PT3853234T - Derivados de anéis tricíclicos fundidos como inibidores da fosfatase de homologia com src-2 - Google Patents

Derivados de anéis tricíclicos fundidos como inibidores da fosfatase de homologia com src-2

Info

Publication number
PT3853234T
PT3853234T PT197796873T PT19779687T PT3853234T PT 3853234 T PT3853234 T PT 3853234T PT 197796873 T PT197796873 T PT 197796873T PT 19779687 T PT19779687 T PT 19779687T PT 3853234 T PT3853234 T PT 3853234T
Authority
PT
Portugal
Prior art keywords
tricyclic ring
phosphatase inhibitors
src homology
fused tricyclic
ring derivatives
Prior art date
Application number
PT197796873T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Nikang Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikang Therapeutics Inc filed Critical Nikang Therapeutics Inc
Publication of PT3853234T publication Critical patent/PT3853234T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT197796873T 2018-09-18 2019-09-17 Derivados de anéis tricíclicos fundidos como inibidores da fosfatase de homologia com src-2 PT3853234T (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862733061P 2018-09-18 2018-09-18
US201862749655P 2018-10-23 2018-10-23
US201962810911P 2019-02-26 2019-02-26
US201962883121P 2019-08-06 2019-08-06
US201962883120P 2019-08-06 2019-08-06

Publications (1)

Publication Number Publication Date
PT3853234T true PT3853234T (pt) 2025-07-29

Family

ID=68084982

Family Applications (1)

Application Number Title Priority Date Filing Date
PT197796873T PT3853234T (pt) 2018-09-18 2019-09-17 Derivados de anéis tricíclicos fundidos como inibidores da fosfatase de homologia com src-2

Country Status (22)

Country Link
US (6) US11459340B2 (https=)
EP (2) EP3853233A1 (https=)
JP (2) JP7542538B2 (https=)
KR (2) KR102834408B1 (https=)
CN (2) CN112996795B (https=)
AU (2) AU2019344899B2 (https=)
BR (1) BR112021005082A2 (https=)
CA (2) CA3113233A1 (https=)
CL (1) CL2021000628A1 (https=)
CO (1) CO2021004436A2 (https=)
CR (1) CR20210175A (https=)
DK (1) DK3853234T3 (https=)
ES (1) ES3036496T3 (https=)
FI (1) FI3853234T3 (https=)
MX (1) MX2021003158A (https=)
PH (1) PH12021550604A1 (https=)
PL (1) PL3853234T3 (https=)
PT (1) PT3853234T (https=)
SA (1) SA521421505B1 (https=)
SG (1) SG11202102679QA (https=)
TW (1) TWI827677B (https=)
WO (2) WO2020061103A1 (https=)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102598895B1 (ko) 2016-07-12 2023-11-07 레볼루션 메디슨즈, 인크. 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진
US11529347B2 (en) 2016-09-22 2022-12-20 Relay Therapeutics, Inc. SHP2 phosphatase inhibitors and methods of use thereof
TW202500565A (zh) 2016-10-24 2025-01-01 美商傳達治療有限公司 Shp2磷酸酶抑制劑及其使用方法
MX2019008695A (es) 2017-01-23 2019-09-11 Revolution Medicines Inc Compuestos biciclicos como inhibidores alostericos de shp2.
MX2019008696A (es) 2017-01-23 2019-09-13 Revolution Medicines Inc Compuestos de piridina como inhibidores de shp2 alostericos.
WO2018218133A1 (en) 2017-05-26 2018-11-29 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
EP3687997A1 (en) 2017-09-29 2020-08-05 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
MX2020003579A (es) * 2017-10-12 2020-07-22 Revolution Medicines Inc Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos.
BR112020009757A2 (pt) 2017-12-15 2020-11-03 Revolution Medicines, Inc. compostos policíclicos como inibidores alostéricos de shp2
SG11202009245TA (en) 2018-03-21 2020-10-29 Relay Therapeutics Inc Shp2 phosphatase inhibitors and methods of use thereof
WO2019183364A1 (en) 2018-03-21 2019-09-26 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof
JP7542538B2 (ja) 2018-09-18 2024-08-30 ニカング セラピューティクス， インコーポレイテッド Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての縮合三環式環誘導体
WO2020072656A1 (en) 2018-10-03 2020-04-09 Gilead Sciences, Inc. Imidozopyrimidine derivatives
CN113365988B (zh) * 2019-01-31 2023-10-03 贝达药业股份有限公司 Shp2抑制剂及其应用
CN114127053B (zh) * 2019-09-06 2023-06-13 四川科伦博泰生物医药股份有限公司 一种取代吡嗪化合物、其制备方法和用途
US20230010886A1 (en) * 2019-09-23 2023-01-12 Suzhou Puhe BioPharma Co., Ltd. Shp2 inhibitors and uses thereof
AU2020354475A1 (en) 2019-09-24 2022-05-05 Relay Therapeutics, Inc. SHP2 phosphatase inhibitors and methods of making and using the same
TW202128688A (zh) 2019-11-08 2021-08-01 美商銳新醫藥公司 雙環雜芳基化合物及其用途
EP4076667A1 (en) 2019-12-20 2022-10-26 Erasca, Inc. Tricyclic pyridones and pyrimidones
IL299131A (en) 2020-06-18 2023-02-01 Revolution Medicines Inc Methods for delaying, preventing and treating acquired resistance to RAS inhibitors
EP4169913A4 (en) * 2020-06-22 2024-10-30 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. SUBSTITUTED PYRAZINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
CN116113418A (zh) * 2020-08-25 2023-05-12 四川科伦博泰生物医药股份有限公司 杂环化合物及其制备方法和用途
MX2023002248A (es) 2020-09-03 2023-05-16 Revolution Medicines Inc Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2.
MX2023003060A (es) 2020-09-15 2023-04-05 Revolution Medicines Inc Derivados indolicos como inhibidores de ras en el tratamiento del cancer.
AU2021347232A1 (en) 2020-09-23 2023-04-27 Erasca, Inc. Tricyclic pyridones and pyrimidones
JP2023553532A (ja) * 2020-12-11 2023-12-21 エラスカ，インク． 癌の処置のための併用療法
CN117083283A (zh) * 2020-12-11 2023-11-17 医睿世康药业研发公司 用于癌症治疗的联合疗法
JP2023553533A (ja) * 2020-12-11 2023-12-21 エラスカ，インク． 癌の処置のための併用療法
WO2022125971A1 (en) * 2020-12-11 2022-06-16 Erasca, Inc. Combination therapies for the treatment of cancer
CN117120449A (zh) * 2020-12-11 2023-11-24 医睿世康药业研发公司 用于癌症治疗的联合疗法
CN117098537A (zh) * 2020-12-11 2023-11-21 医睿世康药业研发公司 用于癌症治疗的联合疗法
WO2022133345A1 (en) 2020-12-18 2022-06-23 Erasca, Inc. Tricyclic pyridones and pyrimidones
CA3202424A1 (en) * 2020-12-18 2022-06-23 Genzyme Corporation Process for preparing shp2 inhibitors
CN116848121A (zh) * 2020-12-18 2023-10-03 建新公司 制备shp2抑制剂的方法
CN117083285A (zh) * 2021-03-31 2023-11-17 南京明德新药研发有限公司 一系列含Se的吡嗪类化合物及其应用
CA3217393A1 (en) 2021-05-05 2022-11-10 Elena S. Koltun Ras inhibitors
AU2022268962A1 (en) 2021-05-05 2023-12-14 Revolution Medicines, Inc. Ras inhibitors for the treatment of cancer
WO2022235866A1 (en) 2021-05-05 2022-11-10 Revolution Medicines, Inc. Covalent ras inhibitors and uses thereof
US20240285624A1 (en) * 2021-06-24 2024-08-29 Erasca, Inc. Erk1/2 or shp2 inhibitors and flt3 inhibitors combination therapy
MX2023015298A (es) * 2021-06-24 2024-03-20 Erasca Inc Terapia de combinación de inhibidores de erk1/2 y shp2.
US20240293422A1 (en) * 2021-06-24 2024-09-05 Erasca, Inc. Shp2 and cdk4/6 inhibitors combination therapies for the treatment of cancer
CA3226206A1 (en) * 2021-07-09 2023-01-12 Kanaph Therapeutics Inc. Shp2 inhibitor and use thereof
CA3224341A1 (en) 2021-09-01 2023-03-09 Novartis Ag Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers
WO2023044065A1 (en) * 2021-09-17 2023-03-23 Erasca, Inc. Jak inhibitor with erk1/2 and/or shp2 inhibitors combination therapy
WO2023059771A1 (en) * 2021-10-06 2023-04-13 Erasca, Inc. Uses of tri-substituted heteroaryl derivatives as src homology-2 phosphatase inhibitors
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
CN119136806A (zh) 2022-03-08 2024-12-13 锐新医药公司 用于治疗免疫难治性肺癌的方法
IL316768A (en) 2022-05-25 2025-01-01 Ikena Oncology Inc MEK inhibitors and their uses
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2024042361A1 (en) * 2022-08-24 2024-02-29 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
TW202440128A (zh) * 2023-01-06 2024-10-16 美商艾瑞斯卡公司 Raf抑制劑及erk1/2及/或shp2抑制劑組合療法
EP4687905A1 (en) 2023-03-30 2026-02-11 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
KR20260005904A (ko) 2023-04-07 2026-01-12 레볼루션 메디슨즈, 인크. 매크로사이클릭 ras 억제제
CN121263418A (zh) 2023-04-07 2026-01-02 锐新医药公司 大环ras抑制剂
KR20250172857A (ko) 2023-04-14 2025-12-09 레볼루션 메디슨즈, 인크. Ras 억제제의 결정형
AU2024252105A1 (en) 2023-04-14 2025-10-16 Revolution Medicines, Inc. Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

Family Cites Families (385)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041077B2 (ja) 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
US4261989A (en) 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
JPS62135830A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料及びその処理方法
JPS62135835A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62135834A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62135832A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62136654A (ja) 1985-12-10 1987-06-19 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料の処理方法
JPS62136651A (ja) 1985-12-10 1987-06-19 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料の処理方法
JPS62136650A (ja) 1985-12-11 1987-06-19 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料及びその処理方法
JPS62206545A (ja) 1986-03-07 1987-09-11 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
GB8729614D0 (en) 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
US5266573A (en) 1989-08-07 1993-11-30 Elf Sanofi Trifluoromethylphenyltetrahydropyridines for the treatment and/or prophylaxis of intestinal motility disorders
US5360459A (en) 1991-05-13 1994-11-01 The Lubrizol Corporation Copper-containing organometallic complexes and concentrates and diesel fuels containing same
JPH05196976A (ja) 1991-11-18 1993-08-06 Toshiba Corp 有機非線形光学材料
JPH05181221A (ja) 1991-12-27 1993-07-23 Konica Corp ハロゲン化銀写真感光材料
GB9201755D0 (en) 1992-01-28 1992-03-11 British Bio Technology Compounds
FR2687932A1 (fr) 1992-02-27 1993-09-03 Oreal Dispersion huile-dans-l'eau susceptible de former des films composites.
EP0647450A1 (en) 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
AU3785597A (en) 1996-08-14 1998-03-06 Takeda Chemical Industries Ltd. Cyclic urea compounds, their production and use as herbicides
US5977134A (en) 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6117973A (en) 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
FR2761687B1 (fr) 1997-04-08 2000-09-15 Centre Nat Rech Scient Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques
JP2000072695A (ja) 1998-08-24 2000-03-07 Sumitomo Pharmaceut Co Ltd 環状化合物
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
ES2252004T3 (es) 1999-05-21 2006-05-16 Biovitrum Ab Nuevos compuestos, su uso y preparacion.
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US6699873B1 (en) 1999-08-04 2004-03-02 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
MXPA02001160A (es) 1999-08-04 2002-07-02 Millennium Pharm Inc Compuestos que se unen a los receptores para melanocortina-4, y metodo de uso de estos.
US6514964B1 (en) 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
ES2252063T3 (es) 1999-09-28 2006-05-16 Eisai Co., Ltd. Compuesto de quinuclidina y medicamento que comprende el compuesto como principio activo.
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
JP4548761B2 (ja) 2000-06-15 2010-09-22 富士フイルムホールディングス株式会社 潤滑剤組成物
WO2002000651A2 (en) 2000-06-27 2002-01-03 Bristol-Myers Squibb Pharma Company Factor xa inhibitors
DE10032633A1 (de) 2000-07-05 2002-01-17 Bayer Ag Verfahren zum Auffinden von Hemmstoffen der Protoporphyrinogen-Oxidase
JP2002122954A (ja) 2000-08-08 2002-04-26 Fuji Photo Film Co Ltd 感光性ハロゲン化銀写真乳剤、これを含有するハロゲン化銀写真感光材料および感光性ハロゲン化銀写真乳剤の感度向上方法
AU2001279955A1 (en) 2000-08-18 2002-03-04 Sterix Limited 2-substituted estradiol derivative for inhibiting superoxid dismutase
US6963001B2 (en) 2000-09-30 2005-11-08 Henkel Corporation Low shrinkage thermosetting resin compositions and methods of use therefor
WO2002028813A1 (en) 2000-09-30 2002-04-11 Loctite Low shrinkage thermosetting resin compositions and methods of use therefor
EP1578341A2 (en) 2000-10-11 2005-09-28 Tularik Inc. Modulation of ccr4 function
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
NZ535574A (en) 2001-01-16 2006-07-28 Astrazeneca Ab Therapeutic heterocyclic compounds
CN1592745A (zh) 2001-01-16 2005-03-09 阿斯特拉曾尼卡有限公司 治疗用苯并－γ－吡喃酮化合物
SE0103646D0 (sv) 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic chroman compounds
JP3616628B2 (ja) 2001-03-01 2005-02-02 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物
RU2003132706A (ru) 2001-04-06 2005-04-20 Байокрист Фармасьютикалз, Инк. (Us) Диариловые соединения в качестве ингибиторов сериновых протеаз
WO2003003008A1 (en) 2001-06-29 2003-01-09 7Tm Pharma A/S Chemical libraries useful for drug discovery processes
WO2003003009A1 (en) 2001-06-29 2003-01-09 7Tm Pharma A/S Use of metal-ion chelates in validating biological molecules as drug targets in test animal models
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
FR2831536A1 (fr) 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
US6897208B2 (en) 2001-10-26 2005-05-24 Aventis Pharmaceuticals Inc. Benzimidazoles
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
JP4547911B2 (ja) 2002-02-01 2010-09-22 アリアド・ファーマシューティカルズ・インコーポレイテッド リン含有化合物およびその用途
US7375134B2 (en) 2002-03-05 2008-05-20 Axys Pharmaceuticals, Inc. Cathepsin cysteine protease inhibitors
AU2003218629A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond uponreaction
TWI275390B (en) 2002-04-30 2007-03-11 Wyeth Corp Process for the preparation of 7-substituted-3- quinolinecarbonitriles
US7183313B2 (en) 2002-08-23 2007-02-27 University Of Connecticut Keto cannabinoids with therapeutic indications
US7071355B2 (en) 2002-12-23 2006-07-04 4 Sc Ag Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
WO2004080966A1 (ja) 2003-03-14 2004-09-23 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
GB0306430D0 (en) 2003-03-20 2003-04-23 Bp Chem Int Ltd Polymerisation and oligomerisation catalysts
JP4847868B2 (ja) 2003-05-14 2011-12-28 ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド 化合物、及び、アミロイドベータの調節におけるその使用
WO2004101529A1 (ja) 2003-05-19 2004-11-25 Ono Pharmaceutical Co., Ltd. 含窒素複素環化合物およびその医薬用途
US7399865B2 (en) 2003-09-15 2008-07-15 Wyeth Protein tyrosine kinase enzyme inhibitors
JP4231379B2 (ja) 2003-10-15 2009-02-25 富士フイルム株式会社 潤滑剤組成物
JP2005170939A (ja) 2003-11-20 2005-06-30 Takeda Chem Ind Ltd 糖尿病の予防・治療剤
DE10355066A1 (de) 2003-11-25 2005-06-23 Basf Ag Verfahren zur asymmetrischen Synthese
US7632946B2 (en) 2004-02-06 2009-12-15 Abbott Laboratories Naphthyridine-based antibacterial compositions
JP2005263787A (ja) 2004-02-17 2005-09-29 Ishihara Sangyo Kaisha Ltd アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
WO2005099688A2 (en) 2004-04-07 2005-10-27 Takeda Pharmaceutical Company Limited Cyclic compounds
EP1595888A1 (en) 2004-05-11 2005-11-16 Degussa AG Cycloolefin phosphine ligands and their use in catalysis
GB0412467D0 (en) 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
EP1760071A4 (en) 2004-06-23 2008-03-05 Ono Pharmaceutical Co COMPOUND WITH S1P RECEPTOR BINDING ABILITY AND USE THEREOF
GB0415879D0 (en) 2004-07-15 2004-08-18 Bp Chem Int Ltd Polymerisation catalyst
GB0418022D0 (en) 2004-08-12 2004-09-15 Bp Chem Int Ltd Polymerisation and oligomerisation catalyst
DK1789390T3 (da) 2004-09-02 2012-02-27 Genentech Inc Pyridyl-inhibitorer af hedgehog-signalering
GB0420396D0 (en) 2004-09-14 2004-10-13 Bp Chem Int Ltd Polyolefins
WO2006038594A1 (ja) 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
GB2436261B (en) 2004-12-11 2010-06-09 Merck Patent Gmbh Liquid crystal compounds,liquid crystal medium and liquid crystal display
JP2008527030A (ja) 2005-01-19 2008-07-24 バイオリポックス エービー 炎症の治療に有用なインドール類
JP4749000B2 (ja) 2005-02-22 2011-08-17 富士フイルム株式会社 グリース組成物
US20070135437A1 (en) 2005-03-04 2007-06-14 Alsgen, Inc. Modulation of neurodegenerative diseases
DE602006016928D1 (de) 2005-03-15 2010-10-28 Fujifilm Corp Oberflächenbehandlungsverfahren unter verwendung einer scheibenartigen verbindung, (schmier)zusammensetzung zur oberflächenbehandlung und oberflächenbehandelter gegenstand
US20060156481A1 (en) 2005-03-22 2006-07-20 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
EP1863774A4 (en) 2005-03-31 2009-07-15 Third Order Nanotechnologies I HETEROCYCLIC CHROMOPHORARY ARCHITECTURES WITH NEW ELECTRONIC ACCEPTOR SYSTEMS
US8796280B2 (en) 2005-04-21 2014-08-05 Merck Serono, S.A. 2,3-disubstituted pyrazinesulfonamides as CRTH2 inhibitors
JP5033119B2 (ja) 2005-04-25 2012-09-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング キナーゼ阻害剤としての新規アザ複素環化合物
WO2006119800A1 (en) 2005-05-09 2006-11-16 Technische Universität Braunschweig Light emitting compound for electroluminescent applications
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
AR056867A1 (es) 2005-06-27 2007-10-31 Bristol Myers Squibb Co Antagonistas heterociclicos n- enlazados del receptor de p2y1 utiles en el tratamiento de condiciones tromboticas. composiciones farmaceuticas.
EP1899299B1 (en) 2005-06-27 2010-10-20 Bristol-Myers Squibb Company C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
WO2007011721A1 (en) 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
WO2007011759A2 (en) 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
JP2007056213A (ja) 2005-08-26 2007-03-08 Fujifilm Corp 焼結含油軸受油用組成物、並びにそれを用いた軸受け装置及び摺動部材
PE20110285A1 (es) 2005-10-19 2011-06-04 Gruenenthal Chemie Derivados de sulfonamidofenil propionamida como ligandos del receptor vaniloide del subtipo 1
FR2892859B1 (fr) 2005-10-27 2008-06-06 Commissariat Energie Atomique Procede de greffage de molecules d'interet sur des surfaces inorganiques, surfaces obtenues et applications
WO2007062222A2 (en) 2005-11-22 2007-05-31 University Of South Florida Inhibition of cell proliferation
WO2007064869A2 (en) 2005-12-01 2007-06-07 Yale University Catalysts for aryl sulfide synthesis and method of producing aryl sulfides
JP2008007634A (ja) 2006-06-29 2008-01-17 Fujifilm Corp 潤滑剤組成物
JP2010501570A (ja) 2006-08-23 2010-01-21 エックスティーエル バイオファーマシューティカルズ リミテッド ４−チオ置換キノリンおよびナフチリジン化合物
WO2008028553A1 (en) 2006-09-02 2008-03-13 Merck Patent Gmbh Particle beam process for the alignment of reactive mesogens
WO2008118626A2 (en) 2007-03-08 2008-10-02 Burnham Institute For Medical Research Inhibitors of jnk and methods for identifying inhibitors of jnk
US7956020B2 (en) 2007-03-29 2011-06-07 Fujifilm Corporation Lubricant composition, mechanical element, and method for producing triazine derivatives
WO2008125811A1 (en) 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
JP5539864B2 (ja) 2007-06-12 2014-07-02 アカオゲン，インコーポレーテッド 抗菌剤
US8063165B2 (en) 2007-06-18 2011-11-22 Bridgestone Corporation Functional polymers prepared with sulfur-containing initiators
JP2009013314A (ja) 2007-07-06 2009-01-22 Toyo Ink Mfg Co Ltd 光硬化型インキ
KR101558193B1 (ko) 2007-08-21 2015-10-12 세노믹스, 인코포레이티드 인간 ｔ2ｒ 쓴맛 수용체 및 이의 용도
US8143276B2 (en) 2007-08-22 2012-03-27 Xtl Biopharmaceuticals Ltd. 4-thio substituted quinoline and naphthyridine compounds
US8907091B2 (en) 2007-08-29 2014-12-09 Methylgene Inc. Processes and intermediates for preparing fused heterocyclic kinase inhibitors
WO2009030318A1 (de) 2007-08-29 2009-03-12 Merck Patent Gmbh Flüssigkristallanzeige
AU2008298948B2 (en) 2007-09-12 2014-09-04 F. Hoffmann-La Roche Ag Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
US9340506B2 (en) 2007-10-08 2016-05-17 Advinus Therapeutics Limited Acetamide derivatives as glucokinase activators, their process and medicinal applications
US8501955B2 (en) 2007-10-08 2013-08-06 Advinus Therapeutics Private Limited Acetamide derivatives as glucokinase activators, their process and medicinal application
US8354528B2 (en) 2007-10-25 2013-01-15 Genentech, Inc. Process for making thienopyrimidine compounds
BRPI0817897A2 (pt) 2007-11-02 2019-09-24 Methylgene Inc composto, composição, e, métodos de inibição da atividade hdac, e de tratamento de uma doença responsiva a um inibidor de atividade hdac
US8304553B2 (en) 2007-12-19 2012-11-06 Nanyang Technological University Method of forming oseltamivir and derivatives thereof
EP2098226A1 (de) 2008-03-06 2009-09-09 Forschungsverbund Berlin e.V. AKAP-PKA-Interaktionshemmer zur Anwendung in der Behandlung von Herzkrankheiten
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
US8168784B2 (en) 2008-06-20 2012-05-01 Abbott Laboratories Processes to make apoptosis promoters
WO2010011666A2 (en) 2008-07-21 2010-01-28 University Of South Florida Indoline scaffold shp-2 inhibitors and cancer treatment method
KR101612577B1 (ko) 2008-07-28 2016-04-14 메르크 파텐트 게엠베하 액정 디스플레이
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
EP2361290B1 (de) 2008-12-22 2013-05-22 Merck Patent GmbH Flüssigkristallanzeige
WO2010075273A1 (en) 2008-12-23 2010-07-01 Schering Corporation Bicyclic heterocycle derivatives and methods of use thereof
DE102010006691A1 (de) 2009-02-06 2010-10-28 Merck Patent Gmbh Flüssigkristallines Medium und Flüssigkristallanzeige
US20120077959A1 (en) 2009-02-16 2012-03-29 Zhang X Peter Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate
WO2010096777A1 (en) 2009-02-23 2010-08-26 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
JP2010217692A (ja) 2009-03-18 2010-09-30 Konica Minolta Holdings Inc 表示素子
US8815918B2 (en) 2009-04-02 2014-08-26 Centro Nacional De Investigaciones Oncologicas (Cnio) Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives
WO2010115098A2 (en) 2009-04-03 2010-10-07 The Scripps Research Institute Palladium-catalyzed ortho-fluorination
DE102010012900A1 (de) 2009-04-23 2010-11-25 Merck Patent Gmbh Flüssigkristallanzeige
KR101705158B1 (ko) 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ 억제제 및 질환 치료방법
WO2011005355A1 (en) 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
US20120245158A1 (en) 2009-06-16 2012-09-27 Xianhai Huang Gamma secretase modulators
EP2443118A1 (en) 2009-06-16 2012-04-25 Schering Corporation Gamma secretase modulators
WO2010147969A2 (en) 2009-06-16 2010-12-23 Schering Corporation Gamma secretase modulators
CA2937222C (en) 2009-06-25 2019-06-04 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
WO2010148422A1 (en) 2009-06-25 2010-12-29 Walter And Eliza Hall Institute Of Medical Research Compounds and methods for treating parasitic infestations
US20120149663A1 (en) 2009-08-18 2012-06-14 Georgetown University Boronic acid compositions and methods related to cancer
CA2772790C (en) 2009-09-04 2017-06-27 Benjamin Bader Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors
EP2292720A1 (en) 2009-09-08 2011-03-09 Merck Patent GmbH Liquid-crystal display
US8877930B2 (en) 2009-11-04 2014-11-04 Massachusetts Institute Of Technology Continuous flow synthesis of amino alcohols using microreactors
KR20110088098A (ko) 2010-01-28 2011-08-03 다우어드밴스드디스플레이머티리얼 유한회사 신규한 유기 발광 화합물 및 이를 채용하고 있는 유기 전계 발광 소자
PH12012501662A1 (en) 2010-02-18 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Triazolo [4,5 - b] pyridin derivatives
MX2012010115A (es) 2010-03-01 2013-02-26 Gtx Inc Compuestos para el tratamiento de cancer.
KR20110101444A (ko) 2010-03-08 2011-09-16 다우어드밴스드디스플레이머티리얼 유한회사 신규한 유기 발광 화합물 및 이를 포함하는 유기 발광 소자
KR20110104765A (ko) 2010-03-17 2011-09-23 다우어드밴스드디스플레이머티리얼 유한회사 신규한 유기 발광 화합물 및 이를 채용하고 있는 유기 전계 발광 소자
WO2011133871A2 (en) 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. 5'-end derivatives
US8598164B2 (en) 2010-05-06 2013-12-03 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
NZ603789A (en) 2010-05-26 2015-03-27 Sunovion Pharmaceuticals Inc Heteroaryl compounds and methods of use thereof
SG186085A1 (en) 2010-06-03 2013-01-30 Alnylam Pharmaceuticals Inc Biodegradable lipids for the delivery of active agents
WO2012016133A2 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
BR112013002112B1 (pt) 2010-07-29 2021-04-06 Rigel Pharmaceuticals, Inc. Composto, composição farmacêutica, e, uso de um composto, ou de um respectivo sal farmaceuticamente aceitável, ou de uma composição
WO2012016188A2 (en) 2010-07-30 2012-02-02 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
WO2012020357A1 (en) 2010-08-09 2012-02-16 Advinus Therapeutics Ltd. Acetamide compounds, their process and pharmaceutical application
WO2012020215A1 (en) 2010-08-09 2012-02-16 Centro Nacional De Investigaciones Oncológicas (Cnio) Amino- imidazolothiadiazoles for use as protein or lipid kinase inhibitors
AR082498A1 (es) 2010-08-20 2012-12-12 Gruenenthal Gmbh Derivados ciclicos de carboxamida y urea sustituidos como ligandos del receptor de vainiloide
RU2013121799A (ru) 2010-10-14 2014-11-20 Конинклейке Филипс Электроникс Н.В. Набор для претаргетинга, способ и агенты, применяемые в нем
US9394290B2 (en) 2010-10-21 2016-07-19 Universitaet Des Saarlandes Campus Saarbruecken Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
WO2012056419A1 (en) 2010-10-28 2012-05-03 Basf Se N-heterocyclic carbene complexes, their preparation and use
US20120108819A1 (en) 2010-10-28 2012-05-03 Basf Se N-Heterocyclic Carbene Complexes, Their Preparation And Use
KR20120045905A (ko) 2010-11-01 2012-05-09 한국화학연구원 헤테로고리 축합된 피리도 화합물 및 이의 제조방법
US9090633B2 (en) 2010-11-18 2015-07-28 Kasina Laila Innova Pharmaceuticals Private Limited Substituted 4-(arylamino) selenophenopyrimidine compounds and methods of use thereof
EP2651405A2 (en) 2010-12-14 2013-10-23 Electrophoretics Limited Casein kinase 1 (ck1 ) inhibitors
RU2013133813A (ru) 2010-12-21 2015-01-27 Конинклейке Филипс Электроникс Н.В. Средства для выведения биомолекул из кровотока
WO2012088438A1 (en) 2010-12-22 2012-06-28 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
JP5618815B2 (ja) 2010-12-24 2014-11-05 富士フイルム株式会社 感活性光線性又は感放射線性樹脂組成物、並びに、この組成物を用いた感活性光線性又は感放射線性膜及びパターン形成方法
US8883793B2 (en) 2010-12-29 2014-11-11 Development Center For Biotechnology Tubulin inhibitors and methods of using the same
EP2678050B1 (en) 2011-02-24 2020-10-14 Emory University Noggin blocking compositions for ossification and methods related thereto
CN103502218B (zh) 2011-03-04 2016-08-17 生命科技公司 用于缀合生物分子的化合物和方法
DE102012003796A1 (de) 2011-03-18 2012-09-20 Merck Patent Gmbh Flüssigkristallines Medium
WO2012129562A2 (en) 2011-03-24 2012-09-27 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
GB2503629B (en) 2011-03-29 2019-04-17 Merck Patent Gmbh Liquid-crystalline medium
US20140163229A1 (en) 2011-04-07 2014-06-12 Cornell University Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same
EP2522369A1 (en) 2011-05-09 2012-11-14 Koninklijke Philips Electronics N.V. Pretargeting kit, method and agents used therein
DK2707101T3 (da) 2011-05-12 2019-05-13 Proteostasis Therapeutics Inc Proteostaseregulatorer
JP6215194B2 (ja) 2011-05-16 2017-10-18 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 生体直交型薬物活性化
EP2524918A1 (en) 2011-05-19 2012-11-21 Centro Nacional de Investigaciones Oncológicas (CNIO) Imidazopyrazines derivates as kinase inhibitors
JP5782836B2 (ja) 2011-05-27 2015-09-24 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子材料、有機エレクトロルミネッセンス素子、表示装置、照明装置、並びに化合物
CN103797009B (zh) 2011-06-03 2017-04-26 麻省理工学院 Z‑选择性闭环复分解反应
EP2726532B1 (en) 2011-06-28 2016-05-18 Merck Patent GmbH Indaceno derivatives as organic semiconductors
KR102082361B1 (ko) 2011-07-07 2020-04-14 메르크 파텐트 게엠베하 액정 매질
JP2014532084A (ja) 2011-07-08 2014-12-04 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 共役ポリマー
EP2753605B1 (en) 2011-09-09 2019-03-27 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
MX352672B (es) 2011-09-27 2017-12-04 Amgen Inc Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
EP2615083A1 (en) 2012-01-10 2013-07-17 Studiengesellschaft Kohle mbH Process for the asymmetric oxidation of organic compounds with peroxides in the presence of a chiral acid catalyst
JP5814141B2 (ja) 2012-01-23 2015-11-17 ユー・ディー・シー アイルランド リミテッド 合成法、その合成法を用いて合成された化合物および有機電界発光素子
KR102251706B1 (ko) 2012-02-22 2021-05-14 메르크 파텐트 게엠베하 액정 매질
EP2834313A1 (en) 2012-04-03 2015-02-11 3M Innovative Properties Company Crosslinkable composition comprising photobase generators
UA115663C2 (uk) 2012-04-20 2017-12-11 Байєр Кропсайнс Аг (тіо)карбоксамідні похідні n-циклоалкіл-n-[(гетероциклілфеніл)метилену]
FR2992317B1 (fr) 2012-06-22 2016-05-13 Diverchim Procede de preparation de peptides chiraux
US8575283B1 (en) 2012-06-28 2013-11-05 Formosa Plastics Corporation, U.S.A. Heterocyclic organic compounds as electron donors for polyolefin catalysts
WO2014031872A2 (en) 2012-08-23 2014-02-27 The Broad Institute, Inc. Small molecule inhibitors for treating parasitic infections
RS61242B1 (sr) 2012-09-04 2021-01-29 Shanghai hengrui pharmaceutical co ltd Derivati imidazolina, postupci njihove pripreme i njihove primene u medicini
IN2015DN02008A (https=) 2012-09-21 2015-08-14 Advinus Therapeutics Ltd
CN104769465A (zh) 2012-10-29 2015-07-08 柯尼卡美能达株式会社 相位差膜、圆偏振片和图像显示装置
JP2016501284A (ja) 2012-11-16 2016-01-18 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ フルオロポリマーシール適合性向上のためのエポキシ化合物含有潤滑油組成物
AU2013348116A1 (en) * 2012-11-20 2015-06-11 Principia Biopharma Inc. Azaindole derivatives as JAK3 inhibitors
WO2014081300A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Channel protein activatable liposomes
US20150297741A1 (en) 2012-11-22 2015-10-22 Tagworks Pharmaceuticals B.V. Bio-orthogonal drug activation
WO2014081299A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Activatable liposomes
WO2014081303A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Chemically cleavable group
US9580653B2 (en) 2012-12-12 2017-02-28 Merck Patent Gmbh Liquid-crystalline medium
JP6335428B2 (ja) 2012-12-21 2018-05-30 出光興産株式会社 有機エレクトロルミネッセンス素子および電子機器
EP2941469A2 (de) 2013-01-03 2015-11-11 Merck Patent GmbH Materialien für elektronische vorrichtungen
JP6322587B2 (ja) 2013-02-08 2018-05-09 株式会社Ｊｏｌｅｄ 有機エレクトロルミネッセンス素子
WO2014127350A1 (en) 2013-02-18 2014-08-21 The Scripps Research Institute Modulators of vasopressin receptors with therapeutic potential
WO2014134127A1 (en) 2013-02-26 2014-09-04 Northeastern University Cannabinergic nitrate esters and related analogs
US9487472B2 (en) 2013-02-26 2016-11-08 President And Fellows Of Harvard College Synthesis of acyclic and cyclic amines using iron-catalyzed nitrene group transfer
US9963452B2 (en) 2013-03-14 2018-05-08 Augusta Pharmaceuticals Inc. Methods, compounds, and compositions for inhibition of ROS
US9290528B1 (en) 2013-03-15 2016-03-22 University Of Kentucky Research Foundation Light-activated compounds
JP5902641B2 (ja) 2013-03-27 2016-04-13 富士フイルム株式会社 光干渉顔料およびその製造方法
AU2014247953A1 (en) 2013-04-05 2015-11-12 Mitobridge, Inc. PPAR agonists
JP6553022B2 (ja) 2013-04-08 2019-07-31 メルク パテント ゲーエムベーハー 有機エレクトロルミネッセント素子
EP2984692B1 (de) 2013-04-08 2018-01-31 Merck Patent GmbH Organische elektrolumineszenzvorrichtung mit thermisch aktiviertem verzögertem fluoreszenzmaterial
AU2014256984B2 (en) 2013-04-26 2019-02-14 Indiana University Research & Technology Corporation Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)
JP2014232188A (ja) 2013-05-29 2014-12-11 コニカミノルタ株式会社 セルロースアシレートフィルム、円偏光板及び画像表示装置
WO2015003146A1 (en) 2013-07-03 2015-01-08 Georgetown University Boronic acid derivatives of resveratrol for activating deacetylase enzymes
EP3016652A4 (en) 2013-07-03 2017-03-08 Indiana University Research and Technology Corporation Shp2 inhibitors and methods of treating autoimmune and/or glomerulonephritis-associated diseases using shp2 inhibitors
WO2015003137A1 (en) 2013-07-03 2015-01-08 University Of Connecticut Polymerization of diene monomers
GB201312991D0 (en) 2013-07-19 2013-09-04 Isis Innovation Process
TWI648383B (zh) 2013-08-02 2019-01-21 德商馬克專利公司 液晶介質
EP3046924A1 (en) 2013-09-20 2016-07-27 IDENIX Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US20160257657A1 (en) 2013-09-20 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
WO2015048547A2 (en) 2013-09-26 2015-04-02 Rigel Pharmaceuticals, Inc. Methods for using and biomarkers for ampk-activating compounds
KR101628288B1 (ko) 2013-09-30 2016-06-08 주식회사 엘지화학 음성 광학 분산도를 갖는 광학 소자 제조용 조성물 및 이로부터 제조된 광학 이방체
EP2857405A1 (en) 2013-10-01 2015-04-08 Studiengesellschaft Kohle mbH Process for the trans-selective hydroboration of internal alkynes
BR112016008632A8 (pt) 2013-10-21 2020-03-17 Merck Patent Gmbh compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica
JP6088995B2 (ja) 2013-10-24 2017-03-01 出光興産株式会社 有機エレクトロルミネッセンス素子および電子機器
JP6522313B2 (ja) 2013-10-24 2019-05-29 出光興産株式会社 有機エレクトロルミネッセンス素子および電子機器
KR101537860B1 (ko) 2013-11-22 2015-07-20 롯데케미칼 주식회사 내감마선 성능이 향상된 폴리카보네이트 수지 조성물 및 이를 이용한 성형품
JP6215674B2 (ja) 2013-11-29 2017-10-18 出光興産株式会社 有機エレクトロルミネッセンス素子および電子機器
JP6309834B2 (ja) 2013-12-11 2018-04-11 株式会社Adeka 着色性組成物
JP2015163671A (ja) 2013-12-13 2015-09-10 株式会社Adeka ラジカル重合性組成物
US10131841B2 (en) 2013-12-16 2018-11-20 Merck Patent Gmbh Liquid-crystalline medium
US10020455B2 (en) 2014-01-07 2018-07-10 Arizona Board Of Regents On Behalf Of Arizona State University Tetradentate platinum and palladium complex emitters containing phenyl-pyrazole and its analogues
US10087151B2 (en) 2014-01-09 2018-10-02 The J. David Gladstone Institutes, A Testimentary Trust Established Under The Will Of J. David Gladstone Substituted benzoxazine and related compounds
CN105899493B (zh) 2014-01-17 2019-03-29 诺华股份有限公司 用于抑制shp2活性的1-(三嗪-3-基/哒嗪-3-基)-哌(-嗪)啶衍生物及其组合物
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
JP6523303B2 (ja) 2014-01-17 2019-05-29 ノバルティス アーゲー Ｓｈｐ２の活性を阻害するための１−ピリダジン／トリアジン−３−イル−ピペラジン／ピペリジン／ピロリジン誘導体およびその組成物
KR20150091942A (ko) 2014-02-04 2015-08-12 삼성전자주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
JP6313604B2 (ja) 2014-02-05 2018-04-18 富士フイルム株式会社 感活性光線性又は感放射線性樹脂組成物、感活性光線性又は感放射線性膜、感活性光線性又は感放射線性膜を備えたマスクブランクス、パターン形成方法、及び電子デバイスの製造方法
EP3110794A1 (en) 2014-02-27 2017-01-04 Merck Patent GmbH Heterocyclic compounds as nav channel inhibitors and uses thereof
JP2017508798A (ja) 2014-03-07 2017-03-30 ザ ジョンズ ホプキンス ユニバーシティ ヒストンリジン特異的デメチラーゼ（ｌｓｄ１）およびヒストンデアセチラーゼ（ｈｄａｃ）の阻害剤
RS61810B1 (sr) 2014-05-13 2021-06-30 Hoffmann La Roche Deuterisana heterociklična jedinjenja i njihova upotreba kao sredstva za snimanje
EP3142637B1 (en) 2014-05-16 2020-07-29 Olaplex, Inc. Keratin treatment formulations and methods
ES2842592T3 (es) 2014-05-19 2021-07-14 Boehringer Ingelheim Animal Health Usa Inc Compuestos antihelmínticos
WO2015187905A1 (en) 2014-06-05 2015-12-10 Merck Patent Gmbh Novel quinoline derivatives and their use in neurodegenerative diseases
US20170174826A1 (en) 2014-07-16 2017-06-22 Agency For Science, Technology And Research Donor-acceptor polymers
US9818959B2 (en) 2014-07-29 2017-11-14 Arizona Board of Regents on behlaf of Arizona State University Metal-assisted delayed fluorescent emitters containing tridentate ligands
WO2016022645A1 (en) 2014-08-06 2016-02-11 Merck Sharp & Dohme Corp. Heterocyclic cgrp receptor antagonists
EP2985334B1 (en) 2014-08-15 2018-06-20 Merck Patent GmbH Liquid-crystalline medium
EP3188271B1 (en) 2014-08-26 2022-05-04 Idemitsu Kosan Co., Ltd Organic electroluminescent element and electronic device
EP2991153B1 (en) 2014-08-28 2023-08-23 Samsung Electronics Co., Ltd. Composite electrolyte and lithium battery including the same
WO2016049565A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Compositions and methods for inhibition of ras
JP2017537940A (ja) 2014-12-10 2017-12-21 マサチューセッツ インスティテュート オブ テクノロジー 増殖性疾患の処置に有用な融合１，３−アゾール誘導体
KR102384224B1 (ko) 2014-12-30 2022-04-08 삼성전자주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
WO2016145383A1 (en) 2015-03-11 2016-09-15 Board Of Regents, University Of Texas System Mth1 inhibitors for treating disease
KR102434696B1 (ko) 2015-03-13 2022-08-22 삼성전자주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
JP2018513853A (ja) 2015-04-10 2018-05-31 アラクセス ファーマ エルエルシー 置換キナゾリン化合物およびその使用方法
JP6789239B2 (ja) 2015-04-15 2020-11-25 アラクセス ファーマ エルエルシー Ｋｒａｓの縮合三環系インヒビターおよびその使用の方法
KR102114536B1 (ko) 2015-05-07 2020-05-22 브리스톨-마이어스 스큅 컴퍼니 RORγ 조정제로서의 트리시클릭 술폰
US9458308B1 (en) 2015-05-12 2016-10-04 Lotte Chemical Corporation Polycarbonate resin composition with increased gamma-radiation resistant property and molded article using the same
US9879039B2 (en) 2015-06-03 2018-01-30 Arizona Board Of Regents On Behalf Of Arizona State University Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues
ES2741746T3 (es) 2015-06-19 2020-02-12 Novartis Ag Compuestos y composiciones para inhibir la actividad de SHP2
ES2824576T3 (es) * 2015-06-19 2021-05-12 Novartis Ag Compuestos y composiciones para inhibir la actividad de SHP2
CN112625028B (zh) 2015-06-19 2024-10-29 诺华股份有限公司 用于抑制shp2活性的化合物和组合物
FR3037952B1 (fr) 2015-06-24 2019-01-25 Compagnie Generale Des Etablissements Michelin Procede de synthese d'oximes aromatiques
EP3112440B1 (en) 2015-07-02 2019-07-24 Merck Patent GmbH Liquid-crystal medium
MX388781B (es) 2015-07-22 2025-03-20 Araxes Pharma Llc Compuestos de quinazolina sustituido y su uso como inhibidores de proteínas kras, hras y/o nras mutantes g12c.
GB201514015D0 (en) 2015-08-07 2015-09-23 Arnér Elias S J And Dept Of Health And Human Services Novel pyridazinones and their use in the treatment of cancer
GB201514018D0 (en) 2015-08-07 2015-09-23 Arnér Elias S J And United States Of America Asrepresented By The Sec Dep Of Health And Human Servic Novel tricyclic compounds and their use in the treatment of cancer
US10201531B2 (en) 2015-08-12 2019-02-12 Mochida Pharmaceutical Co., Ltd. Indazolyl-oxo-isothiazole compounds
EP3133078B1 (en) 2015-08-18 2019-01-30 Samsung Electronics Co., Ltd. Organometallic compound and organic light-emitting device including the same
KR101796227B1 (ko) 2015-08-21 2017-11-10 삼성디스플레이 주식회사 유기 발광 소자
US10240085B2 (en) 2015-08-27 2019-03-26 Samsung Electronics Co., Ltd. Thin film and organic light-emitting device including the same
KR102542465B1 (ko) 2015-09-22 2023-06-12 삼성전자주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
US10882847B2 (en) 2015-09-28 2021-01-05 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058902A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356354A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
EP3356353A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
WO2017058807A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10647703B2 (en) 2015-09-28 2020-05-12 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058915A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
SE541053C2 (sv) 2015-09-30 2019-03-19 Epiroc Rock Drills Ab System och förfarande för borrplansgenerering, borrigg, datorprogram samt datorprogramprodukt
WO2017066705A1 (en) 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
JP2018533939A (ja) 2015-10-19 2018-11-22 アラクセス ファーマ エルエルシー Ｒａｓの阻害剤をスクリーニングするための方法
EP3162875B1 (en) 2015-10-30 2018-05-23 Merck Patent GmbH Polymerisable compounds and the use thereof in liquid-crystal displays
ES2895904T3 (es) 2015-11-02 2022-02-23 Genase Therapeutics B V Tetrahidroindazoles y usos médicos de los mismos
KR20180081596A (ko) * 2015-11-16 2018-07-16 아락세스 파마 엘엘씨 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
WO2017100546A1 (en) 2015-12-09 2017-06-15 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
KR20170069342A (ko) 2015-12-10 2017-06-21 삼성디스플레이 주식회사 유기 발광 소자
CN106892924B (zh) 2015-12-17 2021-01-08 四川科伦博泰生物医药股份有限公司 短效苯并二氮*衍生物、其制备方法及其用途
KR20170075118A (ko) 2015-12-22 2017-07-03 삼성디스플레이 주식회사 유기 발광 소자
KR102579752B1 (ko) 2015-12-22 2023-09-19 삼성디스플레이 주식회사 유기 발광 소자
US10336772B2 (en) 2015-12-28 2019-07-02 Samsung Electronics Co., Ltd. Bicarbazole compound, material for organic light-emitting device including bicarbazole compound, and organic light-emitting device including bicarbazole compound
KR102419178B1 (ko) 2015-12-29 2022-07-11 삼성디스플레이 주식회사 유기 발광 소자
KR102396293B1 (ko) 2015-12-29 2022-05-11 삼성디스플레이 주식회사 유기 발광 소자
WO2017117239A1 (en) 2015-12-30 2017-07-06 Flatley Discovery Lab, Llc Compounds and methods for the treatment of cystic fibrosis
EP3190164B1 (en) 2016-01-05 2019-07-24 Samsung Electronics Co., Ltd Composition, thin film including the composition, and organic light-emitting device including the composition or the thin film
KR102633852B1 (ko) 2016-01-25 2024-02-07 삼성디스플레이 주식회사 카바졸계 화합물 및 이를 포함한 유기 발광 소자
EP3414216B1 (en) 2016-02-08 2020-10-21 AAA Chemistry ApS Arylation of aliphatic amines
KR102628850B1 (ko) 2016-03-07 2024-01-25 삼성디스플레이 주식회사 축합환 화합물 및 이를 포함한 유기 발광 소자
US11179710B2 (en) 2016-03-09 2021-11-23 President And Fellows Of Harvard College Direct palladium-catalyzed aromatic fluorination
CN109152784B (zh) 2016-03-16 2021-12-28 库拉肿瘤学公司 经取代的menin-mll抑制剂及使用方法
WO2017172979A1 (en) 2016-03-30 2017-10-05 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
WO2017170263A1 (ja) 2016-03-31 2017-10-05 株式会社Ｄｎｐファインケミカル 感光性着色樹脂組成物、カラーフィルタ及びその製造方法、並びに表示装置
KR102606277B1 (ko) 2016-04-06 2023-11-27 삼성디스플레이 주식회사 유기 발광 소자
KR102642199B1 (ko) 2016-04-07 2024-03-05 삼성디스플레이 주식회사 유기 발광 소자
JP7039489B2 (ja) 2016-05-18 2022-03-22 ミラティ セラピューティクス， インコーポレイテッド Ｋｒａｓ ｇ１２ｃ阻害剤
AU2017274199B2 (en) 2016-05-31 2021-09-23 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of PTPN11
EA202092441A1 (ru) * 2016-06-07 2021-05-21 Джакобио Фармасьютикалс Ко., Лтд. Новые гетероциклические производные, применимые в качестве ингибиторов shp2
KR102666178B1 (ko) 2016-06-07 2024-05-14 삼성디스플레이 주식회사 유기 발광 소자
MX383856B (es) 2016-06-14 2025-03-14 Novartis Ag Compuestos y composiciones para inhibir la actividad de shp2.
TW201805000A (zh) 2016-06-20 2018-02-16 庫拉腫瘤技術股份有限公司 利用erk抑制劑之鱗狀細胞癌之治療
US20180002604A1 (en) 2016-06-30 2018-01-04 Merck Patent Gmbh Liquid-crystalline medium
KR102598895B1 (ko) * 2016-07-12 2023-11-07 레볼루션 메디슨즈, 인크. 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진
WO2018027892A1 (en) 2016-08-12 2018-02-15 Eli Lilly And Company Amino pyrimidine ssao inhibitors
US11299673B2 (en) 2016-08-12 2022-04-12 Merck Patent Gmbh Liquid-crystal medium
KR102721990B1 (ko) 2016-08-16 2024-10-29 삼성디스플레이 주식회사 유기 발광 소자
WO2018035477A1 (en) 2016-08-19 2018-02-22 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
US11529347B2 (en) 2016-09-22 2022-12-20 Relay Therapeutics, Inc. SHP2 phosphatase inhibitors and methods of use thereof
JP6589795B2 (ja) 2016-09-27 2019-10-16 信越化学工業株式会社 スルホニウム塩、レジスト組成物及びパターン形成方法
WO2018060110A1 (en) 2016-09-28 2018-04-05 Merck Patent Gmbh Polymerisable liquid crystal material and polymerised liquid crystal film
US10280172B2 (en) 2016-09-29 2019-05-07 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US11424410B2 (en) 2016-09-29 2022-08-23 Sumitomo Chemical Company, Limited Light emitting device
EP3523289A1 (en) 2016-10-07 2019-08-14 Araxes Pharma LLC Heterocyclic compounds as inhibitors of ras and methods of use thereof
ES2872005T3 (es) 2016-10-13 2021-11-02 Bristol Myers Squibb Co Sulfonas heterocíclicas como moduladores de ROR gamma
TW202500565A (zh) 2016-10-24 2025-01-01 美商傳達治療有限公司 Shp2磷酸酶抑制劑及其使用方法
US10435369B2 (en) 2016-11-09 2019-10-08 Bristol-Myers Squibb Company Tricyclic sulfones as ROR gamma modulators
WO2018119263A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds derivatives as pd-l1 internalization inducers
WO2018119183A2 (en) 2016-12-22 2018-06-28 Amgen Inc. Kras g12c inhibitors and methods of using the same
US20190343836A1 (en) 2017-01-10 2019-11-14 Novartis Ag Pharmaceutical combination comprising an alk inhibitor and a shp2 inhibitor
MX2019008696A (es) 2017-01-23 2019-09-13 Revolution Medicines Inc Compuestos de piridina como inhibidores de shp2 alostericos.
MX2019008695A (es) 2017-01-23 2019-09-11 Revolution Medicines Inc Compuestos biciclicos como inhibidores alostericos de shp2.
AU2018218519B2 (en) 2017-02-07 2021-08-05 Oblique Therapeutics Ab Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer
US11168069B2 (en) 2017-02-07 2021-11-09 Oblique Therapeutics Ab Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer
WO2018161033A1 (en) 2017-03-02 2018-09-07 Wright, Adrian Small molecule ire1-alpha inhibitors
KR20240026521A (ko) 2017-03-23 2024-02-28 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
KR102395784B1 (ko) 2017-03-27 2022-05-10 삼성전자주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
KR102461719B1 (ko) 2017-05-23 2022-11-01 삼성전자주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물
WO2018218133A1 (en) 2017-05-26 2018-11-29 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
WO2018230595A1 (ja) 2017-06-14 2018-12-20 富士フイルム株式会社 組成物、膜、レンズ、固体撮像素子、化合物
KR20180137311A (ko) 2017-06-16 2018-12-27 삼성전자주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물
US20200123115A1 (en) 2017-06-26 2020-04-23 Esteve Pharmaceuticals, S.A. Compounds having multimodal activity against pain
WO2019018119A1 (en) 2017-07-18 2019-01-24 Pairnomix, Llc METHODS FOR TREATING EPILEPSY AND DISORDERS ASSOCIATED WITH KCNTI
KR20190014187A (ko) 2017-07-27 2019-02-12 삼성디스플레이 주식회사 유기금속 화합물 및 이를 포함하는 유기 발광 소자
GB201712110D0 (en) 2017-07-27 2017-09-13 Thomas Helledays Stiftelse För Medicinsk Forskning New compounds and uses
JP7346015B2 (ja) 2017-09-06 2023-09-19 住友化学株式会社 発光素子
CA3074690A1 (en) 2017-09-07 2019-03-14 Revolution Medicines, Inc. Shp2 inhibitor compositions and methods for treating cancer
WO2019051469A1 (en) 2017-09-11 2019-03-14 Krouzon Pharmaceuticals, Inc. Octahydrocyclopenta[c]pyrrole allosteric inhibitors of shp2
KR102526756B1 (ko) 2017-09-29 2023-04-27 삼성전자주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물
EP3687997A1 (en) 2017-09-29 2020-08-05 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
CN111148819B (zh) 2017-09-29 2023-06-16 默克专利股份有限公司 可聚合化合物及其在液晶显示器中的用途
MX2020003579A (es) 2017-10-12 2020-07-22 Revolution Medicines Inc Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos.
KR102518722B1 (ko) 2017-11-21 2023-04-07 삼성디스플레이 주식회사 유기금속 화합물 및 이를 포함한 유기 발광 소자
BR112020009757A2 (pt) 2017-12-15 2020-11-03 Revolution Medicines, Inc. compostos policíclicos como inibidores alostéricos de shp2
ES2971712T3 (es) 2017-12-22 2024-06-06 Hibercell Inc Derivados de cromenopiridina como inhibidores de la fosfatidilinositol fosfato cinasa
US11572370B2 (en) 2018-01-08 2023-02-07 Biohaven Therapeutics Ltd. CD16A binding agents and uses thereof
KR102595918B1 (ko) 2018-01-18 2023-11-14 삼성디스플레이 주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 상기 유기 발광 소자를 포함한 유기 발광 장치
CN110066277B (zh) 2018-01-24 2021-07-23 上海璎黎药业有限公司 芳香杂环取代烯烃化合物、其制备方法、药物组合物和应用
CN110066276B (zh) 2018-01-24 2020-09-18 上海璎黎药业有限公司 芳香杂环化合物、其中间体、制备方法、药物组合物和应用
KR102824606B1 (ko) 2018-02-13 2025-06-25 삼성디스플레이 주식회사 유기 발광 소자 및 이를 포함한 표시 장치
KR102614939B1 (ko) 2018-02-13 2023-12-19 블루레이 테라퓨틱스 (상하이) 컴퍼니 리미티드 피리미딘-융합고리 화합물 및 그의 제조방법과 용도
WO2019165073A1 (en) 2018-02-21 2019-08-29 Relay Therapeutics, Inc. Shp2 phosphatase inhibitors and methods of use thereof
NZ766835A (en) 2018-03-02 2023-09-29 Otsuka Pharma Co Ltd Pharmaceutical compounds
US12520712B2 (en) 2018-03-08 2026-01-06 Samsung Display Co., Ltd. Organic light-emitting device
EP3537493B1 (en) 2018-03-09 2024-07-31 Samsung Display Co., Ltd Electronic apparatus
WO2019183364A1 (en) 2018-03-21 2019-09-26 Relay Therapeutics, Inc. Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof
RU2020133727A (ru) 2018-03-21 2022-04-21 Сучжоу Пухе Биофарма Ко., Лтд. Ингибиторы shp2 и их применение
SG11202009245TA (en) 2018-03-21 2020-10-29 Relay Therapeutics Inc Shp2 phosphatase inhibitors and methods of use thereof
CN108794485B (zh) 2018-04-28 2020-04-24 北京施安泰医药技术开发有限公司 一类toll样受体调节剂、其药物组合物、制备方法与用途
KR102611661B1 (ko) 2018-05-02 2023-12-08 나비레 파르마, 인코퍼레이티드 Ptpn11의 치환된 헤테로사이클릭 억제제
CN110492006B (zh) 2018-05-14 2020-06-12 江苏三月光电科技有限公司 一种基于含硼有机化合物的电致发光器件
CN108840886A (zh) 2018-06-22 2018-11-20 南京工业大学 一种铂配合物蓝光材料以及有机发光器件
JP7174143B2 (ja) 2018-07-24 2022-11-17 大鵬薬品工業株式会社 Ｓｈｐ２活性を阻害するヘテロ二環性化合物
CN108863982B (zh) 2018-08-04 2022-02-01 南昌航空大学 一种吩噻嗪/吩恶嗪类化合物的有机电合成方法
US11518770B2 (en) 2018-08-06 2022-12-06 Purdue Research Foundation Sesquiterpenoid analogs
LT3833670T (lt) 2018-08-10 2024-06-25 Navire Pharma, Inc. 6-(4-amino-3-metil-2-oksa-8-azaspiro[4.5]dekan-8-il)-3-(2,3-dichlorfenil)-2-metilpirimidin-4(3h)-ono dariniai ir susiję junginiai kaip ptpn11 (shp2) inhibitoriai, skirti vėžiui gydyti
JP7542538B2 (ja) 2018-09-18 2024-08-30 ニカング セラピューティクス， インコーポレイテッド Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての縮合三環式環誘導体
JP2022502385A (ja) 2018-09-29 2022-01-11 ノバルティス アーゲー Ｓｈｐ２の活性を阻害するための化合物の製造方法
CA3112322A1 (en) 2018-09-29 2020-04-02 Novartis Ag Manufacture of compounds and compositions for inhibiting the activity of shp2
CN113473990A (zh) 2018-10-08 2021-10-01 锐新医药公司 用于治疗癌症的shp2抑制剂组合物

Also Published As

Publication number Publication date
AU2019344899B2 (en) 2025-04-03
AU2019344897A1 (en) 2021-04-15
US20200115389A1 (en) 2020-04-16
SG11202102679QA (en) 2021-04-29
DK3853234T3 (da) 2025-07-21
CN113227103B (zh) 2024-10-01
EP3853233A1 (en) 2021-07-28
PH12021550604A1 (en) 2022-02-14
BR112021005082A2 (pt) 2021-06-08
JP2022501430A (ja) 2022-01-06
PL3853234T3 (pl) 2025-09-22
US10894797B2 (en) 2021-01-19
CO2021004436A2 (es) 2021-04-30
JP2022501431A (ja) 2022-01-06
ES3036496T3 (en) 2025-09-19
CN112996795A (zh) 2021-06-18
WO2020061101A1 (en) 2020-03-26
US20210380604A1 (en) 2021-12-09
AU2019344899A1 (en) 2021-04-15
US11034705B2 (en) 2021-06-15
SA521421505B1 (ar) 2024-02-28
CR20210175A (es) 2021-06-01
CA3113234A1 (en) 2020-03-26
CA3113233A1 (en) 2020-03-26
WO2020061103A1 (en) 2020-03-26
TW202026299A (zh) 2020-07-16
US20200277308A1 (en) 2020-09-03
JP7337174B2 (ja) 2023-09-01
EP3853234B1 (en) 2025-04-23
US20230167134A1 (en) 2023-06-01
KR20210060556A (ko) 2021-05-26
KR102834408B1 (ko) 2025-07-15
CL2021000628A1 (es) 2021-09-20
US20210040122A1 (en) 2021-02-11
US20210188876A1 (en) 2021-06-24
KR20210060555A (ko) 2021-05-26
EP3853234A1 (en) 2021-07-28
FI3853234T3 (fi) 2025-07-28
CN112996795B (zh) 2024-11-12
US11459340B2 (en) 2022-10-04
JP7542538B2 (ja) 2024-08-30
TWI827677B (zh) 2024-01-01
MX2021003158A (es) 2021-07-16
US12264167B2 (en) 2025-04-01
AU2019344897B2 (en) 2024-01-18
CN113227103A (zh) 2021-08-06
US11518772B2 (en) 2022-12-06

Similar Documents

Publication Publication Date Title
SG11202102679QA (en) Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors
IL282916A (en) Compressed ring compounds
IL280797A (en) fused ring compounds
IL268737A (en) Processes for the preparation of benzodiapine derivatives
HUE065838T2 (hu) MGAT-2 gátló aktivitással rendelkezõ kondenzált gyûrûs származék
ZA201907755B (en) 5-5 fused rings as c5a inhibitors
IL276592A (en) History of Subtirum
EP3279187A4 (en) 9-membered fused ring derivative
DK3325483T3 (da) Fremgangsmåder til fremstilling af cytotoksiske benzodiazepinderivater
IL287405A (en) Methods of preparing cytotoxic benzodiazepine derivatives
HUE070859T2 (hu) Rapamicin-származékok
SG11202102015QA (en) Fused ring derivative used as fgfr4 inhibitor
IL254528B (en) Fused tricyclic derivatives of 1-(cyclo)alkylpyridine-2-one are useful for cancer treatment
IL283047A (en) Methods for preparing cytotoxic benzodiazepine derivatives
IL283045A (en) Methods for preparing cytotoxic benzodiazepine derivatives
EP3434595B8 (en) Adapter ring for above-wing mounting of below-wing engine
HUP1800250A2 (en) Substituted (aza)indole derivatives
IL281590A (en) Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors
HK40054769A (en) Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors
ZA202101146B (en) Bicyclic heteroaromatic ring derivative
HK40060523A (en) Methods of preparing cytotoxic benzodiazepine derivatives
HK40060522A (en) Methods of preparing cytotoxic benzodiazepine derivatives