AR104714A1 - Compuestos depsipeptídicos como antihelmínticos - Google Patents
Compuestos depsipeptídicos como antihelmínticosInfo
- Publication number
- AR104714A1 AR104714A1 ARP160101476A ARP160101476A AR104714A1 AR 104714 A1 AR104714 A1 AR 104714A1 AR P160101476 A ARP160101476 A AR P160101476A AR P160101476 A ARP160101476 A AR P160101476A AR 104714 A1 AR104714 A1 AR 104714A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- heteroaryl
- heterocyclyl
- group
- Prior art date
Links
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical class O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 title abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 28
- 125000003118 aryl group Chemical group 0.000 abstract 18
- -1 carbocycle Chemical group 0.000 abstract 18
- 125000001072 heteroaryl group Chemical group 0.000 abstract 18
- 125000000623 heterocyclic group Chemical group 0.000 abstract 18
- 125000003282 alkyl amino group Chemical group 0.000 abstract 17
- 125000004414 alkyl thio group Chemical group 0.000 abstract 17
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 17
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 17
- 125000004995 haloalkylthio group Chemical group 0.000 abstract 17
- 229910052736 halogen Inorganic materials 0.000 abstract 17
- 150000002367 halogens Chemical group 0.000 abstract 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 17
- 125000001424 substituent group Chemical group 0.000 abstract 17
- 125000003545 alkoxy group Chemical group 0.000 abstract 16
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 15
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 15
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 15
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 abstract 15
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 abstract 15
- 125000004043 oxo group Chemical group O=* 0.000 abstract 15
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- 125000000232 haloalkynyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 244000045947 parasite Species 0.000 abstract 3
- HCMJWOGOISXSDL-UHFFFAOYSA-N (2-isothiocyanato-1-phenylethyl)benzene Chemical group C=1C=CC=CC=1C(CN=C=S)C1=CC=CC=C1 HCMJWOGOISXSDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- KHEPSBKTSMKGQV-UHFFFAOYSA-N 3-[4-[2-(4-piperidin-4-ylanilino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]pyrazol-1-yl]propanenitrile Chemical group N1CCC(CC1)C1=CC=C(C=C1)NC=1N=C(C2=C(N=1)NC=C2)C=1C=NN(C=1)CCC#N KHEPSBKTSMKGQV-UHFFFAOYSA-N 0.000 abstract 2
- 108010002156 Depsipeptides Proteins 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010061217 Infestation Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P17/00—Pest repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
La presente solicitud provee compuestos depsipeptídicos cíclicos de fórmula (1) y composiciones que comprenden los compuestos que son eficaces contra parásitos perjudiciales para los animales. Los compuestos y composiciones se pueden usar para combatir parásitos internos o externos en mamíferos y aves. La solicitud también provee un método mejorado para erradicar, controlar y prevenir la infestación por parásitos en aves y mamíferos. Reivindicación 1: Un compuesto depsipéptido cíclico caracterizado porque es de fórmula (1), o una sal aceptable para uso farmacéutico o veterinario del mismo, donde: Cy¹ y Cy² son en forma independiente arilo, carbociclo, heteroarilo o heterociclo opcionalmente sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, tioamido, amino, alquilamino, dialquilamino, alquilo, haloalquilo, alquenilo, haloalquenilo, alquinilo, haloalquinilo, SF₅, R⁵S(O)-, R⁵S(O)₂-, R⁵C(O)-, R⁵R⁶NC(O)-, R⁵R⁶NC(O)NR⁵-, R⁵OC(O)-, R⁵C(O)O-, R⁵C(O)NR⁶-, -CN, -NO₂, cicloalquilo, heteroalquilo, heterociclilo, arilo, heteroarilo, -O-heteroarilo, -S-heteroarilo, -O-heterociclilo o -S-heterociclilo, donde cada cicloalquilo, heterociclilo, arilo o heteroarilo opcionalmente también está sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, tioamido, amino, alquilamino, dialquilamino, alquilo, haloalquilo, alquenilo, haloalquenilo, alquinilo, haloalquinilo, SF₅, R⁵S(O)-, R⁵S(O)₂-, R⁵C(O)-, R⁵R⁶NC(O)- R⁵OC(O)-, R⁵C(O)O-, R⁵C(O)NR⁶-, -CN y -NO₂; R⁵ y R⁶ son en forma independiente hidrógeno, alquilo, haloalquilo, tioalquilo, alquiltioalquilo, hidroxialquilo, alcoxialquilo, alquenilo, haloalquenilo, alquinilo, haloalquinilo, o el grupo -CH₂C(O)NHCH₂CF₃; o R⁵ y R⁶ junto con los átomos a los cuales están unidos forman un grupo C₃₋₆ cíclico; R, R, R y R son en forma independiente entre sí hidrógeno o C₁₋₃ alquilo; Rᵃ y Rᵇ son en forma independiente hidrógeno, C₁₋₃ alquilo o C₁₋₃ haloalquilo; y (a) R¹ es C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R², R³ y R⁴ son en forma independiente entre sí C₁₋₈ alquilo; o (b) R² es C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R¹, R³ y R⁴ son en forma independiente entre sí C₁₋₈ alquilo; o (c) R³ es C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R¹, R² y R⁴ son en forma independiente entre sí C₁₋₈ alquilo; o (d) R⁴ es C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R¹, R² y R³ son en forma independiente entre sí C₁₋₈ alquilo; o (e) R¹ y R² son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R³ y R⁴ son en forma independiente entre sí C₁₋₈ alquilo; o (f) R¹ y R³ son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R² y R⁴ son en forma independiente entre sí C₁₋₈ alquilo; o (g) R¹ y R⁴ son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R² y R³ son en forma independiente entre sí C₁₋₈ alquilo; o (h) R² y R⁴ son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R¹ y R³ son en forma independiente entre sí C₁₋₈ alquilo; o (i) R² y R³ son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R¹ y R⁴ son en forma independiente entre sí C₁₋₈ alquilo; o (j) R³ y R⁴ son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R¹ y R² son en forma independiente entre sí C₁₋₈ alquilo; o (k) R¹, R² y R³ son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R⁴ es C₁₋₈ alquilo; o (l) R², R³ y R⁴ son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más o sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R¹ es C₁₋₈ alquilo; o (m) R¹, R³ y R⁴ son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino; y R² es C₁₋₈ alquilo; o (n) R¹, R² y R⁴ son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino y alquilamino, dialquilamino; y R³ es C₁₋₈ alquilo; o (o) R¹, R², R³ y R⁴ son en forma independiente entre sí C₁₋₈ alquilo sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en arilo, heteroarilo, heterociclilo, halógeno, hidroxi, alcoxi, haloalcoxi, alquiltio, haloalquiltio, alquilsulfinilo, haloalquilsulfinilo, alquilsulfonilo, haloalquilsulfonilo, alcoxialcoxi, oxo, ciano, amino, alquilamino y dialquilamino.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163997P | 2015-05-20 | 2015-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104714A1 true AR104714A1 (es) | 2017-08-09 |
Family
ID=56322274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101476A AR104714A1 (es) | 2015-05-20 | 2016-05-20 | Compuestos depsipeptídicos como antihelmínticos |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US10081656B2 (es) |
| EP (2) | EP3298027B1 (es) |
| JP (2) | JP7045191B2 (es) |
| KR (1) | KR20180002886A (es) |
| CN (2) | CN114891070A (es) |
| AR (1) | AR104714A1 (es) |
| AU (2) | AU2016264635B2 (es) |
| BR (1) | BR112017024773A2 (es) |
| CA (1) | CA2986478C (es) |
| CL (1) | CL2017002936A1 (es) |
| CO (1) | CO2017011738A2 (es) |
| CY (1) | CY1124370T1 (es) |
| DK (1) | DK3298027T3 (es) |
| ES (1) | ES2916216T3 (es) |
| HK (1) | HK1245285A1 (es) |
| HR (1) | HRP20211041T1 (es) |
| HU (1) | HUE055535T2 (es) |
| IL (1) | IL255735B (es) |
| LT (1) | LT3298027T (es) |
| MX (2) | MX2021001566A (es) |
| NZ (1) | NZ737610A (es) |
| PH (1) | PH12017502106A1 (es) |
| PL (1) | PL3298027T3 (es) |
| PT (1) | PT3298027T (es) |
| RS (1) | RS62130B1 (es) |
| RU (1) | RU2707298C2 (es) |
| SG (1) | SG10202103403SA (es) |
| SI (1) | SI3298027T1 (es) |
| TW (2) | TWI749509B (es) |
| UY (1) | UY36683A (es) |
| WO (1) | WO2016187534A1 (es) |
| ZA (2) | ZA201707806B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2715556C2 (ru) * | 2015-12-28 | 2020-03-02 | Мериал, Инк. | Противогельминтные депсипептидные соединения |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| CN110167921A (zh) | 2016-11-16 | 2019-08-23 | 勃林格殷格翰动物保健美国公司 | 驱蠕虫缩肽化合物 |
| CA3052054A1 (en) * | 2017-02-08 | 2018-08-16 | Boehringer Ingelheim Animal Health USA Inc. | In vivo model for parasitic worm infection and methods for evaluating antiparasitic compounds, including compounds active against canine heartworm |
| GB201713633D0 (en) * | 2017-08-24 | 2017-10-11 | Walshe Nigel | Methods for production of emodepside from pf 1022a derivatives |
| US20210130315A1 (en) * | 2017-11-07 | 2021-05-06 | Bayer Animal Health Gmbh | Method for the synthesis of cyclic depsipeptides |
| UA125155C2 (uk) * | 2017-11-29 | 2022-01-19 | Зоетіс Сервісіс Ллк | Анти-ендопаразитарні депсипептиди |
| EP3749096A1 (en) | 2018-02-08 | 2020-12-16 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| BR112020022925A2 (pt) * | 2018-05-10 | 2021-02-02 | Zoetis Services Llc | depsipeptídeos endoparasitários |
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