RU2512283C2 - Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов - Google Patents
Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов Download PDFInfo
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- RU2512283C2 RU2512283C2 RU2011120816/04A RU2011120816A RU2512283C2 RU 2512283 C2 RU2512283 C2 RU 2512283C2 RU 2011120816/04 A RU2011120816/04 A RU 2011120816/04A RU 2011120816 A RU2011120816 A RU 2011120816A RU 2512283 C2 RU2512283 C2 RU 2512283C2
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- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
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Landscapes
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2788047C1 (ru) * | 2021-12-30 | 2023-01-16 | федеральное государственное автономное образовательное учреждение высшего образования "Пермский национальный исследовательский политехнический университет" | Седативное средство на основе 3-(2-(4-фторофенил)-2-оксоэтилиден)-3,4-дигидро-2н-бензо[b][1,4]оксазин-2-она |
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| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| BRPI0817101A2 (pt) | 2007-09-14 | 2017-05-09 | Addex Pharmaceuticals Sa | 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas |
| KR20100080597A (ko) | 2007-09-14 | 2010-07-09 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | １,３-이치환된-４-페닐-1ｈ-피리딘-2-온 |
| DK2203439T3 (da) | 2007-09-14 | 2011-04-18 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituerede 4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']-bipyridinyl-2'-oner |
| MX2010005110A (es) | 2007-11-14 | 2010-09-09 | Ortho Mcneil Janssen Pharm | Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2. |
| AU2009289784B2 (en) | 2008-09-02 | 2012-03-22 | Addex Pharma S.A. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| RU2512283C2 (ru) | 2008-11-28 | 2014-04-10 | Янссен Фармасьютикалз, Инк. | Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов |
| JO2907B1 (en) | 2009-05-12 | 2015-09-15 | اديكس فرما اس ايه | Pyridine derivatives 1, 2, 4 trisolo [4, 3-A] and their uses as positive LLs for 2MGLUR receptors |
| NZ596053A (en) * | 2009-05-12 | 2013-05-31 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| CN103298810B (zh) | 2010-11-08 | 2016-03-16 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| US8765767B2 (en) * | 2012-03-16 | 2014-07-01 | Bristol-Myers Squibb Company | Positive allosteric modulators of mGluR2 |
| WO2014133022A1 (ja) * | 2013-02-28 | 2014-09-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | テトラヒドロイミダゾ［１，５－ｄ］［１，４］オキサゼピン誘導体 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| HUE045610T2 (hu) | 2014-01-21 | 2020-01-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk |
| EA033889B1 (ru) | 2014-01-21 | 2019-12-05 | Янссен Фармацевтика Нв | Комбинация на основе лиганда sv2a и положительного аллостерического модулятора метаботропного глутаматергического рецептора 2 подтипа |
| EP3532476B1 (en) * | 2016-10-26 | 2020-08-19 | Janssen Pharmaceutica NV | Fused azaheterocyclic compounds and their use as ampa receptor modulators |
| US10968227B2 (en) | 2016-11-08 | 2021-04-06 | Vanderbilt University | Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| SG11202004484UA (en) | 2017-11-24 | 2020-06-29 | Sumitomo Dainippon Pharma Co Ltd | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINONE DERIVATIVE AND MEDICAL USE THEREOF |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| JP7266010B2 (ja) * | 2019-05-30 | 2023-04-27 | 住友ファーマ株式会社 | ６，７－ジヒドロピラゾロ［１，５－ａ］ピラジノン誘導体又はその塩を含有する医薬 |
| CN116082226A (zh) * | 2022-12-25 | 2023-05-09 | 浙江工业大学 | 一种3-氯-4-碘-2-吡啶胺的制备方法 |
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| MX2011005242A (es) | 2011-09-06 |
| ES2401691T3 (es) | 2013-04-23 |
| EP2373649B1 (en) | 2013-01-23 |
| BRPI0921333A2 (pt) | 2015-12-29 |
| US8691813B2 (en) | 2014-04-08 |
| CN102232074A (zh) | 2011-11-02 |
| AU2009319387A1 (en) | 2011-06-30 |
| US20120035167A1 (en) | 2012-02-09 |
| JP2012510437A (ja) | 2012-05-10 |
| CN102232074B (zh) | 2014-12-03 |
| AU2009319387B2 (en) | 2012-05-10 |
| JP5690277B2 (ja) | 2015-03-25 |
| CA2744138C (en) | 2015-08-11 |
| EP2373649A1 (en) | 2011-10-12 |
| RU2011120816A (ru) | 2013-01-10 |
| WO2010060589A1 (en) | 2010-06-03 |
| CA2744138A1 (en) | 2010-06-03 |
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