BR112021005082A2 - derivados de anel tricíclico fundido como inibidores de src homologia-2 fosfatase - Google Patents

derivados de anel tricíclico fundido como inibidores de src homologia-2 fosfatase Download PDF

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Publication number
BR112021005082A2
BR112021005082A2 BR112021005082-5A BR112021005082A BR112021005082A2 BR 112021005082 A2 BR112021005082 A2 BR 112021005082A2 BR 112021005082 A BR112021005082 A BR 112021005082A BR 112021005082 A2 BR112021005082 A2 BR 112021005082A2
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BR
Brazil
Prior art keywords
methyl
amino
alkyl
pyrido
tetrahydro
Prior art date
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BR112021005082-5A
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English (en)
Portuguese (pt)
Inventor
Jiping Fu
Yan Lou
Yigang HE
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Nikang Therapeutics, Inc.
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Application filed by Nikang Therapeutics, Inc. filed Critical Nikang Therapeutics, Inc.
Publication of BR112021005082A2 publication Critical patent/BR112021005082A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112021005082-5A 2018-09-18 2019-09-17 derivados de anel tricíclico fundido como inibidores de src homologia-2 fosfatase BR112021005082A2 (pt)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862733061P 2018-09-18 2018-09-18
US62/733,061 2018-09-18
US201862749655P 2018-10-23 2018-10-23
US62/749,655 2018-10-23
US201962810911P 2019-02-26 2019-02-26
US62/810,911 2019-02-26
US201962883121P 2019-08-06 2019-08-06
US201962883120P 2019-08-06 2019-08-06
US62/883,120 2019-08-06
US62/883,121 2019-08-06
PCT/US2019/051592 WO2020061103A1 (en) 2018-09-18 2019-09-17 Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors

Publications (1)

Publication Number Publication Date
BR112021005082A2 true BR112021005082A2 (pt) 2021-06-08

Family

ID=68084982

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021005082-5A BR112021005082A2 (pt) 2018-09-18 2019-09-17 derivados de anel tricíclico fundido como inibidores de src homologia-2 fosfatase

Country Status (22)

Country Link
US (6) US11459340B2 (https=)
EP (2) EP3853234B1 (https=)
JP (2) JP7337174B2 (https=)
KR (2) KR20210060555A (https=)
CN (2) CN112996795B (https=)
AU (2) AU2019344899B2 (https=)
BR (1) BR112021005082A2 (https=)
CA (2) CA3113234A1 (https=)
CL (1) CL2021000628A1 (https=)
CO (1) CO2021004436A2 (https=)
CR (1) CR20210175A (https=)
DK (1) DK3853234T3 (https=)
ES (1) ES3036496T3 (https=)
FI (1) FI3853234T3 (https=)
MX (1) MX2021003158A (https=)
PH (1) PH12021550604A1 (https=)
PL (1) PL3853234T3 (https=)
PT (1) PT3853234T (https=)
SA (1) SA521421505B1 (https=)
SG (1) SG11202102679QA (https=)
TW (1) TWI827677B (https=)
WO (2) WO2020061103A1 (https=)

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