CO5560547A2 - Metodos para la preparacion de compuestos de pirrolotriazina utiles como inhibidores de cinasa - Google Patents

Metodos para la preparacion de compuestos de pirrolotriazina utiles como inhibidores de cinasa

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Publication number
CO5560547A2
CO5560547A2 CO05043491A CO05043491A CO5560547A2 CO 5560547 A2 CO5560547 A2 CO 5560547A2 CO 05043491 A CO05043491 A CO 05043491A CO 05043491 A CO05043491 A CO 05043491A CO 5560547 A2 CO5560547 A2 CO 5560547A2
Authority
CO
Colombia
Prior art keywords
methods
compounds
sub
pirrolotriazine
useful
Prior art date
Application number
CO05043491A
Other languages
English (en)
Inventor
Alaric J Dyckman
Leftheris Katerina
Stephen T Wrobleski
Wendel William Doubleday
John A Grosso
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO5560547A2 publication Critical patent/CO5560547A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1.- Un método de formar un pirrol aminado que comprende: hacer reaccionar un compuesto de la Fórmula IV en donde R1 se selecciona de H, alquilo, aralquilo, OR1, OC(O)R1, OC(O)OR1, OC(O)NR1AND#39R1", OS(O)2R1"AND#39, y OS(O)2NR1AND#39R1", en donde los grupos R1AND#39 y R1" pueden ser cada uno en forma independiente H, alquilo, arilo, aralquilo, heterociclo, o grupos cicloalquilo, o pueden tomarse conjuntamente para formar un grupo cicloalquilo, arilo, o heterocíclico, cualquiera de los cuales puede sustituirse de manera opcional, y el grupo R1AND#39" se define como un alquilo, arilo, aralquilo, heterociclo, o cicloalquilo; -SCH3, -OC(=O)R21, -S(=O)R22, -SO2R22, -SO2NR24R25, -CO2R21, -C(=O)NR24R25, -NH2, -NR24R25, NR21SO2NR24R25, -NR21SO2R22, -NR24C(=O)R25, -NR24CO2R25, NR21C(=O)NR24R25, halógeno, nitro, o ciano;A se selecciona de R2X o E, donde X se selecciona de -O-, -OC(=O)-, -S-, -S(=O)-, -SO2- -C(=O)-, -CO2-, -NR10-, -NR10C(=O)-, NR10C(=O)NR11-, -NR10CO2-, -NR10SO2-, -NR10SO2NR11-, SO2NR10-, -C(=O)NR10-, halógeno, nitro, y ciano, o X está ausente; y E es un grupo de retiro de electrones; o R1, tomado conjuntamente con A, puede formar un anillo heterocíclico o aromático, saturado o insaturado, sustituido de manera opcional; R2 se selecciona de: (i) hidrógeno, con la condición de que R2 no es hidrógeno si X es -S(=O)-, -SO2-, -NR10CO2-, o -NR10SO2-; (ii) alquilo, alquenilo, y alquinilo sustituido de manera opcional con hasta cuatro R26; (iii) arilo y heteroarilo sustituido de manera opcional con hasta tres R27; (iv) heterocicIo y cicIoalquilo sustituido de manera opcional con ceto (=O), hasta tres R27, y/o con un puente carbono-carbono de 3 a 4 átomos de carbono; o (v) -C(O)Rb donde Rb es H, OH, alquilo, aralquilo, halo, ORbAND#39, OC(O)RbAND#39, OC(O)ORbAND#39, OC(O)NRbRbAND#39, OS(O)RbAND#39, OS(O)NRbRbAND#39, y Rb y RbAND#39 se seleccionan cada uno independientemente de H, alquilo, aralquilo, heterocicIo o cicIoalquilo, o Rb y RbAND#39 conjuntamente forman un grupo cicIoalquilo, arilo o heterocicIo; sin embargo, R2 está ausente si X es halógeno, nitro o ciano; ...
CO05043491A 2002-11-06 2005-05-05 Metodos para la preparacion de compuestos de pirrolotriazina utiles como inhibidores de cinasa CO5560547A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/289,010 US6867300B2 (en) 2000-11-17 2002-11-06 Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
CO5560547A2 true CO5560547A2 (es) 2005-09-30

Family

ID=32312096

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05043491A CO5560547A2 (es) 2002-11-06 2005-05-05 Metodos para la preparacion de compuestos de pirrolotriazina utiles como inhibidores de cinasa

Country Status (16)

Country Link
US (2) US6867300B2 (es)
EP (1) EP1562949B1 (es)
JP (1) JP4662775B2 (es)
KR (1) KR20050084961A (es)
CN (1) CN100360532C (es)
AT (1) ATE453645T1 (es)
AU (1) AU2003287514A1 (es)
BR (1) BR0316056A (es)
CA (1) CA2505365A1 (es)
CO (1) CO5560547A2 (es)
DE (1) DE60330800D1 (es)
ES (1) ES2337571T3 (es)
MX (1) MXPA05004748A (es)
PL (1) PL377112A1 (es)
TW (1) TWI290555B (es)
WO (1) WO2004043912A2 (es)

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TWI290555B (en) 2007-12-01
WO2004043912A3 (en) 2004-07-01
PL377112A1 (pl) 2006-01-23
ATE453645T1 (de) 2010-01-15
KR20050084961A (ko) 2005-08-29
CA2505365A1 (en) 2004-05-27
BR0316056A (pt) 2005-09-27
EP1562949A2 (en) 2005-08-17
US20030186982A1 (en) 2003-10-02
EP1562949A4 (en) 2007-09-12
TW200413382A (en) 2004-08-01
AU2003287514A1 (en) 2004-06-03
CN100360532C (zh) 2008-01-09
CN1735615A (zh) 2006-02-15
DE60330800D1 (de) 2010-02-11
ES2337571T3 (es) 2010-04-27
JP2006514622A (ja) 2006-05-11
EP1562949B1 (en) 2009-12-30
WO2004043912A2 (en) 2004-05-27
US20050107462A1 (en) 2005-05-19
MXPA05004748A (es) 2005-08-03
JP4662775B2 (ja) 2011-03-30
US6867300B2 (en) 2005-03-15
US7211666B2 (en) 2007-05-01

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