HRP20211041T1 - Anthelmintski depsipeptidni spojevi - Google Patents
Anthelmintski depsipeptidni spojevi Download PDFInfo
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- HRP20211041T1 HRP20211041T1 HRP20211041TT HRP20211041T HRP20211041T1 HR P20211041 T1 HRP20211041 T1 HR P20211041T1 HR P20211041T T HRP20211041T T HR P20211041TT HR P20211041 T HRP20211041 T HR P20211041T HR P20211041 T1 HRP20211041 T1 HR P20211041T1
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- Croatia
- Prior art keywords
- independently
- alkyl
- cyclic depsipeptide
- r5r6nc
- halogen
- Prior art date
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- 230000000507 anthelmentic effect Effects 0.000 title claims 22
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical class O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 108010002156 Depsipeptides Proteins 0.000 claims 20
- 229910052736 halogen Inorganic materials 0.000 claims 19
- 150000002367 halogens Chemical group 0.000 claims 19
- 125000001188 haloalkyl group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000004995 haloalkylthio group Chemical group 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000004414 alkyl thio group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000000262 haloalkenyl group Chemical group 0.000 claims 8
- 125000000232 haloalkynyl group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- -1 thioamido Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000003282 alkyl amino group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000004663 dialkyl amino group Chemical group 0.000 claims 7
- 125000004438 haloalkoxy group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- HCMJWOGOISXSDL-UHFFFAOYSA-N (2-isothiocyanato-1-phenylethyl)benzene Chemical group C=1C=CC=CC=1C(CN=C=S)C1=CC=CC=C1 HCMJWOGOISXSDL-UHFFFAOYSA-N 0.000 claims 6
- KHEPSBKTSMKGQV-UHFFFAOYSA-N 3-[4-[2-(4-piperidin-4-ylanilino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]pyrazol-1-yl]propanenitrile Chemical group N1CCC(CC1)C1=CC=C(C=C1)NC=1N=C(C2=C(N=1)NC=C2)C=1C=NN(C=1)CCC#N KHEPSBKTSMKGQV-UHFFFAOYSA-N 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 claims 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 claims 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 claims 1
- 206010061217 Infestation Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000005247 tetrazinyl group Chemical group N1=NN=NC(=C1)* 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000004001 thioalkyl group Chemical group 0.000 claims 1
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P17/00—Pest repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Medicinal Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
Claims (20)
1. Ciklički depsipeptidni spoj, naznačen time, da je predstavljen formulom (I), ili njegova farmaceutski ili veterinarski prihvatljiva sol:
[image]
u kojoj:
Cy1 i Cy2 su neovisno aril, karbociklik, heteroaril ili heterociklik, opcionalno supstituirani s jednim ili više supstituenata odabranih iz skupine koju čine halogen, hidroksi, alkoksi, haloalkoksi, alkiltio, haloalkiltio, tioamido, amino, alkilamino, dialkilamino, alkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, SF5, R5S(O)-, R5S(O)2-, R5C(O)-, R5R6NC(O)-, R5R6NC(O)NR5-, R5OC(O)-, R5C(O)O-, R5C(O)NR6-, -CN, -NO2, cikloalkil, heteroalkil, heterociklil, aril, heteroaril, -O-heteroaril, -S-heteroaril, -O-heterociklil ili -S-heterociklil, pri čemu je svaki cikloalkil, heterociklil, aril ili heteroaril opcionalno nadalje supstituiran s jednim ili više supstituenata odabranih iz skupine koju čine halogen, hidroksi, alkoksi, haloalkoksi, alkiltio, haloalkiltio, tioamido, amino, alkilamino, dialkilamino, alkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, SF5, R5S(O)-, R5S(O)2-, R5C(O)-, R5R6NC(O)-, R5OC(O)-, R5C(O)O-, R5C(O)NR6-, -CN i -NO2;
R5 i R6 su neovisno vodik, alkil, haloalkil, tioalkil, alkiltioalkil, hidroksialkil, alkoksialkil, alkenil, haloalkenil, alkinil, haloalkinil, ili skupina -CH2C(O)NHCH2CF3; ili R5 i R6 zajedno s atomom/atomima s kojim(a) su vezani, tvore C3-C6 cikličku skupinu;
svaki od R', R'', R''' i R'''' neovisno je vodik ili C1-C3 alkil;
Ra i Rb su neovisno vodik, C1-C3 alkil ili C1-C3 haloalkil; i
(a) svaki od R1 i R3 je neovisno C1-C8 alkil supstituiran s jednim ili više halogena; i svaki od R2 i R4 je neovisno C1-C8 alkil; ili
(b) svaki od R2 i R4 je neovisno C1-C8 alkil supstituiran s jednim ili više halogena; i svaki od R1 i R3 je neovisno C1-C8 alkil; ili
(c) svaki od R1 i R2 je neovisno C1-C8 alkil supstituiran s jednim ili više halogena; i svaki od R3 i R4 je neovisno C1-C8 alkil; ili
(d) svaki od R1 i R4 je neovisno C1-C8 alkil supstituiran s jednim ili više halogena; i svaki od R2 i R3 je neovisno C1-C8 alkil; ili
(e) svaki od R2 i R3 je neovisno C1-C8 alkil supstituiran s jednim ili više halogena; i svaki od R1 i R4 je neovisno C1-C8 alkil; ili
(f) svaki od R3 i R4 je neovisno C1-C8 alkil supstituiran s jednim ili više halogena; i svaki od R1 i R2 je neovisno C1-C8 alkil;
gdje halogen jest fluor.
2. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 1, naznačen time, da R1 i R3 su C1-C8 alkil supstituiran s halogenom.
3. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 1, naznačen time, da R2 i R4 su C1-C8 alkil supstituiran s halogenom.
4. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 1, naznačen time, da dva od R1, R2, R3 i R4 jesu G-1:
[image]
gdje:
R1D i R1E jesu vodik;
R1A jest halogen;
R1B i R1C su neovisno C1-C3 alkil i C1-C3 haloalkil.
5. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 4, naznačen time, da:
R1A jest fluor;
R1B i R1C su neovisno metil ili trifluorometil; i
R1D i R1E jesu vodik.
6. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 4 ili zahtjevu 5, naznačen time, da preostala dva od R1 - R4 su 2-metilpropil ili 2,2-dimetilpropil.
7. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 1, naznačen time, da se dva od R1, R2, R3 i R4 biraju od CH2F, CHF2 i CF3, a preostala dva od R1, R2, R3 i R4 su nesusptituirani 2-metilpropil ili 2,2-dimetilpropil.
8. Anthelmintski ciklički depsipeptid prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da Cy1 i Cy2 su neovisno fenil, 5-člani ili 6-člani heteroaril opcionalno supstituiran s halogenom, hidroksi, alkoksi, haloalkoksi, alkiltio, haloalkiltio, tioamido, amino, alkilamino, dialkilamino, alkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, SF5, R5S(O)-, R5S(O)2-, R5C(O)-, R5R6NC(O)-, R5R6NC(O)NR5-, R5OC(O)-, R5C(O)O-, R5C(O)NR6-, -CN, -NO2, cikloalkil, heteroalkil, heterociklil, aril, heteroaril, -O-heteroaril, -S-heteroaril, -O-heterociklil ili -S-heterociklil, pri čemu je svaki cikloalkil, heteroalkil, aril ili heteroaril opcionalno nadalje supstituiran s jednim ili više supstituenata odabranih iz skupine koju čine halogen, hidroksi, alkoksi, haloalkoksi, alkiltio, haloalkiltio, tioamido, amino, alkilamino, dialkilamino, alkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, SF5, R5S(O)-, R5S(O)2-, R5C(O)-, R5R6NC(O)-, R5R6NC(O)NR5-, R5OC(O)-, R5C(O)O-, R5C(O)NR6-, -CN i -NO2.
9. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 8, naznačen time, da su Cy1 i Cy2 neovisno fenil, 5-člani ili 6-člani heteroaril supstituiran s halogenom, -CN, alkil, haloalkil, alkoksi, haloalkoksi, alkiltio, haloalkiltio, R5R6NC(O)- i heterociklil.
10. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 9, naznačen time, da su Cy1 i Cy2 neovisno fenil, 5-člani ili 6-člani heteroaril supstituiran s heterociklilom, fluoro, trifluorometil, trifluorometoksi ili cijano.
11. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 10, naznačen time, da su Cy1 i Cy2 neovisno fenil ili piridinil supstituiran s morfolinilom, tetrahidropiranilom, tetrazolilom ili -S-tetrazolilom.
12. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 9, naznačen time, da su Cy1 i Cy2 neovisno fenil, tienil, oksazolil, izotiazolil, 1,3-4-tiadazolil, pirazolil, furil, imidazolil, pirolil, piridinil, piridazinil, pirimidinil, pirazinil, ili tetrazinil neovisno opcionalno supstituiran s R5R6NC(O)-, pri čemu su R5 i R6 neovisno vodik, -CH2C(O)NHCH2CF3 ili R5 i R6 zajedno s dušikovim atomom s kojim su vezani, tvore C3-C6 ciklički amin.
13. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 1, naznačen time, da se Cy1 i Cy2 neovisno biraju od R1 do R8:
[image]
[image]
pri čemu svaki od Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8 i Y9 neovisno je C, CH ili N; i
X1, X2, X3, X4, X5, X6 i X7 su neovisno vodik, halogen, hidroksi, alkoksi, haloalkoksi, alkiltio, haloalkiltio, tioamido, amino, alkilamino, dialkilamino, alkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, SF5, R5S(O)-, R5S(O)2-, R5C(O)-, R5R6NC(O)-, R5R6NC(O)NR5-, R5OC(O)-, R5C(O)O-, R5C(O)NR6-, -CN, -NO2, cikloalkil, heteroalkil, heterociklil, aril ili heteroaril, pri čemu je svaki cikloalkil, heteroalkil, heterociklil, aril ili heteroaril opcionalno nadalje neovisno supstituiran s jednim ili više supstituenata odabranih iz skupine koju čine halogen, hidroksi, alkoksi, haloalkoksi, alkiltio, haloalkiltio, tioamido, amino, alkilamino, dialkilamino, alkil, haloalkil, alkenil, haloalkenil, alkinil, haloalkinil, SF5, R5S(O)-, R5S(O)2-, R5C(O)-, R5R6NC(O)-, R5R6NC(O)NR5-, R5OC(O)-, R5C(O)O-, R5C(O)NR6-, -CN i -NO2.
14. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 13, naznačen time, da su X1, X2, X3, X4, X5, X6 i X7 neovisno vodik, halogen, hidroksi, alkoksi, haloalkoksi, alkiltio, haloalkiltio, R5R6NC(O)-, R5R6NC(O)NR5-, tioamido, amino, alkilamino ili dialkilamino.
15. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 13, naznačen time, da se X1, X2, X3, X4, X5, X6 i X7 neovisno biraju od vodika, halogena, alkila, haloalkila, alkenila, haloalkenila, alkinila i haloalkinila.
16. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 13, naznačen time, da su X1, X2, X3, X4, X5, X6 i X7 neovisno vodik, metil etil, propil, izopropil, butil, izobutil, terc-butil, CF3, -CH2CF3, -CHFCF3 ili -CF2CF3.
17. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 13, naznačen time, da su X1, X2, X3, X4, X5, X6 i X7 neovisno vodik, hidroksi, metoksi, trifluorometoksi, -OCH2CF3, -OCHFCF3, -OCF2CF3, metiltio, trifluorometiltio, -SCH2CF3, -SCHFCF3 ili-SCF2CF3.
18. Anthelmintski veterinarski pripravak, naznačen time, da sadrži anthelmintski ciklički depsipeptid prema patentnom zahtjevu 1, ili njegovu farmaceutski ili veterinarski prihvatljivu sol, u kombinaciji s veterinarski prihvatljivim nosačem.
19. Anthelmintski veterinarski pripravak, naznačen time, da sadrži anthelmintski ciklički depsipeptid prema patentnom zahtjevu 1, ili njegovu farmaceutski ili veterinarski prihvatljivu sol, u kombinaciji s drugom antiparazitskom aktivnom tvari i veterinarski prihvatljivim nosačem.
20. Anthelmintski ciklički depsipeptid prema patentnom zahtjevu 1, naznačen time, da je za uporabu u liječenju ili prevenciji parazitne infekcije ili parazitne infestacije kod životinje.
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| US201562163997P | 2015-05-20 | 2015-05-20 | |
| PCT/US2016/033522 WO2016187534A1 (en) | 2015-05-20 | 2016-05-20 | Anthelmintic depsipeptide compounds |
| EP16734488.6A EP3298027B1 (en) | 2015-05-20 | 2016-05-20 | Anthelmintic depsipeptide compounds |
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| HRP20211041T1 true HRP20211041T1 (hr) | 2021-10-01 |
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