MX2007007025A - Nuevos derivados de hidantoina como inhibidores de metaloproteinasa. - Google Patents
Nuevos derivados de hidantoina como inhibidores de metaloproteinasa.Info
- Publication number
- MX2007007025A MX2007007025A MX2007007025A MX2007007025A MX2007007025A MX 2007007025 A MX2007007025 A MX 2007007025A MX 2007007025 A MX2007007025 A MX 2007007025A MX 2007007025 A MX2007007025 A MX 2007007025A MX 2007007025 A MX2007007025 A MX 2007007025A
- Authority
- MX
- Mexico
- Prior art keywords
- metalloproteinase inhibitors
- hydantoin derivatives
- novel hydantoin
- novel
- pharmaceutical compositions
- Prior art date
Links
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 title 1
- 150000001469 hydantoins Chemical class 0.000 title 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 229940124761 MMP inhibitor Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion se refiere a compuestos de la formula (I); en donde R1, R2, A, A1 y B son como se definieron en la especificacion; procesos para su preparacion; composiciones farmaceuticas que los contienen; un proceso para preparar las composiciones farmaceuticas; y su uso en terapia. Los compuestos son utiles como inhibidores de MMP.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0403086A SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Compounds |
PCT/SE2005/001918 WO2006065216A1 (en) | 2004-12-17 | 2005-12-14 | Novel hydantoin derivatives as metalloproteinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007007025A true MX2007007025A (es) | 2007-07-04 |
Family
ID=34075236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007007025A MX2007007025A (es) | 2004-12-17 | 2005-12-14 | Nuevos derivados de hidantoina como inhibidores de metaloproteinasa. |
Country Status (20)
Country | Link |
---|---|
US (1) | US7700604B2 (es) |
EP (1) | EP1831196A4 (es) |
JP (1) | JP2008524211A (es) |
KR (1) | KR20070090923A (es) |
CN (1) | CN101080403B (es) |
AR (1) | AR051796A1 (es) |
AU (1) | AU2005317287B2 (es) |
BR (1) | BRPI0517033A (es) |
CA (1) | CA2590843A1 (es) |
IL (1) | IL183667A0 (es) |
MX (1) | MX2007007025A (es) |
NO (1) | NO20073571L (es) |
NZ (1) | NZ555832A (es) |
RU (2) | RU2378269C2 (es) |
SA (1) | SA05260410B1 (es) |
SE (1) | SE0403086D0 (es) |
TW (1) | TW200635916A (es) |
UA (1) | UA89801C2 (es) |
WO (1) | WO2006065216A1 (es) |
ZA (1) | ZA200705076B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0202539D0 (sv) * | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
US7648992B2 (en) * | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
SE0403085D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
MX2007011378A (es) * | 2005-03-16 | 2008-03-18 | Sensus Metering Systems Inc | Metodo, sistema, aparato y producto de programa de computadora para determinar la ubicacion fisica de un sensor. |
TW200740769A (en) * | 2006-03-16 | 2007-11-01 | Astrazeneca Ab | Novel process |
TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
JP5539965B2 (ja) | 2008-04-28 | 2014-07-02 | レバレジオ コーポレイション | 多発性硬化症を治療するための組成物および方法 |
AR080375A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida |
EP3321256A4 (en) * | 2015-07-09 | 2019-04-03 | Mitsubishi Tanabe Pharma Corporation | NOVEL IMIDE DERIVATIVES AND THEIR USE AS A MEDICINE |
Family Cites Families (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2327890A (en) | 1940-04-17 | 1943-08-24 | Parke Davis & Co | Substituted phenoxyalkyl ethers |
US2745875A (en) | 1953-06-30 | 1956-05-15 | Hoechst Ag | Preparation of nu-acylamino-phenylpropane diols |
US3452040A (en) | 1966-01-05 | 1969-06-24 | American Home Prod | 5,5-disubstituted hydantoins |
US3529019A (en) | 1968-04-23 | 1970-09-15 | Colgate Palmolive Co | Alkylaryloxy alanines |
US3849574A (en) | 1971-05-24 | 1974-11-19 | Colgate Palmolive Co | Alpha-substituted-beta-arylthioalkyl amino-acids,for increasing heart rate |
US4315031A (en) | 1977-09-01 | 1982-02-09 | Science Union Et Cie | Thiosubstituted amino acids |
GB1601310A (en) | 1978-05-23 | 1981-10-28 | Lilly Industries Ltd | Aryl hydantoins |
JPS6172762A (ja) | 1984-09-17 | 1986-04-14 | Kanegafuchi Chem Ind Co Ltd | 光学活性ヒダントイン類の製造法 |
JPS61212292A (ja) | 1985-03-19 | 1986-09-20 | Mitsui Toatsu Chem Inc | D−α−アミノ酸の製造方法 |
CA1325222C (en) | 1985-08-23 | 1993-12-14 | Lederle (Japan), Ltd. | Process for producing 4-biphenylylacetic acid |
GB8618559D0 (en) | 1986-07-30 | 1986-09-10 | Genetics Int Inc | Rhodococcus bacterium |
US4983771A (en) | 1989-09-18 | 1991-01-08 | Hexcel Corporation | Method for resolution of D,L-alpha-phenethylamine with D(-)mandelic acid |
NL9000386A (nl) | 1990-02-16 | 1991-09-16 | Stamicarbon | Werkwijze voor de bereiding van optisch aktief aminozuuramide. |
DK161690D0 (da) | 1990-07-05 | 1990-07-05 | Novo Nordisk As | Fremgangsmaade til fremstilling af enantiomere forbindelser |
IL99957A0 (en) | 1990-11-13 | 1992-08-18 | Merck & Co Inc | Piperidinylcamphorsulfonyl oxytocin antagonists and pharmaceutical compositions containing them |
PH31245A (en) | 1991-10-30 | 1998-06-18 | Janssen Pharmaceutica Nv | 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives. |
US5308853A (en) | 1991-12-20 | 1994-05-03 | Warner-Lambert Company | Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties |
US5246943A (en) | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
NL9201230A (nl) | 1992-07-09 | 1994-02-01 | Dsm Nv | Werkwijze voor de bereiding van optisch aktief methionineamide. |
EP0640594A1 (en) | 1993-08-23 | 1995-03-01 | Fujirebio Inc. | Hydantoin derivative as metalloprotease inhibitor |
JPH09505310A (ja) | 1993-11-16 | 1997-05-27 | メルク エンド カンパニー インコーポレーテッド | ピペリジンショウノウスルホニルオキシトシン拮抗剤 |
EP0709375B1 (en) | 1994-10-25 | 2005-05-18 | AstraZeneca AB | Therapeutic heterocycles |
ZA96211B (en) | 1995-01-12 | 1996-07-26 | Teva Pharma | Compositions containing and methods of using 1- aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
US6048841A (en) | 1995-11-22 | 2000-04-11 | Darwin Discovery, Ltd. | Peptidyl compounds |
GB9616643D0 (en) | 1996-08-08 | 1996-09-25 | Chiroscience Ltd | Compounds |
US5919790A (en) | 1996-10-11 | 1999-07-06 | Warner-Lambert Company | Hydroxamate inhibitors of interleukin-1β converting enzyme |
ATE212619T1 (de) | 1996-10-22 | 2002-02-15 | Upjohn Co | Alpha-amino sulfonyl hydroxamsäure als matrix metalloproteinase inhibitoren |
EP0983239A1 (en) | 1997-05-06 | 2000-03-08 | Novo Nordisk A/S | Novel heterocyclic compounds |
PT877019E (pt) | 1997-05-09 | 2002-05-31 | Hoechst Ag | Acidos diaminocarboxilicos substituidos |
CN1178906C (zh) | 1997-07-31 | 2004-12-08 | 艾博特公司 | 基质金属蛋白酶的逆异羟肟酸盐抑制剂 |
TW514634B (en) | 1997-10-14 | 2002-12-21 | Lilly Co Eli | Process to make chiral compounds |
WO1999024399A1 (en) | 1997-11-12 | 1999-05-20 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
NZ505968A (en) | 1998-02-04 | 2003-03-28 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix- degrading metallproteinases |
US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
JP2002514644A (ja) | 1998-05-14 | 2002-05-21 | デュポン ファーマシューティカルズ カンパニー | メタロプロテイナーゼ阻害剤としての置換アリールヒドロキサム酸 |
WO1999062880A1 (en) | 1998-06-03 | 1999-12-09 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres |
CA2333554A1 (en) | 1998-06-17 | 1999-12-23 | Chu-Baio Xue | Cyclic hydroxamic acids as metalloproteinase inhibitors |
FR2782082B3 (fr) | 1998-08-05 | 2000-09-22 | Sanofi Sa | Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose |
US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
JP2002523492A (ja) | 1998-08-29 | 2002-07-30 | ブリティッシュ バイオテック ファーマシューティカルズ リミテッド | タンパク質分解酵素阻害剤としてのヒドロキサム酸誘導体 |
GB9919776D0 (en) | 1998-08-31 | 1999-10-27 | Zeneca Ltd | Compoujnds |
EP1117616B1 (en) | 1998-10-07 | 2003-04-23 | Yazaki Corporation | Sol-gel process using porous mold |
US6114361A (en) | 1998-11-05 | 2000-09-05 | Pfizer Inc. | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives |
CZ20012006A3 (cs) | 1998-12-18 | 2002-03-13 | Axys Pharmaceuticals, Inc. | Sloučenina a farmaceutický prostředek |
AU1817700A (en) | 1998-12-31 | 2000-07-24 | Aventis Pharmaceuticals Inc. | 1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12 |
US6340691B1 (en) | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
WO2000044770A1 (fr) | 1999-01-28 | 2000-08-03 | Chugai Seiyaku Kabushiki Kaisha | Derives phenethylamine substitues |
US6294694B1 (en) | 1999-06-04 | 2001-09-25 | Wisconsin Alumni Research Foundation | Matrix metalloproteinase inhibitors and method of using same |
GB9916562D0 (en) | 1999-07-14 | 1999-09-15 | Pharmacia & Upjohn Spa | 3-Arylsulfonyl-2-(substituted-methyl) propanoic acid derivatives as matrix metalloproteinase inhibitora |
US20020006920A1 (en) | 1999-07-22 | 2002-01-17 | Robinson Ralph Pelton | Arylsulfonylamino hydroxamic acid derivatives |
US6266453B1 (en) | 1999-07-26 | 2001-07-24 | Computerized Medical Systems, Inc. | Automated image fusion/alignment system and method |
PT1078923E (pt) | 1999-08-02 | 2006-07-31 | Hoffmann La Roche | Processo para a preparacao de derivados de benzotiofeno |
EE200200065A (et) | 1999-08-12 | 2003-04-15 | Pharmacia Italia S.P.A. | 3-aminopürasooli derivaadid, nende valmistamine ja kasutamine vähivastaste toimeainetena ning neid sisaldav farmatseutiline kompositsioon |
SE9904044D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
US6525202B2 (en) | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
US20020065219A1 (en) | 2000-08-15 | 2002-05-30 | Naidu B. Narasimhulu | Water soluble thiazolyl peptide derivatives |
US20020091107A1 (en) | 2000-09-08 | 2002-07-11 | Madar David J. | Oxazolidinone antibacterial agents |
EP1191024A1 (en) | 2000-09-22 | 2002-03-27 | Harald Tschesche | Thiadiazines and their use as inhibitors of metalloproteinases |
CN1509275A (zh) * | 2001-03-15 | 2004-06-30 | 金属蛋白酶抑制剂 | |
SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
CA2447475A1 (en) | 2001-05-25 | 2002-12-05 | Chu-Biao Xue | Hydantion derivatives as inhibitors of matrix metalloproteinases |
GB0114004D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
SE0103710D0 (sv) | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
CA2486350A1 (en) | 2002-06-05 | 2003-12-24 | Kaneka Corporation | Process for producing optically active .alpha.-methylcysteine derivative |
SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
SE0202693D0 (sv) * | 2002-09-11 | 2002-09-11 | Astrazeneca Ab | Compounds |
GB0221246D0 (en) | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
US7041693B2 (en) * | 2002-10-04 | 2006-05-09 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
US7132432B2 (en) * | 2003-06-05 | 2006-11-07 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) |
US20040266832A1 (en) | 2003-06-26 | 2004-12-30 | Li Zheng J. | Crystal forms of 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl pyridine |
TWI220073B (en) | 2003-07-24 | 2004-08-01 | Au Optronics Corp | Method for manufacturing polysilicon film |
SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
SE0401763D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Compounds |
US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
SE0403085D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
TW200740769A (en) | 2006-03-16 | 2007-11-01 | Astrazeneca Ab | Novel process |
TW200831488A (en) | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
-
2004
- 2004-12-17 SE SE0403086A patent/SE0403086D0/sv unknown
-
2005
- 2005-12-14 EP EP05815746A patent/EP1831196A4/en not_active Withdrawn
- 2005-12-14 RU RU2007126745/04A patent/RU2378269C2/ru not_active IP Right Cessation
- 2005-12-14 CA CA002590843A patent/CA2590843A1/en not_active Abandoned
- 2005-12-14 AU AU2005317287A patent/AU2005317287B2/en not_active Ceased
- 2005-12-14 UA UAA200706363A patent/UA89801C2/ru unknown
- 2005-12-14 BR BRPI0517033-8A patent/BRPI0517033A/pt not_active IP Right Cessation
- 2005-12-14 JP JP2007546610A patent/JP2008524211A/ja active Pending
- 2005-12-14 NZ NZ555832A patent/NZ555832A/en not_active IP Right Cessation
- 2005-12-14 MX MX2007007025A patent/MX2007007025A/es not_active Application Discontinuation
- 2005-12-14 CN CN2005800434419A patent/CN101080403B/zh not_active Expired - Fee Related
- 2005-12-14 KR KR1020077013484A patent/KR20070090923A/ko not_active Application Discontinuation
- 2005-12-14 WO PCT/SE2005/001918 patent/WO2006065216A1/en active Application Filing
- 2005-12-14 US US11/721,590 patent/US7700604B2/en not_active Expired - Fee Related
- 2005-12-15 AR ARP050105274A patent/AR051796A1/es unknown
- 2005-12-16 TW TW094144601A patent/TW200635916A/zh unknown
- 2005-12-17 SA SA05260410A patent/SA05260410B1/ar unknown
-
2007
- 2007-06-04 IL IL183667A patent/IL183667A0/en unknown
- 2007-06-12 ZA ZA200705076A patent/ZA200705076B/xx unknown
- 2007-07-10 NO NO20073571A patent/NO20073571L/no not_active Application Discontinuation
-
2009
- 2009-09-10 RU RU2009133846/04A patent/RU2009133846A/ru not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US7700604B2 (en) | 2010-04-20 |
AR051796A1 (es) | 2007-02-07 |
KR20070090923A (ko) | 2007-09-06 |
JP2008524211A (ja) | 2008-07-10 |
EP1831196A1 (en) | 2007-09-12 |
CA2590843A1 (en) | 2006-06-22 |
US20080032997A1 (en) | 2008-02-07 |
EP1831196A4 (en) | 2009-11-04 |
RU2009133846A (ru) | 2011-03-20 |
AU2005317287B2 (en) | 2009-02-05 |
WO2006065216A1 (en) | 2006-06-22 |
ZA200705076B (en) | 2008-12-31 |
NO20073571L (no) | 2007-09-12 |
SE0403086D0 (sv) | 2004-12-17 |
UA89801C2 (en) | 2010-03-10 |
SA05260410B1 (ar) | 2009-02-28 |
RU2007126745A (ru) | 2009-01-27 |
CN101080403B (zh) | 2010-09-08 |
BRPI0517033A (pt) | 2008-09-30 |
RU2378269C2 (ru) | 2010-01-10 |
CN101080403A (zh) | 2007-11-28 |
IL183667A0 (en) | 2007-09-20 |
TW200635916A (en) | 2006-10-16 |
NZ555832A (en) | 2009-02-28 |
AU2005317287A1 (en) | 2006-06-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2007007025A (es) | Nuevos derivados de hidantoina como inhibidores de metaloproteinasa. | |
UA90285C2 (ru) | Производные гидантоина, полезные как ингибиторы металлопротеиназ | |
UA93425C2 (ru) | Производные гидантоина, которые применяются kak mmp ингибиторы | |
TW200616995A (en) | Novel compounds | |
HK1099751A1 (en) | Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd | |
SE0200920D0 (sv) | Novel compounds | |
SE0202539D0 (sv) | Compounds | |
TW200801003A (en) | Novel compounds | |
NO20090628L (no) | Pyridizinon derivativater | |
TW200612947A (en) | Organic compounds | |
MY149512A (en) | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | |
DE602004021472D1 (en) | Pyrimiidinverbindungen | |
TW200745084A (en) | Novel compounds | |
GEP20094664B (en) | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | |
TW200605888A (en) | Novel compounds | |
TW200639156A (en) | New compounds | |
TW200738659A (en) | Novel compounds | |
MX2010009022A (es) | Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso. | |
TW200714598A (en) | Urea derivatives, methods for their manufacture, and uses therefor | |
IL183373A0 (en) | 3-[2-(3-acylamino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pentanoic acid derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof | |
DE602004024213D1 (en) | Aminopropanolderivate | |
MXPA05010020A (es) | Derivados de oxamida. | |
TW200624429A (en) | Novel cysteine protease inhibitors | |
MX2007013305A (es) | Nuevas tiazolidinonas sin nitrogeno basico, su produccion y su uso como agentes farmaceuticos. | |
WO2004024060A3 (en) | Metalloproteinase inhibitors and intermediates for preparation thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |