WO2009106752A3 - Derives de 2-heteroaroyl-imidazol[1,2-a]pyridine, leur preparation et leur application en therapeutique - Google Patents

Derives de 2-heteroaroyl-imidazol[1,2-a]pyridine, leur preparation et leur application en therapeutique Download PDF

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Publication number
WO2009106752A3
WO2009106752A3 PCT/FR2008/001840 FR2008001840W WO2009106752A3 WO 2009106752 A3 WO2009106752 A3 WO 2009106752A3 FR 2008001840 W FR2008001840 W FR 2008001840W WO 2009106752 A3 WO2009106752 A3 WO 2009106752A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
hydrogen atom
heteroaroyl
imidazol
pyridine
Prior art date
Application number
PCT/FR2008/001840
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English (en)
Other versions
WO2009106752A2 (fr
Inventor
Jean-François Peyronel
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Priority to JP2010541089A priority Critical patent/JP2011508763A/ja
Priority to BRPI0821991-5A priority patent/BRPI0821991A2/pt
Priority to CN2008801238363A priority patent/CN101910173A/zh
Priority to CA2710962A priority patent/CA2710962A1/fr
Priority to AU2008351930A priority patent/AU2008351930A1/en
Priority to MX2010007350A priority patent/MX2010007350A/es
Priority to EP08872855A priority patent/EP2240480A2/fr
Publication of WO2009106752A2 publication Critical patent/WO2009106752A2/fr
Publication of WO2009106752A3 publication Critical patent/WO2009106752A3/fr
Priority to IL206667A priority patent/IL206667A0/en
Priority to US12/828,388 priority patent/US20100317688A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composés de formule (I) dans laquelle : X représente un groupe benzodioxole, un groupe hétéroaromatique, relié par un atome de carbone, R2 représente un atome d'hydrogène, un atome d'halogène, un groupe (C1-C6)alkyle, un groupe (C1-C6)alcoxy, un groupe (C1-C6)alkylthio,un groupe (C2-C6)alcényle, un groupe (C2-C6)alcynyle, un groupe -CO-R5, un groupe -CO-NR6R7, un groupe -CO-O-R8, un groupe -NR9-CO-R10, un groupe -NR11R12, un groupe cyano, un groupe phényle, un groupe hétérocyclique; R1 représente un atome d'hydrogène, un halogène, un groupe (C1-C6)alcoxy, un groupe (C1-C6)alkyle, un hydroxy, un amino; R3 représente un atome d'hydrogène, un groupe (C1-C6)alkyle, un atome d'halogène, ou un groupe hydroxy; R4 représente un atome d'hydrogène ou un atome d'halogène, à l'état de base ou de sel d'addition à un acide. Utilisation en thérapeutique.
PCT/FR2008/001840 2008-01-02 2008-12-31 Derives de 2-heteroaroyl-imidazol[1,2-a]pyridine, leur preparation et leur application en therapeutique WO2009106752A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2010541089A JP2011508763A (ja) 2008-01-02 2008-12-31 ２−ヘテロアロイルイミダゾ［１，２−ａ］ピリジン誘導体、この調製および治療用途
BRPI0821991-5A BRPI0821991A2 (pt) 2008-01-02 2008-12-31 Derivados de 2-heteroaroil-imidazo[1,2-alfa] piridina, sua preparação e sua aplicação em terapêutica
CN2008801238363A CN101910173A (zh) 2008-01-02 2008-12-31 2-杂芳酰基咪唑并[1,2-a]吡啶衍生物、其制备方法和治疗用途
CA2710962A CA2710962A1 (fr) 2008-01-02 2008-12-31 Derives de 2-heteroaroyl-imidazo[1,2-.alpha.]pyridine, leur preparation et leur application en therapeutique
AU2008351930A AU2008351930A1 (en) 2008-01-02 2008-12-31 Derivatives of 2-heteroaroyl-imidazol[1,2-A] pyridine, preparation thereof and therapeutic application thereof
MX2010007350A MX2010007350A (es) 2008-01-02 2008-12-31 Derivados de 2-heteroaroil-imidazol[1,2-a]piridina, su preparacion y aplicacion terapeutica.
EP08872855A EP2240480A2 (fr) 2008-01-02 2008-12-31 Derives de 2-heteroaroyl-imidazol(1,2-a)pyridine, leur preparation et leur application en therapeutique
IL206667A IL206667A0 (en) 2008-01-02 2010-06-28 2-HETEROAROYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
US12/828,388 US20100317688A1 (en) 2008-01-02 2010-07-01 2-HETEROAROYLIMIDAZOL[1,2-a]PYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0800009 2008-01-02
FR0800009A FR2925907B1 (fr) 2008-01-02 2008-01-02 DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/828,388 Continuation US20100317688A1 (en) 2008-01-02 2010-07-01 2-HETEROAROYLIMIDAZOL[1,2-a]PYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

Publications (2)

Publication Number Publication Date
WO2009106752A2 WO2009106752A2 (fr) 2009-09-03
WO2009106752A3 true WO2009106752A3 (fr) 2010-02-25

Family

ID=39737072

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/001840 WO2009106752A2 (fr) 2008-01-02 2008-12-31 Derives de 2-heteroaroyl-imidazol[1,2-a]pyridine, leur preparation et leur application en therapeutique

Country Status (17)

Country Link
US (1) US20100317688A1 (fr)
EP (1) EP2240480A2 (fr)
JP (1) JP2011508763A (fr)
KR (1) KR20100099246A (fr)
CN (1) CN101910173A (fr)
AR (1) AR070078A1 (fr)
AU (1) AU2008351930A1 (fr)
BR (1) BRPI0821991A2 (fr)
CA (1) CA2710962A1 (fr)
CL (1) CL2008003932A1 (fr)
FR (1) FR2925907B1 (fr)
IL (1) IL206667A0 (fr)
MX (1) MX2010007350A (fr)
RU (1) RU2010132230A (fr)
TW (1) TW200934779A (fr)
UY (1) UY31593A1 (fr)
WO (1) WO2009106752A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024050061A2 (fr) * 2022-09-01 2024-03-07 Hager Biosciences, Llc Dérivés de pyrazole et d'imidazole utilisés en tant que modulateurs des récepteurs double d'orexine et d'opioïdes kappa, composition, procédés de traitement de troubles neurologiques et psychiatriques

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2638161A1 (fr) * 1988-10-24 1990-04-27 Centre Nat Rech Scient Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US20060211747A1 (en) * 2004-09-15 2006-09-21 Pascal Furet Methods of screening for compounds which inhibit the activity of Cdc34 in a zinc-mediated manner and compounds obtained by this method
WO2008003854A2 (fr) * 2006-07-03 2008-01-10 Sanofi-Aventis Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2925902B1 (fr) * 2008-01-02 2011-01-07 Sanofi Aventis DERIVES D'IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2925904B1 (fr) * 2008-01-02 2010-01-01 Sanofi Aventis DERIVES DE N-HETEROCYCLIQUE-6-HETEROCYCLIQUE-IMIDAZO°1,2-a! PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2925903B1 (fr) * 2008-01-02 2011-01-21 Sanofi Aventis DERIVES 6-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2638161A1 (fr) * 1988-10-24 1990-04-27 Centre Nat Rech Scient Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US20060211747A1 (en) * 2004-09-15 2006-09-21 Pascal Furet Methods of screening for compounds which inhibit the activity of Cdc34 in a zinc-mediated manner and compounds obtained by this method
WO2008003854A2 (fr) * 2006-07-03 2008-01-10 Sanofi-Aventis Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CLEMENTS-JEWERY S ET AL: "(IMIDAZO not 1,2-A 3/4 PYRIMIDIN-2-YL)PHENYLMETHANONES AND RELATED COMPOUNDS AS POTENTIAL NONSEDATIVE ANXIOLYTICS", JOURNAL OF MEDICINAL CHEMISTRY, US AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 31, 1 January 1988 (1988-01-01), pages 1220 - 1226, XP001008773, ISSN: 0022-2623 *
DATABASE REGISTRY [online] CAS; 14 January 2002 (2002-01-14), XP002496015, retrieved from STN Database accession no. 382645-25-2 (RN) *
DATABASE REGISTRY [online] CAS; 14 January 2002 (2002-01-14), XP002496016, retrieved from STN Database accession no. 382640-89-3 (RN) *
DATABASE REGISTRY [online] CAS; 14 January 2002 (2002-01-14), XP002496017, retrieved from STN Database accession no. 382612-77-3 (RN) *

Also Published As

Publication number Publication date
CN101910173A (zh) 2010-12-08
FR2925907B1 (fr) 2010-10-15
MX2010007350A (es) 2010-08-18
KR20100099246A (ko) 2010-09-10
AR070078A1 (es) 2010-03-10
BRPI0821991A2 (pt) 2015-06-23
WO2009106752A2 (fr) 2009-09-03
UY31593A1 (es) 2009-08-03
JP2011508763A (ja) 2011-03-17
AU2008351930A1 (en) 2009-09-03
IL206667A0 (en) 2010-12-30
RU2010132230A (ru) 2012-02-10
CA2710962A1 (fr) 2009-09-03
CL2008003932A1 (es) 2010-02-12
FR2925907A1 (fr) 2009-07-03
TW200934779A (en) 2009-08-16
EP2240480A2 (fr) 2010-10-20
US20100317688A1 (en) 2010-12-16

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