HRP20030890A2 - Imidazo [1,5-a] pyrimido [5,4-d][1] benzazepine derivatives as gaba a receptor modulators - Google Patents

Imidazo [1,5-a] pyrimido [5,4-d][1] benzazepine derivatives as gaba a receptor modulators

Info

Publication number
HRP20030890A2
HRP20030890A2 HR20030890A HRP20030890A HRP20030890A2 HR P20030890 A2 HRP20030890 A2 HR P20030890A2 HR 20030890 A HR20030890 A HR 20030890A HR P20030890 A HRP20030890 A HR P20030890A HR P20030890 A2 HRP20030890 A2 HR P20030890A2
Authority
HR
Croatia
Prior art keywords
pyrimido
gaba
imidazo
receptor modulators
benzazepine derivatives
Prior art date
Application number
HR20030890A
Other languages
English (en)
Inventor
Masciadri Raffaello
William Thomas Andrew
Wichmann Juergen
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20030890A2 publication Critical patent/HRP20030890A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR20030890A 2001-05-18 2003-11-04 Imidazo [1,5-a] pyrimido [5,4-d][1] benzazepine derivatives as gaba a receptor modulators HRP20030890A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01112222 2001-05-18
PCT/EP2002/005121 WO2002094834A1 (en) 2001-05-18 2002-05-08 Imidazo [1,5-a] pyrimido [5,4-d] benzazepine derivatives as gaba a receptor modulators

Publications (1)

Publication Number Publication Date
HRP20030890A2 true HRP20030890A2 (en) 2005-08-31

Family

ID=8177471

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030890A HRP20030890A2 (en) 2001-05-18 2003-11-04 Imidazo [1,5-a] pyrimido [5,4-d][1] benzazepine derivatives as gaba a receptor modulators

Country Status (38)

Country Link
US (1) US6686352B2 (xx)
EP (1) EP1399448B1 (xx)
JP (1) JP4068466B2 (xx)
KR (1) KR100533406B1 (xx)
CN (1) CN1230436C (xx)
AR (1) AR033753A1 (xx)
AT (1) ATE283857T1 (xx)
AU (1) AU2002338898B2 (xx)
BG (1) BG108369A (xx)
BR (1) BR0209859A (xx)
CA (1) CA2446903C (xx)
CZ (1) CZ20033355A3 (xx)
DE (1) DE60202147T2 (xx)
DK (1) DK1399448T3 (xx)
EC (1) ECSP034851A (xx)
ES (1) ES2232778T3 (xx)
GT (1) GT200200087A (xx)
HK (1) HK1066544A1 (xx)
HR (1) HRP20030890A2 (xx)
HU (1) HUP0400743A3 (xx)
IL (2) IL158572A0 (xx)
JO (1) JO2297B1 (xx)
MA (1) MA27024A1 (xx)
MX (1) MXPA03010529A (xx)
MY (1) MY127570A (xx)
NO (1) NO20035104L (xx)
NZ (1) NZ529097A (xx)
PA (1) PA8545201A1 (xx)
PE (1) PE20030041A1 (xx)
PL (1) PL366846A1 (xx)
PT (1) PT1399448E (xx)
RU (1) RU2287531C2 (xx)
SI (1) SI1399448T1 (xx)
SK (1) SK15252003A3 (xx)
TW (1) TWI251489B (xx)
WO (1) WO2002094834A1 (xx)
YU (1) YU90003A (xx)
ZA (1) ZA200308544B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE381566T1 (de) 2004-05-14 2008-01-15 Millennium Pharm Inc Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase
AU2005294575B2 (en) * 2004-10-04 2011-11-24 Millennium Pharmaceuticals, Inc. Lactam compounds useful as protein kinase inhibitors
CA2584757C (en) * 2004-10-20 2012-07-03 F. Hoffmann-La Roche Ag Halogen substituted benzodiazepine derivatives
RU2007112940A (ru) * 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные имидазобензодиазепина
CN101287738B (zh) * 2005-10-11 2011-08-10 弗·哈夫曼-拉罗切有限公司 咪唑并苯并二氮杂*衍生物
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
CL2008003749A1 (es) 2007-12-17 2010-01-15 Janssen Pharmaceutica Nv Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras.
CN101735211B (zh) * 2008-11-04 2012-11-14 复旦大学 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
AR074487A1 (es) * 2008-12-05 2011-01-19 Millennium Pharm Inc Tiolactamas inhibidoras de proteinquinasas plk, composiciones farmaceuticas que las contienen y usos de las mismas para el tratamiento de trastornos proliferativos e inflamatorios, en particular cancer.
WO2010074724A1 (en) 2008-12-22 2010-07-01 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-cd20 antibodies
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
CA2788774A1 (en) 2010-02-19 2011-08-25 Millennium Pharmaceuticals, Inc. Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5h-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoate
CN101891706B (zh) * 2010-04-09 2013-05-29 复旦大学 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) * 2011-10-31 2012-04-25 江苏阿尔法药业有限公司 一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
US9724354B2 (en) 2013-03-22 2017-08-08 Millennium Pharmaceuticals, Inc. Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase
MX2016007808A (es) 2013-12-20 2016-09-07 Agenebio Inc Derivados de benzodiazepina, composiciones, y metodos para tratar el deterioro congnitivo.
CN113264939A (zh) 2015-06-19 2021-08-17 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2019246300A1 (en) 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN110452172B (zh) * 2019-08-21 2021-03-26 爱斯特（成都）生物制药股份有限公司 一种苯并己内酰胺的合成方法
CN112159411A (zh) * 2020-10-15 2021-01-01 南京工业大学 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201311B (xx) 1991-06-17 1993-03-01 Hoffmann La Roche
FR2783828B1 (fr) 1998-09-29 2000-11-10 Synthelabo Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
AU1481701A (en) 1999-11-12 2001-06-06 Neurogen Corporation Bicyclic and tricyclic heteroaromatic compounds
TWI239333B (en) 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators

Also Published As

Publication number Publication date
NO20035104D0 (no) 2003-11-17
DE60202147D1 (de) 2005-01-05
DK1399448T3 (da) 2005-04-11
YU90003A (sh) 2006-08-17
AU2002338898B8 (en) 2002-12-03
NO20035104L (no) 2003-11-17
PL366846A1 (en) 2005-02-07
JP2004531563A (ja) 2004-10-14
HK1066544A1 (en) 2005-03-24
ZA200308544B (en) 2005-01-31
HUP0400743A3 (en) 2007-09-28
IL158572A (en) 2010-02-17
SI1399448T1 (en) 2005-02-28
BR0209859A (pt) 2004-06-15
JO2297B1 (en) 2005-09-12
MA27024A1 (fr) 2004-12-20
CA2446903C (en) 2008-12-30
AR033753A1 (es) 2004-01-07
US20030055042A1 (en) 2003-03-20
PE20030041A1 (es) 2003-02-07
KR20040002975A (ko) 2004-01-07
MXPA03010529A (es) 2004-03-02
NZ529097A (en) 2005-04-29
JP4068466B2 (ja) 2008-03-26
EP1399448A1 (en) 2004-03-24
IL158572A0 (en) 2004-05-12
WO2002094834A1 (en) 2002-11-28
CA2446903A1 (en) 2002-11-28
RU2287531C2 (ru) 2006-11-20
HUP0400743A2 (hu) 2004-07-28
KR100533406B1 (ko) 2005-12-02
CN1230436C (zh) 2005-12-07
RU2003136078A (ru) 2005-05-27
ATE283857T1 (de) 2004-12-15
TWI251489B (en) 2006-03-21
ECSP034851A (es) 2003-12-24
GT200200087A (es) 2003-06-19
SK15252003A3 (sk) 2004-08-03
DE60202147T2 (de) 2005-12-01
BG108369A (bg) 2005-01-31
US6686352B2 (en) 2004-02-03
EP1399448B1 (en) 2004-12-01
ES2232778T3 (es) 2005-06-01
CZ20033355A3 (en) 2004-07-14
MY127570A (en) 2006-12-29
PT1399448E (pt) 2005-03-31
PA8545201A1 (es) 2003-02-28
AU2002338898B2 (en) 2007-03-15
CN1509289A (zh) 2004-06-30

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