EP2004667A4 - Novel 11 beta - hydroxyandrosta-4-ene-3-ones - Google Patents
Novel 11 beta - hydroxyandrosta-4-ene-3-onesInfo
- Publication number
- EP2004667A4 EP2004667A4 EP07736511A EP07736511A EP2004667A4 EP 2004667 A4 EP2004667 A4 EP 2004667A4 EP 07736511 A EP07736511 A EP 07736511A EP 07736511 A EP07736511 A EP 07736511A EP 2004667 A4 EP2004667 A4 EP 2004667A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- hydroxyandrosta
- ene
- beta
- ones
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN131MU2006 | 2006-01-27 | ||
PCT/IN2007/000039 WO2007099548A2 (en) | 2006-01-27 | 2007-01-29 | Novel 11 beta - hydroxyandrosta-4-ene-3-ones |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2004667A2 EP2004667A2 (en) | 2008-12-24 |
EP2004667A4 true EP2004667A4 (en) | 2012-07-18 |
EP2004667B1 EP2004667B1 (en) | 2013-09-04 |
Family
ID=38459436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07736511.2A Not-in-force EP2004667B1 (en) | 2006-01-27 | 2007-01-29 | Novel 11 beta - hydroxyandrosta-4-ene-3-ones |
Country Status (21)
Country | Link |
---|---|
US (1) | US8785425B2 (en) |
EP (1) | EP2004667B1 (en) |
JP (1) | JP5097129B2 (en) |
KR (1) | KR101390272B1 (en) |
CN (1) | CN101384610B (en) |
AP (1) | AP2642A (en) |
AR (1) | AR059216A1 (en) |
AU (1) | AU2007220114B2 (en) |
BR (1) | BRPI0706767A2 (en) |
CA (1) | CA2637548C (en) |
EA (1) | EA017490B9 (en) |
EC (1) | ECSP088689A (en) |
ES (1) | ES2428066T3 (en) |
IL (1) | IL192983A (en) |
MX (1) | MX2008009173A (en) |
NZ (1) | NZ569867A (en) |
SG (1) | SG170049A1 (en) |
TW (1) | TWI374147B (en) |
UA (1) | UA95095C2 (en) |
WO (1) | WO2007099548A2 (en) |
ZA (1) | ZA200806366B (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR059216A1 (en) | 2006-01-27 | 2008-03-19 | Sun Pharmaceutical Ind Ltd | 11B-HYDROXIANDROSTA-4-ENO-3-ONAS |
AU2013202843B2 (en) * | 2006-06-14 | 2015-11-12 | Generics [Uk] Limited | Process for the preparation of S-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1, 4-diene-17-carbothioate and intermediates |
AU2007258949B2 (en) * | 2006-06-14 | 2013-02-21 | Generics [Uk] Limited | Process for the preparation of S-fluoromethyl-6, 9 -difluoro-11 -hydroxy-16 -methyl-17-propionyloxy-3-oxo-androsta-1,4-diene-17 -carbothioate and intermediates |
KR20120018813A (en) | 2009-05-29 | 2012-03-05 | 화이자 리미티드 | Novel glucocorticoid receptor agonists |
AU2011243947A1 (en) | 2010-04-23 | 2012-12-06 | Piramal Enterprises Limited | Nitric oxide releasing prodrugs of therapeutic agents |
KR101103943B1 (en) * | 2011-12-12 | 2012-01-12 | 오수련 | The allies and resellers online affiliate marketing operation method utilize of free use coupon |
WO2013133980A1 (en) * | 2012-03-05 | 2013-09-12 | Bausch & Lomb Incorporated | Nitroxy derivatives of soft steroids |
US9844599B2 (en) | 2013-01-21 | 2017-12-19 | Apparao Satyam | Nitric oxide releasing produgs of therapeutic agents |
CN105431445A (en) * | 2013-05-28 | 2016-03-23 | 太阳医药高级研究有限公司 | Methods for treatment of inflammatory conditions using s-[4-(3-fluoro-3-methylbutyryloxy) but-2-ynyl] 6alpha, 9alpha-difluoro-17alpha-(furan-2-yl) carbonyloxy-11beta -hydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta -carbothioate. |
CN106279341A (en) * | 2015-05-11 | 2017-01-04 | 正大天晴药业集团股份有限公司 | A kind of preparation method of fluticasone furoate |
CN109438543B (en) * | 2018-11-28 | 2020-09-15 | 广州健康元呼吸药物工程技术有限公司 | Preparation method of high-purity fluticasone furoate |
CN111662353A (en) * | 2019-03-05 | 2020-09-15 | 上海谷森医药有限公司 | Preparation method of fluticasone furoate crystal form 1 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2079755A (en) * | 1980-07-10 | 1982-01-27 | Otsuka Pharma Co Ltd | Androstene 17 alpha -carbonate 17 beta -carboxylates (and carbothioates) |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US392976A (en) * | 1888-11-13 | Support for spinning-spindles | ||
US300792A (en) * | 1884-06-24 | John asbeeey nicholson | ||
US3007923A (en) | 1959-01-22 | 1961-11-07 | Lab Francais Chimiotherapie | Process for the fluorination of 9beta, 11beta-epoxy and 5alpha, 6alpha-epoxy steroids |
SE378109B (en) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
US4188385A (en) * | 1978-04-05 | 1980-02-12 | Syntex (U.S.A.) Inc. | Thioetianic acid derivatives |
US4335121A (en) * | 1980-02-15 | 1982-06-15 | Glaxo Group Limited | Androstane carbothioates |
US6610675B1 (en) * | 1980-07-10 | 2003-08-26 | Nicholas S. Bodor | Inactive metabolite approach to soft drug design |
ZA814440B (en) * | 1980-07-10 | 1982-10-27 | Otsuka Pharma Co Ltd | Soft steroids having anti-inflammatory activity |
US4996335A (en) | 1980-07-10 | 1991-02-26 | Nicholas S. Bodor | Soft steroids having anti-inflammatory activity |
CY1359A (en) * | 1981-02-02 | 1987-08-07 | Schering Corp | Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them |
ES2150150T3 (en) * | 1995-12-29 | 2000-11-16 | Glaxo Group Ltd | LACTONE DERIVATIVES OF 17-BETA-CARBOXI, CARBONATE AND AMIDA ANDROSTAN DERIVATIVES. |
US5981517A (en) * | 1996-05-09 | 1999-11-09 | Soft Drugs, Inc. | Androstene derivatives |
ATE260931T1 (en) | 1997-06-30 | 2004-03-15 | Glaxo Group Ltd | METHOD FOR IDENTIFYING COMPOUNDS WITH REDUCED SYSTEMIC ACTIVITY |
GB0125259D0 (en) * | 2001-10-20 | 2001-12-12 | Glaxo Group Ltd | Novel compounds |
US7208613B2 (en) * | 2002-06-20 | 2007-04-24 | Sun Pharmaceutical Industries Limited | Synthesis of s-fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate |
GB0225287D0 (en) | 2002-10-30 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
AR059216A1 (en) | 2006-01-27 | 2008-03-19 | Sun Pharmaceutical Ind Ltd | 11B-HYDROXIANDROSTA-4-ENO-3-ONAS |
-
2007
- 2007-01-26 AR ARP070100355A patent/AR059216A1/en not_active Application Discontinuation
- 2007-01-26 TW TW096103094A patent/TWI374147B/en not_active IP Right Cessation
- 2007-01-29 AU AU2007220114A patent/AU2007220114B2/en not_active Ceased
- 2007-01-29 JP JP2008551960A patent/JP5097129B2/en not_active Expired - Fee Related
- 2007-01-29 WO PCT/IN2007/000039 patent/WO2007099548A2/en active Application Filing
- 2007-01-29 EP EP07736511.2A patent/EP2004667B1/en not_active Not-in-force
- 2007-01-29 NZ NZ569867A patent/NZ569867A/en not_active IP Right Cessation
- 2007-01-29 UA UAA200809718A patent/UA95095C2/en unknown
- 2007-01-29 BR BRPI0706767-4A patent/BRPI0706767A2/en not_active IP Right Cessation
- 2007-01-29 AP AP2008004558A patent/AP2642A/en active
- 2007-01-29 CN CN2007800036603A patent/CN101384610B/en not_active Expired - Fee Related
- 2007-01-29 MX MX2008009173A patent/MX2008009173A/en active IP Right Grant
- 2007-01-29 ES ES07736511T patent/ES2428066T3/en active Active
- 2007-01-29 EA EA200801596A patent/EA017490B9/en not_active IP Right Cessation
- 2007-01-29 SG SG201101431-3A patent/SG170049A1/en unknown
- 2007-01-29 CA CA2637548A patent/CA2637548C/en not_active Expired - Fee Related
- 2007-01-29 KR KR1020087020127A patent/KR101390272B1/en not_active IP Right Cessation
-
2008
- 2008-07-22 IL IL192983A patent/IL192983A/en not_active IP Right Cessation
- 2008-07-22 ZA ZA200806366A patent/ZA200806366B/en unknown
- 2008-07-25 US US12/180,257 patent/US8785425B2/en not_active Expired - Fee Related
- 2008-08-21 EC EC2008008689A patent/ECSP088689A/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2079755A (en) * | 1980-07-10 | 1982-01-27 | Otsuka Pharma Co Ltd | Androstene 17 alpha -carbonate 17 beta -carboxylates (and carbothioates) |
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