SE9303657D0 - Short-acting dihydropyridines - Google Patents
Short-acting dihydropyridinesInfo
- Publication number
- SE9303657D0 SE9303657D0 SE9303657A SE9303657A SE9303657D0 SE 9303657 D0 SE9303657 D0 SE 9303657D0 SE 9303657 A SE9303657 A SE 9303657A SE 9303657 A SE9303657 A SE 9303657A SE 9303657 D0 SE9303657 D0 SE 9303657D0
- Authority
- SE
- Sweden
- Prior art keywords
- hydrogen
- pct
- chloro
- methyl
- nitro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Priority Applications (36)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9303657A SE9303657D0 (sv) | 1993-11-05 | 1993-11-05 | Short-acting dihydropyridines |
ZA947570A ZA947570B (en) | 1993-11-05 | 1994-09-28 | Short-acting dihydropyridines |
TW083108995A TW279859B (sv) | 1993-11-05 | 1994-09-29 | |
IS4218A IS1674B (is) | 1993-11-05 | 1994-09-30 | Hliðstæð aðferð við að framleiða skammvirk tvíhýdrópýridín |
IL11112794A IL111127A (en) | 1993-11-05 | 1994-10-03 | Short-acting calcium antagonist dihydropyridines process for their preparation and pharmaceutical compositions containing them |
SA94150250A SA94150250B1 (ar) | 1993-11-05 | 1994-10-19 | دايهيدرو بيريدين dihydropyridine قصير المفعول |
EG68994A EG20539A (en) | 1993-11-05 | 1994-11-02 | Process for preparing of dihydraphyridines and their use as pharmaceutical compositions in lowering blood pressure |
PL94314128A PL185099B1 (pl) | 1993-11-05 | 1994-11-03 | Dihydropirydyny o krótkim działaniu oraz sposób ich wytwarzania |
ES95900347T ES2150544T3 (es) | 1993-11-05 | 1994-11-03 | Dihidropiridinas de accion breve. |
AU81196/94A AU685532B2 (en) | 1993-11-05 | 1994-11-03 | Short-acting dihydropyridines |
NZ275915A NZ275915A (en) | 1993-11-05 | 1994-11-03 | 4-phenyl substituted dihydropyridine 3,5-dicarboxylic acid ester derivatives and medicaments |
BR9407946A BR9407946A (pt) | 1993-11-05 | 1994-11-03 | Composto processo para sua preparaçao preparaçao farmacêutica contendo o mesmo uso do mesmo e processo e preparaçao farmacêutica para abaixamento da press o sanguínea em mamíferos |
CN94194500A CN1049428C (zh) | 1993-11-05 | 1994-11-03 | 短效的二氢吡啶类化合物及其制备方法和用途 |
SK559-96A SK281467B6 (sk) | 1993-11-05 | 1994-11-03 | Krátko pôsobiace dihydropyridíny, spôsoby ich prípravy, farmaceutické prípravky s ich obsahom a ich použitie |
DE69425152T DE69425152T2 (de) | 1993-11-05 | 1994-11-03 | Dihydropyridine mit kurzer wirkung |
CZ961273A CZ285691B6 (cs) | 1993-11-05 | 1994-11-03 | Krátce působící dihydropyridiny |
AT95900347T ATE194330T1 (de) | 1993-11-05 | 1994-11-03 | Dihydropyridine mit kurzer wirkung |
PT95900347T PT726894E (pt) | 1993-11-05 | 1994-11-03 | Di-hidropiridinas de curta actividade |
DK95900347T DK0726894T3 (da) | 1993-11-05 | 1994-11-03 | Kortvarigt virkende dihydropyridiner |
JP51317095A JP3712209B2 (ja) | 1993-11-05 | 1994-11-03 | 短時間作用型ジヒドロピリジン類 |
RU96112152A RU2139278C1 (ru) | 1993-11-05 | 1994-11-03 | Дигидропиридины, способ их получения, фармацевтическая композиция на их основе и способ снижения кровяного давления |
PCT/SE1994/001031 WO1995012578A1 (en) | 1993-11-05 | 1994-11-03 | Short-acting dihydropyridines |
UA96041753A UA45959C2 (uk) | 1993-11-05 | 1994-11-03 | Дигідропіридини, спосіб їх одержання, фармацевтична композиція для зниження кров'яного тиску та спосіб зниження кров'яного тиску у ссавців |
EE9600051A EE03230B1 (et) | 1993-11-05 | 1994-11-03 | Kiiretoimelised dihüdropüridiinid, nende valmistamise protsessid ja neid sisaldavad ravimvormid |
HU9601187A HU215591B (hu) | 1993-11-05 | 1994-11-03 | Rövid hatástartamú dihidropiridinszármazékok, eljárás előállításukra, és a vegyületeket tartalmazó gyógyászati készítmények |
KR1019960702346A KR100331663B1 (ko) | 1993-11-05 | 1994-11-03 | 단시간작용형디히드로피리딘 |
CA002174969A CA2174969C (en) | 1993-11-05 | 1994-11-03 | Short-acting dihydropyridines |
US08/356,224 US5856346A (en) | 1993-11-05 | 1994-11-03 | Short-acting dihydropyridines |
EP95900347A EP0726894B1 (en) | 1993-11-05 | 1994-11-03 | Short-acting dihydropyridines |
MYPI94002934A MY111770A (en) | 1993-11-05 | 1994-11-04 | Short-acting dihydropyridines |
NO961776A NO305656B1 (no) | 1993-11-05 | 1996-05-02 | Nye dihydropyridinforbindelser, farmas°ytiske preparater inneholdende slike forbindelser samt anvendelse av forbindelsene |
FI961914A FI110429B (sv) | 1993-11-05 | 1996-05-06 | Förfarande för framställning av farmaceutiska dihydropyridiner |
HK98114638A HK1013292A1 (en) | 1993-11-05 | 1998-12-22 | Short-acting dihydropyridines |
GR20000402158T GR3034469T3 (en) | 1993-11-05 | 2000-09-21 | Short-acting dihydropyridines |
FR12C0053C FR12C0053I2 (fr) | 1993-11-05 | 2012-09-18 | Dihydropyridines a activite courte |
LU92209C LU92209I2 (fr) | 1993-11-05 | 2013-06-10 | Clevidipine sous toutes les formes procurant une protection à partir du brevet de base |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9303657A SE9303657D0 (sv) | 1993-11-05 | 1993-11-05 | Short-acting dihydropyridines |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9303657D0 true SE9303657D0 (sv) | 1993-11-05 |
Family
ID=20391655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9303657A SE9303657D0 (sv) | 1993-11-05 | 1993-11-05 | Short-acting dihydropyridines |
Country Status (36)
Country | Link |
---|---|
US (1) | US5856346A (sv) |
EP (1) | EP0726894B1 (sv) |
JP (1) | JP3712209B2 (sv) |
KR (1) | KR100331663B1 (sv) |
CN (1) | CN1049428C (sv) |
AT (1) | ATE194330T1 (sv) |
AU (1) | AU685532B2 (sv) |
BR (1) | BR9407946A (sv) |
CA (1) | CA2174969C (sv) |
CZ (1) | CZ285691B6 (sv) |
DE (1) | DE69425152T2 (sv) |
DK (1) | DK0726894T3 (sv) |
EE (1) | EE03230B1 (sv) |
EG (1) | EG20539A (sv) |
ES (1) | ES2150544T3 (sv) |
FI (1) | FI110429B (sv) |
FR (1) | FR12C0053I2 (sv) |
GR (1) | GR3034469T3 (sv) |
HK (1) | HK1013292A1 (sv) |
HU (1) | HU215591B (sv) |
IL (1) | IL111127A (sv) |
IS (1) | IS1674B (sv) |
LU (1) | LU92209I2 (sv) |
MY (1) | MY111770A (sv) |
NO (1) | NO305656B1 (sv) |
NZ (1) | NZ275915A (sv) |
PL (1) | PL185099B1 (sv) |
PT (1) | PT726894E (sv) |
RU (1) | RU2139278C1 (sv) |
SA (1) | SA94150250B1 (sv) |
SE (1) | SE9303657D0 (sv) |
SK (1) | SK281467B6 (sv) |
TW (1) | TW279859B (sv) |
UA (1) | UA45959C2 (sv) |
WO (1) | WO1995012578A1 (sv) |
ZA (1) | ZA947570B (sv) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9804002D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New manufacturing process |
JP4580649B2 (ja) * | 2001-12-21 | 2010-11-17 | アルコン、インコーポレイテッド | ナノ粒子を殺生物剤の担体として眼科用組成物に使用する方法 |
FR2922439B1 (fr) * | 2007-10-18 | 2010-12-10 | Hill Rom Ind Sa | Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre |
CN102170786B (zh) | 2008-08-01 | 2015-05-27 | 医药公司 | 药物组合物和产生低杂质浓度的药物组合物的方法 |
KR20120100945A (ko) * | 2009-09-30 | 2012-09-12 | 마이크로도스 테라퓨특스, 인코포레이티드 | 레이노 증후군의 치료를 위한 방법들 및 조성물들 |
CN101780036B (zh) * | 2010-03-30 | 2011-11-16 | 武汉武药科技有限公司 | 丁酸氯维地平脂微球注射液及其制备方法 |
CA2701087A1 (en) * | 2010-04-12 | 2011-10-12 | Alphora Research Inc. | Preparation of clevidipine butyrate ring the same |
US8455655B2 (en) | 2010-05-07 | 2013-06-04 | Laboratorios Lesvi, S.L. | Preparation of dihydropyridines |
EP2386544B1 (en) | 2010-05-07 | 2016-02-10 | Laboratorios Lesvi, S.L. | Preparation of dihydropyridines |
US8658676B2 (en) | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
HUE026295T2 (en) | 2010-10-12 | 2016-06-28 | The Medicines Co | Clevidipine emulsion formulations containing antimicrobial agents |
BR112013025368A8 (pt) | 2011-04-01 | 2018-06-12 | The Medicines Co | Medicamento, método para preparar um medicamento útil para reduzir danos por derrame em um sujeito com derrame, método para preparar um medicamento útil para reduzir a pressão sanguínea e reduzir danos por derrame em um sujeito com derrame |
BR112014004370A2 (pt) | 2011-08-26 | 2017-03-21 | Wockhardt Ltd | métodos para tratar distúrbios cardiovasculares |
CN103420899B (zh) * | 2012-05-25 | 2016-01-27 | 四川科伦药物研究有限公司 | 一种丁酸氯维地平的纯化方法 |
EA030354B1 (ru) | 2012-10-26 | 2018-07-31 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Способ уменьшения диспноэ у пациента с острой сердечной недостаточностью |
CN103086956B (zh) * | 2013-01-17 | 2015-11-04 | 北京嘉林药业股份有限公司 | 一种丁酸氯维地平中间体的纯化方法 |
CN103073485B (zh) * | 2013-01-17 | 2015-09-02 | 北京嘉林药业股份有限公司 | 一种丁酸氯维地平的制备方法 |
WO2015179334A1 (en) | 2014-05-19 | 2015-11-26 | The Medicines Company | Clevidipine nanoparticles and pharmaceutical compositions thereof |
CN105367487A (zh) * | 2014-08-23 | 2016-03-02 | 南京海纳医药科技有限公司 | 一种丁酸氯维地平重要中间体新的合成方法 |
CN104370802A (zh) * | 2014-09-24 | 2015-02-25 | 北京蓝丹医药科技有限公司 | 氯维地平衍生物及其制备方法 |
BR112017024773A2 (pt) | 2015-05-20 | 2018-11-06 | Merial, Inc. | compostos depsipeptídeos anti-helmínticos |
CA3009867C (en) | 2015-12-28 | 2022-05-31 | Merial, Inc. | Anthelmintic cyclic depsipeptide compounds |
WO2018093920A1 (en) | 2016-11-16 | 2018-05-24 | Merial, Inc. | Anthelmintic depsipeptide compounds |
RU2755349C1 (ru) * | 2021-02-16 | 2021-09-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
US4154839A (en) * | 1975-11-05 | 1979-05-15 | Bayer Aktiengesellschaft | 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine |
DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
KR940003492B1 (ko) * | 1988-10-27 | 1994-04-23 | 주식회사 유한양행 | 1,4-디하이드로피리딘유도체 및 그의 제조방법 |
US5134139A (en) * | 1989-08-31 | 1992-07-28 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and preparation thereof |
JPH0641075A (ja) * | 1990-09-01 | 1994-02-15 | Kazuo Achinami | 新規な1,4−ジヒドロピリジン化合物及びその製造方法 |
-
1993
- 1993-11-05 SE SE9303657A patent/SE9303657D0/sv unknown
-
1994
- 1994-09-28 ZA ZA947570A patent/ZA947570B/xx unknown
- 1994-09-29 TW TW083108995A patent/TW279859B/zh not_active IP Right Cessation
- 1994-09-30 IS IS4218A patent/IS1674B/is unknown
- 1994-10-03 IL IL11112794A patent/IL111127A/xx not_active IP Right Cessation
- 1994-10-19 SA SA94150250A patent/SA94150250B1/ar unknown
- 1994-11-02 EG EG68994A patent/EG20539A/xx active
- 1994-11-03 HU HU9601187A patent/HU215591B/hu unknown
- 1994-11-03 CZ CZ961273A patent/CZ285691B6/cs not_active IP Right Cessation
- 1994-11-03 WO PCT/SE1994/001031 patent/WO1995012578A1/en active IP Right Grant
- 1994-11-03 EE EE9600051A patent/EE03230B1/xx unknown
- 1994-11-03 CA CA002174969A patent/CA2174969C/en not_active Expired - Lifetime
- 1994-11-03 CN CN94194500A patent/CN1049428C/zh not_active Expired - Lifetime
- 1994-11-03 DE DE69425152T patent/DE69425152T2/de not_active Expired - Lifetime
- 1994-11-03 UA UA96041753A patent/UA45959C2/uk unknown
- 1994-11-03 AT AT95900347T patent/ATE194330T1/de active
- 1994-11-03 NZ NZ275915A patent/NZ275915A/en not_active IP Right Cessation
- 1994-11-03 PL PL94314128A patent/PL185099B1/pl unknown
- 1994-11-03 US US08/356,224 patent/US5856346A/en not_active Expired - Lifetime
- 1994-11-03 SK SK559-96A patent/SK281467B6/sk not_active IP Right Cessation
- 1994-11-03 EP EP95900347A patent/EP0726894B1/en not_active Expired - Lifetime
- 1994-11-03 KR KR1019960702346A patent/KR100331663B1/ko not_active IP Right Cessation
- 1994-11-03 ES ES95900347T patent/ES2150544T3/es not_active Expired - Lifetime
- 1994-11-03 RU RU96112152A patent/RU2139278C1/ru active
- 1994-11-03 PT PT95900347T patent/PT726894E/pt unknown
- 1994-11-03 BR BR9407946A patent/BR9407946A/pt not_active Application Discontinuation
- 1994-11-03 DK DK95900347T patent/DK0726894T3/da active
- 1994-11-03 AU AU81196/94A patent/AU685532B2/en not_active Expired
- 1994-11-03 JP JP51317095A patent/JP3712209B2/ja not_active Expired - Lifetime
- 1994-11-04 MY MYPI94002934A patent/MY111770A/en unknown
-
1996
- 1996-05-02 NO NO961776A patent/NO305656B1/no not_active IP Right Cessation
- 1996-05-06 FI FI961914A patent/FI110429B/sv not_active IP Right Cessation
-
1998
- 1998-12-22 HK HK98114638A patent/HK1013292A1/xx unknown
-
2000
- 2000-09-21 GR GR20000402158T patent/GR3034469T3/el unknown
-
2012
- 2012-09-18 FR FR12C0053C patent/FR12C0053I2/fr active Active
-
2013
- 2013-06-10 LU LU92209C patent/LU92209I2/fr unknown
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