WO2005118540A3 - Composes organiques - Google Patents

Composes organiques Download PDF

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Publication number
WO2005118540A3
WO2005118540A3 PCT/EP2005/052416 EP2005052416W WO2005118540A3 WO 2005118540 A3 WO2005118540 A3 WO 2005118540A3 EP 2005052416 W EP2005052416 W EP 2005052416W WO 2005118540 A3 WO2005118540 A3 WO 2005118540A3
Authority
WO
WIPO (PCT)
Prior art keywords
aromatase inhibitors
bicyclic
nitrogen
containing heterocycles
compounds
Prior art date
Application number
PCT/EP2005/052416
Other languages
English (en)
Other versions
WO2005118540A2 (fr
Inventor
Peter Herold
Robert Mah
Vincenzo Tschinke
Christoph Schumacher
Michael Quirmbach
Original Assignee
Speedel Experimenta Ag
Peter Herold
Robert Mah
Vincenzo Tschinke
Christoph Schumacher
Michael Quirmbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Experimenta Ag, Peter Herold, Robert Mah, Vincenzo Tschinke, Christoph Schumacher, Michael Quirmbach filed Critical Speedel Experimenta Ag
Priority to US11/597,585 priority Critical patent/US20080076784A1/en
Priority to JP2007513939A priority patent/JP2008500997A/ja
Priority to CA002568163A priority patent/CA2568163A1/fr
Priority to BRPI0510409-2A priority patent/BRPI0510409A/pt
Priority to EP05747969A priority patent/EP1765777A2/fr
Publication of WO2005118540A2 publication Critical patent/WO2005118540A2/fr
Publication of WO2005118540A3 publication Critical patent/WO2005118540A3/fr
Priority to IL179408A priority patent/IL179408A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des nouveaux composés hétérocycliques de formule générale (I), (I*), dans lesquelles R, R1, R2, X, Y, Z et n ont les significations définies dans la description. Elle porte également sur leur procédé de préparation et sur leur utilisation en tant que médicaments, notamment en tant qu'inhibiteurs de l'aromatase.
PCT/EP2005/052416 2004-05-28 2005-05-27 Composes organiques WO2005118540A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US11/597,585 US20080076784A1 (en) 2004-05-28 2005-05-27 Bicyclic, Nitrogen-Containing Heterocycles and Aromatase Inhibitors
JP2007513939A JP2008500997A (ja) 2004-05-28 2005-05-27 アロマターゼ阻害剤としての二環式の窒素含有複素環
CA002568163A CA2568163A1 (fr) 2004-05-28 2005-05-27 Composes organiques
BRPI0510409-2A BRPI0510409A (pt) 2004-05-28 2005-05-27 heterociclos bicìclicos contendo nitrogênio como inibidores da aromatase
EP05747969A EP1765777A2 (fr) 2004-05-28 2005-05-27 Heterocycles bicycliques azotés comme inhibiteurs d' aromatase
IL179408A IL179408A0 (en) 2004-05-28 2006-11-20 Bicyclic, nitrogen-containing heterocycles as aromatase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH915/04 2004-05-28
CH9152004 2004-05-28

Publications (2)

Publication Number Publication Date
WO2005118540A2 WO2005118540A2 (fr) 2005-12-15
WO2005118540A3 true WO2005118540A3 (fr) 2006-02-02

Family

ID=34968588

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2005/052416 WO2005118540A2 (fr) 2004-05-28 2005-05-27 Composes organiques
PCT/EP2005/052419 WO2005118581A1 (fr) 2004-05-28 2005-05-27 Derives tetrahydro-imidazo[1,5-a] pyridine tenant lieu d'inhibiteurs de l'aldosterone syntase

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/052419 WO2005118581A1 (fr) 2004-05-28 2005-05-27 Derives tetrahydro-imidazo[1,5-a] pyridine tenant lieu d'inhibiteurs de l'aldosterone syntase

Country Status (10)

Country Link
US (2) US8680079B2 (fr)
EP (2) EP1749005A1 (fr)
JP (2) JP5179174B2 (fr)
CN (2) CN1960991A (fr)
AR (2) AR049126A1 (fr)
BR (2) BRPI0510409A (fr)
CA (2) CA2568159A1 (fr)
IL (2) IL179408A0 (fr)
TW (2) TW200616623A (fr)
WO (2) WO2005118540A2 (fr)

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* Cited by examiner, † Cited by third party
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US8680079B2 (en) 2004-05-28 2014-03-25 Novartis Ag Tetrahydro-imidazo [1,5-A] pyridyin derivatives as aldosterone synthase inhibitors
TW200617010A (en) * 2004-07-09 2006-06-01 Speedel Experimenta Ag Organic compounds
AR056888A1 (es) * 2005-12-09 2007-10-31 Speedel Experimenta Ag Derivados de heterociclil imidazol
TW200804284A (en) * 2006-03-31 2008-01-16 Speedel Experimenta Ag Process for preparing 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one
EP1842543A1 (fr) 2006-04-05 2007-10-10 Speedel Pharma AG Composition pharmaceutique comprennant un inhibiteur de l'aldosteron synthase et un antagoniste de recepteur mineralcorticoide
TW200808812A (en) 2006-04-12 2008-02-16 Speedel Experimenta Ag Imidazo compounds
TW200813071A (en) 2006-04-12 2008-03-16 Speedel Experimenta Ag Spiro-imidazo compounds
TW200808813A (en) * 2006-04-12 2008-02-16 Speedel Experimenta Ag Imidazo compounds
EP2319923B1 (fr) * 2008-07-24 2013-12-25 Meiji Seika Pharma Co., Ltd. Gènes de biosynthèse de pyripyropène a
CA2742964C (fr) * 2008-11-07 2020-07-07 University Of Sheffield Medicament et procede de diagnostic
DK2426124T3 (da) 2009-05-13 2013-09-30 Meiji Seika Pharma Co Ltd Fremgangsmåde til fremstilling af pyripyropene derivater
EP2594557B1 (fr) 2009-05-28 2016-08-10 Novartis AG Dérivés aminopropioniques substitués en tant qu'inhibiteurs de néprilysine
MX2011012627A (es) 2009-05-28 2011-12-14 Novartis Ag Derivados aminobutiricos sustituidos como inhibidores de nepralisina.
ES2663351T3 (es) * 2009-11-17 2018-04-12 Novartis Ag Derivados de aril-piridina como inhibidores de la aldosterona sintasa
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
UA111151C2 (uk) 2010-03-01 2016-04-11 Мейдзі Сейка Фарма Ко., Лтд. Спосіб одержання похідних пірипіропену
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
TWI627167B (zh) 2011-07-08 2018-06-21 諾華公司 用於高三酸甘油酯個體治療動脈粥狀硬化之方法
CN103958478B (zh) * 2011-11-30 2017-08-01 霍夫曼-拉罗奇有限公司 双环二氢异喹啉‑1‑酮衍生物
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
CN105073762B (zh) 2013-02-14 2017-03-08 诺华股份有限公司 作为nep(中性内肽酶)抑制剂的取代的联苯丁酰膦酸衍生物
EP3024845A1 (fr) 2013-07-25 2016-06-01 Novartis AG Polypeptides cycliques pour le traitement de l'insuffisance cardiaque
UY35671A (es) 2013-07-25 2015-02-27 Novartis Ag Bioconjugados de polipéptidos de apelina sintética
RU2016116433A (ru) * 2013-10-17 2017-11-22 Ф. Хоффманн-Ля Рош Аг Новые производные фенил-дигидропиридина в качестве ингибиторов альдостерон синтазы
CN105593212B (zh) * 2013-10-17 2019-06-04 豪夫迈·罗氏有限公司 作为醛固酮合酶抑制剂的苯基-二氢吡啶衍生物
RU2016116435A (ru) * 2013-10-17 2017-11-22 Ф. Хоффманн-Ля Рош Аг Производные фенил-дигидропиридина в качестве ингибиторов альдостеронсинтазы
SG11201704758XA (en) 2015-01-23 2017-08-30 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
JOP20190086A1 (ar) 2016-10-21 2019-04-18 Novartis Ag مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
BR112019018700A2 (pt) 2017-03-10 2020-04-07 Embera Neurotherapeutics Inc composições farmacêuticas e seus usos
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
EP3887363A1 (fr) 2018-11-27 2021-10-06 Novartis AG Composés pentamères cycliques servant d'inhibiteurs de proprotéine convertase subtilisine/kexine de type 9 (pcsk9) pour le traitement d'un trouble métabolique
CN113166204A (zh) 2018-11-27 2021-07-23 诺华股份有限公司 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状肽
TW202333563A (zh) 2021-11-12 2023-09-01 瑞士商諾華公司 用於治療疾病或障礙之二胺基環戊基吡啶衍生物
AR127698A1 (es) 2021-11-23 2024-02-21 Novartis Ag Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889861A (en) * 1982-12-21 1989-12-26 Ciba-Geigy Corp. Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
EP0356673A2 (fr) * 1988-09-02 1990-03-07 FARMITALIA CARLO ERBA S.r.l. 5,6,7,8-Tétrahydroimidazo[1,5-a]pyridines substituées et leur procédé de préparation
WO1993015079A1 (fr) * 1992-01-27 1993-08-05 Janssen Pharmaceutica N.V. Derives de 1h-benzimidazole a substitutions pyrroloimidazolyle et imidazopyridinyle utilises comme inhibiteurs d'aromatase
WO1993024497A1 (fr) * 1992-05-29 1993-12-09 Procter & Gamble Pharmaceuticals, Inc. Composes de phosphonate cycliques thio-substitues, destines au traitement d'un metabolisme anormal de calcium et de phosphate
WO1997000257A1 (fr) * 1995-06-14 1997-01-03 Yamanouchi Pharmaceutical Co., Ltd. Derives d'imidazole fusionnes et composition medicinale les contenant
WO2001007046A1 (fr) * 1999-07-23 2001-02-01 Merck & Co., Inc. Inhibiteurs de la prenyl-proteine transferase
JP2001151696A (ja) * 1999-11-22 2001-06-05 Keiko Tanaka アクチニジンから造る腫瘍の増殖ならびに転移抑制酵素と異質なたんぱく細胞の除去剤
WO2002040484A2 (fr) * 2000-11-17 2002-05-23 Takeda Chemical Industries, Ltd. Nouveaux derives imidazole, procede de production correspondant et utilisation de ces derives

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4617307A (en) * 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
JPH0670064B2 (ja) 1986-12-08 1994-09-07 三井石油化学工業株式会社 二環性イミダゾ−ル誘導体
US5057521A (en) 1988-10-26 1991-10-15 Ciba-Geigy Corporation Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
CA2026792A1 (fr) * 1989-11-01 1991-05-02 Michael N. Greco Derives de substitution (6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl) et (5,6,7,8-tetrahydro-imidazo[1,5-a]pyridin-5-yl) du 1h-benzotriazole
JPH0971586A (ja) * 1995-09-07 1997-03-18 Yamanouchi Pharmaceut Co Ltd 新規な二環性縮合イミダゾール誘導体
US8680079B2 (en) 2004-05-28 2014-03-25 Novartis Ag Tetrahydro-imidazo [1,5-A] pyridyin derivatives as aldosterone synthase inhibitors
JP2008500998A (ja) 2004-05-28 2008-01-17 シュペーデル・エクスペリメンタ・アーゲー 複素環式化合物およびアルドステロンシンターゼ阻害薬としてのそれらの使用
TW200608978A (en) 2004-05-28 2006-03-16 Speedel Experimenta Ag Organic compounds
TW200716105A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Imidazole compounds
TW200716634A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
TW200808812A (en) 2006-04-12 2008-02-16 Speedel Experimenta Ag Imidazo compounds
TW200808813A (en) 2006-04-12 2008-02-16 Speedel Experimenta Ag Imidazo compounds
TW200813071A (en) 2006-04-12 2008-03-16 Speedel Experimenta Ag Spiro-imidazo compounds

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889861A (en) * 1982-12-21 1989-12-26 Ciba-Geigy Corp. Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
EP0356673A2 (fr) * 1988-09-02 1990-03-07 FARMITALIA CARLO ERBA S.r.l. 5,6,7,8-Tétrahydroimidazo[1,5-a]pyridines substituées et leur procédé de préparation
WO1993015079A1 (fr) * 1992-01-27 1993-08-05 Janssen Pharmaceutica N.V. Derives de 1h-benzimidazole a substitutions pyrroloimidazolyle et imidazopyridinyle utilises comme inhibiteurs d'aromatase
WO1993024497A1 (fr) * 1992-05-29 1993-12-09 Procter & Gamble Pharmaceuticals, Inc. Composes de phosphonate cycliques thio-substitues, destines au traitement d'un metabolisme anormal de calcium et de phosphate
WO1997000257A1 (fr) * 1995-06-14 1997-01-03 Yamanouchi Pharmaceutical Co., Ltd. Derives d'imidazole fusionnes et composition medicinale les contenant
WO2001007046A1 (fr) * 1999-07-23 2001-02-01 Merck & Co., Inc. Inhibiteurs de la prenyl-proteine transferase
JP2001151696A (ja) * 1999-11-22 2001-06-05 Keiko Tanaka アクチニジンから造る腫瘍の増殖ならびに転移抑制酵素と異質なたんぱく細胞の除去剤
WO2002040484A2 (fr) * 2000-11-17 2002-05-23 Takeda Chemical Industries, Ltd. Nouveaux derives imidazole, procede de production correspondant et utilisation de ces derives

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANALES DE QUIMICA, SERIE C: QUIMICA ORGANICA Y BIOQUIMICA , 84(2), 176-82 CODEN: AQSBD6; ISSN: 0211-1357, 1988 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ELGUERO, J. ET AL: "Heterocyclic chemistry. VII. Synthesis of heterocycles from (+)-3-methylcyclohexanone", XP002339513, retrieved from STN Database accession no. 1989:439307 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TANAKA, KEIKO: "Actinidine as tumor proliferation and metastasis-inhibiting enzyme for removal of albuminoids", XP002339511, retrieved from STN Database accession no. 2001:403419 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TERENT'EV, P. B. ET AL: "Cyclodimerization of vinylpyridines", XP002339512, retrieved from STN Database accession no. 1981:46665 *
DICKINSON, E. M. ET AL: "Pyrindan alkaloids from Tecoma stans", TETRAHEDRON , 25(7), 1523-9 CODEN: TETRAB; ISSN: 0040-4020, 1969, XP002339496 *
FRANCK, BURCHARD ET AL: "Pyridine alkaloids. 6. Valerianine, a tertiary monoterpene alkaloid from valerian", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION IN ENGLISH , 9(11), 891 CODEN: ACIEAY; ISSN: 0570-0833, 1970, XP002339497 *
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII , (9), 1248-54 CODEN: KGSSAQ; ISSN: 0453-8234, 1980 *

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IL179406A0 (en) 2007-05-15
AR049126A1 (es) 2006-06-28
BRPI0511621A (pt) 2008-01-02
BRPI0510409A (pt) 2007-10-23
JP2008500997A (ja) 2008-01-17
US20070225232A1 (en) 2007-09-27
JP2008501000A (ja) 2008-01-17
EP1749005A1 (fr) 2007-02-07
IL179408A0 (en) 2007-05-15
AR049125A1 (es) 2006-06-28
EP1765777A2 (fr) 2007-03-28
JP5179174B2 (ja) 2013-04-10
CN1960991A (zh) 2007-05-09
CA2568159A1 (fr) 2005-12-15
CN1968930A (zh) 2007-05-23
CA2568163A1 (fr) 2005-12-15
WO2005118581A1 (fr) 2005-12-15
US20080076784A1 (en) 2008-03-27
US8680079B2 (en) 2014-03-25

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