BR112022017394A2 - Terapia de combinação com um inibidor de idh mutante - Google Patents
Terapia de combinação com um inibidor de idh mutanteInfo
- Publication number
- BR112022017394A2 BR112022017394A2 BR112022017394A BR112022017394A BR112022017394A2 BR 112022017394 A2 BR112022017394 A2 BR 112022017394A2 BR 112022017394 A BR112022017394 A BR 112022017394A BR 112022017394 A BR112022017394 A BR 112022017394A BR 112022017394 A2 BR112022017394 A2 BR 112022017394A2
- Authority
- BR
- Brazil
- Prior art keywords
- combination therapy
- inhibitor
- mutant
- mutant hdi
- hdi inhibitor
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 238000002648 combination therapy Methods 0.000 title abstract 3
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 abstract 2
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002256 antimetabolite Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940075628 hypomethylating agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
TERAPIA DE COMBINAÇÃO COM UM INIBIDOR DE IDH MUTANTE. A presente invenção refere-se à terapia de combinação com (a) um inibidor de IDH mutante tendo a Fórmula I e (b) um ou mais de um agente antimetabólito, um agente hipometilante e um inibidor de Flt3 (Flt3) mutante, para o tratamento de câncer
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062993254P | 2020-03-23 | 2020-03-23 | |
US202063024713P | 2020-05-14 | 2020-05-14 | |
US202063053875P | 2020-07-20 | 2020-07-20 | |
PCT/US2021/023436 WO2021194946A1 (en) | 2020-03-23 | 2021-03-22 | Combination therapy with a mutant idh inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022017394A2 true BR112022017394A2 (pt) | 2022-10-18 |
Family
ID=75478296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022017394A BR112022017394A2 (pt) | 2020-03-23 | 2021-03-22 | Terapia de combinação com um inibidor de idh mutante |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230146387A1 (pt) |
EP (1) | EP4125915B1 (pt) |
JP (1) | JP2023525445A (pt) |
KR (1) | KR20220155378A (pt) |
CN (1) | CN115335060A (pt) |
AU (1) | AU2021242260B2 (pt) |
BR (1) | BR112022017394A2 (pt) |
CA (1) | CA3172669A1 (pt) |
IL (1) | IL296092A (pt) |
MX (1) | MX2022011844A (pt) |
WO (1) | WO2021194946A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023018955A1 (en) | 2021-08-13 | 2023-02-16 | Eli Lilly And Company | Solid forms of 7-[[(1s)-1-[4-[(1s)-2-cyclopropyl-1-(4-prop-2- enoylpiperazin-1-yl)ethyl]phenyl]ethyl]amino]-1-ethyl-4h- pyrimido[4,5-d] [1,3]oxazin-2-one |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102276022B1 (ko) | 2016-12-16 | 2021-07-13 | 일라이 릴리 앤드 캄파니 | 돌연변이체 idh1 및 idh2 억제제로서의 7-페닐에틸아미노-4h-피리미도[4,5-d][1,3]옥사진-2-온 화합물 |
-
2021
- 2021-03-22 AU AU2021242260A patent/AU2021242260B2/en active Active
- 2021-03-22 BR BR112022017394A patent/BR112022017394A2/pt unknown
- 2021-03-22 CN CN202180024244.1A patent/CN115335060A/zh active Pending
- 2021-03-22 WO PCT/US2021/023436 patent/WO2021194946A1/en active Application Filing
- 2021-03-22 US US17/912,383 patent/US20230146387A1/en active Pending
- 2021-03-22 IL IL296092A patent/IL296092A/en unknown
- 2021-03-22 JP JP2022557831A patent/JP2023525445A/ja active Pending
- 2021-03-22 KR KR1020227036320A patent/KR20220155378A/ko active Search and Examination
- 2021-03-22 MX MX2022011844A patent/MX2022011844A/es unknown
- 2021-03-22 EP EP21718410.0A patent/EP4125915B1/en active Active
- 2021-03-22 CA CA3172669A patent/CA3172669A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3172669A1 (en) | 2021-09-30 |
WO2021194946A1 (en) | 2021-09-30 |
AU2021242260A1 (en) | 2022-09-29 |
MX2022011844A (es) | 2023-01-04 |
IL296092A (en) | 2022-11-01 |
EP4125915A1 (en) | 2023-02-08 |
AU2021242260B2 (en) | 2023-12-14 |
EP4125915B1 (en) | 2024-04-17 |
CN115335060A (zh) | 2022-11-11 |
JP2023525445A (ja) | 2023-06-16 |
US20230146387A1 (en) | 2023-05-11 |
KR20220155378A (ko) | 2022-11-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112020017090A8 (pt) | Imunoterapias relacionadas com microbioma | |
CL2023003603A1 (es) | Terapia de combinación de un inhibidor de mat2a y uno de prmt tipo ii | |
BR112018004175B8 (pt) | Composto pirazolo[3,4-d]pirimidina, composição farmacêutica e usos terapêuticos do dito composto | |
MX2020009757A (es) | Producto combinado de inhibidor de bcl-2 e inhibidor de mdm2 y uso de este en la prevencion y/o tratamiento de enfermedades. | |
BR112018003845A2 (pt) | auxiliares cirúrgicos com medicamentos afetados por materiais ativadores | |
BR112022012637A2 (pt) | Composto de piridazinil-tiazolcarboxamida, composição farmacêutica e inibidor da dgk ¿ que compreendem o mesmo e uso do dito composto para tratar câncer relacionado à ativação das células imunes ou câncer tendo resistência à terapia com anticorpo anti-pd-1 / anticorpo anti-pd-l1 | |
BR112015029144A2 (pt) | formulações de gel para guiar radioterapia | |
BR112021020302A2 (pt) | Composição, e método de tratamento de um sujeito com câncer | |
BRPI0510657A (pt) | tratamento com cisplatina e com um inibidor de egfr | |
BR112021022789A2 (pt) | Métodos, sistemas e dispositivos para a seleção de pacientes para tl1a | |
BR112015026247A2 (pt) | métodos para o tratamento de câncer com o uso de terapia combinada com inibidor de cinase tor | |
BR112017022653A2 (pt) | ?métodos para o tratamento ou para a prevenção de uma doença, da artrite reumatoide, da prostatite e da bph? | |
BR112017006406A2 (pt) | composições e métodos para o tratamento e profilaxia de infecções de sítio cirúrgico | |
BR112022017394A2 (pt) | Terapia de combinação com um inibidor de idh mutante | |
CL2021001976A1 (es) | Tratamiento de lesiones cutáneas y prurito en pacientes con prurigo nodular | |
BR112019009495A2 (pt) | métodos de tratamento de distúrbios inflamatórios com compostos de fc multivalentes | |
CO2022000426A2 (es) | Inhibidores de calicreína plasmática | |
BR112023025916A2 (pt) | Combinação de um inibidor de braf e um inibidor de mek, uso de uma combinação, método para o tratamento ou profilaxia de câncer, composições farmacêuticas e invenção | |
BR112018017233A2 (pt) | uso de i. butyriciproducens e/ou e. hallii, e, composição | |
CO2022000266A2 (es) | Inhibidores de enzimas | |
BR112022012281A2 (pt) | Combinações | |
BR112022012280A2 (pt) | Combinações | |
BR112022017466A2 (pt) | Terapia combinada com um inibidor de idh mutante e um inibidor de bcl-2 | |
BRPI0409473A (pt) | combinação de um inibidor de cox-2 e um agente antineoplásico do tipo alquilante para o tratamento de neoplasia | |
BR112022012283A2 (pt) | Combinações |