EA200870336A1 - Полициклические производные циннамида - Google Patents

Полициклические производные циннамида

Info

Publication number
EA200870336A1
EA200870336A1 EA200870336A EA200870336A EA200870336A1 EA 200870336 A1 EA200870336 A1 EA 200870336A1 EA 200870336 A EA200870336 A EA 200870336A EA 200870336 A EA200870336 A EA 200870336A EA 200870336 A1 EA200870336 A1 EA 200870336A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
substituted
zinnamide
polycyclic derivatives
alkyl group
Prior art date
Application number
EA200870336A
Other languages
English (en)
Other versions
EA016464B1 (ru
Inventor
Тейдзи Кимура
Норитака Китазава
Тосихико Канеко
Нобуаки Сато
Коки Кавано
Коити Ито
Эрико Дои
Мамору Такаиси
Такео Сасаки
Такаси Доко
Такехико Миягава
Хироаки Хагивара
Original Assignee
Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эйсай Ар Энд Ди Менеджмент Ко., Лтд. filed Critical Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
Publication of EA200870336A1 publication Critical patent/EA200870336A1/ru
Publication of EA016464B1 publication Critical patent/EA016464B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Раскрыто соединение, представленное формулой (I), или его фармакологически приемлемая соль, где Arпредставляет собой имидазолильную группу, которая может быть замещена Салкильной группой или тому подобным, Arпредставляет собой фенильную группу, которая может быть замещена Салкоксигруппой или тому подобным, Xпредставляет собой двойную связь или тому подобное и Het представляет собой имидазолильную группу, которая может быть замещена Салкильной группой или тому подобным. Соединение или соль полезно(а) в качестве терапевтического или профилактического средства против заболевания, вызываемого Аβ.
EA200870336A 2006-03-09 2007-03-08 Полициклические производные арилимидазола EA016464B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US78051706P 2006-03-09 2006-03-09
JP2006063562 2006-03-09
US86170206P 2006-11-30 2006-11-30
JP2006322728 2006-11-30
PCT/JP2007/054532 WO2007102580A1 (ja) 2006-03-09 2007-03-08 多環式シンナミド誘導体

Publications (2)

Publication Number Publication Date
EA200870336A1 true EA200870336A1 (ru) 2009-02-27
EA016464B1 EA016464B1 (ru) 2012-05-30

Family

ID=38474999

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870336A EA016464B1 (ru) 2006-03-09 2007-03-08 Полициклические производные арилимидазола

Country Status (16)

Country Link
EP (1) EP1992618B1 (ru)
KR (1) KR101464651B1 (ru)
AR (1) AR059955A1 (ru)
AU (1) AU2007223158B2 (ru)
CA (1) CA2643796A1 (ru)
CY (1) CY1112767T1 (ru)
EA (1) EA016464B1 (ru)
GE (1) GEP20115139B (ru)
HK (2) HK1122027A1 (ru)
HN (1) HN2008001374A (ru)
HR (1) HRP20120174T1 (ru)
IL (1) IL193770A (ru)
MA (1) MA30268B1 (ru)
MX (1) MX2008011221A (ru)
PL (1) PL1992618T3 (ru)
WO (1) WO2007102580A1 (ru)

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JP2012051805A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd テトラヒドロトリアゾロピリジン誘導体の製造方法
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JP2012051807A (ja) * 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
JPWO2011007756A1 (ja) * 2009-07-13 2012-12-27 武田薬品工業株式会社 複素環化合物及びその用途
US8871760B2 (en) * 2009-09-21 2014-10-28 Roche Palo Alto Llc [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators
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Also Published As

Publication number Publication date
HK1122027A1 (en) 2009-05-08
HN2008001374A (es) 2011-03-15
IL193770A0 (en) 2009-05-04
KR101464651B1 (ko) 2014-11-24
MA30268B1 (fr) 2009-03-02
EP1992618A4 (en) 2010-11-10
AR059955A1 (es) 2008-05-14
EP1992618A1 (en) 2008-11-19
HRP20120174T1 (hr) 2012-03-31
KR20080108481A (ko) 2008-12-15
MX2008011221A (es) 2008-09-11
PL1992618T3 (pl) 2012-06-29
EA016464B1 (ru) 2012-05-30
AU2007223158B2 (en) 2012-04-12
GEP20115139B (en) 2011-01-10
HK1128085A1 (en) 2009-10-16
EP1992618B1 (en) 2012-01-18
AU2007223158A1 (en) 2007-09-13
CA2643796A1 (en) 2007-09-13
IL193770A (en) 2012-10-31
WO2007102580A1 (ja) 2007-09-13
CY1112767T1 (el) 2016-02-10

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU