GEP20053734B - Beta-Amino Tetrahydroimidazo (1, 2-A)Pyrazines And Tetrahydrotrioazolo (4, 3-A)Pyrazines as Dipeptidyl Peptidase Inhibitors for Treatment or Prevention of Diabetes - Google Patents

Beta-Amino Tetrahydroimidazo (1, 2-A)Pyrazines And Tetrahydrotrioazolo (4, 3-A)Pyrazines as Dipeptidyl Peptidase Inhibitors for Treatment or Prevention of Diabetes

Info

Publication number
GEP20053734B
GEP20053734B GE5445A GEAP2002005445A GEP20053734B GE P20053734 B GEP20053734 B GE P20053734B GE 5445 A GE5445 A GE 5445A GE AP2002005445 A GEAP2002005445 A GE AP2002005445A GE P20053734 B GEP20053734 B GE P20053734B
Authority
GE
Georgia
Prior art keywords
pyrazines
dipeptidyl peptidase
tetrahydrotrioazolo
diabetes
beta
Prior art date
Application number
GE5445A
Other languages
English (en)
Inventor
Scott D Edmondson
Michael H Fisher
Dooseop Kim
Malcolm Maccoss
Emma R Parmee
Ann E Weber
Jinyou Xu
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GEP20053734(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of GEP20053734B publication Critical patent/GEP20053734B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
GE5445A 2001-07-06 2002-07-05 Beta-Amino Tetrahydroimidazo (1, 2-A)Pyrazines And Tetrahydrotrioazolo (4, 3-A)Pyrazines as Dipeptidyl Peptidase Inhibitors for Treatment or Prevention of Diabetes GEP20053734B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06

Publications (1)

Publication Number Publication Date
GEP20053734B true GEP20053734B (en) 2006-01-10

Family

ID=23172273

Family Applications (2)

Application Number Title Priority Date Filing Date
GE5445A GEP20053734B (en) 2001-07-06 2002-07-05 Beta-Amino Tetrahydroimidazo (1, 2-A)Pyrazines And Tetrahydrotrioazolo (4, 3-A)Pyrazines as Dipeptidyl Peptidase Inhibitors for Treatment or Prevention of Diabetes
GEAP20028042A GEP20063734B (en) 2001-07-06 2002-07-05 Beta-Amino Tetrahydroimidazo (1, 2-A)Pyrazines And Tetrahydrotrioazolo (4, 3-A)Pyrazines as Dipeptidyl Peptidase Inhibitors for Treatment or Prevention of Diabetes

Family Applications After (1)

Application Number Title Priority Date Filing Date
GEAP20028042A GEP20063734B (en) 2001-07-06 2002-07-05 Beta-Amino Tetrahydroimidazo (1, 2-A)Pyrazines And Tetrahydrotrioazolo (4, 3-A)Pyrazines as Dipeptidyl Peptidase Inhibitors for Treatment or Prevention of Diabetes

Country Status (45)

Country Link
US (9) US7125873B2 (Direct)
EP (4) EP2226324A1 (Direct)
JP (1) JP3762407B2 (Direct)
KR (1) KR100606871B1 (Direct)
CN (2) CN1290848C (Direct)
AR (1) AR036114A1 (Direct)
AT (2) ATE471148T1 (Direct)
AU (1) AU2002320303B2 (Direct)
BE (1) BE2007C047I2 (Direct)
BG (1) BG108493A (Direct)
BR (1) BRPI0210866B8 (Direct)
CA (1) CA2450740C (Direct)
CR (1) CR7235A (Direct)
CY (3) CY2007019I2 (Direct)
DE (4) DE60236767D1 (Direct)
DK (2) DK1625847T3 (Direct)
DO (1) DOP2002000438A (Direct)
EA (2) EA012701B1 (Direct)
EC (1) ECSP044935A (Direct)
ES (2) ES2259713T3 (Direct)
FR (2) FR07C0041I2 (Direct)
GE (2) GEP20053734B (Direct)
HR (1) HRP20031098B1 (Direct)
HU (2) HU225695B1 (Direct)
IL (3) IL159109A0 (Direct)
IS (2) IS2218B (Direct)
JO (1) JO2230B1 (Direct)
LT (1) LTC1412357I2 (Direct)
LU (2) LUC91360I2 (Direct)
MA (1) MA27053A1 (Direct)
ME (1) ME00439B (Direct)
MX (1) MXPA04000018A (Direct)
MY (1) MY127961A (Direct)
NL (2) NL300287I2 (Direct)
NO (4) NO321999B1 (Direct)
NZ (1) NZ529833A (Direct)
PE (1) PE20030654A1 (Direct)
PL (1) PL196278B6 (Direct)
PT (2) PT1412357E (Direct)
RS (1) RS50737B (Direct)
SI (1) SI1412357T1 (Direct)
TW (1) TWI226331B (Direct)
UA (1) UA74912C2 (Direct)
WO (1) WO2003004498A1 (Direct)
ZA (1) ZA200309294B (Direct)

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