PE20090674A1 - Compuestos multiciclicos - Google Patents
Compuestos multiciclicosInfo
- Publication number
- PE20090674A1 PE20090674A1 PE2008001455A PE2008001455A PE20090674A1 PE 20090674 A1 PE20090674 A1 PE 20090674A1 PE 2008001455 A PE2008001455 A PE 2008001455A PE 2008001455 A PE2008001455 A PE 2008001455A PE 20090674 A1 PE20090674 A1 PE 20090674A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- triazolo
- tetrahydro
- imidazol
- pyridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE Ar1 ES IMIDAZOLILO SUSTITUIDO CON ALQUILO C1-C6; Ar2 ES FENILO, PIRIDINILOSUSTITUIDO O NO POR 1-3 SUSTITUYENTES DE H, HALOGENO, HIDROXILO, ALCOXI C1-C6; X1 ES -CR1=CR2-; R1 Y R2 SON CADA UNO H, ALQUILO C1-C6, HALOGENO; HET ES DE PREFERENCIA UN DERIVADO 5,6,7,8-TETRAHIDRO-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN. SON COMPUESTOS PREFERIDOS: 4-(4-CLOROFENIL)-2-{(E)-2-[6-METOXI-5-(4-METIL-1H-IMIDAZOL-1-IL)PIRIDIN-2-IL]VENIL}-4,5,6,7-TETRAHIDRO-[1,2,4]TRIAZOLO[1,5-a]PIRIMIDINA; 2-{(E)-2-[6-METOXI-5-(4-METIL-1H-IMIDAZOL-1-IL)PIRIDIN-2-IL]VINIL}-4-FENIL-4,5,6,7-TETRAHIDRO-[1,2,4]TRIAZOLO[1,5-a]PIRIMIDINA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ALZHEIMER O SINDROME DE DOWN
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007225045 | 2007-08-31 | ||
JP2008020009 | 2008-01-31 | ||
JP2008123057 | 2008-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090674A1 true PE20090674A1 (es) | 2009-06-19 |
Family
ID=40387302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001455A PE20090674A1 (es) | 2007-08-31 | 2008-08-28 | Compuestos multiciclicos |
Country Status (19)
Country | Link |
---|---|
US (1) | US9453000B2 (es) |
EP (2) | EP2181992B8 (es) |
JP (1) | JP5433418B2 (es) |
KR (1) | KR20100055456A (es) |
CN (1) | CN101815713B (es) |
AR (1) | AR068121A1 (es) |
AU (1) | AU2008292390B2 (es) |
BR (1) | BRPI0815773A2 (es) |
CA (1) | CA2694401C (es) |
CL (1) | CL2008002542A1 (es) |
ES (1) | ES2529648T3 (es) |
IL (1) | IL203778A (es) |
MX (1) | MX2010002098A (es) |
MY (1) | MY150507A (es) |
NZ (1) | NZ583515A (es) |
PE (1) | PE20090674A1 (es) |
TW (1) | TW200916469A (es) |
WO (1) | WO2009028588A1 (es) |
ZA (1) | ZA201000474B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
US8129530B2 (en) * | 2007-08-31 | 2012-03-06 | H. Lundbeck A/S | Catecholamine derivatives and prodrugs thereof |
CN101815713B (zh) | 2007-08-31 | 2013-09-11 | 卫材R&D管理有限公司 | 多环化合物 |
US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
RU2011111534A (ru) * | 2008-08-27 | 2012-10-10 | ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) | Способ получения определенных цинниамидных соединений |
SI2889033T1 (en) | 2008-11-19 | 2018-08-31 | Forum Pharmaceuticals Inc. | Treatment of negative symptoms of schizophrenia with (R) -7-chloro-N- (chonylidin-3-yl) benzo (B) thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
JP2012121809A (ja) * | 2009-02-26 | 2012-06-28 | Eisai R & D Management Co Ltd | 多環式化合物の製造法およびその中間体 |
PE20120172A1 (es) | 2009-02-26 | 2012-03-08 | Eisai Randd Man Co Ltd | Compuestos heterociclicos fusionados que contiene nitrogeno como inhibidores de la produccion de beta-amiloide |
JP2012051805A (ja) * | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | テトラヒドロトリアゾロピリジン誘導体の製造方法 |
US8703954B2 (en) | 2009-02-26 | 2014-04-22 | Eisai R&D Management Co., Ltd. | Salt of tetrahydrotriazolopyridine derivative and crystal thereof |
EP2429522A4 (en) * | 2009-05-11 | 2013-01-09 | Univ California | METHOD FOR REDUCING THE CONCENTRATION OF UBIQUITINATED PROTEINS |
PE20120324A1 (es) * | 2009-05-11 | 2012-04-17 | Envivo Pharmaceuticals Inc | Combinacion que comprende (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y donezepilo como moduladora de trastornos cognitivos |
US20120165541A1 (en) * | 2009-07-31 | 2012-06-28 | Sandoz Ag | Method for the preparation of w-amino- alkaneamides and w-amino-alkanethioamides as well as intermediates of this method |
EP2523949B1 (en) | 2010-01-15 | 2014-08-20 | Janssen Pharmaceuticals Inc. | Novel substituted triazole derivatives as gamma secretase modulators |
CA2989633A1 (en) | 2010-05-17 | 2011-11-24 | Forum Pharmaceuticals Inc. | A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate |
CA2830027C (en) | 2011-03-31 | 2016-04-26 | Pfizer Inc. | Novel bicyclic pyridinones |
AU2013259871A1 (en) | 2012-05-08 | 2014-11-20 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
BR112014028395B1 (pt) | 2012-05-16 | 2022-02-01 | Janssen Pharmaceuticals, Inc. | Derivados 3,4-di-hidro-2h-pirido[1,2-a]pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer e composição farmacêutica que os compreende |
UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
US10112943B2 (en) | 2012-12-20 | 2018-10-30 | Janssen Pharmaceutica Nv | Substituted imidazoles as gamma secretase modulators |
WO2014111457A1 (en) | 2013-01-17 | 2014-07-24 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
US10372396B2 (en) * | 2013-02-21 | 2019-08-06 | Lenovo ( Singapore) Pte. Ltd. | Discovery and connection to wireless displays |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
MX368391B (es) | 2015-02-03 | 2019-09-30 | Pfizer | Ciclopropabenzofuranil-piridopirazindionas novedosas. |
BR112019024987A2 (pt) * | 2017-06-02 | 2020-06-16 | Xeris Pharmaceuticals, Inc. | Formulações de fármaco de molécula pequena resistente à precipitação |
US20210221784A1 (en) * | 2018-02-05 | 2021-07-22 | Université De Strasbourg | Compounds and compositions for the treatment of pain |
CA3129243A1 (en) * | 2019-02-07 | 2020-08-13 | Alsatech, Inc. | Polyvalent derivatives of emoxypine |
Family Cites Families (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1101156A (en) * | 1965-09-22 | 1968-01-31 | Hickson & Welch Ltd | Triazole derivatives and their use as optical whitening agents |
FR2314731A1 (fr) | 1975-06-19 | 1977-01-14 | Nelson Res & Dev | Azacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients |
US3989816A (en) * | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
US4508718A (en) | 1984-01-16 | 1985-04-02 | Warner-Lambert Company | Cardiotonic and antihypertensive oxadiazinone compounds |
ES2061432T3 (es) | 1985-10-09 | 1994-12-16 | Shell Int Research | Nuevas amidas de acido acrilico. |
US4783463A (en) | 1985-10-23 | 1988-11-08 | Rorer Pharmaceutical Corporation | Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure |
DE3541716A1 (de) | 1985-11-26 | 1987-05-27 | Celamerck Gmbh & Co Kg | Neue acrylsaeureamide |
FI91754C (fi) | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
FI902321A0 (fi) | 1989-05-19 | 1990-05-09 | Eisai Co Ltd | Butensyraderivat. |
JPH03206042A (ja) * | 1990-01-06 | 1991-09-09 | Takeda Chem Ind Ltd | 降圧剤 |
ES2100943T3 (es) | 1990-02-08 | 1997-07-01 | Eisai Co Ltd | Derivado de bencenosulfonamida. |
AU680870B2 (en) | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
GB9402807D0 (en) | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
WO1996010559A1 (en) | 1994-10-04 | 1996-04-11 | Fujisawa Pharmaceutical Co., Ltd. | Urea derivatives and their use as acat-inhibitors |
JPH08283219A (ja) | 1995-04-07 | 1996-10-29 | Eisai Co Ltd | アラルキルアミノアルキルアミド誘導体 |
CZ251896A3 (en) | 1995-09-12 | 1997-04-16 | Hoffmann Ka Roche Ag F | Cephalosporin derivatives |
CA2234967A1 (en) | 1995-10-19 | 1997-04-24 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
EP0912567B1 (en) | 1996-05-10 | 2002-04-10 | Icos Corporation | Carboline derivatives |
PL331338A1 (en) | 1996-07-22 | 1999-07-05 | Monsanto Co | Thiosulphonamidic metaloprotease inhibitors |
US5672612A (en) | 1996-09-09 | 1997-09-30 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
WO1998024785A1 (en) | 1996-12-02 | 1998-06-11 | Fujisawa Pharmaceutical Co., Ltd. | Indole-urea derivatives with 5-ht antagonist properties |
WO1998043970A1 (en) | 1997-03-31 | 1998-10-08 | Takeda Chemical Industries, Ltd. | Azole compounds, their production and their use |
JP3108997B2 (ja) | 1997-03-31 | 2000-11-13 | 武田薬品工業株式会社 | アゾール化合物、その製造法および用途 |
TR199902455T2 (xx) | 1997-04-16 | 2000-01-21 | Abbott Laboratories | 5,7-Dis�bstit�e 4-Aminopirido (2,3-D) Pirimidin bile�ikleri ve bunlar�n adenosin kinaz inhibit�rleri olarak kullan�m� |
TW379224B (en) | 1997-12-02 | 2000-01-11 | Fujisawa Pharmaceutical Co | Urea derivatives |
EP1051181B1 (en) | 1997-12-31 | 2004-03-17 | The University Of Kansas | Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof |
GB9816984D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
US6048678A (en) * | 1998-12-28 | 2000-04-11 | Eastman Kodak Company | Protective overcoat coating compositions |
US6235728B1 (en) | 1999-02-19 | 2001-05-22 | Bristol-Myers Squibb Company | Water-soluble prodrugs of azole compounds |
JP2002537376A (ja) | 1999-02-26 | 2002-11-05 | マーク・アンド・カンパニー・インコーポレイテッド | 新規スルホンアミドおよびそれらの使用 |
AU2899400A (en) | 1999-03-04 | 2000-09-21 | Nortran Pharmaceuticals Inc. | Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics |
WO2001068585A1 (fr) | 2000-03-14 | 2001-09-20 | Fujisawa Pharmaceutical Co., Ltd. | Nouveaux composes amides |
US20010051642A1 (en) | 2000-04-17 | 2001-12-13 | Kyunghye Ahn | Method for treating Alzheimer's disease |
EP1278734A2 (en) | 2000-04-24 | 2003-01-29 | Merck Frosst Canada & Co. | Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
MXPA03004862A (es) | 2000-12-04 | 2005-02-14 | Hoffmann La Roche | Derivados de feniletenilo o feniletinilo como antagonistas del receptor de glutamato. |
GB0108770D0 (en) | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
EP1427412A1 (en) | 2001-09-13 | 2004-06-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Methods of treating cytokine mediated diseases |
CA2460541A1 (en) | 2001-09-14 | 2003-04-03 | Helle Birk Olsen | Novel ligands for the hisb10 zn2+ sites of the r-state insulin hexamer |
US20050085509A1 (en) * | 2001-11-22 | 2005-04-21 | Kanji Takahashi | Piperidin-2-one derivative compounds and drugs containing these compounds as the active ingredient |
JP2005518371A (ja) | 2001-12-10 | 2005-06-23 | アムジエン・インコーポレーテツド | バニロイド受容体リガンド及び治療に於けるこれらの使用 |
CN1289469C (zh) | 2001-12-20 | 2006-12-13 | 布里斯托尔-迈尔斯斯奎布公司 | α-(N-磺酰氨基)乙酰胺衍生物作为β-淀粉样蛋白抑制剂 |
JP2003206280A (ja) | 2001-12-28 | 2003-07-22 | Takeda Chem Ind Ltd | ビアリール化合物およびその用途 |
WO2003062206A2 (en) | 2002-01-23 | 2003-07-31 | Arena Pharmaceuticals, Inc. | Small molecule modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
US20050049267A1 (en) | 2002-03-01 | 2005-03-03 | Pintex Pharmaceuticals, Inc. | Pin1-modulating compounds and methods of use thereof |
GB0207436D0 (en) | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
US7053088B2 (en) | 2002-05-22 | 2006-05-30 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
SI2527315T1 (sl) | 2002-05-31 | 2014-06-30 | Proteotech Inc., | Spojine, sestavki in metode za zdravljenje amiloidnih bolezni in sinukleinopatij, kot so Alzheimerjeva bolezen, diabetes tipa 2 in Parkinsonova bolezen |
AU2003247758A1 (en) | 2002-06-27 | 2004-01-19 | Elan Pharmaceuticals, Inc. | Methods for treating alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere |
WO2004007455A1 (de) | 2002-07-12 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Heterozyklisch substituierte benzoylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US6900354B2 (en) | 2002-07-15 | 2005-05-31 | Hoffman-La Roche Inc. | 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives |
CN1747936A (zh) * | 2003-02-12 | 2006-03-15 | 特兰斯泰克制药公司 | 作为治疗试剂的取代吡咯衍生物 |
KR20050111629A (ko) | 2003-04-01 | 2005-11-25 | 플러스 케미칼스 비.브이. | 무정형 심바스타틴 칼슘 및 그의 제조방법 |
CA2525547C (en) * | 2003-05-14 | 2012-07-03 | Torreypines Therapeutics, Inc. | Compounds and uses thereof in modulating amyloid beta |
CN1787822A (zh) * | 2003-05-14 | 2006-06-14 | 托里派因斯疗法公司 | 化合物及其在调节淀粉样蛋白β中的用途 |
WO2005020921A2 (en) | 2003-08-29 | 2005-03-10 | Exelixis, Inc. | C-kit modulators and methods of use |
KR100854872B1 (ko) | 2003-12-22 | 2008-08-28 | 화이자 인코포레이티드 | 바소프레신 길항제로서의 트리아졸 유도체 |
CN1922151A (zh) * | 2004-02-12 | 2007-02-28 | 特兰斯泰克制药公司 | 取代的吡咯衍生物、组合物和使用方法 |
JP4625838B2 (ja) | 2004-03-09 | 2011-02-02 | メルク・シャープ・エンド・ドーム・コーポレイション | Hivインテグラーゼ阻害薬 |
JP4101852B2 (ja) * | 2004-05-26 | 2008-06-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シンナミド化合物 |
EP1786422A2 (en) | 2004-08-16 | 2007-05-23 | Prosidion Limited | Aryl urea derivatives for treating obesity |
ES2338904T3 (es) | 2004-10-26 | 2010-05-13 | EISAI R&D MANAGEMENT CO., LTD. | Forma amorfa de compuestos de cinamida. |
US20060241038A1 (en) | 2005-04-20 | 2006-10-26 | Eisai Co., Ltd. | Therapeutic agent for Abeta related disorders |
WO2007034282A2 (en) * | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists |
WO2007058304A1 (ja) | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド化合物の塩またはそれらの溶媒和物 |
KR20080076907A (ko) | 2005-11-18 | 2008-08-20 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 유도체의 제조 방법 |
US20070117839A1 (en) | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
JP5221144B2 (ja) | 2005-11-24 | 2013-06-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | モルホリンタイプ・シンナミド化合物 |
PL1992618T3 (pl) | 2006-03-09 | 2012-06-29 | Eisai R&D Man Co Ltd | Policykliczna pochodna cynamidowa |
TWI378091B (en) * | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
SA07280403B1 (ar) | 2006-07-28 | 2010-12-01 | إيساي أر أند دي منجمنت كو. ليمتد | ملح رباعي لمركب سيناميد |
WO2008097538A1 (en) * | 2007-02-08 | 2008-08-14 | Merck & Co., Inc. | Therapeutic agents |
PE20081791A1 (es) * | 2007-02-28 | 2009-02-07 | Eisai Randd Man Co Ltd | Dos derivados ciclicos de oxomorfolina |
WO2008137102A2 (en) | 2007-05-04 | 2008-11-13 | Torreypines Therapeutics, Inc. | Methods of modulating amyloid beta and compounds useful therefor |
EP2155737A1 (en) | 2007-05-07 | 2010-02-24 | Schering Corporation | Gamma secretase modulators |
CN101675045B (zh) | 2007-05-11 | 2012-11-28 | 弗·哈夫曼-拉罗切有限公司 | 作为β-淀粉样蛋白调节剂的杂芳基苯胺 |
WO2008156580A1 (en) | 2007-06-13 | 2008-12-24 | Merck & Co., Inc. | Triazole derivatives for treating alzheimer's disease and related conditions |
EP2185522A1 (en) | 2007-08-06 | 2010-05-19 | Schering Corporation | Gamma secretase modulators |
US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
CN101815713B (zh) | 2007-08-31 | 2013-09-11 | 卫材R&D管理有限公司 | 多环化合物 |
CA2707712A1 (en) | 2007-12-06 | 2009-06-11 | Schering Corporation | Gamma secretase modulators |
WO2009126311A1 (en) * | 2008-04-11 | 2009-10-15 | The University Of Texas, M.D. Anderson Cancer Center | Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy |
RU2011111534A (ru) | 2008-08-27 | 2012-10-10 | ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) | Способ получения определенных цинниамидных соединений |
JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
US8703954B2 (en) | 2009-02-26 | 2014-04-22 | Eisai R&D Management Co., Ltd. | Salt of tetrahydrotriazolopyridine derivative and crystal thereof |
PT2401256E (pt) | 2009-02-26 | 2013-05-13 | Boehringer Ingelheim Int | Compostos como antagonistas da bradicinina b1 |
JP5520969B2 (ja) | 2009-02-26 | 2014-06-11 | グラクソ グループ リミテッド | Ccr4受容体アンタゴニストとして使用するピラゾール誘導体 |
JPWO2010098466A1 (ja) | 2009-02-27 | 2012-09-06 | Hoya株式会社 | 成形型およびプラスチックレンズの製造方法 |
US8946266B2 (en) * | 2009-07-15 | 2015-02-03 | Janssen Pharmaceuticals, Inc. | Substituted triazole and imidazole derivatives as gamma secretase modulators |
US8381014B2 (en) * | 2010-05-06 | 2013-02-19 | International Business Machines Corporation | Node controller first failure error management for a distributed system |
-
2008
- 2008-08-28 CN CN200880104785XA patent/CN101815713B/zh not_active Expired - Fee Related
- 2008-08-28 ES ES12191398.2T patent/ES2529648T3/es active Active
- 2008-08-28 NZ NZ583515A patent/NZ583515A/en not_active IP Right Cessation
- 2008-08-28 PE PE2008001455A patent/PE20090674A1/es not_active Application Discontinuation
- 2008-08-28 MX MX2010002098A patent/MX2010002098A/es active IP Right Grant
- 2008-08-28 CL CL2008002542A patent/CL2008002542A1/es unknown
- 2008-08-28 EP EP08828870.9A patent/EP2181992B8/en active Active
- 2008-08-28 JP JP2009530168A patent/JP5433418B2/ja not_active Expired - Fee Related
- 2008-08-28 BR BRPI0815773A patent/BRPI0815773A2/pt not_active IP Right Cessation
- 2008-08-28 EP EP12191398.2A patent/EP2559693B1/en active Active
- 2008-08-28 CA CA2694401A patent/CA2694401C/en not_active Expired - Fee Related
- 2008-08-28 WO PCT/JP2008/065365 patent/WO2009028588A1/ja active Application Filing
- 2008-08-28 TW TW097132893A patent/TW200916469A/zh unknown
- 2008-08-28 AU AU2008292390A patent/AU2008292390B2/en not_active Ceased
- 2008-08-28 AR ARP080103739A patent/AR068121A1/es unknown
- 2008-08-28 MY MYPI20100422 patent/MY150507A/en unknown
- 2008-08-28 US US12/671,873 patent/US9453000B2/en active Active
- 2008-08-28 KR KR1020107005314A patent/KR20100055456A/ko active IP Right Grant
-
2010
- 2010-01-21 ZA ZA2010/00474A patent/ZA201000474B/en unknown
- 2010-02-08 IL IL203778A patent/IL203778A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2009028588A1 (ja) | 2009-03-05 |
ZA201000474B (en) | 2011-05-25 |
EP2559693A1 (en) | 2013-02-20 |
US20110009619A1 (en) | 2011-01-13 |
MY150507A (en) | 2014-01-30 |
EP2181992A1 (en) | 2010-05-05 |
BRPI0815773A2 (pt) | 2019-09-24 |
EP2181992B1 (en) | 2013-05-01 |
IL203778A (en) | 2013-11-28 |
EP2181992A4 (en) | 2011-09-14 |
AR068121A1 (es) | 2009-11-04 |
CA2694401C (en) | 2012-12-04 |
JP5433418B2 (ja) | 2014-03-05 |
KR20100055456A (ko) | 2010-05-26 |
CN101815713B (zh) | 2013-09-11 |
JPWO2009028588A1 (ja) | 2010-12-02 |
ES2529648T3 (es) | 2015-02-24 |
US9453000B2 (en) | 2016-09-27 |
NZ583515A (en) | 2011-05-27 |
AU2008292390B2 (en) | 2013-04-04 |
EP2559693B1 (en) | 2014-11-26 |
TW200916469A (en) | 2009-04-16 |
CA2694401A1 (en) | 2009-03-05 |
AU2008292390A1 (en) | 2009-03-05 |
CL2008002542A1 (es) | 2009-01-02 |
CN101815713A (zh) | 2010-08-25 |
EP2181992B8 (en) | 2013-06-26 |
MX2010002098A (es) | 2010-03-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20090674A1 (es) | Compuestos multiciclicos | |
PE20081845A1 (es) | Nuevos derivados de aminopirimidina como inhibidores de plk1 | |
PE20120058A1 (es) | Derivados de imidazopirazina como inhibidores de syk | |
PE20091694A1 (es) | DERIVADOS POLISUSTITUIDOS DE 6-HETEROARIL-IMIDAZO[1,2-a] PIRIDINAS COMO MODULADORES DE LOS RECEPTORES NOT Y SU PREPARACION | |
PE20080772A1 (es) | Nuevos derivados de bipiridina sustituidos y su uso | |
PE20090714A1 (es) | Imidazopiridazinas y pirrolo-pirimidinas sustituidas como inhibidores de cinasa de lipido | |
PE20070004A1 (es) | Imidazoquinolinas como inhibidores de quinasa de lipido | |
PE20091818A1 (es) | DERIVADOS POLISUSTITUIDOS DE 2-ARIL-6-FENIL-IMIDAZO[1,2-a] PIRIDINAS, SU PREPARACION Y SU APLICACION EN TERAPEUTICA | |
PE20091211A1 (es) | Derivados de pirazolopirimidina como moduladores de pde9a | |
PE20120224A1 (es) | Derivados de 1h-imidazo-[4,5-c]-quinolinona | |
PE20140192A1 (es) | Derivados de bencimidazol como inhibidores de cinasa pi3 | |
PE20110545A1 (es) | Compuestos de triazolopiridina como inhibidores de jak | |
PE20070752A1 (es) | Triazolopiridazinas como moduladores de quinasa | |
PE20090596A1 (es) | Imidazoles biciclicos fusionados | |
PE20090288A1 (es) | Derivados de quinoxalina como inhibidores de la pi3 quinasa | |
PE20090511A1 (es) | Imidazopiridinonas | |
PE20130611A1 (es) | Triazolopiridinas sustituidas | |
PE20110575A1 (es) | INHIBIDORES DE mTOR CINASA PARA INDICADORES DE ONCOLOGIA Y ENFERMEDADES ASOCIADAS CON LA TRAYECTORIA mTOR/PI3K/AKT | |
PE20110063A1 (es) | DERIVADOS DE [1, 2, 4]TRIAZOLO[1, 5-a]PIRIDINA COMO INHIBIDORES DE JAK | |
DE602007012142D1 (en) | 3-heteroaryl (amino bzw. amido)-1- (biphenyl bzw. phenylthiazolyl) carbonylpiperdinderivate als orexinrezeptor-inhibitoren | |
PE20091819A1 (es) | DERIVADOS POLISUSTITUIDOS DE 2-HETEROARIL-6-FENIL-IMIDAZO[1,2-a] PIRIDINAS, SU PREPARACION Y SU APLIACION EN TERAPEUTICA | |
PE20141059A1 (es) | Indazoles | |
PE20090960A1 (es) | Derivados de quinazolinadiona, su preparacion y sus aplicaciones terapeuticas | |
PE20141351A1 (es) | Triazolopiridinas | |
PE20110411A1 (es) | Imidazopiridazinacarbonitrilos como inhibidores de quinasa |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |