EA201200259A1 - Гетероциклы с микробиоцидными свойствами - Google Patents
Гетероциклы с микробиоцидными свойствамиInfo
- Publication number
- EA201200259A1 EA201200259A1 EA201200259A EA201200259A EA201200259A1 EA 201200259 A1 EA201200259 A1 EA 201200259A1 EA 201200259 A EA201200259 A EA 201200259A EA 201200259 A EA201200259 A EA 201200259A EA 201200259 A1 EA201200259 A1 EA 201200259A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- denotes
- alkyl
- cyano
- haloalkyl
- halogen
- Prior art date
Links
- 230000003641 microbiacidal effect Effects 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 cyano, hydroxy Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Предметом настоящего изобретения являются гетероциклические соединения формулы (I), которые обладают микробиоцидной активностью, в частности фунгицидным действием, а также методы применения соединений формулы (I) для борьбы с микробамигде А обозначает x-C(RR-C(=O)-, x-C(RR-C(=S)-, x-O-C(=O)-, x-O-C(=S)-, х-NR-C(=O)-, x-N(R)-C(=S)-, x-C(RR)-SO- или x-N=C(R)-, причем х в каждом случае обозначает связь, присоединенную к R; Т обозначает CRили N; Y, Y, Yи Yнезависимо обозначают CRили N; Q обозначает О или S; n равняется 1 или 2; р равняется 1 или 2, при условии, что, если n равно 2, р равняется 1; Rобозначает фенил, пиридил, имидазолил или пиразолил, где каждый фенил, пиридил, имидазолил и пиразолил, как вариант, замещен 1-3 заместителями, независимо выбранными из (С-С)алкила, (С-С)галоалкила, галогена, циано, гидрокси и амино; каждый из R, R, R, R, R, R, R, R, R, R, R, R, R, Rи Rнезависимо обозначает водород, галоген, циано, (С-С)алкил или (C-С)галоалкил; каждый из R, Rи Rнезависимо обозначает водород или (С-С)алкил; а Rобозначает фенил, бензил или группу (а)где каждый фенил, бензил и каждая группа (а), как вариант, замещен(а) 1-3 заместителями, независимо выбранными из (С-С)алкила, (С-С)галоалкила, галогена, циано, гидрокси и амино; либо соль или N-окись настоящих соединений.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09167741 | 2009-08-12 | ||
| PCT/EP2010/061464 WO2011018415A2 (en) | 2009-08-12 | 2010-08-06 | Microbiocidal heterocycles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201200259A1 true EA201200259A1 (ru) | 2012-09-28 |
| EA021137B1 EA021137B1 (ru) | 2015-04-30 |
Family
ID=42683487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201200259A EA021137B1 (ru) | 2009-08-12 | 2010-08-06 | Гетероциклы с микробиоцидными свойствами |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US8367844B2 (ru) |
| EP (1) | EP2464630B1 (ru) |
| JP (1) | JP5778674B2 (ru) |
| KR (1) | KR101750027B1 (ru) |
| CN (1) | CN102471277B (ru) |
| AP (1) | AP3383A (ru) |
| AR (1) | AR077835A1 (ru) |
| AU (1) | AU2010283767B2 (ru) |
| BR (1) | BR112012003124A2 (ru) |
| CA (1) | CA2768636C (ru) |
| CL (1) | CL2012000339A1 (ru) |
| CO (1) | CO6612179A2 (ru) |
| CR (1) | CR20120064A (ru) |
| EA (1) | EA021137B1 (ru) |
| ES (1) | ES2588330T3 (ru) |
| GE (1) | GEP20146113B (ru) |
| HN (1) | HN2012000308A (ru) |
| HR (1) | HRP20160951T1 (ru) |
| HU (1) | HUE029097T2 (ru) |
| IL (1) | IL217645A (ru) |
| JO (1) | JO3140B1 (ru) |
| MX (1) | MX2012001689A (ru) |
| MY (1) | MY157410A (ru) |
| NI (1) | NI201200025A (ru) |
| NZ (1) | NZ597503A (ru) |
| PL (1) | PL2464630T3 (ru) |
| PT (1) | PT2464630T (ru) |
| SA (1) | SA110310646B1 (ru) |
| TW (1) | TWI488849B (ru) |
| UA (1) | UA107938C2 (ru) |
| UY (1) | UY32840A (ru) |
| WO (1) | WO2011018415A2 (ru) |
| ZA (1) | ZA201200368B (ru) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130100903A (ko) | 2010-04-28 | 2013-09-12 | 바이엘 크롭사이언스 아게 | 살진균제로서의 케토헤테로아릴피페리딘 및 케토헤테로아릴피페라진 유도체 |
| ES2660611T3 (es) * | 2010-05-27 | 2018-03-23 | Bayer Cropscience Ag | Derivados de ácido piridinilcarboxílico como fungicidas |
| US20120122928A1 (en) | 2010-08-11 | 2012-05-17 | Bayer Cropscience Ag | Heteroarylpiperidine and -Piperazine Derivatives as Fungicides |
| US8759527B2 (en) | 2010-08-25 | 2014-06-24 | Bayer Cropscience Ag | Heteroarylpiperidine and -piperazine derivatives as fungicides |
| EP2632922B1 (de) | 2010-10-27 | 2019-02-27 | Bayer CropScience Aktiengesellschaft | Heteroarylpiperidin und -piperazinderivate als fungizide |
| CN114133382A (zh) | 2011-06-30 | 2022-03-04 | 先正达参股股份有限公司 | 杀微生物杂环 |
| ES2565067T3 (es) | 2011-12-27 | 2016-03-31 | Bayer Intellectual Property Gmbh | Derivados de heteroarilpiperidina y de heteroarilpiperazina como fungicidas |
| MY170524A (en) | 2012-02-02 | 2019-08-09 | Idorsia Pharmaceuticals Ltd | 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives |
| WO2014062938A1 (en) * | 2012-10-19 | 2014-04-24 | Bristol-Myers Squibb Company | Rory modulators |
| EP2801575A1 (en) | 2013-05-07 | 2014-11-12 | Bayer CropScience AG | Heteroaryldihydropyridine derivatives as fungicides |
| WO2014206896A1 (en) | 2013-06-24 | 2014-12-31 | Bayer Cropscience Ag | Piperidinecarboxylic acid derivatives as fungicides |
| EA030067B1 (ru) | 2013-07-22 | 2018-06-29 | Идорсиа Фармасьютиклз Лтд | Производные 1-(пиперазин-1-ил)-2-([1,2,4]триазол-1-ил)этанона |
| EP3039023A1 (en) | 2013-08-28 | 2016-07-06 | Bayer CropScience Aktiengesellschaft | Malonic ester derivatives of heteroarylpiperidines and -piperazines as fungicides |
| AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
| WO2015144571A1 (en) | 2014-03-24 | 2015-10-01 | Bayer Cropscience Ag | Phenylpiperidinecarboxamide derivatives as fungicides |
| EP3174397B1 (en) | 2014-07-31 | 2019-12-25 | Syngenta Participations AG | Fungicidal compositions |
| WO2016024350A1 (ja) | 2014-08-13 | 2016-02-18 | 株式会社エス・ディー・エス バイオテック | 縮合１１員環化合物及びそれらを含有する農園芸用殺菌剤 |
| PT3245203T (pt) | 2015-01-15 | 2019-02-08 | Idorsia Pharmaceuticals Ltd | Derivados de hidroxialquil-piperazina como modeladores do recetor cxcr3 |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| US11274076B2 (en) | 2016-02-08 | 2022-03-15 | Gowan Company, L.L.C. | Process for preparing 1, 2-benzenedimethanol compound |
| WO2017138069A1 (ja) | 2016-02-08 | 2017-08-17 | 株式会社エス・ディー・エス バイオテック | 殺菌性組成物 |
| CA3024556A1 (en) * | 2016-05-12 | 2017-11-16 | The Regents Of The University Of Michigan | Ash1l inhibitors and methods of treatment therewith |
| US11110864B2 (en) | 2017-08-23 | 2021-09-07 | Magna Mirrors Of America, Inc. | Interior rearview mirror assembly with full screen video display |
| US11110177B2 (en) | 2017-11-10 | 2021-09-07 | The Regents Of The University Of Michigan | ASH1L degraders and methods of treatment therewith |
| CN114380802B (zh) * | 2022-01-07 | 2023-11-17 | 贵州大学 | 一类含咔唑基咪唑盐类化合物及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340685C (en) | 1988-07-29 | 1999-07-27 | Frederick Meins | Dna sequences encoding polypeptides having beta-1,3-glucanase activity |
| ES2199931T3 (es) | 1989-03-24 | 2004-03-01 | Syngenta Participations Ag | Plantas transgenicas resistentes a enfermedades. |
| US5639949A (en) | 1990-08-20 | 1997-06-17 | Ciba-Geigy Corporation | Genes for the synthesis of antipathogenic substances |
| US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| US6262058B1 (en) | 1996-03-11 | 2001-07-17 | Syngenta Crop Protection, Inc. | Pyrimidin-4-one derivatives as pesticide |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| GB0214406D0 (en) | 2002-06-21 | 2002-07-31 | Plant Bioscience Ltd | Plant-derived transferase genes |
| DK1567493T3 (da) * | 2002-11-26 | 2009-06-08 | Pfizer Prod Inc | Phenyl-substituerede piperidin-forbindelser til anvendelse som PPAR-aktivatorer |
| NZ543287A (en) * | 2003-04-15 | 2008-08-29 | Merck & Co Inc | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| EP1663953A1 (en) * | 2003-09-24 | 2006-06-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| AU2005249380C1 (en) * | 2004-04-23 | 2012-09-20 | Exelixis, Inc. | Kinase modulators and methods of use |
| AU2005247172A1 (en) * | 2004-05-25 | 2005-12-08 | Pfizer Products Inc. | Use of PPAR agonists to treat ruminants |
| TW200738701A (en) * | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| WO2008013622A2 (en) | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| WO2008091594A2 (en) | 2007-01-24 | 2008-07-31 | E. I. Du Pont De Nemours And Company | Fungicidal mixtures |
| US8420673B2 (en) | 2007-01-25 | 2013-04-16 | E I Du Pont De Nemours And Company | Fungicidal amides |
| WO2009034390A1 (en) * | 2007-09-14 | 2009-03-19 | Arrow Therapeutics Limited | Heterocyclic derivatives and their use in treating hepatitis c |
| TWI428091B (zh) | 2007-10-23 | 2014-03-01 | Du Pont | 殺真菌劑混合物 |
| JP2011511056A (ja) * | 2008-02-05 | 2011-04-07 | ファイザー・インク | Ｃｎｓ障害および代謝障害治療のためのピリジニルアミド |
-
2010
- 2010-06-08 UA UAA201202483A patent/UA107938C2/uk unknown
- 2010-08-06 AU AU2010283767A patent/AU2010283767B2/en not_active Ceased
- 2010-08-06 US US13/390,023 patent/US8367844B2/en not_active Expired - Fee Related
- 2010-08-06 JP JP2012524206A patent/JP5778674B2/ja not_active Expired - Fee Related
- 2010-08-06 PL PL10739639.2T patent/PL2464630T3/pl unknown
- 2010-08-06 WO PCT/EP2010/061464 patent/WO2011018415A2/en active Application Filing
- 2010-08-06 EA EA201200259A patent/EA021137B1/ru not_active IP Right Cessation
- 2010-08-06 HU HUE10739639A patent/HUE029097T2/en unknown
- 2010-08-06 EP EP10739639.2A patent/EP2464630B1/en not_active Not-in-force
- 2010-08-06 MX MX2012001689A patent/MX2012001689A/es active IP Right Grant
- 2010-08-06 ES ES10739639.2T patent/ES2588330T3/es active Active
- 2010-08-06 PT PT107396392T patent/PT2464630T/pt unknown
- 2010-08-06 MY MYPI2011006187A patent/MY157410A/en unknown
- 2010-08-06 GE GEAP201012624A patent/GEP20146113B/en unknown
- 2010-08-06 AP AP2012006152A patent/AP3383A/xx active
- 2010-08-06 KR KR1020127006326A patent/KR101750027B1/ko active IP Right Grant
- 2010-08-06 BR BR112012003124-4A patent/BR112012003124A2/pt not_active Application Discontinuation
- 2010-08-06 CA CA2768636A patent/CA2768636C/en not_active Expired - Fee Related
- 2010-08-06 CN CN201080035394.4A patent/CN102471277B/zh not_active Expired - Fee Related
- 2010-08-06 NZ NZ597503A patent/NZ597503A/xx not_active IP Right Cessation
- 2010-08-09 SA SA110310646A patent/SA110310646B1/ar unknown
- 2010-08-10 AR ARP100102924A patent/AR077835A1/es active IP Right Grant
- 2010-08-10 TW TW099126588A patent/TWI488849B/zh not_active IP Right Cessation
- 2010-08-10 JO JOP/2010/0282A patent/JO3140B1/ar active
- 2010-08-12 UY UY0001032840A patent/UY32840A/es not_active Application Discontinuation
-
2012
- 2012-01-17 ZA ZA2012/00368A patent/ZA201200368B/en unknown
- 2012-01-19 IL IL217645A patent/IL217645A/en not_active IP Right Cessation
- 2012-02-08 CO CO12022027A patent/CO6612179A2/es active IP Right Grant
- 2012-02-08 CR CR20120064A patent/CR20120064A/es unknown
- 2012-02-08 NI NI201200025A patent/NI201200025A/es unknown
- 2012-02-09 HN HN2012000308A patent/HN2012000308A/es unknown
- 2012-02-09 CL CL2012000339A patent/CL2012000339A1/es unknown
-
2013
- 2013-02-05 US US13/759,761 patent/US20130144064A1/en not_active Abandoned
-
2016
- 2016-07-26 HR HRP20160951TT patent/HRP20160951T1/hr unknown
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