WO2009069736A1 - Composé azoté - Google Patents

Composé azoté Download PDF

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Publication number
WO2009069736A1
WO2009069736A1 PCT/JP2008/071627 JP2008071627W WO2009069736A1 WO 2009069736 A1 WO2009069736 A1 WO 2009069736A1 JP 2008071627 W JP2008071627 W JP 2008071627W WO 2009069736 A1 WO2009069736 A1 WO 2009069736A1
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WO
WIPO (PCT)
Prior art keywords
hydrogen atom
formula
nitrogenated compound
nitrogenated
substituent
Prior art date
Application number
PCT/JP2008/071627
Other languages
English (en)
Japanese (ja)
Inventor
Koji Yanagawa
Kiyotoshi Mori
Yoshisuke Nakasato
Jun Funahashi
Original Assignee
Kyowa Hakko Kirin Co., Ltd.
Funahashi, Mami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co., Ltd., Funahashi, Mami filed Critical Kyowa Hakko Kirin Co., Ltd.
Publication of WO2009069736A1 publication Critical patent/WO2009069736A1/fr

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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
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    • C07D215/20—Oxygen atoms
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Abstract

L'invention porte sur un composé azoté représenté par la formule (I) [où A représente un aryle qui peut avoir un substituant ou similaire; les B représentent indépendamment un atome d'hydrogène, un halogène ou similaire; n représente un entier de pas moins de 1 et jusqu'au nombre maximal qui peut être substitué; R9 représente un atome d'hydrogène ou similaire; et R10 représente un groupe représenté par la formule (III) (où R11 représente un groupe hétérocyclique aromatique ou similaire; et R12 représente un atome d'hydrogène ou similaire) ou similaire], ou un sel pharmaceutiquement acceptable de ce composé.
PCT/JP2008/071627 2007-11-28 2008-11-28 Composé azoté WO2009069736A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007307939 2007-11-28
JP2007-307939 2007-11-28

Publications (1)

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WO2009069736A1 true WO2009069736A1 (fr) 2009-06-04

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PCT/JP2008/071627 WO2009069736A1 (fr) 2007-11-28 2008-11-28 Composé azoté

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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
WO2011161030A1 (fr) 2010-06-21 2011-12-29 Sanofi Dérivés de méthoxyphényle à substitution hétérocyclique par un groupe oxo, leur procédé de production et leur utilisation comme modulateurs du récepteur gpr40
WO2012004269A1 (fr) 2010-07-05 2012-01-12 Sanofi Dérivés d'acide ( 2 -aryloxy -acétylamino) - phényl - propionique, procédé de production et utilisation comme médicament
WO2012004270A1 (fr) 2010-07-05 2012-01-12 Sanofi Dérivés 1,3-propanedioxyde à substitution spirocyclique, procédé de préparation et utilisation comme médicament
WO2012010413A1 (fr) 2010-07-05 2012-01-26 Sanofi Acides hydroxy-phényl-hexiniques substitués par aryloxy-alkylène, procédé de production et utilisation comme médicament
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
US9815776B2 (en) 2015-04-21 2017-11-14 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US9814698B2 (en) 2015-04-21 2017-11-14 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US9834507B2 (en) 2015-04-21 2017-12-05 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10017471B2 (en) 2015-04-21 2018-07-10 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10035763B2 (en) 2015-04-21 2018-07-31 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10093613B2 (en) 2015-04-21 2018-10-09 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10441570B2 (en) 2015-04-21 2019-10-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) Ligands and methods of use thereof
US10654809B2 (en) 2016-06-10 2020-05-19 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10806720B2 (en) 2015-04-21 2020-10-20 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10865184B2 (en) 2015-04-21 2020-12-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US11230523B2 (en) 2016-06-10 2022-01-25 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005003098A1 (fr) * 2003-07-01 2005-01-13 Schering Aktiengesellschaft Derives de pentanol substitues par un heterocycle, procede de production de ces composes et leur utilisation comme agents anti-inflammatoires
JP2005519897A (ja) * 2002-01-14 2005-07-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド グルココルチコイドミメチックス、その製造方法、それを含む医薬製剤及びその使用
WO2006015870A1 (fr) * 2004-08-12 2006-02-16 Glaxo Group Limited Dérivés de tétrahydronaphthalène servant de modulateurs du récepteur des glucocorticoïdes
JP2006516256A (ja) * 2003-01-03 2006-06-29 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド １−プロパノール及び１−プロピルアミン誘導体ならびにグルココルチコイドリガンドとしての使用
WO2006108699A1 (fr) * 2005-04-14 2006-10-19 Glaxo Group Limited Indazoles en tant que ligands de recepteur glucocorticoide
WO2006135826A1 (fr) * 2005-06-10 2006-12-21 Boehringer Ingelheim International Gmbh Mimetiques de glucocorticoides, procedes de fabrication de ceux-ci, compositions pharmaceutiques et leurs utilisations
WO2008043789A1 (fr) * 2006-10-13 2008-04-17 Glaxo Group Limited Nouveaux composés

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005519897A (ja) * 2002-01-14 2005-07-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド グルココルチコイドミメチックス、その製造方法、それを含む医薬製剤及びその使用
JP2006516256A (ja) * 2003-01-03 2006-06-29 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド １−プロパノール及び１−プロピルアミン誘導体ならびにグルココルチコイドリガンドとしての使用
WO2005003098A1 (fr) * 2003-07-01 2005-01-13 Schering Aktiengesellschaft Derives de pentanol substitues par un heterocycle, procede de production de ces composes et leur utilisation comme agents anti-inflammatoires
WO2006015870A1 (fr) * 2004-08-12 2006-02-16 Glaxo Group Limited Dérivés de tétrahydronaphthalène servant de modulateurs du récepteur des glucocorticoïdes
WO2006108699A1 (fr) * 2005-04-14 2006-10-19 Glaxo Group Limited Indazoles en tant que ligands de recepteur glucocorticoide
WO2006135826A1 (fr) * 2005-06-10 2006-12-21 Boehringer Ingelheim International Gmbh Mimetiques de glucocorticoides, procedes de fabrication de ceux-ci, compositions pharmaceutiques et leurs utilisations
WO2008043789A1 (fr) * 2006-10-13 2008-04-17 Glaxo Group Limited Nouveaux composés

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
WO2011161030A1 (fr) 2010-06-21 2011-12-29 Sanofi Dérivés de méthoxyphényle à substitution hétérocyclique par un groupe oxo, leur procédé de production et leur utilisation comme modulateurs du récepteur gpr40
WO2012004269A1 (fr) 2010-07-05 2012-01-12 Sanofi Dérivés d'acide ( 2 -aryloxy -acétylamino) - phényl - propionique, procédé de production et utilisation comme médicament
WO2012004270A1 (fr) 2010-07-05 2012-01-12 Sanofi Dérivés 1,3-propanedioxyde à substitution spirocyclique, procédé de préparation et utilisation comme médicament
WO2012010413A1 (fr) 2010-07-05 2012-01-26 Sanofi Acides hydroxy-phényl-hexiniques substitués par aryloxy-alkylène, procédé de production et utilisation comme médicament
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
US10093613B2 (en) 2015-04-21 2018-10-09 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10806720B2 (en) 2015-04-21 2020-10-20 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US9834507B2 (en) 2015-04-21 2017-12-05 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10017471B2 (en) 2015-04-21 2018-07-10 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10035763B2 (en) 2015-04-21 2018-07-31 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US9815776B2 (en) 2015-04-21 2017-11-14 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10441570B2 (en) 2015-04-21 2019-10-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) Ligands and methods of use thereof
US10597354B2 (en) 2015-04-21 2020-03-24 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US11873282B2 (en) 2015-04-21 2024-01-16 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US9814698B2 (en) 2015-04-21 2017-11-14 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10865184B2 (en) 2015-04-21 2020-12-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US11648234B2 (en) 2015-04-21 2023-05-16 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use
US11591290B2 (en) 2015-04-21 2023-02-28 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US11273147B2 (en) 2015-04-21 2022-03-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US11230523B2 (en) 2016-06-10 2022-01-25 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US11230531B2 (en) 2016-06-10 2022-01-25 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10654809B2 (en) 2016-06-10 2020-05-19 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof

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