MX2010002098A - Compuesto policiclico. - Google Patents

Compuesto policiclico.

Info

Publication number
MX2010002098A
MX2010002098A MX2010002098A MX2010002098A MX2010002098A MX 2010002098 A MX2010002098 A MX 2010002098A MX 2010002098 A MX2010002098 A MX 2010002098A MX 2010002098 A MX2010002098 A MX 2010002098A MX 2010002098 A MX2010002098 A MX 2010002098A
Authority
MX
Mexico
Prior art keywords
sub
group
substituted
polycyclic compound
alkyl group
Prior art date
Application number
MX2010002098A
Other languages
English (en)
Inventor
Teiji Kimura
Noritaka Kitazawa
Nobuaki Sato
Daisuke Shinmyo
Toshihiko Kaneko
Koichi Ito
Koki Kawano
Takehiko Miyagawa
Mamoru Takaishi
Takeo Sasaki
Hiroaki Hagiwara
Yu Yoshida
Takashi Doko
Toshiyuki Uemura
Daiju Hasegawa
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2010002098A publication Critical patent/MX2010002098A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se da a conocer un compuesto representado por la fórmula (I): (ver fórmula I) o una sal farmacológicamente aceptable del mismo, el cual es efectivo como un agente terapéutico o profiláctico para una enfermedad inducida por Aß, en donde Ar1 representa un grupo imidazolilo el cual puede ser sustituido por un grupo alquilo de 1 a 6 átomos de carbono, o similares; Ar2 representa un grupo fenilo el cual puede ser sustituido por un grupo alcoxi de 1 a 6 átomos de carbono o similares; X1 representa un enlace doble o similares; y Het representa un grupo triazolilo o similares el cual puede ser sustituido por un grupo alquilo de 1 a 6 átomos de carbono o similares, o similares.
MX2010002098A 2007-08-31 2008-08-28 Compuesto policiclico. MX2010002098A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007225045 2007-08-31
JP2008020009 2008-01-31
JP2008123057 2008-05-09
PCT/JP2008/065365 WO2009028588A1 (ja) 2007-08-31 2008-08-28 多環式化合物

Publications (1)

Publication Number Publication Date
MX2010002098A true MX2010002098A (es) 2010-03-30

Family

ID=40387302

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002098A MX2010002098A (es) 2007-08-31 2008-08-28 Compuesto policiclico.

Country Status (19)

Country Link
US (1) US9453000B2 (es)
EP (2) EP2559693B1 (es)
JP (1) JP5433418B2 (es)
KR (1) KR20100055456A (es)
CN (1) CN101815713B (es)
AR (1) AR068121A1 (es)
AU (1) AU2008292390B2 (es)
BR (1) BRPI0815773A2 (es)
CA (1) CA2694401C (es)
CL (1) CL2008002542A1 (es)
ES (1) ES2529648T3 (es)
IL (1) IL203778A (es)
MX (1) MX2010002098A (es)
MY (1) MY150507A (es)
NZ (1) NZ583515A (es)
PE (1) PE20090674A1 (es)
TW (1) TW200916469A (es)
WO (1) WO2009028588A1 (es)
ZA (1) ZA201000474B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
CA2694401C (en) 2007-08-31 2012-12-04 Eisai R&D Management Co., Ltd. Polycyclic compound
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
US20090124651A1 (en) * 2007-08-31 2009-05-14 H. Lundbeck A/S Catecholamine derivatives and prodrugs thereof
EP2324009A1 (en) * 2008-08-27 2011-05-25 Eisai R&D Management Co., Ltd. Process for preparing certain cinnamide compounds
DK2540297T3 (en) 2008-11-19 2015-07-13 Forum Pharmaceuticals Inc The treatment of cognitive disorders with (R) -7-chloro-N- (quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
MX2011006782A (es) 2009-02-26 2011-07-20 Eisai R&D Man Co Ltd Sal de derivado de tetrahidrotriazolopiridina y un cristal de la misma.
JP2012051805A (ja) * 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd テトラヒドロトリアゾロピリジン誘導体の製造方法
MX2011008501A (es) 2009-02-26 2011-09-01 Eisai R&D Man Co Ltd Compuestos heterociclicos fusionados que contienen nitrogeno y su uso como inhibidores de la produccion de beta-amiloide.
JP2012121809A (ja) * 2009-02-26 2012-06-28 Eisai R & D Management Co Ltd 多環式化合物の製造法およびその中間体
CA2761049A1 (en) * 2009-05-11 2010-11-18 The Regents Of The Univeristy Of California Method of decreasing ubiquitylated protein levels
CA2761716A1 (en) * 2009-05-11 2010-11-18 Envivo Pharmaceuticals, Inc. Treatment of cognitive disorders with certain alpha-7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors
CA2769392A1 (en) * 2009-07-31 2011-02-03 Sandoz Ag Method for the preparation of w-amino-alkaneamides and w-amino-alkanethioamides as well as intermediates of this method
CN102906083A (zh) 2010-01-15 2013-01-30 杨森制药公司 作为γ分泌酶调节剂的新的取代的三唑衍生物
BR112012029237A2 (pt) 2010-05-17 2016-11-29 Envivo Pharmaceuticals Inc forma cristalina de cloridrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo[b] tiofeno-2-carboxamida monohidratado
CA2830027C (en) 2011-03-31 2016-04-26 Pfizer Inc. Novel bicyclic pyridinones
RU2635522C2 (ru) 2012-05-08 2017-11-13 Форум Фармасьютикалз, Инк. Способы поддержания, лечения или улучшения когнитивной функции
JP6106745B2 (ja) 2012-05-16 2017-04-05 ヤンセン ファーマシューティカルズ,インコーポレーテッド (特に)アルツハイマー病の治療に有用な置換3,4−ジヒドロ−2H−ピリド[1,2−a]ピラジン−1,6−ジオン誘導体
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
CN104918938B (zh) 2012-12-20 2017-08-15 詹森药业有限公司 新颖的作为γ分泌酶调节剂的三环3,4‑二氢‑2H‑吡啶并[1,2‑a]吡嗪‑1,6‑二酮衍生物
EP2945944B1 (en) 2013-01-17 2016-11-09 Janssen Pharmaceutica, N.V. Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
US10372396B2 (en) * 2013-02-21 2019-08-06 Lenovo ( Singapore) Pte. Ltd. Discovery and connection to wireless displays
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
EP3253755B1 (en) 2015-02-03 2020-08-26 Pfizer Inc Novel cyclopropabenzofuranyl pyridopyrazinediones
KR20240036128A (ko) * 2017-06-02 2024-03-19 엑스에리스 파머수티클스, 인크. 침전 방지 저분자 약물 제제
KR20200118005A (ko) * 2018-02-05 2020-10-14 위니베르시떼 드 스트라스부르 통증 치료용 화합물 및 조성물
JP2022519779A (ja) * 2019-02-07 2022-03-24 アルサテック,インコーポレイテッド エモキシピンの多価誘導体
WO2024127030A1 (en) * 2022-12-15 2024-06-20 Sitryx Therapeutics Limited Substituted pyridines for use in treating or preventing inflammatory diseases or diseases associated with an undesirable immune response

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1101156A (en) 1965-09-22 1968-01-31 Hickson & Welch Ltd Triazole derivatives and their use as optical whitening agents
US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
FR2314731A1 (fr) 1975-06-19 1977-01-14 Nelson Res & Dev Azacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients
US4508718A (en) 1984-01-16 1985-04-02 Warner-Lambert Company Cardiotonic and antihypertensive oxadiazinone compounds
ES2061432T3 (es) 1985-10-09 1994-12-16 Shell Int Research Nuevas amidas de acido acrilico.
US4783463A (en) 1985-10-23 1988-11-08 Rorer Pharmaceutical Corporation Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure
DE3541716A1 (de) 1985-11-26 1987-05-27 Celamerck Gmbh & Co Kg Neue acrylsaeureamide
FI91754C (fi) 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
FI902321A0 (fi) 1989-05-19 1990-05-09 Eisai Co Ltd Butensyraderivat.
JPH03206042A (ja) * 1990-01-06 1991-09-09 Takeda Chem Ind Ltd 降圧剤
ATE153655T1 (de) 1990-02-08 1997-06-15 Eisai Co Ltd Benzensulfonamidderivat
AU680870B2 (en) 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
GB9402807D0 (en) 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
AU3577995A (en) 1994-10-04 1996-04-26 Fujisawa Pharmaceutical Co., Ltd. Urea derivatives and their use as acat-inhibitors
JPH08283219A (ja) 1995-04-07 1996-10-29 Eisai Co Ltd アラルキルアミノアルキルアミド誘導体
CZ251896A3 (en) 1995-09-12 1997-04-16 Hoffmann Ka Roche Ag F Cephalosporin derivatives
WO1997014417A1 (en) 1995-10-19 1997-04-24 Merck & Co., Inc. Fibrinogen receptor antagonists
YU49898A (sh) 1996-05-10 2000-03-21 Icos Corporation Hemijska jedinjenja
NZ333825A (en) 1996-07-22 2000-10-27 Monsanto Co Metalloprotease inhibitors particularly MMP-13
US5672612A (en) 1996-09-09 1997-09-30 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
JP2001508767A (ja) 1996-12-02 2001-07-03 藤沢薬品工業株式会社 5―ht拮抗作用を有するインドール―ウレア誘導体
JP3108997B2 (ja) 1997-03-31 2000-11-13 武田薬品工業株式会社 アゾール化合物、その製造法および用途
WO1998043970A1 (en) 1997-03-31 1998-10-08 Takeda Chemical Industries, Ltd. Azole compounds, their production and their use
AU7108398A (en) 1997-04-16 1998-11-11 Abbott Laboratories 5,7-disubstituted 4-aminopyrido{2,3-d}pyrimidine compounds and their use as adenosine kinase inhibitors
TW379224B (en) 1997-12-02 2000-01-11 Fujisawa Pharmaceutical Co Urea derivatives
DE69822514T2 (de) 1997-12-31 2005-03-24 The University Of Kansas, Lawrence Wasserlösliche pro-pharmaka von arzneistoffen, die ein tertiäres amin enthalten, und verfahren zu ihrer herstellung
GB9816984D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
US6048678A (en) * 1998-12-28 2000-04-11 Eastman Kodak Company Protective overcoat coating compositions
US6235728B1 (en) 1999-02-19 2001-05-22 Bristol-Myers Squibb Company Water-soluble prodrugs of azole compounds
JP2002537376A (ja) 1999-02-26 2002-11-05 マーク・アンド・カンパニー・インコーポレイテッド 新規スルホンアミドおよびそれらの使用
AU2899400A (en) 1999-03-04 2000-09-21 Nortran Pharmaceuticals Inc. Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics
AU2001241128A1 (en) 2000-03-14 2001-09-24 Fujisawa Pharmaceutical Co. Ltd. Novel amide compounds
US20010051642A1 (en) 2000-04-17 2001-12-13 Kyunghye Ahn Method for treating Alzheimer's disease
EP1278734A2 (en) 2000-04-24 2003-01-29 Merck Frosst Canada & Co. Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
WO2002046166A1 (en) * 2000-12-04 2002-06-13 F. Hoffmann-La Roche Ag Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists
GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
CA2458029A1 (en) 2001-09-13 2003-03-20 Boehringer Ingelheim Pharmaceuticals, Inc. Methods of treating cytokine mediated diseases
BR0212522A (pt) 2001-09-14 2004-08-10 Novo Nordisk As Ligando de ligação de zinco, hexâmero de insulina, preparação aquosa de insulina e métodos de prolongar a ação de uma preparação de insulina e de preparar um ligando de ligação de zinco
WO2003043988A1 (fr) 2001-11-22 2003-05-30 Ono Pharmaceutical Co., Ltd. Composes derives de piperidine-2-one et medicaments contenant lesdits composes comme principes actifs
MXPA04005427A (es) 2001-12-10 2005-04-19 Amgen Inc Ligandos de receptor vainilloide y su uso en tratamientos.
DE60232276D1 (de) 2001-12-20 2009-06-18 Bristol Myers Squibb Co Alpha-(n-sulfonamid)acetamidderivate als beta-amyloidinhibitoren
JP2003206280A (ja) 2001-12-28 2003-07-22 Takeda Chem Ind Ltd ビアリール化合物およびその用途
EP1509505A2 (en) 2002-01-23 2005-03-02 Arena Pharmaceuticals, Inc. SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
AU2003225668A1 (en) 2002-03-01 2003-09-16 Pintex Pharmaceutical, Inc. Pin1-modulating compounds and methods of use thereof
GB0207436D0 (en) 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
ES2355472T3 (es) 2002-05-22 2011-03-28 Amgen Inc. Derivados de aminopirimidina para su uso como ligandos del receptor vaniloide para el tratamiento del dolor.
ES2473581T3 (es) 2002-05-31 2014-07-07 Proteotech Inc. Compuestos, composiciones y métodos para el tratamiento de amiloidosis y sinucleinopat�as tales como la enfermedad de Alzheimer, la diabetes de tipo 2 y la enfermedad de Parkinson
US7459476B2 (en) 2002-06-27 2008-12-02 Elan Pharmaceuticals, Inc. Methods for treating Alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
MXPA05000053A (es) 2002-07-12 2005-04-08 Aventis Pharma Gmbh Benzoilureas heterociclicamente sustituidas, metodo para su produccion y su uso como medicamentos.
US6900354B2 (en) 2002-07-15 2005-05-31 Hoffman-La Roche Inc. 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives
EP1594847A2 (en) 2003-02-12 2005-11-16 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
TW200510362A (en) 2003-04-01 2005-03-16 Plus Chemicals Bv Amorphous simvastatin calcium and methods for the preparation thereof
CN1787822A (zh) * 2003-05-14 2006-06-14 托里派因斯疗法公司 化合物及其在调节淀粉样蛋白β中的用途
CN102584813B (zh) * 2003-05-14 2016-07-06 Ngc药物公司 化合物及其在调节淀粉样蛋白β中的用途
WO2005020921A2 (en) 2003-08-29 2005-03-10 Exelixis, Inc. C-kit modulators and methods of use
AP2331A (en) 2003-12-22 2011-12-05 Pfizer Triazole derivatives as vasopressin antagonists.
NZ548208A (en) 2004-02-12 2010-09-30 Transtech Pharma Inc Substituted azole derivatives, compositions, and methods of use
JP4625838B2 (ja) 2004-03-09 2011-02-02 メルク・シャープ・エンド・ドーム・コーポレイション Hivインテグラーゼ阻害薬
KR101128065B1 (ko) 2004-05-26 2012-04-12 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 화합물
JP2008509982A (ja) 2004-08-16 2008-04-03 プロシディオン・リミテッド アリール尿素誘導体
US7923563B2 (en) 2004-10-26 2011-04-12 Eisai R&D Management Co., Ltd. Amorphous object of cinnamide compound
US20060241038A1 (en) 2005-04-20 2006-10-26 Eisai Co., Ltd. Therapeutic agent for Abeta related disorders
WO2007034282A2 (en) * 2005-09-19 2007-03-29 Pfizer Products Inc. Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists
AU2006316005A1 (en) 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
JPWO2007058304A1 (ja) 2005-11-18 2009-05-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物の塩またはそれらの溶媒和物
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
JP5221144B2 (ja) 2005-11-24 2013-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 モルホリンタイプ・シンナミド化合物
US20070117839A1 (en) 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
EP1992618B1 (en) 2006-03-09 2012-01-18 Eisai R&D Management Co., Ltd. Polycyclic cinnamide derivative
US7737141B2 (en) 2006-07-28 2010-06-15 Eisai R&D Management Co., Ltd. Prodrug of cinnamide compound
CA2677296A1 (en) * 2007-02-08 2008-08-14 Merck & Co., Inc. Therapeutic agents
US20080207900A1 (en) 2007-02-28 2008-08-28 Teiji Kimura Two cyclic oxomorphorin derivatives
WO2008137102A2 (en) 2007-05-04 2008-11-13 Torreypines Therapeutics, Inc. Methods of modulating amyloid beta and compounds useful therefor
JP5209043B2 (ja) 2007-05-07 2013-06-12 メルク・シャープ・アンド・ドーム・コーポレーション ガンマセクレターゼ調節剤
ES2358863T3 (es) 2007-05-11 2011-05-16 F. Hoffmann-La Roche Ag Hetarilanilinas como moduladores de beta-amiloide.
EP2166854A4 (en) 2007-06-13 2012-05-16 Merck Sharp & Dohme TRIAZOLE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND ASSOCIATED STATES
EP2185522A1 (en) 2007-08-06 2010-05-19 Schering Corporation Gamma secretase modulators
CA2694401C (en) 2007-08-31 2012-12-04 Eisai R&D Management Co., Ltd. Polycyclic compound
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
US8450343B2 (en) 2007-12-06 2013-05-28 Xianhai Huang Gamma secretase modulators
US20110086850A1 (en) * 2008-04-11 2011-04-14 Board Of Regents, The University Of Texas System Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy
EP2324009A1 (en) 2008-08-27 2011-05-25 Eisai R&D Management Co., Ltd. Process for preparing certain cinnamide compounds
MX2011008553A (es) 2009-02-26 2011-09-09 Boehringer Ingelheim Int Compuestos como antagonistas de bradiquinina b1.
MX2011006782A (es) 2009-02-26 2011-07-20 Eisai R&D Man Co Ltd Sal de derivado de tetrahidrotriazolopiridina y un cristal de la misma.
BRPI1013396A2 (pt) 2009-02-26 2016-03-29 Glaxo Group Ltd composto, produto farmacêutico de combinação, uso de um composto, método para tratar uma doença ou condição, e, processo para a preparação de um composto.
JP2012051806A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
WO2010098466A1 (ja) 2009-02-27 2010-09-02 Hoya株式会社 成形型およびプラスチックレンズの製造方法
US8946266B2 (en) 2009-07-15 2015-02-03 Janssen Pharmaceuticals, Inc. Substituted triazole and imidazole derivatives as gamma secretase modulators
US8381014B2 (en) * 2010-05-06 2013-02-19 International Business Machines Corporation Node controller first failure error management for a distributed system

Also Published As

Publication number Publication date
ES2529648T3 (es) 2015-02-24
EP2559693B1 (en) 2014-11-26
IL203778A (en) 2013-11-28
EP2181992A1 (en) 2010-05-05
NZ583515A (en) 2011-05-27
EP2181992A4 (en) 2011-09-14
CA2694401C (en) 2012-12-04
MY150507A (en) 2014-01-30
PE20090674A1 (es) 2009-06-19
JP5433418B2 (ja) 2014-03-05
EP2559693A1 (en) 2013-02-20
AR068121A1 (es) 2009-11-04
WO2009028588A1 (ja) 2009-03-05
EP2181992B8 (en) 2013-06-26
TW200916469A (en) 2009-04-16
AU2008292390B2 (en) 2013-04-04
CN101815713A (zh) 2010-08-25
US20110009619A1 (en) 2011-01-13
US9453000B2 (en) 2016-09-27
ZA201000474B (en) 2011-05-25
JPWO2009028588A1 (ja) 2010-12-02
CL2008002542A1 (es) 2009-01-02
CA2694401A1 (en) 2009-03-05
KR20100055456A (ko) 2010-05-26
EP2181992B1 (en) 2013-05-01
AU2008292390A1 (en) 2009-03-05
BRPI0815773A2 (pt) 2019-09-24
CN101815713B (zh) 2013-09-11

Similar Documents

Publication Publication Date Title
MX2010002098A (es) Compuesto policiclico.
MY148703A (en) Polycyclic cinnamide derivatives
EA200870336A1 (ru) Полициклические производные циннамида
TW200612958A (en) Substituted imidazole derivatives
HK1133008A1 (en) Imidazole derivative
WO2008111441A1 (ja) 医薬組成物
WO2008108386A1 (ja) 医薬組成物
WO2008108378A3 (en) Bicyclic oxomorpholine derivative
WO2009069736A1 (ja) 含窒素化合物
RS53003B (en) C7-FLUORO SUBSTITUTED TETRACYCLINE UNITS
MX2010001566A (es) Derivado de aminopirazolamida.
TW200637539A (en) CTGF inhibitors
WO2007126900A3 (en) Antifungal agents
TN2009000287A1 (en) Cyclized derivatives as eg-5inhibitors
UA96759C2 (en) 2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS
WO2007146856A3 (en) Substituted gamma lactams as therapeutic agents
WO2009004322A3 (en) Derivatives of nystatin and their use as antifungal agents
CY1112554T1 (el) Παραγωγο 4-(3-βενζοϋλαμινοφαινυλ)-6,7-διμεθοξυ-2-μεθυλαμινοκιναζολινης
UA97855C2 (en) Polycyclic compound
UA95472C2 (en) Polycyclic cinnamide derivatives
TW200801016A (en) Thienopyridine-2-carboxamide derivatives
TN2012000617A1 (en) 2,3,5-trisubstituted thiophene compounds and uses thereof
WO2008146691A1 (ja) 肝炎の予防又は治療のための医薬組成物
WO2008102716A1 (ja) Adhd関連疾患治療剤
TW200634000A (en) 2-(pyrazol-1-yl)pyridine derivatives

Legal Events

Date Code Title Description
FG Grant or registration