BR112016008632A8 - compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica - Google Patents
compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica Download PDFInfo
- Publication number
- BR112016008632A8 BR112016008632A8 BR112016008632A BR112016008632A BR112016008632A8 BR 112016008632 A8 BR112016008632 A8 BR 112016008632A8 BR 112016008632 A BR112016008632 A BR 112016008632A BR 112016008632 A BR112016008632 A BR 112016008632A BR 112016008632 A8 BR112016008632 A8 BR 112016008632A8
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- Prior art keywords
- pharmaceutical composition
- btk inhibitors
- heteroaryl compounds
- compounds
- btk
- Prior art date
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- 229940124291 BTK inhibitor Drugs 0.000 title abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000004892 pyridazines Chemical class 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract
a presente invenção refere-se a compostos de piridina, pi-rimidina, pirazina, e piridazina, e composições farmaceuticamente aceitáveis dos mesmos, úteis como inibidores de btk.
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US201361893613P | 2013-10-21 | 2013-10-21 | |
PCT/US2014/061455 WO2015061247A2 (en) | 2013-10-21 | 2014-10-21 | Heteroaryl compounds as btk inhibitors and uses thereof |
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BR112016008632A8 true BR112016008632A8 (pt) | 2020-03-17 |
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BR112016008632A BR112016008632A8 (pt) | 2013-10-21 | 2014-10-21 | compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica |
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EP (1) | EP3060550B1 (pt) |
JP (1) | JP6487430B2 (pt) |
KR (1) | KR20160063366A (pt) |
CN (1) | CN105939998B (pt) |
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BR (1) | BR112016008632A8 (pt) |
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HR (1) | HRP20191430T1 (pt) |
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PL (1) | PL3060550T3 (pt) |
PT (1) | PT3060550T (pt) |
RS (1) | RS59140B1 (pt) |
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