CA2389767C - Quinazoline derivatives as vegf inhibitors - Google Patents
Quinazoline derivatives as vegf inhibitors Download PDFInfo
- Publication number
- CA2389767C CA2389767C CA2389767A CA2389767A CA2389767C CA 2389767 C CA2389767 C CA 2389767C CA 2389767 A CA2389767 A CA 2389767A CA 2389767 A CA2389767 A CA 2389767A CA 2389767 C CA2389767 C CA 2389767C
- Authority
- CA
- Canada
- Prior art keywords
- quinazoline
- ylmethoxy
- methoxy
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 239000002525 vasculotropin inhibitor Substances 0.000 title description 2
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- 125000001424 substituent group Chemical group 0.000 claims abstract description 17
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 3
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99402759.7 | 1999-11-05 | ||
| EP99402759 | 1999-11-05 | ||
| EP99402877 | 1999-11-19 | ||
| EP99402877.7 | 1999-11-19 | ||
| PCT/GB2000/004181 WO2001032651A1 (en) | 1999-11-05 | 2000-11-01 | Quinazoline derivatives as vegf inhibitors |
Publications (2)
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|---|---|
| CA2389767A1 CA2389767A1 (en) | 2001-05-10 |
| CA2389767C true CA2389767C (en) | 2010-03-23 |
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|---|---|---|---|
| CA2389767A Expired - Lifetime CA2389767C (en) | 1999-11-05 | 2000-11-01 | Quinazoline derivatives as vegf inhibitors |
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| GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| DE60039206D1 (de) | 1999-11-05 | 2008-07-24 | Astrazeneca Ab | Neue Quinazolin-Derivate |
| GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| BR0109828A (pt) | 2000-04-07 | 2002-12-17 | Astrazeneca Ab | Composto, processo para a prepapação do mesmo ou de um sal deste, composição farmacêutica, uso do composto ou de um sal deste farmaceuticamente aceitável, e, método para a produção de um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente em necessidade de tal tratamento |
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| WO2003063904A2 (en) * | 2002-01-29 | 2003-08-07 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Tissue adhesion formation control |
| ES2381781T3 (es) | 2002-02-01 | 2012-05-31 | Astrazeneca Ab | Compuestos de quinazolina |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| ES2400339T3 (es) | 2002-07-15 | 2013-04-09 | Symphony Evolution, Inc. | Compuestos, composiciones farmacéuticas de los mismos y su uso en el tratamiento del cáncer |
| AU2003249000B2 (en) * | 2002-08-09 | 2007-04-05 | Astrazeneca Ab | Combination of ZD6474, an inhibitor of the vasuclar endothelial growth factor receptor, with radiotherapy in the treatment of cancer |
| DE10237423A1 (de) | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
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| DK1562955T3 (da) | 2002-11-04 | 2008-06-02 | Astrazeneca Ab | Quinazolinderivater som Src-tyrosinkinaseinhibitorer |
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| CA2531862C (en) * | 2003-07-10 | 2011-10-25 | Astrazenca Ab | Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
| GB0316176D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
| EP2341067A1 (en) | 2003-07-18 | 2011-07-06 | Amgen, Inc | Specific binding agents to hepatocyte growth factor |
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| US20080119479A1 (en) * | 2004-04-01 | 2008-05-22 | Stephen Robert Wedge | Combination Comprising Zd6474 And Imatinib |
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| EP1765313A2 (en) * | 2004-06-24 | 2007-03-28 | Novartis Vaccines and Diagnostics, Inc. | Compounds for immunopotentiation |
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| MX2007006230A (es) | 2004-11-30 | 2007-07-25 | Amgen Inc | Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer. |
| WO2006068953A2 (en) | 2004-12-21 | 2006-06-29 | Astrazeneca Ab | Antibodies directed to angiopoietin-2 and uses thereof |
| CN1854130B (zh) * | 2005-04-15 | 2011-04-20 | 中国医学科学院药物研究所 | 喹唑啉衍生物、及其制法和药物组合物与用途 |
| EP2361905B1 (en) | 2005-05-18 | 2013-03-06 | Array Biopharma Inc. | Heterocyclic Inhibitors of MEK and methods of use thereof |
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| AU2011203358B2 (en) * | 2005-09-30 | 2013-05-30 | Genzyme Corporation | Chemical process |
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