MX2010002098A - Compuesto policiclico. - Google Patents
Compuesto policiclico.Info
- Publication number
- MX2010002098A MX2010002098A MX2010002098A MX2010002098A MX2010002098A MX 2010002098 A MX2010002098 A MX 2010002098A MX 2010002098 A MX2010002098 A MX 2010002098A MX 2010002098 A MX2010002098 A MX 2010002098A MX 2010002098 A MX2010002098 A MX 2010002098A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- group
- substituted
- polycyclic compound
- alkyl group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se da a conocer un compuesto representado por la fórmula (I): (ver fórmula I) o una sal farmacológicamente aceptable del mismo, el cual es efectivo como un agente terapéutico o profiláctico para una enfermedad inducida por Aß, en donde Ar1 representa un grupo imidazolilo el cual puede ser sustituido por un grupo alquilo de 1 a 6 átomos de carbono, o similares; Ar2 representa un grupo fenilo el cual puede ser sustituido por un grupo alcoxi de 1 a 6 átomos de carbono o similares; X1 representa un enlace doble o similares; y Het representa un grupo triazolilo o similares el cual puede ser sustituido por un grupo alquilo de 1 a 6 átomos de carbono o similares, o similares.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007225045 | 2007-08-31 | ||
JP2008020009 | 2008-01-31 | ||
JP2008123057 | 2008-05-09 | ||
PCT/JP2008/065365 WO2009028588A1 (ja) | 2007-08-31 | 2008-08-28 | 多環式化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010002098A true MX2010002098A (es) | 2010-03-30 |
Family
ID=40387302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010002098A MX2010002098A (es) | 2007-08-31 | 2008-08-28 | Compuesto policiclico. |
Country Status (19)
Country | Link |
---|---|
US (1) | US9453000B2 (es) |
EP (2) | EP2559693B1 (es) |
JP (1) | JP5433418B2 (es) |
KR (1) | KR20100055456A (es) |
CN (1) | CN101815713B (es) |
AR (1) | AR068121A1 (es) |
AU (1) | AU2008292390B2 (es) |
BR (1) | BRPI0815773A2 (es) |
CA (1) | CA2694401C (es) |
CL (1) | CL2008002542A1 (es) |
ES (1) | ES2529648T3 (es) |
IL (1) | IL203778A (es) |
MX (1) | MX2010002098A (es) |
MY (1) | MY150507A (es) |
NZ (1) | NZ583515A (es) |
PE (1) | PE20090674A1 (es) |
TW (1) | TW200916469A (es) |
WO (1) | WO2009028588A1 (es) |
ZA (1) | ZA201000474B (es) |
Families Citing this family (29)
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TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
MX2011006782A (es) | 2009-02-26 | 2011-07-20 | Eisai R&D Man Co Ltd | Sal de derivado de tetrahidrotriazolopiridina y un cristal de la misma. |
JP2012051805A (ja) * | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | テトラヒドロトリアゾロピリジン誘導体の製造方法 |
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JP2012121809A (ja) * | 2009-02-26 | 2012-06-28 | Eisai R & D Management Co Ltd | 多環式化合物の製造法およびその中間体 |
CA2761049A1 (en) * | 2009-05-11 | 2010-11-18 | The Regents Of The Univeristy Of California | Method of decreasing ubiquitylated protein levels |
CA2761716A1 (en) * | 2009-05-11 | 2010-11-18 | Envivo Pharmaceuticals, Inc. | Treatment of cognitive disorders with certain alpha-7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors |
CA2769392A1 (en) * | 2009-07-31 | 2011-02-03 | Sandoz Ag | Method for the preparation of w-amino-alkaneamides and w-amino-alkanethioamides as well as intermediates of this method |
CN102906083A (zh) | 2010-01-15 | 2013-01-30 | 杨森制药公司 | 作为γ分泌酶调节剂的新的取代的三唑衍生物 |
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RU2635522C2 (ru) | 2012-05-08 | 2017-11-13 | Форум Фармасьютикалз, Инк. | Способы поддержания, лечения или улучшения когнитивной функции |
JP6106745B2 (ja) | 2012-05-16 | 2017-04-05 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | (特に)アルツハイマー病の治療に有用な置換3,4−ジヒドロ−2H−ピリド[1,2−a]ピラジン−1,6−ジオン誘導体 |
UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
CN104918938B (zh) | 2012-12-20 | 2017-08-15 | 詹森药业有限公司 | 新颖的作为γ分泌酶调节剂的三环3,4‑二氢‑2H‑吡啶并[1,2‑a]吡嗪‑1,6‑二酮衍生物 |
EP2945944B1 (en) | 2013-01-17 | 2016-11-09 | Janssen Pharmaceutica, N.V. | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
US10372396B2 (en) * | 2013-02-21 | 2019-08-06 | Lenovo ( Singapore) Pte. Ltd. | Discovery and connection to wireless displays |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
EP3253755B1 (en) | 2015-02-03 | 2020-08-26 | Pfizer Inc | Novel cyclopropabenzofuranyl pyridopyrazinediones |
KR20240036128A (ko) * | 2017-06-02 | 2024-03-19 | 엑스에리스 파머수티클스, 인크. | 침전 방지 저분자 약물 제제 |
KR20200118005A (ko) * | 2018-02-05 | 2020-10-14 | 위니베르시떼 드 스트라스부르 | 통증 치료용 화합물 및 조성물 |
JP2022519779A (ja) * | 2019-02-07 | 2022-03-24 | アルサテック,インコーポレイテッド | エモキシピンの多価誘導体 |
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CA2694401C (en) | 2007-08-31 | 2012-12-04 | Eisai R&D Management Co., Ltd. | Polycyclic compound |
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2008
- 2008-08-28 CA CA2694401A patent/CA2694401C/en not_active Expired - Fee Related
- 2008-08-28 EP EP12191398.2A patent/EP2559693B1/en active Active
- 2008-08-28 AR ARP080103739A patent/AR068121A1/es unknown
- 2008-08-28 EP EP08828870.9A patent/EP2181992B8/en active Active
- 2008-08-28 PE PE2008001455A patent/PE20090674A1/es not_active Application Discontinuation
- 2008-08-28 US US12/671,873 patent/US9453000B2/en active Active
- 2008-08-28 KR KR1020107005314A patent/KR20100055456A/ko active IP Right Grant
- 2008-08-28 JP JP2009530168A patent/JP5433418B2/ja not_active Expired - Fee Related
- 2008-08-28 ES ES12191398.2T patent/ES2529648T3/es active Active
- 2008-08-28 MY MYPI20100422 patent/MY150507A/en unknown
- 2008-08-28 BR BRPI0815773A patent/BRPI0815773A2/pt not_active IP Right Cessation
- 2008-08-28 NZ NZ583515A patent/NZ583515A/en not_active IP Right Cessation
- 2008-08-28 CN CN200880104785XA patent/CN101815713B/zh not_active Expired - Fee Related
- 2008-08-28 CL CL2008002542A patent/CL2008002542A1/es unknown
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- 2008-08-28 WO PCT/JP2008/065365 patent/WO2009028588A1/ja active Application Filing
- 2008-08-28 AU AU2008292390A patent/AU2008292390B2/en not_active Ceased
- 2008-08-28 TW TW097132893A patent/TW200916469A/zh unknown
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Also Published As
Publication number | Publication date |
---|---|
ES2529648T3 (es) | 2015-02-24 |
EP2559693B1 (en) | 2014-11-26 |
IL203778A (en) | 2013-11-28 |
EP2181992A1 (en) | 2010-05-05 |
NZ583515A (en) | 2011-05-27 |
EP2181992A4 (en) | 2011-09-14 |
CA2694401C (en) | 2012-12-04 |
MY150507A (en) | 2014-01-30 |
PE20090674A1 (es) | 2009-06-19 |
JP5433418B2 (ja) | 2014-03-05 |
EP2559693A1 (en) | 2013-02-20 |
AR068121A1 (es) | 2009-11-04 |
WO2009028588A1 (ja) | 2009-03-05 |
EP2181992B8 (en) | 2013-06-26 |
TW200916469A (en) | 2009-04-16 |
AU2008292390B2 (en) | 2013-04-04 |
CN101815713A (zh) | 2010-08-25 |
US20110009619A1 (en) | 2011-01-13 |
US9453000B2 (en) | 2016-09-27 |
ZA201000474B (en) | 2011-05-25 |
JPWO2009028588A1 (ja) | 2010-12-02 |
CL2008002542A1 (es) | 2009-01-02 |
CA2694401A1 (en) | 2009-03-05 |
KR20100055456A (ko) | 2010-05-26 |
EP2181992B1 (en) | 2013-05-01 |
AU2008292390A1 (en) | 2009-03-05 |
BRPI0815773A2 (pt) | 2019-09-24 |
CN101815713B (zh) | 2013-09-11 |
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