WO2009106749A3 - Dérivés de n-heterocyclique-imidazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique - Google Patents

Dérivés de n-heterocyclique-imidazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique Download PDF

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Publication number
WO2009106749A3
WO2009106749A3 PCT/FR2008/001834 FR2008001834W WO2009106749A3 WO 2009106749 A3 WO2009106749 A3 WO 2009106749A3 FR 2008001834 W FR2008001834 W FR 2008001834W WO 2009106749 A3 WO2009106749 A3 WO 2009106749A3
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WO
WIPO (PCT)
Prior art keywords
group
alkyl
hydrogen atom
heterocyclic
alkoxy
Prior art date
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PCT/FR2008/001834
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English (en)
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WO2009106749A2 (fr
Inventor
Jean-François Peyronel
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Sanofi-Aventis
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Publication date
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Priority to CA2710860A priority Critical patent/CA2710860A1/fr
Priority to AU2008351927A priority patent/AU2008351927A1/en
Priority to EA201070813A priority patent/EA201070813A1/ru
Priority to EP08872909A priority patent/EP2225242A2/fr
Priority to JP2010541083A priority patent/JP2011509250A/ja
Priority to CN2008801238170A priority patent/CN101910172A/zh
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Priority to MX2010007349A priority patent/MX2010007349A/es
Priority to BRPI0821992-3A priority patent/BRPI0821992A2/pt
Publication of WO2009106749A2 publication Critical patent/WO2009106749A2/fr
Publication of WO2009106749A3 publication Critical patent/WO2009106749A3/fr
Priority to IL206671A priority patent/IL206671A0/en
Priority to ZA2010/04643A priority patent/ZA201004643B/en
Priority to US12/828,370 priority patent/US20100317673A1/en
Priority to MA33057A priority patent/MA32059B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Composés de formule (I) dans laquelle : X représente un groupe hétérocyclique; R1 représente un atome d'hydrogène, un atome d'halogène, un groupe (C1-C6)alcoxy, un groupe (C2-C6)alkyle), un groupe NRaRb; R2 représente un atome d'hydrogène, un groupe (C1-C6)alkyle éventuellement substitué, un groupe (C1-C6)alcoxy éventuellement substitué, un groupe (C2-C6)alcényle, un groupe (C2-C6)alcynyle, un groupe -CO-R5, un groupe -CO-NR6R7,un groupe -CO-O-R8, un groupe -NR9-CO-R10, un groupe -NR11R12, un groupe -N=CH-NRaRb, un atome d'halogène, un groupe cyano, nitro, hydroxyiminoalkyle, alcoxyiminoalkyle, un groupe (C1-C6)alkylthio, un groupe (C1-C6)alkylsulfinyle, un groupe (C1-C6)alkylsulfonyle, un groupe ((C1 C6)alkyl)3)silyléthynyle, un groupe -SO2-NR9R10, un groupe phényle éventuellement substitué; R3 représente un atome d'hydrogène, un groupe (C2-C6)alkyle un groupe (C1-C6)alcoxy ou un atome d'halogène; R4 représente un atome d'hydrogène, un groupe (C1-C4)alkyle, un groupe (C1-C4)alcoxy ou un atome de fluor, à l'état de base ou de sel d'addition à un acide. Utilisation en thérapeutique.
PCT/FR2008/001834 2008-01-02 2008-12-31 Dérivés de n-heterocyclique-imidazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique WO2009106749A2 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
BRPI0821992-3A BRPI0821992A2 (pt) 2008-01-02 2008-12-31 Derivados de n-heterocíclico-imidazo[1,2-a]piridina-2-carboxamida s, respectivo preparo e respectiva aplicação em terapêutica
CN2008801238170A CN101910172A (zh) 2008-01-02 2008-12-31 N-杂环咪唑并[1，2-a]吡啶-2-甲酰胺衍生物、其制备方法及其治疗应用
AU2008351927A AU2008351927A1 (en) 2008-01-02 2008-12-31 Derivatives of N-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof
EA201070813A EA201070813A1 (ru) 2008-01-02 2008-12-31 Производные n-гетероциклоимидазо[1,2-а]пиридин-2-карбоксамидов, их получение и применение в терапии
EP08872909A EP2225242A2 (fr) 2008-01-02 2008-12-31 Dérivés de n-heterocyclique-imidazoý1,2-a¨pyridine-2-carboxamides, leur préparation et leur application en thérapeutique
JP2010541083A JP2011509250A (ja) 2008-01-02 2008-12-31 Ｎ−複素環式イミダゾ［１，２−ａ］ピリジン−２−カルボキサミドの誘導体、この調製およびこの治療的用途
MX2010007349A MX2010007349A (es) 2008-01-02 2008-12-31 Derivados de n-heterociclico-imidazo[1,2-a]piridina-2-carboxamidas , su preparacion y su aplicacion terapeutica.
CA2710860A CA2710860A1 (fr) 2008-01-02 2008-12-31 Derives de n-heterocyclique-imidazo[1,2-.alpha.]pyridine-2-carboxamides, leur preparation et leur application en therapeutique
IL206671A IL206671A0 (en) 2008-01-02 2010-06-28 N-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US12/828,370 US20100317673A1 (en) 2008-01-02 2010-07-01 N-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
ZA2010/04643A ZA201004643B (en) 2008-01-02 2010-07-01 Derivatives of n-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides,preparation thereof and therapeutic application thereof
MA33057A MA32059B1 (fr) 2008-01-02 2010-08-02 Dérivés de n-heterocyclique-imidazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0800003A FR2925901B1 (fr) 2008-01-02 2008-01-02 DERIVES DE N-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR0800003 2008-01-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/828,370 Continuation US20100317673A1 (en) 2008-01-02 2010-07-01 N-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
WO2009106749A2 WO2009106749A2 (fr) 2009-09-03
WO2009106749A3 true WO2009106749A3 (fr) 2010-05-06

Family

ID=39712153

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/001834 WO2009106749A2 (fr) 2008-01-02 2008-12-31 Dérivés de n-heterocyclique-imidazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique

Country Status (20)

Country Link
US (1) US20100317673A1 (fr)
EP (1) EP2225242A2 (fr)
JP (1) JP2011509250A (fr)
KR (1) KR20100099244A (fr)
CN (1) CN101910172A (fr)
AR (1) AR070072A1 (fr)
AU (1) AU2008351927A1 (fr)
BR (1) BRPI0821992A2 (fr)
CA (1) CA2710860A1 (fr)
CL (1) CL2008003933A1 (fr)
CO (1) CO6331306A2 (fr)
EA (1) EA201070813A1 (fr)
FR (1) FR2925901B1 (fr)
IL (1) IL206671A0 (fr)
MA (1) MA32059B1 (fr)
MX (1) MX2010007349A (fr)
TW (1) TW200934777A (fr)
UY (2) UY3816Q (fr)
WO (1) WO2009106749A2 (fr)
ZA (1) ZA201004643B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2903108B1 (fr) * 2006-07-03 2008-08-29 Sanofi Aventis Sa Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique.
CA3027814A1 (fr) 2010-12-13 2012-06-21 Array Biopharma Inc. Composes a base de n-(1h-indazol-4-yl) imidazo [1,2-a] pyridine-3-carboxamide substitue en tant qu'intermediaires pour inhibiteurs de la tyrosine kinase du recepteur de type iii
WO2012147890A1 (fr) * 2011-04-27 2012-11-01 持田製薬株式会社 Nouveau dérivé d'azole
EP2939675B1 (fr) 2012-12-28 2019-09-04 Shin Nippon Biomedical Laboratories, Ltd. Inhibiteur de l'activité d'oct3 contenant un dérivé d'imidazopyridine en tant que principe actif, et agent de détection d'oct3
CN113905787A (zh) * 2019-04-05 2022-01-07 斯托姆治疗有限公司 Mettl3抑制化合物
WO2022074379A1 (fr) * 2020-10-06 2022-04-14 Storm Therapeutics Limited Composés inhibiteurs de mettl3

Citations (3)

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US20050165049A1 (en) * 2004-01-23 2005-07-28 Christopher Hulme Vanilloid receptor ligands and their use in treatments
WO2008003856A1 (fr) * 2006-07-03 2008-01-10 Sanofi-Aventis Dérivés d'imidazo[1,2-a]pyridine-2-carboxamides leur préparation et leur application en thérapeutique

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JP5358962B2 (ja) * 2007-02-06 2013-12-04 住友化学株式会社 組成物及び該組成物を用いてなる発光素子
WO2009086303A2 (fr) * 2007-12-21 2009-07-09 University Of Rochester Procédé permettant de modifier la durée de vie d'organismes eucaryotes

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US5260303A (en) * 1991-03-07 1993-11-09 G. D. Searle & Co. Imidazopyridines as serotonergic 5-HT3 antagonists
US20050165049A1 (en) * 2004-01-23 2005-07-28 Christopher Hulme Vanilloid receptor ligands and their use in treatments
WO2008003856A1 (fr) * 2006-07-03 2008-01-10 Sanofi-Aventis Dérivés d'imidazo[1,2-a]pyridine-2-carboxamides leur préparation et leur application en thérapeutique

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Also Published As

Publication number Publication date
FR2925901B1 (fr) 2011-03-04
ZA201004643B (en) 2011-09-28
MX2010007349A (es) 2010-08-18
AU2008351927A1 (en) 2009-09-03
CN101910172A (zh) 2010-12-08
MA32059B1 (fr) 2011-02-01
BRPI0821992A2 (pt) 2015-06-23
EA201070813A1 (ru) 2010-12-30
WO2009106749A2 (fr) 2009-09-03
US20100317673A1 (en) 2010-12-16
UY3816Q (es) 2008-09-30
AR070072A1 (es) 2010-03-10
TW200934777A (en) 2009-08-16
IL206671A0 (en) 2010-12-30
CA2710860A1 (fr) 2009-09-03
CO6331306A2 (es) 2011-10-20
JP2011509250A (ja) 2011-03-24
EP2225242A2 (fr) 2010-09-08
CL2008003933A1 (es) 2010-02-12
UY31587A1 (es) 2009-08-03
KR20100099244A (ko) 2010-09-10
FR2925901A1 (fr) 2009-07-03

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