BR0316056A - Processo para a preparação de compostos de pirrolotriazina úteis como inibidores de cinase - Google Patents

Processo para a preparação de compostos de pirrolotriazina úteis como inibidores de cinase

Info

Publication number
BR0316056A
BR0316056A BR0316056-4A BR0316056A BR0316056A BR 0316056 A BR0316056 A BR 0316056A BR 0316056 A BR0316056 A BR 0316056A BR 0316056 A BR0316056 A BR 0316056A
Authority
BR
Brazil
Prior art keywords
sub
preparation
kinase inhibitors
compounds useful
pyrrolotriazine compounds
Prior art date
Application number
BR0316056-4A
Other languages
English (en)
Inventor
Jollie Duaine Godfrey
John Hynes
Alaric J Dyckman
Katherina Leftheris
Zhongping Shi
Stephen T Wrobleski
Wendel William Doubleday
John A Grosso
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0316056A publication Critical patent/BR0316056A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"PROCESSOS PARA A PREPARAçãO DE COMPOSTOS DE PIRROLOTRIAZINA úTEIS COMO INIBIDORES DE CINASE". A presente invenção refere-se a processos de preparar compostos farmacêuticos de inibição de cinase tendo a fórmula (I): ou um sal farmaceuticamente aceitável ou solvato deste, em que R~ 1~ a R~ 6~ e Z são como descrito no relatório descritivo. Os processos de acordo com a invenção utilizam um processo de aminação, no qual um pirrol é reagido com haloamina, preferivelmente cloramina. Esta etapa é seguida por ciclização para formar o núcleo de pirrolotriazina.
BR0316056-4A 2002-11-06 2003-11-03 Processo para a preparação de compostos de pirrolotriazina úteis como inibidores de cinase BR0316056A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/289,010 US6867300B2 (en) 2000-11-17 2002-11-06 Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
PCT/US2003/035220 WO2004043912A2 (en) 2002-11-06 2003-11-03 Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
BR0316056A true BR0316056A (pt) 2005-09-27

Family

ID=32312096

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316056-4A BR0316056A (pt) 2002-11-06 2003-11-03 Processo para a preparação de compostos de pirrolotriazina úteis como inibidores de cinase

Country Status (16)

Country Link
US (2) US6867300B2 (pt)
EP (1) EP1562949B1 (pt)
JP (1) JP4662775B2 (pt)
KR (1) KR20050084961A (pt)
CN (1) CN100360532C (pt)
AT (1) ATE453645T1 (pt)
AU (1) AU2003287514A1 (pt)
BR (1) BR0316056A (pt)
CA (1) CA2505365A1 (pt)
CO (1) CO5560547A2 (pt)
DE (1) DE60330800D1 (pt)
ES (1) ES2337571T3 (pt)
MX (1) MXPA05004748A (pt)
PL (1) PL377112A1 (pt)
TW (1) TWI290555B (pt)
WO (1) WO2004043912A2 (pt)

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WO2009094427A1 (en) 2008-01-23 2009-07-30 Bristol-Myers Squibb Company 4-pyridinone compounds and their use for cancer
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WO2012031057A1 (en) 2010-09-01 2012-03-08 Bristol-Myers Squibb Company Bms- 582949 for the treatment of resistant rheumatic disease
CN102153558B (zh) * 2011-02-23 2012-11-21 扬州永济医药新技术有限公司 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
CN103450204B (zh) 2012-05-31 2016-08-17 中国科学院上海药物研究所 吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
US9724352B2 (en) 2012-05-31 2017-08-08 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
CN104003990B (zh) * 2013-02-21 2017-09-15 江苏先声药业有限公司 杂环胺类Hedgehog信号通路抑制剂
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CN104788460B (zh) * 2015-03-27 2016-11-09 陕西师范大学 4-芳氨基吡咯并[2,1-f][1,2,4]三嗪衍生物的制备方法
WO2019168874A1 (en) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
CN108516977A (zh) * 2018-07-10 2018-09-11 刘凤娟 一种用于治疗恶性肿瘤的map激酶抑制剂的合成方法
CN111234067B (zh) * 2018-11-29 2021-08-03 中国石油化工股份有限公司 用于烯烃聚合的固体催化剂组分和催化剂及其应用
CN113372263B (zh) * 2021-05-21 2022-04-19 温州医科大学 一种2-氯-3-胺基萘醌化合物的制备方法
CN113292503B (zh) * 2021-05-22 2022-05-13 台州市第一人民医院 一种2-溴-3-胺基萘醌化合物的制备方法
CN116789674B (zh) * 2022-08-24 2024-05-24 杭州高光制药有限公司 Nlrp3炎性小体抑制剂

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Also Published As

Publication number Publication date
AU2003287514A1 (en) 2004-06-03
US20030186982A1 (en) 2003-10-02
DE60330800D1 (de) 2010-02-11
US6867300B2 (en) 2005-03-15
PL377112A1 (pl) 2006-01-23
US7211666B2 (en) 2007-05-01
US20050107462A1 (en) 2005-05-19
TWI290555B (en) 2007-12-01
WO2004043912A3 (en) 2004-07-01
MXPA05004748A (es) 2005-08-03
CA2505365A1 (en) 2004-05-27
ATE453645T1 (de) 2010-01-15
WO2004043912A2 (en) 2004-05-27
EP1562949B1 (en) 2009-12-30
ES2337571T3 (es) 2010-04-27
JP4662775B2 (ja) 2011-03-30
EP1562949A4 (en) 2007-09-12
TW200413382A (en) 2004-08-01
JP2006514622A (ja) 2006-05-11
CO5560547A2 (es) 2005-09-30
KR20050084961A (ko) 2005-08-29
EP1562949A2 (en) 2005-08-17
CN100360532C (zh) 2008-01-09
CN1735615A (zh) 2006-02-15

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.