, 4]-BENZODIAZEPINA-10-CARBOXILATO, 10-(3-CICLOPROPIL-1, 2, 4-OXADIAZOL-5-IL)-3-FLUORO-9H-IMIDAZO [1, 5-A][1, 2, 4]TRIAZOLO [4, 3-D][1, 4]BENZODIAZEPINA, ETIL-3-CLORO-9H-IMIDAZO[1, 5-A][1, 2, 4] TRIAZOLO[4, 3-D][1, 4]-BENZODIAZEPINA-10-CARBOXILATO Y 3-CLORO-10-(3-CICLOPROPIL-1, 2, 4-OXADIAZOL-5-IL)-9H-IMIDAZO [1, 5-A][1, 2, 4]TRIAZOLO [4, 3-D][1, 4]BENZODIAZEPINA. ESTOS COMPUESTOS PRESENTAN UNA BUENA AFINIDAD PARA EL RECEPTOR GABA A ALFA5 Y POR CONSIGUIENTE SON UTILES DURANTE EL TRATAMIENTO DE ENFERMEDADES, RELACIONADAS CON ESTE RECEPTOR.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00124332 | 2000-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8532401A1 true PA8532401A1 (es) | 2002-08-26 |
Family
ID=8170315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20018532401A PA8532401A1 (es) | 2000-11-16 | 2001-11-15 | Derivados de imidazol [1,5-a][1,2,4]triazolo[4,3-d][1,4] benzodiazepina |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US6743789B2 (es) |
| EP (1) | EP1337535B1 (es) |
| JP (1) | JP4088151B2 (es) |
| KR (1) | KR100504300B1 (es) |
| CN (1) | CN1191255C (es) |
| AR (1) | AR031345A1 (es) |
| AT (1) | ATE268776T1 (es) |
| AU (2) | AU1700702A (es) |
| BG (1) | BG107817A (es) |
| BR (1) | BR0115393A (es) |
| CA (1) | CA2427576C (es) |
| CZ (1) | CZ295256B6 (es) |
| DE (1) | DE60103776T2 (es) |
| DK (1) | DK1337535T3 (es) |
| EC (1) | ECSP034607A (es) |
| ES (1) | ES2220831T3 (es) |
| GC (1) | GC0000375A (es) |
| GT (1) | GT200100230A (es) |
| HK (1) | HK1062442A1 (es) |
| HR (1) | HRP20030360A2 (es) |
| HU (1) | HUP0303281A3 (es) |
| IL (1) | IL155813A0 (es) |
| JO (1) | JO2359B1 (es) |
| MA (1) | MA26962A1 (es) |
| MX (1) | MXPA03004251A (es) |
| MY (1) | MY141675A (es) |
| NO (1) | NO324706B1 (es) |
| NZ (1) | NZ525413A (es) |
| PA (1) | PA8532401A1 (es) |
| PE (1) | PE20020583A1 (es) |
| PL (1) | PL362925A1 (es) |
| PT (1) | PT1337535E (es) |
| RU (1) | RU2278865C2 (es) |
| SI (1) | SI1337535T1 (es) |
| SK (1) | SK7232003A3 (es) |
| TR (1) | TR200402073T4 (es) |
| TW (1) | TWI239333B (es) |
| UY (1) | UY27026A1 (es) |
| WO (1) | WO2002040487A2 (es) |
| YU (1) | YU35603A (es) |
| ZA (1) | ZA200303435B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6686352B2 (en) * | 2001-05-18 | 2004-02-03 | Hoffmann-La Roche Inc. | Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives |
| US7626029B2 (en) * | 2003-06-19 | 2009-12-01 | Daiichi Pharmaceutical Co., Ltd. | Method of selectively introducing amino substituent |
| EP1691811B1 (en) | 2003-12-11 | 2014-07-23 | Sunovion Pharmaceuticals Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| CA2577060A1 (en) | 2004-08-13 | 2006-02-23 | Amgen Inc. | Substituted benzofused heterocycles |
| BRPI0517412A (pt) * | 2004-10-12 | 2008-10-07 | Hoffmann La Roche | derivados de benzodiazepina substituìdos |
| EP1807432A1 (en) | 2004-10-20 | 2007-07-18 | F. Hoffmann-Roche AG | Halogen substituted benzodiazepine derivatives |
| CA2584259C (en) | 2004-10-20 | 2013-04-02 | F. Hoffmann-La Roche Ag | Imidazo-benzodiazepine derivatives |
| CA2590333C (en) * | 2004-12-14 | 2013-01-08 | F. Hoffmann-La Roche Ag | Tetracyclic imidazo-benzodiazepines as gaba receptors modulators |
| US8510055B2 (en) | 2005-08-03 | 2013-08-13 | The Johns Hopkins University | Methods for characterizing and treating cognitive impairment in aging and disease |
| EP2682481A3 (en) * | 2005-08-03 | 2014-09-17 | The Johns-Hopkins University | Methods for characterizing and treating cognitive impairment in aging and disease |
| AU2006301377B2 (en) * | 2005-10-11 | 2012-03-08 | F. Hoffmann-La Roche Ag | Imidazo benzodiazepine derivatives |
| CA2625210A1 (en) * | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| WO2009139916A1 (en) * | 2008-05-16 | 2009-11-19 | Synta Pharmaceuticals Corp. | Tricyclic triazole compounds that modulate hsp90 activity |
| CA2739900C (en) * | 2008-11-18 | 2016-11-08 | F. Hoffmann-La Roche Ag | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
| CN102227428B (zh) * | 2008-11-28 | 2015-03-25 | 弗·哈夫曼-拉罗切有限公司 | 用作加压素via受体拮抗剂的二氢四氮杂苯并薁的芳基环己基醚 |
| CU20090172A6 (es) | 2009-10-09 | 2011-10-05 | Facultad De Quimica Universidad De La Habana | Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular |
| CA2818025A1 (en) | 2010-11-15 | 2012-05-24 | Agenebio, Inc. | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| JP2015529254A (ja) * | 2012-09-21 | 2015-10-05 | ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド | 喘息における気道の過敏症及び炎症を制御するための新規なｇａｂａａアゴニスト及び使用方法 |
| EP3083569B1 (en) * | 2013-12-20 | 2022-01-26 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| WO2016205739A1 (en) * | 2015-06-19 | 2016-12-22 | Belew Mekonnen | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US10059718B2 (en) * | 2016-01-04 | 2018-08-28 | Tabomedex Biosciences, LLC | Fused quadracyclic compounds, compositions and uses thereof |
| US10973479B2 (en) | 2016-05-16 | 2021-04-13 | Canon Medical Systems Corporation | X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system |
| BR112019012821A2 (pt) | 2016-12-19 | 2019-11-26 | Agenebio Inc | derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo |
| US20180170941A1 (en) * | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| KR102512548B1 (ko) | 2017-12-22 | 2023-03-22 | 삼성디스플레이 주식회사 | 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물 |
| CN112601749B (zh) * | 2018-06-19 | 2024-03-26 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法 |
| KR102151969B1 (ko) * | 2019-12-11 | 2020-09-04 | 주식회사 지투비 | 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창 |
| CN112979658B (zh) * | 2021-02-22 | 2022-05-31 | 南湖实验室 | 一种氟马西尼的制备方法 |
| WO2024039886A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK174086D0 (da) | 1986-04-16 | 1986-04-16 | Ferrosan As | Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme |
| TW201311B (es) | 1991-06-17 | 1993-03-01 | Hoffmann La Roche |
-
2001
- 2001-11-07 TW TW090127658A patent/TWI239333B/zh not_active IP Right Cessation
- 2001-11-08 RU RU2003116895/04A patent/RU2278865C2/ru not_active IP Right Cessation
- 2001-11-08 US US10/007,883 patent/US6743789B2/en not_active Expired - Fee Related
- 2001-11-08 NZ NZ525413A patent/NZ525413A/en unknown
- 2001-11-08 AU AU1700702A patent/AU1700702A/xx active Pending
- 2001-11-08 CZ CZ20031597A patent/CZ295256B6/cs not_active IP Right Cessation
- 2001-11-08 HU HU0303281A patent/HUP0303281A3/hu unknown
- 2001-11-08 AT AT01996541T patent/ATE268776T1/de not_active IP Right Cessation
- 2001-11-08 YU YU35603A patent/YU35603A/sh unknown
- 2001-11-08 KR KR10-2003-7006609A patent/KR100504300B1/ko not_active IP Right Cessation
- 2001-11-08 BR BR0115393-5A patent/BR0115393A/pt not_active IP Right Cessation
- 2001-11-08 CN CNB018189415A patent/CN1191255C/zh not_active Expired - Fee Related
- 2001-11-08 SK SK723-2003A patent/SK7232003A3/sk unknown
- 2001-11-08 EP EP01996541A patent/EP1337535B1/en not_active Expired - Lifetime
- 2001-11-08 TR TR2004/02073T patent/TR200402073T4/xx unknown
- 2001-11-08 JP JP2002543495A patent/JP4088151B2/ja not_active Expired - Fee Related
- 2001-11-08 IL IL15581301A patent/IL155813A0/xx unknown
- 2001-11-08 DK DK01996541T patent/DK1337535T3/da active
- 2001-11-08 DE DE60103776T patent/DE60103776T2/de not_active Expired - Lifetime
- 2001-11-08 MX MXPA03004251A patent/MXPA03004251A/es active IP Right Grant
- 2001-11-08 ES ES01996541T patent/ES2220831T3/es not_active Expired - Lifetime
- 2001-11-08 WO PCT/EP2001/012887 patent/WO2002040487A2/en active IP Right Grant
- 2001-11-08 PT PT01996541T patent/PT1337535E/pt unknown
- 2001-11-08 AU AU2002217007A patent/AU2002217007B2/en not_active Ceased
- 2001-11-08 PL PL01362925A patent/PL362925A1/xx not_active Application Discontinuation
- 2001-11-08 CA CA002427576A patent/CA2427576C/en not_active Expired - Fee Related
- 2001-11-08 SI SI200130125T patent/SI1337535T1/xx unknown
- 2001-11-12 JO JO2001183A patent/JO2359B1/en active
- 2001-11-13 GC GCP20011724 patent/GC0000375A/en active
- 2001-11-14 PE PE2001001135A patent/PE20020583A1/es not_active Application Discontinuation
- 2001-11-15 UY UY27026A patent/UY27026A1/es not_active Application Discontinuation
- 2001-11-15 MY MYPI20015253A patent/MY141675A/en unknown
- 2001-11-15 GT GT200100230A patent/GT200100230A/es unknown
- 2001-11-15 PA PA20018532401A patent/PA8532401A1/es unknown
- 2001-11-15 AR ARP010105323A patent/AR031345A1/es not_active Application Discontinuation
-
2003
- 2003-05-05 ZA ZA200303435A patent/ZA200303435B/en unknown
- 2003-05-07 HR HR20030360A patent/HRP20030360A2/hr not_active Application Discontinuation
- 2003-05-15 EC EC2003004607A patent/ECSP034607A/es unknown
- 2003-05-15 NO NO20032208A patent/NO324706B1/no unknown
- 2003-05-16 MA MA27163A patent/MA26962A1/fr unknown
- 2003-05-16 BG BG107817A patent/BG107817A/bg unknown
-
2004
- 2004-07-21 HK HK04105348A patent/HK1062442A1/xx not_active IP Right Cessation
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