DE09004973T1 - Formulierung mit gesteuerter Freisetzung - Google Patents
Formulierung mit gesteuerter Freisetzung Download PDFInfo
- Publication number
- DE09004973T1 DE09004973T1 DE09004973T DE09004973T DE09004973T1 DE 09004973 T1 DE09004973 T1 DE 09004973T1 DE 09004973 T DE09004973 T DE 09004973T DE 09004973 T DE09004973 T DE 09004973T DE 09004973 T1 DE09004973 T1 DE 09004973T1
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- DE
- Germany
- Prior art keywords
- dosage form
- controlled release
- tramadol
- matrix
- alcohol
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Präparat mit kontrollierter Freisetzung, umfassend Tramadol oder ein pharmazeutisch verträgliches Salz davon, zur oralen Verabreichung.
Claims (15)
- Präparat mit kontrollierter Freisetzung, umfassend Tramadol oder ein pharmazeutisch verträgliches Salz davon, zur oralen Verabreichung.
- Präparat mit kontrollierter Freisetzung gemäß Anspruch 1, enthaltend 50 bis 800 mg Tramadol (berechnet als Tramadol-Hydrochlorid).
- Präparat mit kontrollierter Freisetzung gemäß Anspruch 1 oder 2, folgende in-vitro-Auflösungsrate aufweist (gemessen wie hierin definiert):
Zeit (h) % freigesetzt 1 0–50 2 0–75 4 3–95 8 10–100 12 20–100 16 30–100 24 50–100 36 > 80 - Präparat mit kontrollierter Freisetzung gemäß Anspruch 1 oder 2, welche folgende in-vitro-Auflösungsrate aufweist (gemessen wie hierin definiert):
Zeit (h) % freigesetzt 1 20–50 2 40–75 4 60–95 8 80–100 12 90–100 - Präparat mit kontrollierter Freisetzung gemäß Anspruch 1 oder 2, welche folgende in-vitro-Auflösungsrate aufweist (gemessen wie vorstehend definiert):
Zeit (h) % freigesetzt 1 0–50 2 0–75 4 10–95 8 35–100 12 55–100 16 70–100 24 > 90 - Präparat mit kontrollierter Freisetzung gemäß Anspruch 1 oder 2, welche folgende in-vitro-Auflösungsrate aufweist (gemessen wie hierin definiert):
Zeit (h) % freigesetzt 1 0–30 2 0–40 4 3–55 8 10–65 12 20–75 16 30–88 24 50–100 36 > 80 - Eine feste, orale Dosierungsform mit kontrollierter Freisetzung gemäß einem der Ansprüche 1 bis 6, umfassend eine therapeutisch wirksame Menge Tramadol oder ein Salz davon in einer Matrix, welche geeignet ist, dass Tramadol oder Salz davon bei oraler Verabreichung kontrolliert freizusetzen.
- Eine Dosierungsform gemäß einem der Ansprüche 7, dadurch gekennzeichnet dass die Matrix eine kontrolliert freisetzende Matrix umfasst, welche mindestens ein Alkyl umfasst, bevorzugt C1 bis C6 Alkyl, Cellulose, mindestens einen C12 bis C36, bevorzugt C14 bis C22, aliphatischen Alkohol und optional mindestens ein Polyalkylglykol, bevorzugt Polyethylenglykol.
- Eine Dosierungsform gemäß Anspruch 8, dadurch gekennzeichnet dass die mindestens eine Alkylcellulose Ethylcellulose ist.
- Eine Dosierungsform gemäß Anspruch 8 oder 9, dadurch gekennzeichnet, dass die Dosierungsform von 1 bis 20% w/w, bevorzugt 2 bis 15% w/w einer oder mehrerer Akylcellulosen enthält.
- Eine Dosierungsform gemäß einem der Ansprüche 8 bis 10, dadurch gekennzeichnet, dass der aliphatische Alkohol Laurylalkohol, Myristylalkohol, Stearylalkohol, oder bevorzugt Cetylalkohol oder Cetostearylalkohol umfasst.
- Ein Prozess gemäß einem der Anspüche 8 bis 11, dadurch gekennzeichnet, dass die Dosierungsform von 5 bis 30% w/w aliphatischen Alkohol enthält, bevorzugt von 10 bis 25% w/w aliphatischen Alkohol.
- Eine Dosierungsform gemäß einem der Ansprüche 1 bis 6, in der Form von mit Film überzogenen Sphäroiden, dadurch gekennzeichnet, dass die Sphäroidmatrix ein sphäronisierendes Agenz umfasst, bevorzugt mikrokristalline Cellulose.
- Eine Dosierungsform gemäß einem der Ansprüche 1 bis 6, in der Form von Multipartikulaten, wobei die Matrix einen hydrophoben schmelzbaren Träger oder Weichmacher mit einem Schmelzpunkt von 35 bis 140°C umfasst und optional einen Bestandteil zur Kontrolle der Freisetzung welcher ein wasserlösliches schmelzbares Material, oder ein partikuläres lösliches oder unlösliches organisches oder anorganisches Material umfasst.
- Eine Dosierungsform gemäß einem der Ansprüche 1 bis 6, welche eine Tablette umfasst, geformt durch komprimieren eines Multipartikulats gemäß Anspruch 14.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4315525A DE4315525B4 (de) | 1993-05-10 | 1993-05-10 | Pharmazeutische Zusammensetzung |
DE4315525 | 1993-05-10 | ||
GB9324045 | 1993-11-23 | ||
GB9324045A GB2284760B (en) | 1993-11-23 | 1993-11-23 | A method of preparing pharmaceutical compositions by melt pelletisation |
GB9404544 | 1994-03-09 | ||
GB9404544A GB9404544D0 (en) | 1994-03-09 | 1994-03-09 | Controlled release formulation |
GB9404928A GB2287880A (en) | 1994-03-14 | 1994-03-14 | Production of sustained release compositions |
GB9404928 | 1994-03-14 | ||
EP09004973.5A EP2103303B1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltige formulierung mit gesteuerter freisetzung |
Publications (2)
Publication Number | Publication Date |
---|---|
DE09004973T1 true DE09004973T1 (de) | 2010-01-14 |
DE09004973T8 DE09004973T8 (de) | 2010-10-21 |
Family
ID=27435744
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69427472T Expired - Lifetime DE69427472T3 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
DE0699436T Pending DE699436T1 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
DE09004973T Active DE09004973T8 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit gesteuerter Freisetzung |
DE69435295T Expired - Lifetime DE69435295D1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE69434479T Expired - Lifetime DE69434479T2 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE69400215T Revoked DE69400215T2 (de) | 1993-05-10 | 1994-04-29 | Tramadol enthaltendes Arzneimittel mit verzögerter Wirkstoffabgabe |
DE0729751T Pending DE729751T1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit verzögerter Wirkstoffabgabe |
DE9422335U Expired - Lifetime DE9422335U1 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit kontrollierter Freisetzung |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69427472T Expired - Lifetime DE69427472T3 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
DE0699436T Pending DE699436T1 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435295T Expired - Lifetime DE69435295D1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE69434479T Expired - Lifetime DE69434479T2 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE69400215T Revoked DE69400215T2 (de) | 1993-05-10 | 1994-04-29 | Tramadol enthaltendes Arzneimittel mit verzögerter Wirkstoffabgabe |
DE0729751T Pending DE729751T1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit verzögerter Wirkstoffabgabe |
DE9422335U Expired - Lifetime DE9422335U1 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit kontrollierter Freisetzung |
Country Status (22)
Country | Link |
---|---|
US (6) | US5591452A (de) |
EP (6) | EP0624366B1 (de) |
JP (3) | JP3045924B2 (de) |
CN (2) | CN1094755C (de) |
AT (5) | ATE201989T1 (de) |
AU (2) | AU6196394A (de) |
CA (1) | CA2123160C (de) |
CZ (1) | CZ288517B6 (de) |
DE (8) | DE69427472T3 (de) |
DK (4) | DK1468679T3 (de) |
ES (5) | ES2159591T5 (de) |
FI (3) | FI942092A (de) |
GR (2) | GR3020084T3 (de) |
HU (1) | HU228177B1 (de) |
ID (1) | ID25988A (de) |
IL (3) | IL119660A (de) |
NO (3) | NO306446B1 (de) |
NZ (1) | NZ260408A (de) |
PT (3) | PT1527775E (de) |
SG (1) | SG67347A1 (de) |
SK (2) | SK283143B6 (de) |
TW (1) | TW496736B (de) |
Families Citing this family (198)
Publication number | Priority date | Publication date | Assignee | Title |
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US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5478577A (en) | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
NZ260408A (en) | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol |
DE4329794C2 (de) * | 1993-09-03 | 1997-09-18 | Gruenenthal Gmbh | Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung |
US5891471A (en) | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
KR100354702B1 (ko) | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
US5843480A (en) | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
GB9422154D0 (en) * | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
US5698210A (en) | 1995-03-17 | 1997-12-16 | Lee County Mosquito Control District | Controlled delivery compositions and processes for treating organisms in a column of water or on land |
US5912268A (en) * | 1995-05-22 | 1999-06-15 | Alza Corporation | Dosage form and method for treating incontinence |
US6262115B1 (en) * | 1995-05-22 | 2001-07-17 | Alza Coporation | Method for the management of incontinence |
GB9519363D0 (en) * | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
BR9808325A (pt) * | 1997-03-11 | 2000-05-16 | Darwin Discovery Ltd | Formas de dosagem compreendendo porções separadas de r- e senanciÈmeros |
DE19710008A1 (de) * | 1997-03-12 | 1998-09-17 | Basf Ag | Feste, mindestens zweiphasige Zubereitungsformen eines Opioid-Analgeticums mit verzögerter Freisetzung |
ES2248908T7 (es) | 1997-06-06 | 2014-11-24 | Depomed, Inc. | Formas de dosificación de fármacos por vía oral y retención gástrica para liberación continuada de fármacos altamente solubles |
US6635280B2 (en) | 1997-06-06 | 2003-10-21 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
AU8293498A (en) | 1997-07-02 | 1999-01-25 | Euro-Celtique S.A. | Stabilized sustained release tramadol formulations |
DE19729487A1 (de) * | 1997-07-10 | 1999-01-14 | Dresden Arzneimittel | Verfahren zur Herstellung von Wirkstoff-Zubereitungen mit kontrollierter Freisetzung aus einer Matrix |
JP2001526229A (ja) * | 1997-12-22 | 2001-12-18 | ユーロ−セルティーク,エス.エイ. | オピオイド投薬剤形の乱用を防止する方法 |
HU1500214D0 (hu) | 1997-12-22 | 2002-03-28 | Euro Celtique Sa | Opioid agonista és antagonista hatóanyagot tartalmazó gyógyszerkészítmény |
US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
JP4367722B2 (ja) * | 1998-04-17 | 2009-11-18 | 大正製薬株式会社 | マルチプルユニットタイプ徐放性錠剤 |
AU746084B2 (en) * | 1998-04-17 | 2002-04-11 | Taisho Pharmaceutical Co., Ltd. | Multiple-unit sustained release tablets |
US6156342A (en) * | 1998-05-26 | 2000-12-05 | Andex Pharmaceuticals, Inc. | Controlled release oral dosage form |
US20060128806A1 (en) * | 1998-05-28 | 2006-06-15 | Medical Research Institute | Controlled release arginine alpha-ketoglutarate |
US6264974B1 (en) | 1998-07-07 | 2001-07-24 | Salvagnini Italia Spa | Buccal and sublingual administration of physostigmine |
DE29818454U1 (de) * | 1998-10-15 | 1999-01-14 | Euroceltique S.A., Luxemburg/Luxembourg | Opioid-Analgetikum |
US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
AU3469100A (en) * | 1999-01-05 | 2000-07-24 | Copley Pharmaceutical Inc. | Sustained release formulation with reduced moisture sensitivity |
DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
CA2388560A1 (en) * | 1999-08-31 | 2001-03-08 | Grunenthal Gmbh | Sustained-release form of administration containing tramadol saccharinate |
SK285128B6 (sk) * | 1999-12-28 | 2006-07-07 | Zentiva, A. S. | Liečivý prípravok s riadeným uvoľňovaním obsahujúci tramadol hydrochlorid a spôsob jeho prípravy |
OA12215A (en) | 2000-02-08 | 2006-05-09 | Euro Celtique Sa | Tamper-resistant oral opioid agonist formulations. |
US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
WO2001064202A2 (en) | 2000-03-01 | 2001-09-07 | Euro-Celtique S.A. | Tramadol for the treatment of functional gastrointestinal disorders |
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1994
- 1994-04-27 NZ NZ260408A patent/NZ260408A/en not_active IP Right Cessation
- 1994-04-27 IL IL11966094A patent/IL119660A/en not_active IP Right Cessation
- 1994-04-27 IL IL109460A patent/IL109460A/en not_active IP Right Cessation
- 1994-04-29 AT AT95114527T patent/ATE201989T1/de active
- 1994-04-29 SG SG1996008705A patent/SG67347A1/en unknown
- 1994-04-29 ES ES95114527T patent/ES2159591T5/es not_active Expired - Lifetime
- 1994-04-29 DK DK04014719T patent/DK1468679T3/da active
- 1994-04-29 DK DK04030658.1T patent/DK1527775T3/da active
- 1994-04-29 EP EP94303128A patent/EP0624366B1/de not_active Revoked
- 1994-04-29 ES ES94303128T patent/ES2088312T3/es not_active Expired - Lifetime
- 1994-04-29 DE DE69427472T patent/DE69427472T3/de not_active Expired - Lifetime
- 1994-04-29 PT PT04030658T patent/PT1527775E/pt unknown
- 1994-04-29 DE DE0699436T patent/DE699436T1/de active Pending
- 1994-04-29 PT PT04014719T patent/PT1468679E/pt unknown
- 1994-04-29 DE DE09004973T patent/DE09004973T8/de active Active
- 1994-04-29 DK DK95114527.5T patent/DK0699436T4/da active
- 1994-04-29 EP EP96101147A patent/EP0729751A1/de not_active Ceased
- 1994-04-29 DE DE69435295T patent/DE69435295D1/de not_active Expired - Lifetime
- 1994-04-29 EP EP04030658A patent/EP1527775B1/de not_active Expired - Lifetime
- 1994-04-29 EP EP04014719A patent/EP1468679B1/de not_active Expired - Lifetime
- 1994-04-29 DK DK94303128.6T patent/DK0624366T3/da active
- 1994-04-29 EP EP95114527A patent/EP0699436B2/de not_active Expired - Lifetime
- 1994-04-29 AT AT04030658T patent/ATE468850T1/de active
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- 1994-04-29 DE DE69434479T patent/DE69434479T2/de not_active Expired - Lifetime
- 1994-04-29 PT PT95114527T patent/PT699436E/pt unknown
- 1994-04-29 AT AT94303128T patent/ATE138566T1/de not_active IP Right Cessation
- 1994-04-29 DE DE69400215T patent/DE69400215T2/de not_active Revoked
- 1994-04-29 AT AT04014719T patent/ATE303140T1/de active
- 1994-04-29 DE DE0729751T patent/DE729751T1/de active Pending
- 1994-04-29 EP EP09004973.5A patent/EP2103303B1/de not_active Expired - Lifetime
- 1994-04-29 ES ES09004973T patent/ES2331046T1/es active Pending
- 1994-04-29 ES ES04030658T patent/ES2346651T3/es not_active Expired - Lifetime
- 1994-04-29 DE DE9422335U patent/DE9422335U1/de not_active Expired - Lifetime
- 1994-05-04 CZ CZ19941093A patent/CZ288517B6/cs not_active IP Right Cessation
- 1994-05-06 HU HU9401478A patent/HU228177B1/hu unknown
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- 1994-05-09 NO NO941719A patent/NO306446B1/no not_active IP Right Cessation
- 1994-05-09 CA CA002123160A patent/CA2123160C/en not_active Expired - Lifetime
- 1994-05-09 AU AU61963/94A patent/AU6196394A/en not_active Abandoned
- 1994-05-10 SK SK1437-98A patent/SK283143B6/sk not_active IP Right Cessation
- 1994-05-10 US US08/241,129 patent/US5591452A/en not_active Expired - Lifetime
- 1994-05-10 SK SK541-94A patent/SK279971B6/sk not_active IP Right Cessation
- 1994-05-10 ID IDP991104D patent/ID25988A/id unknown
- 1994-05-10 CN CN94105356A patent/CN1094755C/zh not_active Expired - Lifetime
- 1994-05-10 JP JP6096671A patent/JP3045924B2/ja not_active Expired - Lifetime
- 1994-05-12 TW TW085103273A patent/TW496736B/zh not_active IP Right Cessation
-
1995
- 1995-05-24 US US08/449,772 patent/US6326027B1/en not_active Expired - Lifetime
-
1996
- 1996-05-30 GR GR960401422T patent/GR3020084T3/el unknown
- 1996-07-10 US US08/677,798 patent/US6254887B1/en not_active Expired - Lifetime
- 1996-11-20 IL IL11966096A patent/IL119660A0/xx unknown
-
1997
- 1997-10-07 AU AU39957/97A patent/AU3995797A/en not_active Abandoned
-
1998
- 1998-08-14 JP JP22971898A patent/JP3267561B2/ja not_active Expired - Lifetime
-
1999
- 1999-05-17 CN CNB991066421A patent/CN1146410C/zh not_active Expired - Lifetime
- 1999-07-15 NO NO19993484A patent/NO313124B1/no not_active IP Right Cessation
- 1999-11-25 AT AT0081699U patent/AT3413U3/de not_active IP Right Cessation
-
2001
- 2001-03-06 US US09/800,204 patent/US7074430B2/en not_active Expired - Fee Related
- 2001-07-19 NO NO20013566A patent/NO331650B1/no unknown
- 2001-09-06 GR GR20010401419T patent/GR3036565T3/el unknown
- 2001-09-27 JP JP2001297270A patent/JP3443574B2/ja not_active Expired - Lifetime
-
2003
- 2003-04-14 FI FI20030560A patent/FI121565B/fi not_active IP Right Cessation
-
2006
- 2006-05-16 US US11/435,015 patent/US20060269603A1/en not_active Abandoned
-
2008
- 2008-05-14 US US12/152,474 patent/US20090117191A1/en not_active Abandoned
-
2010
- 2010-08-17 FI FI20105856A patent/FI122717B/fi not_active IP Right Cessation
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