EA200801596A1 - Новые 11-бета-гидроксиандроста-4-ен-3-оны - Google Patents
Новые 11-бета-гидроксиандроста-4-ен-3-оныInfo
- Publication number
- EA200801596A1 EA200801596A1 EA200801596A EA200801596A EA200801596A1 EA 200801596 A1 EA200801596 A1 EA 200801596A1 EA 200801596 A EA200801596 A EA 200801596A EA 200801596 A EA200801596 A EA 200801596A EA 200801596 A1 EA200801596 A1 EA 200801596A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hydroxyandrost
- beta
- new
- hydroxyandrosta
- proviso
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
11β-Гидроксиандроста-4-ен-3-он, соединение формулы I, и его физиологически приемлемая сольгде Rпредставляет собой часть, которая выбрана из группы, состоящей из (А), (В) и (С), с тем условием, что когда Rпредставляет собой часть (С), Z представляет собой S
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN131MU2006 | 2006-01-27 | ||
PCT/IN2007/000039 WO2007099548A2 (en) | 2006-01-27 | 2007-01-29 | Novel 11 beta - hydroxyandrosta-4-ene-3-ones |
Publications (3)
Publication Number | Publication Date |
---|---|
EA200801596A1 true EA200801596A1 (ru) | 2009-04-28 |
EA017490B1 EA017490B1 (ru) | 2012-12-28 |
EA017490B9 EA017490B9 (ru) | 2013-04-30 |
Family
ID=38459436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801596A EA017490B9 (ru) | 2006-01-27 | 2007-01-29 | 11-бета-гидроксиандроста-4-ен-3-оны |
Country Status (21)
Country | Link |
---|---|
US (1) | US8785425B2 (ru) |
EP (1) | EP2004667B1 (ru) |
JP (1) | JP5097129B2 (ru) |
KR (1) | KR101390272B1 (ru) |
CN (1) | CN101384610B (ru) |
AP (1) | AP2642A (ru) |
AR (1) | AR059216A1 (ru) |
AU (1) | AU2007220114B2 (ru) |
BR (1) | BRPI0706767A2 (ru) |
CA (1) | CA2637548C (ru) |
EA (1) | EA017490B9 (ru) |
EC (1) | ECSP088689A (ru) |
ES (1) | ES2428066T3 (ru) |
IL (1) | IL192983A (ru) |
MX (1) | MX2008009173A (ru) |
NZ (1) | NZ569867A (ru) |
SG (1) | SG170049A1 (ru) |
TW (1) | TWI374147B (ru) |
UA (1) | UA95095C2 (ru) |
WO (1) | WO2007099548A2 (ru) |
ZA (1) | ZA200806366B (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR059216A1 (es) | 2006-01-27 | 2008-03-19 | Sun Pharmaceutical Ind Ltd | 11b-hidroxiandrosta-4-eno-3-onas |
DK2044099T3 (da) * | 2006-06-14 | 2012-07-02 | Generics Uk Ltd | Fremgangsmåde til fremstillingen af s-fluormethyl-6,9-difluor-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1,4-dien-17-carbothiat og mellemprodukter |
AU2013202843B2 (en) * | 2006-06-14 | 2015-11-12 | Generics [Uk] Limited | Process for the preparation of S-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1, 4-diene-17-carbothioate and intermediates |
WO2010136940A1 (en) | 2009-05-29 | 2010-12-02 | Pfizer Limited | Novel glucocorticoid receptor agonists |
AU2011243947A1 (en) | 2010-04-23 | 2012-12-06 | Piramal Enterprises Limited | Nitric oxide releasing prodrugs of therapeutic agents |
KR101103943B1 (ko) * | 2011-12-12 | 2012-01-12 | 오수련 | 무료이용쿠폰을 활용한 제휴사 및 리셀러의 온라인 제휴마케팅 운영방법 |
WO2013133980A1 (en) * | 2012-03-05 | 2013-09-12 | Bausch & Lomb Incorporated | Nitroxy derivatives of soft steroids |
CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
CA2912400A1 (en) * | 2013-05-28 | 2014-12-04 | Sun Pharma Advanced Research Company Limited | Methods for treatment of inflammatory conditions using s-[4-(3-fluoro-3-methylbutyryloxy)but-2-ynyl]6.alpha.,9.alpha.-difluoro-17.alpha.-(furan-2-yl)carbonyloxy-11.beta.-hydroxy-16.alpha.-methyl-3-oxoandrosta-1,4-diene-17.beta.-carbothioate |
CN106279341A (zh) * | 2015-05-11 | 2017-01-04 | 正大天晴药业集团股份有限公司 | 一种糠酸氟替卡松的制备方法 |
CN109438543B (zh) * | 2018-11-28 | 2020-09-15 | 广州健康元呼吸药物工程技术有限公司 | 一种高纯度糠酸氟替卡松的制备方法 |
CN111662353A (zh) * | 2019-03-05 | 2020-09-15 | 上海谷森医药有限公司 | 一种糠酸氟替卡松晶型1的制备方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US392976A (en) * | 1888-11-13 | Support for spinning-spindles | ||
US300792A (en) * | 1884-06-24 | John asbeeey nicholson | ||
US3007923A (en) | 1959-01-22 | 1961-11-07 | Lab Francais Chimiotherapie | Process for the fluorination of 9beta, 11beta-epoxy and 5alpha, 6alpha-epoxy steroids |
SE378109B (ru) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
US4188385A (en) * | 1978-04-05 | 1980-02-12 | Syntex (U.S.A.) Inc. | Thioetianic acid derivatives |
PH24267A (en) * | 1980-02-15 | 1990-05-29 | Glaxo Group Ltd | Androstane carbothioates and pharmaceutical compositions containing the same |
ZA814440B (en) * | 1980-07-10 | 1982-10-27 | Otsuka Pharma Co Ltd | Soft steroids having anti-inflammatory activity |
US4996335A (en) * | 1980-07-10 | 1991-02-26 | Nicholas S. Bodor | Soft steroids having anti-inflammatory activity |
SE449106B (sv) * | 1980-07-10 | 1987-04-06 | Otsuka Pharma Co Ltd | Steroid med anti-inflammatorisk verkan samt komposition innehallande denna |
US6610675B1 (en) * | 1980-07-10 | 2003-08-26 | Nicholas S. Bodor | Inactive metabolite approach to soft drug design |
CY1359A (en) * | 1981-02-02 | 1987-08-07 | Schering Corp | Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them |
SI0876392T1 (en) * | 1995-12-29 | 2000-12-31 | Glaxo Group Limited | Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives |
US5981517A (en) * | 1996-05-09 | 1999-11-09 | Soft Drugs, Inc. | Androstene derivatives |
JP2000513380A (ja) | 1997-06-30 | 2000-10-10 | グラクソ、グループ、リミテッド | 化合物 |
GB0125259D0 (en) * | 2001-10-20 | 2001-12-12 | Glaxo Group Ltd | Novel compounds |
EP1534733A2 (en) | 2002-06-20 | 2005-06-01 | Sun Pharmaceuticals Industries Ltd. | Convenient synthesis of s-fluoromethyl 6alpha, 9alpha-difluoro-11beta-hydroxy-16alpha- methyl-17alpha-propionyloxy-3-oxoandrosta-1, 4-diene-17beta-carbothioate |
GB0225287D0 (en) | 2002-10-30 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
AR059216A1 (es) | 2006-01-27 | 2008-03-19 | Sun Pharmaceutical Ind Ltd | 11b-hidroxiandrosta-4-eno-3-onas |
-
2007
- 2007-01-26 AR ARP070100355A patent/AR059216A1/es not_active Application Discontinuation
- 2007-01-26 TW TW096103094A patent/TWI374147B/zh not_active IP Right Cessation
- 2007-01-29 EP EP07736511.2A patent/EP2004667B1/en not_active Not-in-force
- 2007-01-29 ES ES07736511T patent/ES2428066T3/es active Active
- 2007-01-29 NZ NZ569867A patent/NZ569867A/xx not_active IP Right Cessation
- 2007-01-29 BR BRPI0706767-4A patent/BRPI0706767A2/pt not_active IP Right Cessation
- 2007-01-29 WO PCT/IN2007/000039 patent/WO2007099548A2/en active Application Filing
- 2007-01-29 MX MX2008009173A patent/MX2008009173A/es active IP Right Grant
- 2007-01-29 AP AP2008004558A patent/AP2642A/xx active
- 2007-01-29 JP JP2008551960A patent/JP5097129B2/ja not_active Expired - Fee Related
- 2007-01-29 KR KR1020087020127A patent/KR101390272B1/ko not_active IP Right Cessation
- 2007-01-29 SG SG201101431-3A patent/SG170049A1/en unknown
- 2007-01-29 UA UAA200809718A patent/UA95095C2/ru unknown
- 2007-01-29 AU AU2007220114A patent/AU2007220114B2/en not_active Ceased
- 2007-01-29 CN CN2007800036603A patent/CN101384610B/zh not_active Expired - Fee Related
- 2007-01-29 CA CA2637548A patent/CA2637548C/en not_active Expired - Fee Related
- 2007-01-29 EA EA200801596A patent/EA017490B9/ru not_active IP Right Cessation
-
2008
- 2008-07-22 IL IL192983A patent/IL192983A/en not_active IP Right Cessation
- 2008-07-22 ZA ZA200806366A patent/ZA200806366B/xx unknown
- 2008-07-25 US US12/180,257 patent/US8785425B2/en not_active Expired - Fee Related
- 2008-08-21 EC EC2008008689A patent/ECSP088689A/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200801596A1 (ru) | Новые 11-бета-гидроксиандроста-4-ен-3-оны | |
ME01992B (me) | Jedinjenje diarilhidantoina | |
EA200801560A1 (ru) | Бифенилкарбоксамиды | |
CY1109911T1 (el) | Πυρρολοβενζοδιαζεπινες | |
RS54123B1 (en) | THERAPEUTIC COMBINATION CONTAINING DOLUTEGRAVIR, ABACAVIR AND LAMIVUDINE | |
EA200700188A1 (ru) | Производные замещенного 2-алкилхиназолинона как ингибиторы parp | |
EA200900018A1 (ru) | Керамический фильтр | |
CY1110149T1 (el) | Ειδικη ενωση γλυκοκορτικοστεροειδους που εχει αντιφλεγμονωδη δραστικοτητα | |
EA201101587A1 (ru) | 4-циано-3-бензоиламино-n-фенилбензамиды для использования в борьбе с вредителями | |
RS52323B (en) | 2'-FLUORO-2'-DEOKSITETRAHIDROURIDINI KAO INHIBITORI CITIDIN DEAMINAZE | |
EA200801608A1 (ru) | Производные бензимидазолонкарбоновой кислоты | |
EA200800760A1 (ru) | ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα | |
EA201000113A1 (ru) | Пиразольные соединения | |
RU2417590C3 (ru) | Фунгицидная композиция | |
EA200801534A1 (ru) | 3`-алкоксиспироциклопентилзамещенные тетрамовые и тетроновые кислоты | |
EA200801381A1 (ru) | Производные пиримидина | |
EA201071264A1 (ru) | Аминодигидротиазиновые производные в качестве ингибиторов bace для лечения болезни альцгеймера | |
EA200800321A1 (ru) | Ингибиторы гистондеацетилазы | |
EA200970149A1 (ru) | Производные n-(аминогетероарил)-1h-индол-2-карбоксамидов, их получение и их применение в терапии | |
EA201490518A1 (ru) | Пирролбензодиазепины | |
EA200701822A1 (ru) | Пиразолилкарбоксанилиды | |
EA201170456A1 (ru) | Синергические комбинации макроциклического ингибитора вируса гепатита с и нуклеозида | |
EA201200031A1 (ru) | Инсектицидные соединения | |
EA200970124A1 (ru) | Производные 2-арилиндола в качестве ингибиторов npges-1 | |
HRP20080529T3 (en) | Amide prodrug of gemcitabine, compositions and use thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TH4A | Publication of the corrected specification to eurasian patent | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |