BR112013015774A2 - compostos de pirazol tendo efeito terapêutico sobre mieloma múltiplo. - Google Patents
compostos de pirazol tendo efeito terapêutico sobre mieloma múltiplo.Info
- Publication number
- BR112013015774A2 BR112013015774A2 BR112013015774-7A BR112013015774A BR112013015774A2 BR 112013015774 A2 BR112013015774 A2 BR 112013015774A2 BR 112013015774 A BR112013015774 A BR 112013015774A BR 112013015774 A2 BR112013015774 A2 BR 112013015774A2
- Authority
- BR
- Brazil
- Prior art keywords
- phenyl
- alkyl
- multiple myeloma
- pyrazole compound
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010-268758 | 2010-12-01 | ||
| JP2010268758 | 2010-12-01 | ||
| JP2011-217818 | 2011-09-30 | ||
| JP2011217818 | 2011-09-30 | ||
| PCT/JP2011/077829 WO2012074067A1 (ja) | 2010-12-01 | 2011-12-01 | 多発性骨髄腫の治療効果を有するピラゾール化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013015774A2 true BR112013015774A2 (pt) | 2018-05-22 |
Family
ID=46171992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013015774-7A BR112013015774A2 (pt) | 2010-12-01 | 2011-12-01 | compostos de pirazol tendo efeito terapêutico sobre mieloma múltiplo. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8658686B2 (pt) |
| EP (1) | EP2647629B1 (pt) |
| JP (1) | JP5857972B2 (pt) |
| KR (1) | KR20130121857A (pt) |
| CN (1) | CN103237793B (pt) |
| BR (1) | BR112013015774A2 (pt) |
| CA (1) | CA2819215C (pt) |
| DK (1) | DK2647629T3 (pt) |
| ES (1) | ES2541289T3 (pt) |
| HK (1) | HK1187898A1 (pt) |
| IL (1) | IL226663A (pt) |
| MY (1) | MY165634A (pt) |
| NZ (1) | NZ611169A (pt) |
| PL (1) | PL2647629T3 (pt) |
| RU (1) | RU2583430C2 (pt) |
| SG (1) | SG190957A1 (pt) |
| WO (1) | WO2012074067A1 (pt) |
| ZA (1) | ZA201303877B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2961746B1 (en) | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| MX2016010436A (es) | 2014-02-14 | 2016-10-31 | Inception 2 Inc | Compuestos de pirazolona y usos de los mismos. |
| BR112019014061A2 (pt) | 2017-01-23 | 2020-02-04 | Basf Se | compostos de fórmula i, intermediários b, intermediários c, intermediários ii e intermediários d, composição, uso, método para combater fungos fitopatogênicos, semente e processo para a síntese dos compostos de fórmula i |
| AU2018333913B2 (en) | 2017-09-14 | 2022-11-17 | Daiichi Sankyo Company, Limited | Compound having cyclic structure |
| US20210002265A1 (en) * | 2018-03-02 | 2021-01-07 | Université de Lausanne | Pyrazole derivatives as inhibitors of the wnt signalling pathway |
| KR102459196B1 (ko) * | 2022-04-08 | 2022-10-27 | 케이블루바이오 주식회사 | 신규한 크로마논 화합물을 유효성분으로 포함하는 다발성골수종의 예방 또는 치료용 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2319279A1 (de) * | 1973-04-17 | 1974-11-07 | Bayer Ag | Pyrazolone-(5), verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| JPS6277371A (ja) | 1985-09-30 | 1987-04-09 | Neos Co Ltd | 含フツ素ピラゾ−ル誘導体 |
| HUP0302002A3 (en) | 2000-05-11 | 2007-02-28 | Consejo Superior Investigacion | Heterocyclic inhibitors of glycogen synthase kinase gsk-3, their use and pharmaceutical compositions containing them |
| AU2002228783A1 (en) | 2000-12-05 | 2002-06-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| CL2004000234A1 (es) * | 2003-02-12 | 2005-04-15 | Biogen Idec Inc | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid |
| ATE553090T1 (de) | 2005-07-06 | 2012-04-15 | Merck Canada Inc | Cathepsincysteinproteasehemmer |
| WO2007105058A2 (en) * | 2006-03-16 | 2007-09-20 | Pfizer Products Inc. | Pyrazole compounds |
| KR20090094125A (ko) | 2006-12-08 | 2009-09-03 | 엑셀리시스, 인코포레이티드 | Ｌｘｒ 및 ｆｘｒ 조절자 |
| JP5275371B2 (ja) * | 2008-03-11 | 2013-08-28 | インサイト・コーポレイション | Ｊａｋ阻害剤としてのアゼチジン誘導体およびシクロブタン誘導体 |
| BRPI1012159B1 (pt) * | 2009-05-22 | 2022-01-25 | Incyte Holdings Corporation | Compostos derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d] pirimidinas e pirrol-3-il-pirrolo[2,3-d] pirimidinas como inibidores de janus cinase, composições farmacêuticas compreendendo os referidos compostos e usos dos mesmos |
-
2011
- 2011-12-01 CA CA2819215A patent/CA2819215C/en not_active Expired - Fee Related
- 2011-12-01 KR KR1020137013962A patent/KR20130121857A/ko active IP Right Grant
- 2011-12-01 DK DK11845115.2T patent/DK2647629T3/en active
- 2011-12-01 EP EP11845115.2A patent/EP2647629B1/en active Active
- 2011-12-01 RU RU2013129861/04A patent/RU2583430C2/ru not_active IP Right Cessation
- 2011-12-01 US US13/991,024 patent/US8658686B2/en active Active
- 2011-12-01 CN CN201180057443.9A patent/CN103237793B/zh active Active
- 2011-12-01 NZ NZ611169A patent/NZ611169A/en not_active IP Right Cessation
- 2011-12-01 BR BR112013015774-7A patent/BR112013015774A2/pt active Search and Examination
- 2011-12-01 MY MYPI2013001987A patent/MY165634A/en unknown
- 2011-12-01 SG SG2013042395A patent/SG190957A1/en unknown
- 2011-12-01 WO PCT/JP2011/077829 patent/WO2012074067A1/ja active Application Filing
- 2011-12-01 PL PL11845115T patent/PL2647629T3/pl unknown
- 2011-12-01 JP JP2012546943A patent/JP5857972B2/ja active Active
- 2011-12-01 ES ES11845115.2T patent/ES2541289T3/es active Active
-
2013
- 2013-05-28 ZA ZA2013/03877A patent/ZA201303877B/en unknown
- 2013-05-30 IL IL226663A patent/IL226663A/en active IP Right Grant
-
2014
- 2014-01-10 HK HK14100322.3A patent/HK1187898A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012074067A1 (ja) | 2012-06-07 |
| ES2541289T3 (es) | 2015-07-17 |
| DK2647629T3 (en) | 2015-07-27 |
| IL226663A (en) | 2016-11-30 |
| NZ611169A (en) | 2014-05-30 |
| EP2647629A4 (en) | 2014-04-23 |
| JP5857972B2 (ja) | 2016-02-10 |
| RU2583430C2 (ru) | 2016-05-10 |
| MY165634A (en) | 2018-04-18 |
| CA2819215C (en) | 2018-05-01 |
| SG190957A1 (en) | 2013-07-31 |
| AU2011337594B2 (en) | 2016-03-10 |
| EP2647629A1 (en) | 2013-10-09 |
| CA2819215A1 (en) | 2012-06-07 |
| ZA201303877B (en) | 2014-07-30 |
| US20130253204A1 (en) | 2013-09-26 |
| KR20130121857A (ko) | 2013-11-06 |
| CN103237793A (zh) | 2013-08-07 |
| EP2647629B1 (en) | 2015-06-17 |
| RU2013129861A (ru) | 2015-01-10 |
| HK1187898A1 (en) | 2014-04-17 |
| AU2011337594A1 (en) | 2013-06-20 |
| JPWO2012074067A1 (ja) | 2014-05-19 |
| PL2647629T3 (pl) | 2015-12-31 |
| CN103237793B (zh) | 2015-06-10 |
| US8658686B2 (en) | 2014-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |