WO2009069736A1 - Nitrogenated compound - Google Patents

Nitrogenated compound Download PDF

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Publication number
WO2009069736A1
WO2009069736A1 PCT/JP2008/071627 JP2008071627W WO2009069736A1 WO 2009069736 A1 WO2009069736 A1 WO 2009069736A1 JP 2008071627 W JP2008071627 W JP 2008071627W WO 2009069736 A1 WO2009069736 A1 WO 2009069736A1
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WIPO (PCT)
Prior art keywords
hydrogen atom
formula
nitrogenated compound
nitrogenated
substituent
Prior art date
Application number
PCT/JP2008/071627
Other languages
French (fr)
Japanese (ja)
Inventor
Koji Yanagawa
Kiyotoshi Mori
Yoshisuke Nakasato
Jun Funahashi
Original Assignee
Kyowa Hakko Kirin Co., Ltd.
Funahashi, Mami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Kyowa Hakko Kirin Co., Ltd., Funahashi, Mami filed Critical Kyowa Hakko Kirin Co., Ltd.
Publication of WO2009069736A1 publication Critical patent/WO2009069736A1/en

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    • C07ORGANIC CHEMISTRY
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    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
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    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Disclosed is a nitrogenated compound represented by the formula (I) [wherein A represents an aryl which may have a substituent or the like; B's independently represent a hydrogen atom, a halogen or the like; n represents an integer of not less than 1 and up to the maximum number which can be substituted; R9 represents a hydrogen atom or the like; and R10 represents a group represented by the formula (III) (wherein R11 represents an aromatic heterocyclic group or the like; and R12 represents a hydrogen atom or the like) or the like], or a pharmaceutically acceptable salt thereof.
PCT/JP2008/071627 2007-11-28 2008-11-28 Nitrogenated compound WO2009069736A1 (en)

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JP2007-307939 2007-11-28
JP2007307939 2007-11-28

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WO2009069736A1 true WO2009069736A1 (en) 2009-06-04

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Cited By (18)

* Cited by examiner, † Cited by third party
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WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
WO2011161030A1 (en) 2010-06-21 2011-12-29 Sanofi Heterocyclic substituted methoxyphenyl derivatives having an oxo group, method for producing same, and use thereof as gpr40 receptor modulators
WO2012004269A1 (en) 2010-07-05 2012-01-12 Sanofi (2-aryloxy-acetylamino)-phenyl-propionic acid derivatives, method for producing same and use thereof as pharmaceuticals
WO2012004270A1 (en) 2010-07-05 2012-01-12 Sanofi Spirocyclically substituted 1,3-propane dioxide derivatives, methods for the production thereof and use of the same as medicament
WO2012010413A1 (en) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylene substituted hydroxyphenyl hexynoic acids, methods for the production thereof and use of the same as medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9814698B2 (en) 2015-04-21 2017-11-14 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US9815776B2 (en) 2015-04-21 2017-11-14 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US9834507B2 (en) 2015-04-21 2017-12-05 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
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