ATE283857T1 - Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren - Google Patents

Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren

Info

Publication number
ATE283857T1
ATE283857T1 AT02771640T AT02771640T ATE283857T1 AT E283857 T1 ATE283857 T1 AT E283857T1 AT 02771640 T AT02771640 T AT 02771640T AT 02771640 T AT02771640 T AT 02771640T AT E283857 T1 ATE283857 T1 AT E283857T1
Authority
AT
Austria
Prior art keywords
döbenz
aöpyrimido
gaba
imidazo
receptor modulators
Prior art date
Application number
AT02771640T
Other languages
English (en)
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE283857T1 publication Critical patent/ATE283857T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT02771640T 2001-05-18 2002-05-08 Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren ATE283857T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01112222 2001-05-18
PCT/EP2002/005121 WO2002094834A1 (en) 2001-05-18 2002-05-08 Imidazo [1,5-a] pyrimido [5,4-d] benzazepine derivatives as gaba a receptor modulators

Publications (1)

Publication Number Publication Date
ATE283857T1 true ATE283857T1 (de) 2004-12-15

Family

ID=8177471

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02771640T ATE283857T1 (de) 2001-05-18 2002-05-08 Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren

Country Status (38)

Country Link
US (1) US6686352B2 (de)
EP (1) EP1399448B1 (de)
JP (1) JP4068466B2 (de)
KR (1) KR100533406B1 (de)
CN (1) CN1230436C (de)
AR (1) AR033753A1 (de)
AT (1) ATE283857T1 (de)
AU (1) AU2002338898B2 (de)
BG (1) BG108369A (de)
BR (1) BR0209859A (de)
CA (1) CA2446903C (de)
CZ (1) CZ20033355A3 (de)
DE (1) DE60202147T2 (de)
DK (1) DK1399448T3 (de)
EC (1) ECSP034851A (de)
ES (1) ES2232778T3 (de)
GT (1) GT200200087A (de)
HK (1) HK1066544A1 (de)
HR (1) HRP20030890A2 (de)
HU (1) HUP0400743A3 (de)
IL (2) IL158572A0 (de)
JO (1) JO2297B1 (de)
MA (1) MA27024A1 (de)
MX (1) MXPA03010529A (de)
MY (1) MY127570A (de)
NO (1) NO20035104L (de)
NZ (1) NZ529097A (de)
PA (1) PA8545201A1 (de)
PE (1) PE20030041A1 (de)
PL (1) PL366846A1 (de)
PT (1) PT1399448E (de)
RU (1) RU2287531C2 (de)
SI (1) SI1399448T1 (de)
SK (1) SK15252003A3 (de)
TW (1) TWI251489B (de)
WO (1) WO2002094834A1 (de)
YU (1) YU90003A (de)
ZA (1) ZA200308544B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0511139B8 (pt) 2004-05-14 2021-05-25 Millennium Pharm Inc compostos que inibem quinase aurora e composição farmacêutica contendo os mesmos
EP1799684B1 (de) * 2004-10-04 2014-12-03 Millennium Pharmaceuticals, Inc. Als proteinkinaseinhibotren geeignete lactamverbindungen
CA2584757C (en) * 2004-10-20 2012-07-03 F. Hoffmann-La Roche Ag Halogen substituted benzodiazepine derivatives
RU2007112940A (ru) * 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные имидазобензодиазепина
BRPI0617204A2 (pt) 2005-10-11 2011-07-19 Hoffmann La Roche derivados de imidazo benzodiazepina
PE20080145A1 (es) * 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
US8288397B2 (en) 2007-12-17 2012-10-16 Janssen Pharmaceutica Nv Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
CN101735211B (zh) * 2008-11-04 2012-11-14 复旦大学 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
EP2373657B1 (de) 2008-12-05 2016-09-14 Millennium Pharmaceuticals, Inc. 5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-thione als plk inhibitoren
WO2010074724A1 (en) 2008-12-22 2010-07-01 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-cd20 antibodies
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
RU2012140021A (ru) 2010-02-19 2014-03-27 Миллениум Фармасьютикалз, Инк. КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 4-{[9-ХЛОР-7-(2-ФТОР-6-МЕТОКСИФЕНИЛ)-5Н-ПИРИМИДО[5,4-d][2]БЕНЗАЗЕПИН-2-ИЛ]АМИНО}-2-МЕТОКСИБЕНЗОАТА НАТРИЯ
CN101891706B (zh) * 2010-04-09 2013-05-29 复旦大学 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) * 2011-10-31 2012-04-25 江苏阿尔法药业有限公司 一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
EP2976086B1 (de) 2013-03-22 2020-10-14 Millennium Pharmaceuticals, Inc. Kombination aus katalytischen mtorc 1/2-inhibitoren und selektiven inhibitoren der aurora-a-kinase
US10329301B2 (en) * 2013-12-20 2019-06-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US10815242B2 (en) 2015-06-19 2020-10-27 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2017015316A1 (en) 2015-07-21 2017-01-26 Millennium Pharmaceuticals, Inc. Administration of aurora kinase inhibitor and chemotherapeutic agents
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2019246300A1 (en) 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN110452172B (zh) * 2019-08-21 2021-03-26 爱斯特（成都）生物制药股份有限公司 一种苯并己内酰胺的合成方法
CN112159411A (zh) * 2020-10-15 2021-01-01 南京工业大学 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201311B (de) 1991-06-17 1993-03-01 Hoffmann La Roche
FR2783828B1 (fr) 1998-09-29 2000-11-10 Synthelabo Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
WO2001034603A2 (en) 1999-11-12 2001-05-17 Neurogen Corporation Bicyclic and tricyclic heteroaromatic compounds
TWI239333B (en) 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators

Also Published As

Publication number Publication date
IL158572A0 (en) 2004-05-12
PE20030041A1 (es) 2003-02-07
JP4068466B2 (ja) 2008-03-26
DE60202147T2 (de) 2005-12-01
HUP0400743A3 (en) 2007-09-28
RU2287531C2 (ru) 2006-11-20
US6686352B2 (en) 2004-02-03
AR033753A1 (es) 2004-01-07
NO20035104D0 (no) 2003-11-17
DE60202147D1 (de) 2005-01-05
HRP20030890A2 (en) 2005-08-31
BR0209859A (pt) 2004-06-15
EP1399448B1 (de) 2004-12-01
WO2002094834A1 (en) 2002-11-28
ES2232778T3 (es) 2005-06-01
MA27024A1 (fr) 2004-12-20
DK1399448T3 (da) 2005-04-11
HUP0400743A2 (hu) 2004-07-28
GT200200087A (es) 2003-06-19
CN1230436C (zh) 2005-12-07
PL366846A1 (en) 2005-02-07
CZ20033355A3 (en) 2004-07-14
KR100533406B1 (ko) 2005-12-02
CN1509289A (zh) 2004-06-30
HK1066544A1 (en) 2005-03-24
AU2002338898B2 (en) 2007-03-15
PA8545201A1 (es) 2003-02-28
YU90003A (sh) 2006-08-17
JO2297B1 (en) 2005-09-12
SK15252003A3 (sk) 2004-08-03
US20030055042A1 (en) 2003-03-20
TWI251489B (en) 2006-03-21
NO20035104L (no) 2003-11-17
KR20040002975A (ko) 2004-01-07
RU2003136078A (ru) 2005-05-27
PT1399448E (pt) 2005-03-31
IL158572A (en) 2010-02-17
EP1399448A1 (de) 2004-03-24
AU2002338898B8 (en) 2002-12-03
ZA200308544B (en) 2005-01-31
JP2004531563A (ja) 2004-10-14
CA2446903A1 (en) 2002-11-28
SI1399448T1 (en) 2005-02-28
ECSP034851A (es) 2003-12-24
MY127570A (en) 2006-12-29
CA2446903C (en) 2008-12-30
BG108369A (bg) 2005-01-31
MXPA03010529A (es) 2004-03-02
NZ529097A (en) 2005-04-29

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