EA200870336A1 - Полициклические производные циннамида - Google Patents
Полициклические производные циннамидаInfo
- Publication number
- EA200870336A1 EA200870336A1 EA200870336A EA200870336A EA200870336A1 EA 200870336 A1 EA200870336 A1 EA 200870336A1 EA 200870336 A EA200870336 A EA 200870336A EA 200870336 A EA200870336 A EA 200870336A EA 200870336 A1 EA200870336 A1 EA 200870336A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- substituted
- zinnamide
- polycyclic derivatives
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
Раскрыто соединение, представленное формулой (I), или его фармакологически приемлемая соль, где Arпредставляет собой имидазолильную группу, которая может быть замещена Салкильной группой или тому подобным, Arпредставляет собой фенильную группу, которая может быть замещена Салкоксигруппой или тому подобным, Xпредставляет собой двойную связь или тому подобное и Het представляет собой имидазолильную группу, которая может быть замещена Салкильной группой или тому подобным. Соединение или соль полезно(а) в качестве терапевтического или профилактического средства против заболевания, вызываемого Аβ.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78051706P | 2006-03-09 | 2006-03-09 | |
JP2006063562 | 2006-03-09 | ||
US86170206P | 2006-11-30 | 2006-11-30 | |
JP2006322728 | 2006-11-30 | ||
PCT/JP2007/054532 WO2007102580A1 (ja) | 2006-03-09 | 2007-03-08 | 多環式シンナミド誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200870336A1 true EA200870336A1 (ru) | 2009-02-27 |
EA016464B1 EA016464B1 (ru) | 2012-05-30 |
Family
ID=38474999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200870336A EA016464B1 (ru) | 2006-03-09 | 2007-03-08 | Полициклические производные арилимидазола |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1992618B1 (ru) |
KR (1) | KR101464651B1 (ru) |
AR (1) | AR059955A1 (ru) |
AU (1) | AU2007223158B2 (ru) |
CA (1) | CA2643796A1 (ru) |
CY (1) | CY1112767T1 (ru) |
EA (1) | EA016464B1 (ru) |
GE (1) | GEP20115139B (ru) |
HK (2) | HK1122027A1 (ru) |
HN (1) | HN2008001374A (ru) |
HR (1) | HRP20120174T1 (ru) |
IL (1) | IL193770A (ru) |
MA (1) | MA30268B1 (ru) |
MX (1) | MX2008011221A (ru) |
PL (1) | PL1992618T3 (ru) |
WO (1) | WO2007102580A1 (ru) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
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MY149038A (en) | 2004-05-26 | 2013-07-15 | Eisai R&D Man Co Ltd | Cinnamide compound |
KR20070083781A (ko) | 2004-10-26 | 2007-08-24 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물의 비정질체 |
BRPI0618814A2 (pt) | 2005-11-24 | 2014-04-29 | Eisai R&D Man Co Ltd | Composto ou um sal farmacologicamente aceitável do mesmo, e, agente farmacêutico |
TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
AR062095A1 (es) | 2006-07-28 | 2008-10-15 | Eisai R&D Man Co Ltd | Profarmaco de compuesto cinamida |
CA2677296A1 (en) * | 2007-02-08 | 2008-08-14 | Merck & Co., Inc. | Therapeutic agents |
US20080207900A1 (en) | 2007-02-28 | 2008-08-28 | Teiji Kimura | Two cyclic oxomorphorin derivatives |
WO2008138753A1 (en) | 2007-05-11 | 2008-11-20 | F. Hoffmann-La Roche Ag | Hetarylanilines as modulators for amyloid beta |
AU2008263207B2 (en) * | 2007-06-01 | 2013-10-03 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
CL2008002542A1 (es) * | 2007-08-31 | 2009-01-02 | Eisai R&D Man Co Ltd | Compuestos derivados de imidazolil piridina ligados a un heterociclo mediante un vinilo, moduladores de la actividad de amiloide-beta; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de enfermedades tales como alzheimer, demencia, sindrome de down o amiloidosis. |
US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
MX2010005028A (es) | 2007-11-05 | 2010-05-27 | Schering Corp | Moduladores de gamma secretasa. |
MX2010006379A (es) * | 2007-12-11 | 2010-09-07 | Schering Corp | Moduladores de la secretasa gamma. |
KR20100135711A (ko) | 2007-12-20 | 2010-12-27 | 엔비보 파마슈티칼즈, 인코퍼레이티드 | 사중치환된 벤젠 |
KR101204213B1 (ko) | 2007-12-21 | 2012-11-26 | 에프. 호프만-라 로슈 아게 | 오렉신 수용체 길항제로서의 헤테로아릴 유도체 |
CN101910142B (zh) | 2008-01-11 | 2013-07-10 | 弗·哈夫曼-拉罗切有限公司 | β-淀粉状蛋白的调节剂 |
AU2009216851B2 (en) | 2008-02-22 | 2013-11-07 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
RU2011111534A (ru) * | 2008-08-27 | 2012-10-10 | ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) | Способ получения определенных цинниамидных соединений |
CA2736924C (en) | 2008-10-09 | 2016-06-28 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
WO2010054064A1 (en) * | 2008-11-06 | 2010-05-14 | Schering Corporation | Gamma secretase modulators |
US20120129846A1 (en) * | 2008-11-06 | 2012-05-24 | Zhaoning Zhu | Gamma secretase modulators |
CN102209537A (zh) | 2008-11-10 | 2011-10-05 | 弗·哈夫曼-拉罗切有限公司 | 杂环γ分泌酶调节剂 |
JP2012508748A (ja) | 2008-11-13 | 2012-04-12 | シェーリング コーポレイション | γ−セクレターゼ調節剤 |
AR074701A1 (es) * | 2008-12-22 | 2011-02-02 | Schering Corp | Moduladores de gamma secretasa |
TW201030002A (en) * | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
JP2012051807A (ja) * | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
JP2012051805A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | テトラヒドロトリアゾロピリジン誘導体の製造方法 |
BRPI1007883A2 (pt) | 2009-02-26 | 2016-02-23 | Eisai R&D Man Co Ltd | sal, e, cristal. |
JP2012121809A (ja) * | 2009-02-26 | 2012-06-28 | Eisai R & D Management Co Ltd | 多環式化合物の製造法およびその中間体 |
TW201035101A (en) * | 2009-02-26 | 2010-10-01 | Eisai R&D Man Co Ltd | Nitrogen-containing fused heterocyclic compound |
CN102482276A (zh) | 2009-07-13 | 2012-05-30 | 武田药品工业株式会社 | 杂环化合物及其用途 |
US8871760B2 (en) * | 2009-09-21 | 2014-10-28 | Roche Palo Alto Llc | [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators |
KR20120123677A (ko) * | 2010-01-15 | 2012-11-09 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 신규 치환된 비사이클릭 트리아졸 유도체 |
US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
CA2791914C (en) | 2010-03-05 | 2019-01-15 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
SG187917A1 (en) * | 2010-09-02 | 2013-04-30 | Takeda Pharmaceutical | Fused triazoles for the treatment or prophylaxis of mild cognitive impairment |
JP2014012641A (ja) * | 2010-10-29 | 2014-01-23 | Dainippon Sumitomo Pharma Co Ltd | 新規ピリジン誘導体 |
US9303000B2 (en) * | 2011-01-17 | 2016-04-05 | Karyopharm Therapeutics Inc. | Olefin containing nuclear transport modulators and uses thereof |
PT2736887T (pt) | 2011-07-29 | 2018-01-15 | Karyopharm Therapeutics Inc | Modeladores de transporte nuclear contendo hidrazida e utilizações dos mesmos |
WO2013019561A1 (en) | 2011-07-29 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
US9708276B2 (en) | 2011-10-12 | 2017-07-18 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer |
KR20200115688A (ko) | 2012-05-09 | 2020-10-07 | 바이오젠 엠에이 인코포레이티드 | 핵 수송 조절인자 및 이의 용도 |
KR102096625B1 (ko) | 2012-05-16 | 2020-04-03 | 얀센 파마슈티칼즈, 인코포레이티드 | (무엇보다도) 알츠하이머병의 치료에 유용한 치환 3,4-디하이드로-2h-피리도[1,2-a]피라진-1,6-디온 유도체 |
EP2687528A1 (en) * | 2012-07-17 | 2014-01-22 | Ares Trading S.A. | Fused triazole derivatives as gamma secretase modulators |
EP2953949B1 (en) | 2012-12-20 | 2016-09-28 | Janssen Pharmaceutica NV | Novel tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
AU2014206834B2 (en) | 2013-01-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
EP2968278B8 (en) | 2013-03-15 | 2019-05-22 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
ME03421B (me) | 2013-06-21 | 2020-01-20 | Karyopharm Therapeutics Inc | 1,2,4-triazoli kao modulatori nuklearnog transporta i njihova upotreba |
WO2015042297A1 (en) | 2013-09-20 | 2015-03-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Compounds for treating prostate can cancer |
US20160257657A1 (en) | 2013-09-20 | 2016-09-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
EA201790384A1 (ru) | 2014-08-15 | 2017-08-31 | Кариофарм Терапевтикс, Инк. | Полиморфы селинексора |
US10709706B2 (en) | 2015-12-31 | 2020-07-14 | Karopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
WO2017117529A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
US10980806B2 (en) | 2016-03-24 | 2021-04-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2956702A (en) * | 2000-12-04 | 2002-06-18 | Hoffmann La Roche | Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists |
CA2514363A1 (en) * | 2003-02-12 | 2004-08-26 | Transtech Pharma, Inc. | Substituted azole derivatives as therapeutic agents |
JP4898458B2 (ja) * | 2004-02-12 | 2012-03-14 | トランス テック ファーマ,インコーポレイテッド | 置換アゾール誘導体、組成物及び使用方法 |
MY149038A (en) * | 2004-05-26 | 2013-07-15 | Eisai R&D Man Co Ltd | Cinnamide compound |
-
2007
- 2007-03-08 MX MX2008011221A patent/MX2008011221A/es active IP Right Grant
- 2007-03-08 AR ARP070100958A patent/AR059955A1/es not_active Application Discontinuation
- 2007-03-08 EA EA200870336A patent/EA016464B1/ru not_active IP Right Cessation
- 2007-03-08 PL PL07738023T patent/PL1992618T3/pl unknown
- 2007-03-08 CA CA002643796A patent/CA2643796A1/en not_active Abandoned
- 2007-03-08 WO PCT/JP2007/054532 patent/WO2007102580A1/ja active Application Filing
- 2007-03-08 AU AU2007223158A patent/AU2007223158B2/en not_active Ceased
- 2007-03-08 GE GEAP200710893A patent/GEP20115139B/en unknown
- 2007-03-08 EP EP07738023A patent/EP1992618B1/en active Active
- 2007-03-08 KR KR1020087023309A patent/KR101464651B1/ko not_active IP Right Cessation
-
2008
- 2008-08-28 IL IL193770A patent/IL193770A/en not_active IP Right Cessation
- 2008-09-05 HN HN2008001374A patent/HN2008001374A/es unknown
- 2008-09-08 MA MA31220A patent/MA30268B1/fr unknown
-
2009
- 2009-03-11 HK HK09102339.7A patent/HK1122027A1/xx not_active IP Right Cessation
- 2009-06-19 HK HK09105547.8A patent/HK1128085A1/xx not_active IP Right Cessation
-
2012
- 2012-02-16 CY CY20121100165T patent/CY1112767T1/el unknown
- 2012-02-22 HR HR20120174T patent/HRP20120174T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
AU2007223158A1 (en) | 2007-09-13 |
EP1992618B1 (en) | 2012-01-18 |
EA016464B1 (ru) | 2012-05-30 |
EP1992618A1 (en) | 2008-11-19 |
CA2643796A1 (en) | 2007-09-13 |
AR059955A1 (es) | 2008-05-14 |
KR101464651B1 (ko) | 2014-11-24 |
HK1122027A1 (en) | 2009-05-08 |
IL193770A (en) | 2012-10-31 |
MX2008011221A (es) | 2008-09-11 |
PL1992618T3 (pl) | 2012-06-29 |
HRP20120174T1 (hr) | 2012-03-31 |
HK1128085A1 (en) | 2009-10-16 |
HN2008001374A (es) | 2011-03-15 |
AU2007223158B2 (en) | 2012-04-12 |
WO2007102580A1 (ja) | 2007-09-13 |
CY1112767T1 (el) | 2016-02-10 |
MA30268B1 (fr) | 2009-03-02 |
GEP20115139B (en) | 2011-01-10 |
EP1992618A4 (en) | 2010-11-10 |
IL193770A0 (en) | 2009-05-04 |
KR20080108481A (ko) | 2008-12-15 |
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Legal Events
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |