DE60202147D1 - Imidazo(1,5-a!pyrimido)5,4-d!benz azepinderivate als gaba-a-rezeptormodulatoren - Google Patents

Imidazo(1,5-a!pyrimido)5,4-d!benz azepinderivate als gaba-a-rezeptormodulatoren

Info

Publication number
DE60202147D1
DE60202147D1 DE60202147T DE60202147T DE60202147D1 DE 60202147 D1 DE60202147 D1 DE 60202147D1 DE 60202147 T DE60202147 T DE 60202147T DE 60202147 T DE60202147 T DE 60202147T DE 60202147 D1 DE60202147 D1 DE 60202147D1
Authority
DE
Germany
Prior art keywords
pyrimido
gaba
imidazo
receptor modulators
azepine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60202147T
Other languages
English (en)
Other versions
DE60202147T2 (de
Inventor
Raffaello Masciadri
William Thomas
Juergen Wichmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE60202147D1 publication Critical patent/DE60202147D1/de
Publication of DE60202147T2 publication Critical patent/DE60202147T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60202147T 2001-05-18 2002-05-08 Imidazo(1,5-a)pyrimido(5,4-d)(1)benzazepinderivate als GABA-A-Rezeptormodulatoren Expired - Lifetime DE60202147T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01112222 2001-05-18
EP01112222 2001-05-18
PCT/EP2002/005121 WO2002094834A1 (en) 2001-05-18 2002-05-08 Imidazo [1,5-a] pyrimido [5,4-d] benzazepine derivatives as gaba a receptor modulators

Publications (2)

Publication Number Publication Date
DE60202147D1 true DE60202147D1 (de) 2005-01-05
DE60202147T2 DE60202147T2 (de) 2005-12-01

Family

ID=8177471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60202147T Expired - Lifetime DE60202147T2 (de) 2001-05-18 2002-05-08 Imidazo(1,5-a)pyrimido(5,4-d)(1)benzazepinderivate als GABA-A-Rezeptormodulatoren

Country Status (38)

Country Link
US (1) US6686352B2 (de)
EP (1) EP1399448B1 (de)
JP (1) JP4068466B2 (de)
KR (1) KR100533406B1 (de)
CN (1) CN1230436C (de)
AR (1) AR033753A1 (de)
AT (1) ATE283857T1 (de)
AU (1) AU2002338898B2 (de)
BG (1) BG108369A (de)
BR (1) BR0209859A (de)
CA (1) CA2446903C (de)
CZ (1) CZ20033355A3 (de)
DE (1) DE60202147T2 (de)
DK (1) DK1399448T3 (de)
EC (1) ECSP034851A (de)
ES (1) ES2232778T3 (de)
GT (1) GT200200087A (de)
HK (1) HK1066544A1 (de)
HR (1) HRP20030890A2 (de)
HU (1) HUP0400743A3 (de)
IL (2) IL158572A0 (de)
JO (1) JO2297B1 (de)
MA (1) MA27024A1 (de)
MX (1) MXPA03010529A (de)
MY (1) MY127570A (de)
NO (1) NO20035104D0 (de)
NZ (1) NZ529097A (de)
PA (1) PA8545201A1 (de)
PE (1) PE20030041A1 (de)
PL (1) PL366846A1 (de)
PT (1) PT1399448E (de)
RU (1) RU2287531C2 (de)
SI (1) SI1399448T1 (de)
SK (1) SK15252003A3 (de)
TW (1) TWI251489B (de)
WO (1) WO2002094834A1 (de)
YU (1) YU90003A (de)
ZA (1) ZA200308544B (de)

Families Citing this family (25)

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ES2540987T3 (es) 2004-05-14 2015-07-15 Millennium Pharmaceuticals, Inc. Métodos para preparar inhibidores de la aurora cinasa
CA2582235A1 (en) * 2004-10-04 2006-04-20 Millennium Pharmaceuticals, Inc. Lactam compounds useful as protein kinase inhibitors
EP1805184B1 (de) * 2004-10-20 2013-01-09 F. Hoffmann-La Roche AG Imidazobenzodiazepin-derivate
MX2007004640A (es) * 2004-10-20 2007-06-08 Hoffmann La Roche Derivados de benzodiazepina sustituidos con halogeno.
EP1937688B1 (de) * 2005-10-11 2010-08-11 F. Hoffmann-La Roche AG Imidazobenzdiazepinderivate
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
US8288397B2 (en) 2007-12-17 2012-10-16 Janssen Pharmaceutica Nv Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
CN101735211B (zh) * 2008-11-04 2012-11-14 复旦大学 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
JP5684719B2 (ja) 2008-12-05 2015-03-18 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｐｌｋ阻害剤としての５，７−ジヒドロ−６ｈ−ピリミド［５、−４ｄ］［１］ベンゾアゼピン−６−チオン
MX2011006725A (es) 2008-12-22 2011-09-15 Millennium Pharm Inc Combinacion de inhibidores de aurora cinasa y anticuerpos anti-cd20.
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
RU2012140021A (ru) 2010-02-19 2014-03-27 Миллениум Фармасьютикалз, Инк. КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 4-{[9-ХЛОР-7-(2-ФТОР-6-МЕТОКСИФЕНИЛ)-5Н-ПИРИМИДО[5,4-d][2]БЕНЗАЗЕПИН-2-ИЛ]АМИНО}-2-МЕТОКСИБЕНЗОАТА НАТРИЯ
CN101891706B (zh) * 2010-04-09 2013-05-29 复旦大学 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) * 2011-10-31 2012-04-25 江苏阿尔法药业有限公司 一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
US9724354B2 (en) 2013-03-22 2017-08-08 Millennium Pharmaceuticals, Inc. Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase
EP3083569B1 (de) 2013-12-20 2022-01-26 Agenebio, Inc. Benzodiazepinderivate, zusammensetzungen und verfahren zur behandlung von kognitiven störungen
CA2990004C (en) 2015-06-19 2024-04-23 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EA202190076A1 (ru) 2018-06-19 2021-09-22 Эйджинбайо, Инк. Производные бензодиазепина, композиции и способы лечения когнитивных нарушений
CN110452172B (zh) * 2019-08-21 2021-03-26 爱斯特（成都）生物制药股份有限公司 一种苯并己内酰胺的合成方法
CN112159411A (zh) * 2020-10-15 2021-01-01 南京工业大学 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201311B (de) 1991-06-17 1993-03-01 Hoffmann La Roche
FR2783828B1 (fr) 1998-09-29 2000-11-10 Synthelabo Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
ATE236158T1 (de) 1999-11-12 2003-04-15 Neurogen Corp Bicyclische und tricyclische heteroaromatische verbindungen
TWI239333B (en) 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators

Also Published As

Publication number Publication date
RU2003136078A (ru) 2005-05-27
IL158572A0 (en) 2004-05-12
KR20040002975A (ko) 2004-01-07
EP1399448B1 (de) 2004-12-01
US20030055042A1 (en) 2003-03-20
ECSP034851A (es) 2003-12-24
SK15252003A3 (sk) 2004-08-03
PA8545201A1 (es) 2003-02-28
BR0209859A (pt) 2004-06-15
GT200200087A (es) 2003-06-19
DK1399448T3 (da) 2005-04-11
WO2002094834A1 (en) 2002-11-28
EP1399448A1 (de) 2004-03-24
TWI251489B (en) 2006-03-21
YU90003A (sh) 2006-08-17
HUP0400743A3 (en) 2007-09-28
BG108369A (bg) 2005-01-31
JP4068466B2 (ja) 2008-03-26
CN1230436C (zh) 2005-12-07
AR033753A1 (es) 2004-01-07
PL366846A1 (en) 2005-02-07
IL158572A (en) 2010-02-17
MA27024A1 (fr) 2004-12-20
HUP0400743A2 (hu) 2004-07-28
KR100533406B1 (ko) 2005-12-02
RU2287531C2 (ru) 2006-11-20
SI1399448T1 (en) 2005-02-28
DE60202147T2 (de) 2005-12-01
ES2232778T3 (es) 2005-06-01
US6686352B2 (en) 2004-02-03
JP2004531563A (ja) 2004-10-14
CZ20033355A3 (en) 2004-07-14
CN1509289A (zh) 2004-06-30
ATE283857T1 (de) 2004-12-15
JO2297B1 (en) 2005-09-12
AU2002338898B8 (en) 2002-12-03
CA2446903A1 (en) 2002-11-28
CA2446903C (en) 2008-12-30
NO20035104L (no) 2003-11-17
MY127570A (en) 2006-12-29
NO20035104D0 (no) 2003-11-17
PE20030041A1 (es) 2003-02-07
AU2002338898B2 (en) 2007-03-15
PT1399448E (pt) 2005-03-31
HK1066544A1 (en) 2005-03-24
HRP20030890A2 (en) 2005-08-31
MXPA03010529A (es) 2004-03-02
NZ529097A (en) 2005-04-29
ZA200308544B (en) 2005-01-31

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