UA85871C2 - Інгібітори дипептидилпептидази - Google Patents
Інгібітори дипептидилпептидази Download PDFInfo
- Publication number
- UA85871C2 UA85871C2 UAA200610844A UAA200610844A UA85871C2 UA 85871 C2 UA85871 C2 UA 85871C2 UA A200610844 A UAA200610844 A UA A200610844A UA A200610844 A UAA200610844 A UA A200610844A UA 85871 C2 UA85871 C2 UA 85871C2
- Authority
- UA
- Ukraine
- Prior art keywords
- alkyl
- group
- phenyl
- compound
- substituted
- Prior art date
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- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 title description 6
- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 title description 6
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 abstract description 298
- 238000000034 method Methods 0.000 abstract description 90
- 102000035195 Peptidases Human genes 0.000 abstract description 10
- 108091005804 Peptidases Proteins 0.000 abstract description 10
- 239000004365 Protease Substances 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 6
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 abstract 1
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 description 479
- -1 unsaturated aliphatic radical Chemical class 0.000 description 265
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 158
- 239000000203 mixture Substances 0.000 description 142
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 130
- 125000001072 heteroaryl group Chemical group 0.000 description 130
- 125000003118 aryl group Chemical group 0.000 description 127
- 125000000753 cycloalkyl group Chemical group 0.000 description 123
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 120
- 125000005842 heteroatom Chemical group 0.000 description 110
- 125000001841 imino group Chemical group [H]N=* 0.000 description 89
- 239000003112 inhibitor Substances 0.000 description 89
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 88
- 125000003545 alkoxy group Chemical group 0.000 description 74
- 125000004104 aryloxy group Chemical group 0.000 description 71
- 125000005553 heteroaryloxy group Chemical group 0.000 description 71
- 239000001257 hydrogen Substances 0.000 description 64
- 229910052739 hydrogen Inorganic materials 0.000 description 64
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 62
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 60
- 235000002639 sodium chloride Nutrition 0.000 description 58
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 57
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 56
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 51
- 229910052757 nitrogen Inorganic materials 0.000 description 49
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 48
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- 125000003710 aryl alkyl group Chemical group 0.000 description 46
- 229910052736 halogen Inorganic materials 0.000 description 45
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- 239000000243 solution Substances 0.000 description 43
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 42
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- 125000004093 cyano group Chemical group *C#N 0.000 description 30
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- 125000000304 alkynyl group Chemical group 0.000 description 23
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 23
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 22
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 22
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 22
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 10
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- AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 description 9
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US55357104P | 2004-03-15 | 2004-03-15 | |
US62952404P | 2004-11-18 | 2004-11-18 | |
PCT/US2004/042209 WO2005095381A1 (en) | 2004-03-15 | 2004-12-15 | Dipeptidyl peptidase inhibitors |
Publications (1)
Publication Number | Publication Date |
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UA85871C2 true UA85871C2 (uk) | 2009-03-10 |
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UAA200610844A UA85871C2 (uk) | 2004-03-15 | 2004-12-15 | Інгібітори дипептидилпептидази |
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EP1608317B1 (en) | 2003-03-25 | 2012-09-26 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7470700B2 (en) | 2003-08-13 | 2008-12-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
JP2007505121A (ja) | 2003-09-08 | 2007-03-08 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
WO2005030751A2 (en) * | 2003-09-08 | 2005-04-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
AU2004318013B8 (en) * | 2004-03-15 | 2011-10-06 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7931661B2 (en) * | 2004-06-14 | 2011-04-26 | Usgi Medical, Inc. | Apparatus and methods for performing transluminal gastrointestinal procedures |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
JP2008524331A (ja) | 2004-12-21 | 2008-07-10 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
CA2622472C (en) * | 2005-09-14 | 2013-11-19 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
US20070060528A1 (en) * | 2005-09-14 | 2007-03-15 | Christopher Ronald J | Administration of dipeptidyl peptidase inhibitors |
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CN101360723A (zh) | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | 制备嘧啶二酮衍生物的方法 |
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UA95789C2 (ru) * | 2005-12-28 | 2011-09-12 | Такеда Фармасьютикал Компани Лимитед | Средство для защиты поджелудочной железы и его применение |
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EA200802054A1 (ru) | 2006-04-12 | 2009-04-28 | Пробиодруг Аг | Ингибиторы фермента |
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