WO2004024060A3 - Metalloproteinase inhibitors and intermediates for preparation thereof - Google Patents
Metalloproteinase inhibitors and intermediates for preparation thereof Download PDFInfo
- Publication number
- WO2004024060A3 WO2004024060A3 PCT/SE2003/001406 SE0301406W WO2004024060A3 WO 2004024060 A3 WO2004024060 A3 WO 2004024060A3 SE 0301406 W SE0301406 W SE 0301406W WO 2004024060 A3 WO2004024060 A3 WO 2004024060A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- intermediates
- metalloproteinase inhibitors
- pharmaceutical compositions
- therapy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003258941A AU2003258941A1 (en) | 2002-09-11 | 2003-09-10 | Metalloproteinase inhibitors and intermediates for preparation thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0202692A SE0202692D0 (en) | 2002-09-11 | 2002-09-11 | Compounds |
SE0202692-0 | 2002-09-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004024060A2 WO2004024060A2 (en) | 2004-03-25 |
WO2004024060A3 true WO2004024060A3 (en) | 2004-06-24 |
Family
ID=20288962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE2003/001406 WO2004024060A2 (en) | 2002-09-11 | 2003-09-10 | Metalloproteinase inhibitors and intermediates for preparation thereof |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2003258941A1 (en) |
SE (1) | SE0202692D0 (en) |
WO (1) | WO2004024060A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0100902D0 (en) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0103710D0 (en) | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
SE0202539D0 (en) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
EP1771169A1 (en) | 2004-07-14 | 2007-04-11 | PTC Therapeutics, Inc. | Methods for treating hepatitis c |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
NZ553329A (en) | 2004-07-22 | 2010-09-30 | Ptc Therapeutics Inc | Thienopyridines for treating hepatitis C |
US7858666B2 (en) | 2007-06-08 | 2010-12-28 | Mannkind Corporation | IRE-1α inhibitors |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2745875A (en) * | 1953-06-30 | 1956-05-15 | Hoechst Ag | Preparation of nu-acylamino-phenylpropane diols |
GB1117616A (en) * | 1964-09-23 | 1968-06-19 | Warner Lambert Pharmaceutical | Process for preparing 1-(p-acetylphenyl)-2-(2,2-dichloroacetamido)-1,3-propanediol |
WO1993020053A1 (en) * | 1992-03-27 | 1993-10-14 | Yamanouchi Pharmaceutical Co., Ltd. | Pyridylserine derivative |
EP1191024A1 (en) * | 2000-09-22 | 2002-03-27 | Harald Tschesche | Thiadiazines and their use as inhibitors of metalloproteinases |
WO2002074752A1 (en) * | 2001-03-15 | 2002-09-26 | Astrazeneca Ab | Metalloproteinase inhibitors |
WO2002074750A1 (en) * | 2001-03-15 | 2002-09-26 | Astrazeneca Ab | Metalloproteinase inhibitors |
-
2002
- 2002-09-11 SE SE0202692A patent/SE0202692D0/en unknown
-
2003
- 2003-09-10 WO PCT/SE2003/001406 patent/WO2004024060A2/en not_active Application Discontinuation
- 2003-09-10 AU AU2003258941A patent/AU2003258941A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2745875A (en) * | 1953-06-30 | 1956-05-15 | Hoechst Ag | Preparation of nu-acylamino-phenylpropane diols |
GB1117616A (en) * | 1964-09-23 | 1968-06-19 | Warner Lambert Pharmaceutical | Process for preparing 1-(p-acetylphenyl)-2-(2,2-dichloroacetamido)-1,3-propanediol |
WO1993020053A1 (en) * | 1992-03-27 | 1993-10-14 | Yamanouchi Pharmaceutical Co., Ltd. | Pyridylserine derivative |
EP1191024A1 (en) * | 2000-09-22 | 2002-03-27 | Harald Tschesche | Thiadiazines and their use as inhibitors of metalloproteinases |
WO2002074752A1 (en) * | 2001-03-15 | 2002-09-26 | Astrazeneca Ab | Metalloproteinase inhibitors |
WO2002074750A1 (en) * | 2001-03-15 | 2002-09-26 | Astrazeneca Ab | Metalloproteinase inhibitors |
Non-Patent Citations (7)
Title |
---|
CROCE PIERO DALLA ET AL.: "Stereoselective aldol addition of a chiral glycine enolate synthon to heteroaromatic aldehydes", HETEROCYCLES, vol. 52, no. 3, 2000, pages 1337 - 1344 * |
DATABASE ACS [online] SAKAMOTO SHUICHI ET AL.: "Preparation of pyridylserine derivatives as psychotropics", XP002973688, accession no. STN Database accession no. 1994:299315 * |
RIICHIRO NAKAJIMA ET AL.: "The utility of 4-(2-thinyl)pyridines as a derivatization reagent for hplc and ce", ANALYTICAL SCIENCES, vol. 7, no. SUPPL., 1991, pages 177 - 180, XP002973684 * |
SEI-ICHI SAITO ET AL.: "A new synthesis of deglyco-bleomycin A2 aiming at the total synthesis of bleomycin", TETRAHEDRON LETTERS, vol. 23, no. 5, 1982, pages 529 - 532, XP002973686 * |
TAKASHI OWA ET AL.: "Man-designed bleomycins: significance of the binding sites as enzyme models and of the stereochemistry of the linker moiety", TETRAHEDRON, vol. 48, no. 7, 1992, pages 1193 - 1208, XP002973683 * |
TOSHIAKI MIYAKE ET AL.: "Studies on glycosylation of erythro-beta-hydroxy-L-histidine. A key step of bleomycin total synthesis", BULL. CHEM. SOC. JPN., vol. 59, 1986, pages 1387 - 1395, XP002973685 * |
WHITTAKER MARK ET AL.: "Design and therapeutic application of matrix metalloproteinase inhibitors", CHEM. REV., vol. 99, 1999, pages 2735 - 2776, XP002943426 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003258941A8 (en) | 2004-04-30 |
SE0202692D0 (en) | 2002-09-11 |
WO2004024060A2 (en) | 2004-03-25 |
AU2003258941A1 (en) | 2004-04-30 |
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