MA35452B1 - 3-pyrimidin-4-yl-oxazolidin-2-ones comme inhibiteurs d'idh mutante - Google Patents
3-pyrimidin-4-yl-oxazolidin-2-ones comme inhibiteurs d'idh mutanteInfo
- Publication number
- MA35452B1 MA35452B1 MA36849A MA36849A MA35452B1 MA 35452 B1 MA35452 B1 MA 35452B1 MA 36849 A MA36849 A MA 36849A MA 36849 A MA36849 A MA 36849A MA 35452 B1 MA35452 B1 MA 35452B1
- Authority
- MA
- Morocco
- Prior art keywords
- oxazolidin
- pyrimidin
- ones
- mutant idh
- idh inhibitors
- Prior art date
Links
- DPXAMRSETFKEGX-UHFFFAOYSA-N O=C1OCCN1C1=CC=NC=N1 Chemical class O=C1OCCN1C1=CC=NC=N1 DPXAMRSETFKEGX-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
L'invention concerne un composé de formule (i) ou un sel pharmaceutiquement acceptable de celui-ci, dans lequel r
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161539553P | 2011-09-27 | 2011-09-27 | |
PCT/IB2012/055133 WO2013046136A1 (fr) | 2011-09-27 | 2012-09-26 | 3-pyrimidin-4-yl-oxazolidin-2-ones comme inhibiteurs d'idh mutante |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35452B1 true MA35452B1 (fr) | 2014-09-01 |
Family
ID=47178237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36849A MA35452B1 (fr) | 2011-09-27 | 2014-03-25 | 3-pyrimidin-4-yl-oxazolidin-2-ones comme inhibiteurs d'idh mutante |
Country Status (31)
Country | Link |
---|---|
US (1) | US8957068B2 (fr) |
EP (1) | EP2771337B1 (fr) |
JP (1) | JP6026544B2 (fr) |
KR (1) | KR20140069235A (fr) |
CN (1) | CN103958506B (fr) |
AP (1) | AP3907A (fr) |
AR (1) | AR088175A1 (fr) |
AU (1) | AU2012313888B2 (fr) |
BR (1) | BR112014007310A2 (fr) |
CA (1) | CA2849995A1 (fr) |
CL (1) | CL2014000746A1 (fr) |
CO (1) | CO6920291A2 (fr) |
CR (1) | CR20140143A (fr) |
CU (1) | CU24269B1 (fr) |
DO (1) | DOP2014000058A (fr) |
EA (1) | EA025183B1 (fr) |
ES (1) | ES2645968T3 (fr) |
GE (1) | GEP20166432B (fr) |
GT (1) | GT201400057A (fr) |
IL (1) | IL231786A (fr) |
MA (1) | MA35452B1 (fr) |
MX (1) | MX342326B (fr) |
NI (1) | NI201400026A (fr) |
PE (1) | PE20141581A1 (fr) |
SG (1) | SG11201400989TA (fr) |
TN (1) | TN2014000128A1 (fr) |
TW (1) | TWI547493B (fr) |
UA (1) | UA111503C2 (fr) |
UY (1) | UY34352A (fr) |
WO (1) | WO2013046136A1 (fr) |
ZA (1) | ZA201402144B (fr) |
Families Citing this family (59)
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US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
WO2013134079A1 (fr) * | 2012-03-05 | 2013-09-12 | Amgen Inc. | Composés d'oxazolidinone et leurs dérivés |
US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
EA028033B1 (ru) * | 2013-03-14 | 2017-09-29 | Новартис Аг | 3-пиримидин-4-ил-оксазолидин-2-оны в качестве ингибиторов мутантного idh |
KR20150127197A (ko) * | 2013-03-14 | 2015-11-16 | 노파르티스 아게 | 돌연변이 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온 |
WO2015003360A2 (fr) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs méthodes d'utilisation |
JP6529492B2 (ja) * | 2013-07-11 | 2019-06-12 | アジオス ファーマシューティカルズ, インコーポレイテッド | 癌の処置のためのidh2突然変異体阻害剤としての2,4−または4,6−ジアミノピリミジン化合物 |
WO2015003355A2 (fr) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs méthodes d'utilisation |
WO2015010297A1 (fr) * | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs méthodes d'utilisation |
US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
EP3363790B1 (fr) | 2013-09-06 | 2020-02-19 | Aurigene Discovery Technologies Limited | Dérivés 1,2,4-oxadiazole utilisés comme immunomodulateurs |
WO2015127172A1 (fr) * | 2014-02-20 | 2015-08-27 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs procédés d'utilisation |
CN106659765B (zh) | 2014-04-04 | 2021-08-13 | 德玛医药 | 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途 |
CA2952287C (fr) * | 2014-06-17 | 2023-05-16 | Chiesi Farmaceutici S.P.A. | Derives d'indolizine utiles en tant qu'inhibiteurs de phosphoinositide 3-kinases |
PT3447050T (pt) | 2014-09-19 | 2020-09-17 | Forma Therapeutics Inc | Derivados da piridin-2(1h)-ona-quinolinona como inibidores da isocitrato-desidrogenase mutante |
US9771349B2 (en) | 2014-09-19 | 2017-09-26 | Forma Therapeutics, Inc. | Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
US9815817B2 (en) * | 2014-09-19 | 2017-11-14 | Forma Therapeutics, Inc. | Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors |
CA2961807A1 (fr) | 2014-09-19 | 2016-03-24 | Forma Therapeutics, Inc. | Derives de phenylquinoleinone en tant qu'inhibiteurs d'isocitrate deshydrogenase mutante |
CA2962329C (fr) | 2014-09-22 | 2023-12-19 | Yu-Sheng Chao | Composes heterocycliques et utilisation de ces composes |
BR112017006425B8 (pt) * | 2014-10-01 | 2023-05-16 | Daiichi Sankyo Co Ltd | Compostos derivados de isoxazol, seus usos, inibidores de isocitrato desidrogenase 1 mutante e da produção de d-2 hidroxiglutamato, agente antitumoral e composição farmacêutica compreendendo os mesmos |
CN107108554B (zh) * | 2014-10-23 | 2020-11-06 | 德国癌症研究中心 | 作为midh1抑制剂用于治疗肿瘤的1-环己基-2-苯基氨基苯并咪唑 |
WO2016089833A1 (fr) | 2014-12-05 | 2016-06-09 | Merck Sharp & Dohme Corp. | Nouveaux composés tricycliques comme inhibiteurs d'enzymes idh mutantes |
CN107428690B (zh) | 2014-12-22 | 2021-04-13 | 美国政府健康及人类服务部 | 可用于治疗癌症的突变idh1抑制剂 |
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CN114044760A (zh) | 2015-03-10 | 2022-02-15 | 奥瑞基尼探索技术有限公司 | 作为免疫调节剂的1,2,4-噁二唑和噻二唑化合物 |
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TWI681959B (zh) * | 2015-06-09 | 2020-01-11 | 日商第一三共股份有限公司 | 作為變異型異檸檬酸脫氫酶1阻礙劑之異噁唑衍生物 |
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CN107216312B (zh) * | 2016-03-22 | 2023-08-01 | 上海海和药物研究开发股份有限公司 | 一种具有突变型idh抑制活性的化合物、其制备方法及用途 |
JP6682043B2 (ja) * | 2016-06-06 | 2020-04-15 | イーライ リリー アンド カンパニー | 変異体idh1阻害剤 |
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WO2019061324A1 (fr) | 2017-09-29 | 2019-04-04 | Curis Inc. | Formes cristallines d'immunomodulateurs |
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CN111825666B (zh) * | 2019-04-23 | 2024-03-08 | 上海仕谱生物科技有限公司 | 二聚或多聚体形式的突变型idh抑制剂 |
CA3146375A1 (fr) * | 2019-07-10 | 2021-01-14 | Aucentra Therapeutics Pty Ltd | Derives de 4-(imidazo [l, 2-a] pyridine-3-yl)-n-(pyridinyl) pyrimidine-2-amine en tant qu'agents therapeutiques |
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