DE60103776D1 - Benzodiazepinderivate als gaba-a-rezeptormodulatoren - Google Patents

Benzodiazepinderivate als gaba-a-rezeptormodulatoren

Info

Publication number
DE60103776D1
DE60103776D1 DE60103776T DE60103776T DE60103776D1 DE 60103776 D1 DE60103776 D1 DE 60103776D1 DE 60103776 T DE60103776 T DE 60103776T DE 60103776 T DE60103776 T DE 60103776T DE 60103776 D1 DE60103776 D1 DE 60103776D1
Authority
DE
Germany
Prior art keywords
gaba
receptor modulators
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60103776T
Other languages
English (en)
Other versions
DE60103776T2 (de
Inventor
Raffaello Masciadri
William Thomas
Juergen Wichmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60103776D1 publication Critical patent/DE60103776D1/de
Application granted granted Critical
Publication of DE60103776T2 publication Critical patent/DE60103776T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60103776T 2000-11-16 2001-11-08 Benzodiazepinderivate als gaba-a-rezeptormodulatoren Expired - Lifetime DE60103776T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16
EP00124332 2000-11-16
PCT/EP2001/012887 WO2002040487A2 (en) 2000-11-16 2001-11-08 Benzodiazepine derivatives as gaba a receptor modulators

Publications (2)

Publication Number Publication Date
DE60103776D1 true DE60103776D1 (de) 2004-07-15
DE60103776T2 DE60103776T2 (de) 2005-07-14

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60103776T Expired - Lifetime DE60103776T2 (de) 2000-11-16 2001-11-08 Benzodiazepinderivate als gaba-a-rezeptormodulatoren

Country Status (41)

Country Link
US (1) US6743789B2 (de)
EP (1) EP1337535B1 (de)
JP (1) JP4088151B2 (de)
KR (1) KR100504300B1 (de)
CN (1) CN1191255C (de)
AR (1) AR031345A1 (de)
AT (1) ATE268776T1 (de)
AU (2) AU2002217007B2 (de)
BG (1) BG107817A (de)
BR (1) BR0115393A (de)
CA (1) CA2427576C (de)
CZ (1) CZ295256B6 (de)
DE (1) DE60103776T2 (de)
DK (1) DK1337535T3 (de)
EC (1) ECSP034607A (de)
ES (1) ES2220831T3 (de)
GC (1) GC0000375A (de)
GT (1) GT200100230A (de)
HK (1) HK1062442A1 (de)
HR (1) HRP20030360A2 (de)
HU (1) HUP0303281A3 (de)
IL (1) IL155813A0 (de)
JO (1) JO2359B1 (de)
MA (1) MA26962A1 (de)
MX (1) MXPA03004251A (de)
MY (1) MY141675A (de)
NO (1) NO324706B1 (de)
NZ (1) NZ525413A (de)
PA (1) PA8532401A1 (de)
PE (1) PE20020583A1 (de)
PL (1) PL362925A1 (de)
PT (1) PT1337535E (de)
RU (1) RU2278865C2 (de)
SI (1) SI1337535T1 (de)
SK (1) SK7232003A3 (de)
TR (1) TR200402073T4 (de)
TW (1) TWI239333B (de)
UY (1) UY27026A1 (de)
WO (1) WO2002040487A2 (de)
YU (1) YU35603A (de)
ZA (1) ZA200303435B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
US7626029B2 (en) * 2003-06-19 2009-12-01 Daiichi Pharmaceutical Co., Ltd. Method of selectively introducing amino substituent
WO2005060968A1 (en) 2003-12-11 2005-07-07 Sepracor Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
WO2006020959A2 (en) 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
RU2007112675A (ru) * 2004-10-12 2008-11-20 Ф.Хоффманн-Ля Рош Аг (Ch) ПРОИЗВОДНЫЕ ИМИДАЗО[1,5-a]ТРИАЗОЛО[1,5-d]БЕНЗОДИАЗЕПИНА ДЛЯ ЛЕЧЕНИЯ КОГНИТИВНЫХ РАССТРОЙСТВ
WO2006045429A1 (en) * 2004-10-20 2006-05-04 F. Hoffmann-La Roche Ag Halogen substituted benzodiazepine derivatives
JP4783375B2 (ja) 2004-10-20 2011-09-28 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジゼピン誘導体
JP4783380B2 (ja) 2004-12-14 2011-09-28 エフ．ホフマン−ラ ロシュ アーゲー Ｇａｂａレセプタ調節物質としての四環系イミダゾ−ベンゾジアゼピン類
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
EP1924712B1 (de) * 2005-08-03 2018-10-03 The Johns Hopkins University Verfahren zur charakterisierung und behandlung einer kognitiven beeinträchtigung bei altern und krankheit
BRPI0617204A2 (pt) * 2005-10-11 2011-07-19 Hoffmann La Roche derivados de imidazo benzodiazepina
WO2007053596A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US9156836B2 (en) * 2008-05-16 2015-10-13 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate HSP90 activity
CN102216304B (zh) 2008-11-18 2014-07-09 弗·哈夫曼-拉罗切有限公司 二氢四氮杂苯并薁的烷基环己基醚
JP5452608B2 (ja) * 2008-11-28 2014-03-26 エフ．ホフマン−ラ ロシュ アーゲー バソプレシン介在受容体アンタゴニストとしての使用のためのジヒドロテトラアザベンゾアズレンのアリールシクロヘキシルエーテル
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
US9145372B2 (en) 2010-11-15 2015-09-29 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
JP2015529254A (ja) * 2012-09-21 2015-10-05 ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド 喘息における気道の過敏症及び炎症を制御するための新規なｇａｂａａアゴニスト及び使用方法
CA3123897C (en) 2013-12-20 2024-02-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CA2990004C (en) * 2015-06-19 2024-04-23 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
US20180170941A1 (en) * 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
JP2021528427A (ja) * 2018-06-19 2021-10-21 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (de) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
CA2427576C (en) 2007-11-06
PL362925A1 (en) 2004-11-02
KR20030045192A (ko) 2003-06-09
ATE268776T1 (de) 2004-06-15
MY141675A (en) 2010-06-15
WO2002040487A3 (en) 2002-09-26
US20020103371A1 (en) 2002-08-01
RU2003116895A (ru) 2005-02-20
EP1337535B1 (de) 2004-06-09
TWI239333B (en) 2005-09-11
NO20032208D0 (no) 2003-05-15
UY27026A1 (es) 2002-06-20
BG107817A (bg) 2004-07-30
ECSP034607A (es) 2003-06-25
BR0115393A (pt) 2004-07-06
GT200100230A (es) 2002-07-04
NO20032208L (no) 2003-05-15
GC0000375A (en) 2007-03-31
SI1337535T1 (en) 2004-10-31
ES2220831T3 (es) 2004-12-16
JO2359B1 (en) 2006-12-12
NZ525413A (en) 2005-02-25
YU35603A (sh) 2006-05-25
PA8532401A1 (es) 2002-08-26
AR031345A1 (es) 2003-09-17
MXPA03004251A (es) 2003-09-22
JP2004517070A (ja) 2004-06-10
AU2002217007B2 (en) 2006-11-30
CN1474820A (zh) 2004-02-11
CA2427576A1 (en) 2002-05-23
DK1337535T3 (da) 2004-10-25
TR200402073T4 (tr) 2004-10-21
HUP0303281A3 (en) 2005-05-30
CN1191255C (zh) 2005-03-02
PE20020583A1 (es) 2002-07-06
CZ295256B6 (cs) 2005-06-15
CZ20031597A3 (cs) 2003-11-12
SK7232003A3 (en) 2004-03-02
WO2002040487A2 (en) 2002-05-23
KR100504300B1 (ko) 2005-07-28
HUP0303281A2 (hu) 2004-01-28
HRP20030360A2 (en) 2005-04-30
US6743789B2 (en) 2004-06-01
DE60103776T2 (de) 2005-07-14
NO324706B1 (no) 2007-12-03
RU2278865C2 (ru) 2006-06-27
ZA200303435B (en) 2004-08-05
IL155813A0 (en) 2003-12-23
MA26962A1 (fr) 2004-12-20
JP4088151B2 (ja) 2008-05-21
PT1337535E (pt) 2004-09-30
HK1062442A1 (en) 2004-11-05
EP1337535A2 (de) 2003-08-27
AU1700702A (en) 2002-05-27

Similar Documents

Publication Publication Date Title
DE60103776D1 (de) Benzodiazepinderivate als gaba-a-rezeptormodulatoren
ATE293962T1 (de) Adenosin-rezeptor modulatoren
NO20021690D0 (no) Benzodiazepin-derivater
NO20021691D0 (no) Benzodiazepinderivater
ATE260914T1 (de) Triazolyltropanderivate als ccr5-modulatoren
NO20032453L (no) Substituerte imidazopyridiner
ATE253067T1 (de) Diazabicyloderivate als nikotin-acetylcholin- rezeptorliganden
DE50105334D1 (de) Neue carbamat-substituierte pyrazolopyridinderivate
NO20015272L (no) Glukokortikoid reseptor modulatorer
NO20005508L (no) Adenosin-A3-reseptormodulatorer
ATE283857T1 (de) Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren
DK1218382T3 (da) Bicykliske imidazo-3-ylaminderivater
DE50015443D1 (de) Bicyclische imidazo-5-yl-aminderivate
NO20013997D0 (no) Reseptoranalyse
PT1165495E (pt) Derivados de resorcinol
ATE244716T1 (de) Neue n-triazolylmethyl-piperazinderivate als neurokininrezeptor-antagonisten
DE60003072D1 (de) Thiazolidindion-derivate als antidiabetika
DE60106974D1 (de) Aminotriazolopyridinderivate als adenosinrezeptorliganden
NO20031354D0 (no) Benzodiazepinderivater
DE60210333D1 (de) Tetracyclische heteroverbindungen als modulatoren des östrogenrezeptors
NO20021753D0 (no) Pentacykliske taksanforbindelser
NO20021295L (no) Nikotinsyreacetylcholin-reseptor
DE50015688D1 (de) Pflastersteinsystem
DE60012953D1 (de) 3-amino-2-phenylpiperidinderivate als substanz p antagonisten
NO20015378L (no) Cyklokarbamatderivater som progesteronreseptormodulatorer

Legal Events

Date Code Title Description
8364 No opposition during term of opposition