WO2008126901A1 - Composé hétérocyclique contenant de l'azote et composition pharmaceutique le contenant - Google Patents

Composé hétérocyclique contenant de l'azote et composition pharmaceutique le contenant Download PDF

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Publication number
WO2008126901A1
WO2008126901A1 PCT/JP2008/057095 JP2008057095W WO2008126901A1 WO 2008126901 A1 WO2008126901 A1 WO 2008126901A1 JP 2008057095 W JP2008057095 W JP 2008057095W WO 2008126901 A1 WO2008126901 A1 WO 2008126901A1
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WO
WIPO (PCT)
Prior art keywords
group
pharmaceutical composition
nitrogen
disclosed
heterocyclic compound
Prior art date
Application number
PCT/JP2008/057095
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English (en)
Japanese (ja)
Inventor
Norihiko Kikuchi
Yasushi Takigawa
Kazuo Shimizu
Hideki Fujikura
Masato Iizuka
Takahiro Toyoshima
Toshinobu Sasaki
Chikara Hoshino
Masakazu Takeda
Original Assignee
Kissei Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Kissei Pharmaceutical Co., Ltd. filed Critical Kissei Pharmaceutical Co., Ltd.
Priority to JP2009509374A priority Critical patent/JP5330990B2/ja
Publication of WO2008126901A1 publication Critical patent/WO2008126901A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Abstract

L'invention concerne un nouveau composé pourvu d'une activité inhibitrice d'oxydase de xanthine. Une composition pharmaceutique qui contient un tel composé en tant que principe actif est également décrite. Un composé hétérocyclique contenant de l'azote représenté par la formule générale (I) au-dessous ou analogue, un sel pharmaceutiquement acceptable de celui-ci, ou une composition pharmaceutique contenant l'une quelconque d'entre eux en tant que principe actif sont spécifiquement décrits. (I) (Dans la formule, Y1 représente N ou C(R4) ; Y2 représente N ou C(R5) ; R4 et R5 représentent indépendamment un groupe alkyle, un atome d'hydrogène ou analogue ; un de R1 et R2 représente un groupe aryle facultativement substitué, un groupe alcoxy ou un groupe hétérocyclique facultativement substitué ; l'autre de R1 et R2 représente un groupe halogénoalkyle, un groupe cyano, un atome d'halogène ou analogue ; et R3 représente un groupe 5-tétrazolyle ou un groupe carboxy.)
PCT/JP2008/057095 2007-04-11 2008-04-10 Composé hétérocyclique contenant de l'azote et composition pharmaceutique le contenant WO2008126901A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009509374A JP5330990B2 (ja) 2007-04-11 2008-04-10 含窒素複素環化合物およびそれを含有する医薬組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-104095 2007-04-11
JP2007104095 2007-04-11

Publications (1)

Publication Number Publication Date
WO2008126901A1 true WO2008126901A1 (fr) 2008-10-23

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ID=39863996

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Application Number Title Priority Date Filing Date
PCT/JP2008/057095 WO2008126901A1 (fr) 2007-04-11 2008-04-10 Composé hétérocyclique contenant de l'azote et composition pharmaceutique le contenant

Country Status (2)

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JP (1) JP5330990B2 (fr)
WO (1) WO2008126901A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010044403A1 (fr) * 2008-10-15 2010-04-22 キッセイ薬品工業株式会社 Dérivé hétéroaryle à 5 chaînons et utilisation de celui-ci dans un but médical
WO2010044410A1 (fr) * 2008-10-15 2010-04-22 キッセイ薬品工業株式会社 Derive d'acide biaryle isonicotinique et son application medicale
WO2010113942A1 (fr) * 2009-03-31 2010-10-07 キッセイ薬品工業株式会社 Dérivé d'indolizine et son utilisation pour des objectifs médicaux
US7947707B2 (en) 2005-10-07 2011-05-24 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
WO2012043638A1 (fr) * 2010-09-29 2012-04-05 キッセイ薬品工業株式会社 Dérivé d'(aza)indolizine et son utilisation pharmaceutique
JP2012188380A (ja) * 2011-03-10 2012-10-04 Meiji Univ 芳香族へテロ環化合物のニトリル化法
WO2013027801A1 (fr) * 2011-08-24 2013-02-28 キッセイ薬品工業株式会社 Dérivé hétérocyclique condensé et son utilisation pharmaceutique
JP2014510133A (ja) * 2011-04-06 2014-04-24 エルジー・ライフ・サイエンシーズ・リミテッド １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法
WO2014132994A1 (fr) * 2013-02-27 2014-09-04 キッセイ薬品工業株式会社 Procédé de production d'un dérivé hétérocyclique azoté et d'un intermédiaire de production de celui-ci
EP3256449A4 (fr) * 2015-02-11 2018-11-14 Daewoong Pharmaceutical Co., Ltd. Bloqueurs des canaux sodiques
WO2019069973A1 (fr) * 2017-10-04 2019-04-11 日本たばこ産業株式会社 Composé hétéroaryle contenant de l'azote, et son utilisation pharmaceutique
CN111285854A (zh) * 2018-12-07 2020-06-16 北京颖泰嘉和生物科技股份有限公司 咯菌腈的制备方法

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JP2000001431A (ja) * 1998-06-15 2000-01-07 Kotobuki Seiyaku Kk 尿酸排泄剤
JP3220987B2 (ja) * 1996-10-25 2001-10-22 ウェルファイド株式会社 １−フェニルピラゾール化合物およびその医薬用途
JP2005529850A (ja) * 2002-02-19 2005-10-06 ファルマシア・イタリア・エス・ピー・エー 三環系ピラゾール誘導体、その製造方法および抗腫瘍剤としてのその使用
WO2007043401A1 (fr) * 2005-10-07 2007-04-19 Kissei Pharmaceutical Co., Ltd. Compose heterocyclique azote et composition pharmaceutique le contenant

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
JP3220987B2 (ja) * 1996-10-25 2001-10-22 ウェルファイド株式会社 １−フェニルピラゾール化合物およびその医薬用途
JP2000001431A (ja) * 1998-06-15 2000-01-07 Kotobuki Seiyaku Kk 尿酸排泄剤
JP2005529850A (ja) * 2002-02-19 2005-10-06 ファルマシア・イタリア・エス・ピー・エー 三環系ピラゾール誘導体、その製造方法および抗腫瘍剤としてのその使用
WO2007043401A1 (fr) * 2005-10-07 2007-04-19 Kissei Pharmaceutical Co., Ltd. Compose heterocyclique azote et composition pharmaceutique le contenant
WO2007043400A1 (fr) * 2005-10-07 2007-04-19 Kissei Pharmaceutical Co., Ltd. Compose heterocyclique aromatique azote et composition pharmaceutique le contenant

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947707B2 (en) 2005-10-07 2011-05-24 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
WO2010044410A1 (fr) * 2008-10-15 2010-04-22 キッセイ薬品工業株式会社 Derive d'acide biaryle isonicotinique et son application medicale
WO2010044403A1 (fr) * 2008-10-15 2010-04-22 キッセイ薬品工業株式会社 Dérivé hétéroaryle à 5 chaînons et utilisation de celui-ci dans un but médical
US8748452B2 (en) 2009-03-31 2014-06-10 Kissei Pharmaceutical Co., Ltd. Indolizine derivative and use thereof for medical purposes
WO2010113942A1 (fr) * 2009-03-31 2010-10-07 キッセイ薬品工業株式会社 Dérivé d'indolizine et son utilisation pour des objectifs médicaux
CN102365281A (zh) * 2009-03-31 2012-02-29 橘生药品工业株式会社 中氮茚衍生物及其医药用途
KR101772963B1 (ko) 2009-03-31 2017-08-31 깃세이 야쿠힌 고교 가부시키가이샤 인돌리진 유도체 및 그 의약용도
JP5638513B2 (ja) * 2009-03-31 2014-12-10 キッセイ薬品工業株式会社 インドリジン誘導体及びその医薬用途
CN102365281B (zh) * 2009-03-31 2014-11-12 橘生药品工业株式会社 中氮茚衍生物及其医药用途
CN103221412B (zh) * 2010-09-29 2015-08-19 橘生药品工业株式会社 (氮杂)中氮茚衍生物及其药物用途
WO2012043638A1 (fr) * 2010-09-29 2012-04-05 キッセイ薬品工業株式会社 Dérivé d'(aza)indolizine et son utilisation pharmaceutique
US9643969B2 (en) 2010-09-29 2017-05-09 Kissei Pharmaceutical Co., Ltd. (aza)indolizine derivative and pharmaceutical use thereof
CN103221412A (zh) * 2010-09-29 2013-07-24 橘生药品工业株式会社 （氮杂）中氮茚衍生物及其药物用途
JP5906191B2 (ja) * 2010-09-29 2016-04-20 キッセイ薬品工業株式会社 （アザ）インドリジン誘導体及びその医薬用途
JP2012188380A (ja) * 2011-03-10 2012-10-04 Meiji Univ 芳香族へテロ環化合物のニトリル化法
JP2014510133A (ja) * 2011-04-06 2014-04-24 エルジー・ライフ・サイエンシーズ・リミテッド １−（３−シアノ−１−イソプロピル−インドール−５−イル）ピラゾール−４−カルボン酸の結晶形とその製造方法
JPWO2013027801A1 (ja) * 2011-08-24 2015-03-19 キッセイ薬品工業株式会社 縮合へテロ環誘導体及びその医薬用途
CN103889989B (zh) * 2011-08-24 2016-01-20 橘生药品工业株式会社 稠合杂环衍生物及其制药用途
WO2013027801A1 (fr) * 2011-08-24 2013-02-28 キッセイ薬品工業株式会社 Dérivé hétérocyclique condensé et son utilisation pharmaceutique
CN103889989A (zh) * 2011-08-24 2014-06-25 橘生药品工业株式会社 稠合杂环衍生物及其制药用途
US9115144B2 (en) 2011-08-24 2015-08-25 Kissei Pharmaceutical Co., Ltd. Fused heterocyclic derivative and pharmaceutical use thereof
WO2014132994A1 (fr) * 2013-02-27 2014-09-04 キッセイ薬品工業株式会社 Procédé de production d'un dérivé hétérocyclique azoté et d'un intermédiaire de production de celui-ci
US10590078B2 (en) 2015-02-11 2020-03-17 Daewoong Pharmaceutical Co., Ltd. Sodium channel blockers
EP3256449A4 (fr) * 2015-02-11 2018-11-14 Daewoong Pharmaceutical Co., Ltd. Bloqueurs des canaux sodiques
WO2019069973A1 (fr) * 2017-10-04 2019-04-11 日本たばこ産業株式会社 Composé hétéroaryle contenant de l'azote, et son utilisation pharmaceutique
JP2019065009A (ja) * 2017-10-04 2019-04-25 日本たばこ産業株式会社 含窒素ヘテロアリール化合物およびその医薬用途
CN111148735A (zh) * 2017-10-04 2020-05-12 日本烟草产业株式会社 含氮杂芳基化合物及其药物用途
US10752596B2 (en) 2017-10-04 2020-08-25 Japan Tobacco Inc. Nitrogen-containing heteroaryl compound and pharmaceutical use thereof
JP7125882B2 (ja) 2017-10-04 2022-08-25 日本たばこ産業株式会社 含窒素ヘテロアリール化合物およびその医薬用途
CN111148735B (zh) * 2017-10-04 2023-08-08 日本烟草产业株式会社 含氮杂芳基化合物及其药物用途
CN111285854A (zh) * 2018-12-07 2020-06-16 北京颖泰嘉和生物科技股份有限公司 咯菌腈的制备方法
CN111285854B (zh) * 2018-12-07 2022-01-11 北京颖泰嘉和生物科技股份有限公司 咯菌腈的制备方法

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JP5330990B2 (ja) 2013-10-30

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