ES2401691T3 - Derivados de indol y de benzoxacina como moduladores de los receptores metabotrópicos de glutamato - Google Patents
Derivados de indol y de benzoxacina como moduladores de los receptores metabotrópicos de glutamato Download PDFInfo
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- ES2401691T3 ES2401691T3 ES09756444T ES09756444T ES2401691T3 ES 2401691 T3 ES2401691 T3 ES 2401691T3 ES 09756444 T ES09756444 T ES 09756444T ES 09756444 T ES09756444 T ES 09756444T ES 2401691 T3 ES2401691 T3 ES 2401691T3
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- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
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Landscapes
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| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
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| BRPI0918055A2 (pt) | 2008-09-02 | 2015-12-01 | Addex Pharmaceuticals Sa | derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato. |
| JP5656848B2 (ja) | 2008-10-16 | 2015-01-21 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体 |
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| SG176021A1 (en) | 2009-05-12 | 2011-12-29 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| ES2409006T3 (es) | 2009-05-12 | 2013-06-24 | Janssen Pharmaceuticals Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| PL2649069T3 (pl) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2 |
| US9012448B2 (en) | 2010-11-08 | 2015-04-21 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
| WO2012062759A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| US8765767B2 (en) * | 2012-03-16 | 2014-07-01 | Bristol-Myers Squibb Company | Positive allosteric modulators of mGluR2 |
| SI2963043T1 (sl) * | 2013-02-28 | 2018-09-28 | Eisai R&D Management Co., Ltd. | Derivat tetrahidroimidazo(1,5-d)(1,4)oksazepina |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| PT3096790T (pt) | 2014-01-21 | 2019-10-15 | Janssen Pharmaceutica Nv | Combinações compreendendo moduladores alostéricos positivos ou agonistas ortostéricos do recetor glutamatérgico metabotrópico do subtipo 2 e seu uso |
| EA202192105A3 (ru) | 2014-02-04 | 2022-02-28 | Янссен Фармацевтика Нв | Комбинации, содержащие положительные аллостерические модуляторы или ортостерические агонисты метаботропного глутаматергического рецептора 2 подтипа, и их применение |
| EA037731B1 (ru) * | 2016-10-26 | 2021-05-14 | Янссен Фармацевтика Нв | Конденсированные азагетероциклические соединения и их применение в качестве модуляторов ampa-рецептора |
| US10968227B2 (en) | 2016-11-08 | 2021-04-06 | Vanderbilt University | Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| MY201041A (en) | 2017-11-24 | 2024-01-31 | Sumitomo Pharma Co Ltd | Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group ii metabotropic glutamate receptor |
| WO2020087031A1 (en) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| JP7266010B2 (ja) | 2019-05-30 | 2023-04-27 | 住友ファーマ株式会社 | ６，７－ジヒドロピラゾロ［１，５－ａ］ピラジノン誘導体又はその塩を含有する医薬 |
| CN116082226A (zh) * | 2022-12-25 | 2023-05-09 | 浙江工业大学 | 一种3-氯-4-碘-2-吡啶胺的制备方法 |
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| SU509578A1 (ru) | 1974-09-19 | 1976-04-05 | Стерлитамакский Химический Завод | Способ получени пропилендиаминов |
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| JPS5382783U (enExample) | 1976-12-13 | 1978-07-08 | ||
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| ZA782648B (en) | 1977-05-23 | 1979-06-27 | Ici Australia Ltd | The prevention,control or eradication of infestations of ixodid ticks |
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| US5032602A (en) | 1988-12-14 | 1991-07-16 | Bayer Aktiengesellschaft | Inhibiting HMG-CoA reductase with novel substituted 2-pyridones and pyrid-2-thiones |
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-
2009
- 2009-11-24 CA CA2744138A patent/CA2744138C/en not_active Expired - Fee Related
- 2009-11-24 CN CN200980147852.0A patent/CN102232074B/zh not_active Expired - Fee Related
- 2009-11-24 BR BRPI0921333A patent/BRPI0921333A2/pt not_active Application Discontinuation
- 2009-11-24 WO PCT/EP2009/008346 patent/WO2010060589A1/en not_active Ceased
- 2009-11-24 AU AU2009319387A patent/AU2009319387B2/en not_active Ceased
- 2009-11-24 MX MX2011005242A patent/MX2011005242A/es not_active Application Discontinuation
- 2009-11-24 RU RU2011120816/04A patent/RU2512283C2/ru not_active IP Right Cessation
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- 2009-11-24 JP JP2011537882A patent/JP5690277B2/ja not_active Expired - Fee Related
- 2009-11-24 ES ES09756444T patent/ES2401691T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2744138A1 (en) | 2010-06-03 |
| CN102232074B (zh) | 2014-12-03 |
| EP2373649B1 (en) | 2013-01-23 |
| WO2010060589A1 (en) | 2010-06-03 |
| US8691813B2 (en) | 2014-04-08 |
| AU2009319387B2 (en) | 2012-05-10 |
| JP5690277B2 (ja) | 2015-03-25 |
| US20120035167A1 (en) | 2012-02-09 |
| RU2011120816A (ru) | 2013-01-10 |
| MX2011005242A (es) | 2011-09-06 |
| BRPI0921333A2 (pt) | 2015-12-29 |
| CA2744138C (en) | 2015-08-11 |
| RU2512283C2 (ru) | 2014-04-10 |
| AU2009319387A1 (en) | 2011-06-30 |
| EP2373649A1 (en) | 2011-10-12 |
| CN102232074A (zh) | 2011-11-02 |
| JP2012510437A (ja) | 2012-05-10 |
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