PL377112A1 - Sposoby wytwarzania związków pirolotriazynowych użytecznych jako inhibitory kinazy - Google Patents

Sposoby wytwarzania związków pirolotriazynowych użytecznych jako inhibitory kinazy

Info

Publication number
PL377112A1
PL377112A1 PL377112A PL37711203A PL377112A1 PL 377112 A1 PL377112 A1 PL 377112A1 PL 377112 A PL377112 A PL 377112A PL 37711203 A PL37711203 A PL 37711203A PL 377112 A1 PL377112 A1 PL 377112A1
Authority
PL
Poland
Prior art keywords
methods
sub
preparation
kinase inhibitors
compounds useful
Prior art date
Application number
PL377112A
Other languages
English (en)
Inventor
Jollie Duaine Godfrey Jr.
John Hynes Jr.
Alaric J. Dyckman
Katerina Leftheris
Zhongping Shi
Stephen T. Wrobleski
Wendel William Doubleday
John A. Grosso
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of PL377112A1 publication Critical patent/PL377112A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL377112A 2002-11-06 2003-11-03 Sposoby wytwarzania związków pirolotriazynowych użytecznych jako inhibitory kinazy PL377112A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/289,010 US6867300B2 (en) 2000-11-17 2002-11-06 Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
PL377112A1 true PL377112A1 (pl) 2006-01-23

Family

ID=32312096

Family Applications (1)

Application Number Title Priority Date Filing Date
PL377112A PL377112A1 (pl) 2002-11-06 2003-11-03 Sposoby wytwarzania związków pirolotriazynowych użytecznych jako inhibitory kinazy

Country Status (16)

Country Link
US (2) US6867300B2 (pl)
EP (1) EP1562949B1 (pl)
JP (1) JP4662775B2 (pl)
KR (1) KR20050084961A (pl)
CN (1) CN100360532C (pl)
AT (1) ATE453645T1 (pl)
AU (1) AU2003287514A1 (pl)
BR (1) BR0316056A (pl)
CA (1) CA2505365A1 (pl)
CO (1) CO5560547A2 (pl)
DE (1) DE60330800D1 (pl)
ES (1) ES2337571T3 (pl)
MX (1) MXPA05004748A (pl)
PL (1) PL377112A1 (pl)
TW (1) TWI290555B (pl)
WO (1) WO2004043912A2 (pl)

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US7514435B2 (en) * 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
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JP5249776B2 (ja) 2005-12-02 2013-07-31 バイエル・ヘルスケア・エルエルシー 過剰増殖性疾患および血管新生と関連する疾患を処置するために有用な置換された４−アミノ−ピロロトリアジン誘導体
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TW201035100A (en) 2008-12-19 2010-10-01 Cephalon Inc Pyrrolotriazines as ALK and JAK2 inhibitors
WO2012031057A1 (en) 2010-09-01 2012-03-08 Bristol-Myers Squibb Company Bms- 582949 for the treatment of resistant rheumatic disease
CN102153558B (zh) * 2011-02-23 2012-11-21 扬州永济医药新技术有限公司 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
CN103450204B (zh) 2012-05-31 2016-08-17 中国科学院上海药物研究所 吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
US9724352B2 (en) 2012-05-31 2017-08-08 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
CN104003990B (zh) * 2013-02-21 2017-09-15 江苏先声药业有限公司 杂环胺类Hedgehog信号通路抑制剂
US9050345B2 (en) 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
CN104788460B (zh) * 2015-03-27 2016-11-09 陕西师范大学 4-芳氨基吡咯并[2,1-f][1,2,4]三嗪衍生物的制备方法
US11760701B2 (en) 2018-02-27 2023-09-19 The Research Foundation For The State University Of New Yrok Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
CN108516977A (zh) * 2018-07-10 2018-09-11 刘凤娟 一种用于治疗恶性肿瘤的map激酶抑制剂的合成方法
CN111234067B (zh) * 2018-11-29 2021-08-03 中国石油化工股份有限公司 用于烯烃聚合的固体催化剂组分和催化剂及其应用
CN113372263B (zh) * 2021-05-21 2022-04-19 温州医科大学 一种2-氯-3-胺基萘醌化合物的制备方法
CN113292503B (zh) * 2021-05-22 2022-05-13 台州市第一人民医院 一种2-溴-3-胺基萘醌化合物的制备方法
CN116789674B (zh) * 2022-08-24 2024-05-24 杭州高光制药有限公司 Nlrp3炎性小体抑制剂

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Also Published As

Publication number Publication date
TWI290555B (en) 2007-12-01
WO2004043912A3 (en) 2004-07-01
ATE453645T1 (de) 2010-01-15
CO5560547A2 (es) 2005-09-30
KR20050084961A (ko) 2005-08-29
CA2505365A1 (en) 2004-05-27
BR0316056A (pt) 2005-09-27
EP1562949A2 (en) 2005-08-17
US20030186982A1 (en) 2003-10-02
EP1562949A4 (en) 2007-09-12
TW200413382A (en) 2004-08-01
AU2003287514A1 (en) 2004-06-03
CN100360532C (zh) 2008-01-09
CN1735615A (zh) 2006-02-15
DE60330800D1 (de) 2010-02-11
ES2337571T3 (es) 2010-04-27
JP2006514622A (ja) 2006-05-11
EP1562949B1 (en) 2009-12-30
WO2004043912A2 (en) 2004-05-27
US20050107462A1 (en) 2005-05-19
MXPA05004748A (es) 2005-08-03
JP4662775B2 (ja) 2011-03-30
US6867300B2 (en) 2005-03-15
US7211666B2 (en) 2007-05-01

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