HK1219432A1 - 以嘧啶化合物爲有效成分的醫藥組合物 - Google Patents
以嘧啶化合物爲有效成分的醫藥組合物Info
- Publication number
- HK1219432A1 HK1219432A1 HK16107576.9A HK16107576A HK1219432A1 HK 1219432 A1 HK1219432 A1 HK 1219432A1 HK 16107576 A HK16107576 A HK 16107576A HK 1219432 A1 HK1219432 A1 HK 1219432A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pharmaceutical composition
- active ingredient
- pyrimidine compound
- pyrimidine
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013176355 | 2013-08-28 | ||
| PCT/JP2014/072349 WO2015030021A1 (ja) | 2013-08-28 | 2014-08-27 | ピリミジン化合物を有効成分とする医薬組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1219432A1 true HK1219432A1 (zh) | 2017-04-07 |
Family
ID=52586573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16107576.9A HK1219432A1 (zh) | 2013-08-28 | 2016-06-29 | 以嘧啶化合物爲有效成分的醫藥組合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20160199371A1 (zh) |
| EP (1) | EP3040072A4 (zh) |
| JP (1) | JPWO2015030021A1 (zh) |
| KR (1) | KR20160040719A (zh) |
| CN (1) | CN105492009A (zh) |
| AR (1) | AR097455A1 (zh) |
| AU (1) | AU2014312919A1 (zh) |
| CA (1) | CA2922352A1 (zh) |
| HK (1) | HK1219432A1 (zh) |
| IL (1) | IL244206A0 (zh) |
| MX (1) | MX2016002589A (zh) |
| PH (1) | PH12016500372A1 (zh) |
| RU (1) | RU2016106774A (zh) |
| SG (1) | SG11201601461RA (zh) |
| TW (1) | TW201605452A (zh) |
| WO (1) | WO2015030021A1 (zh) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| CN107652289B (zh) | 2012-06-13 | 2020-07-21 | 因塞特控股公司 | 作为fgfr抑制剂的取代的三环化合物 |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| JP6449244B2 (ja) | 2013-04-19 | 2019-01-09 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｆｇｆｒ抑制剤としての二環式複素環 |
| JO3515B1 (ar) | 2013-10-18 | 2020-07-05 | Eisai R&D Man Co Ltd | مثبطات fgfr4 بيريميدين |
| BR112016008276B1 (pt) | 2013-10-25 | 2021-03-02 | Novartis Ag | derivados bicíclicos de piridila fundidos ao anel, seus usos e seu intermediário, e composição farmacêutica |
| JP6585167B2 (ja) | 2014-10-03 | 2019-10-02 | ノバルティス アーゲー | Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体の使用 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134320A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9802917B2 (en) | 2015-03-25 | 2017-10-31 | Novartis Ag | Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide |
| JP6431622B2 (ja) | 2015-04-14 | 2018-11-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 結晶性ｆｇｆｒ４阻害剤化合物およびその使用 |
| US11357769B2 (en) | 2016-05-10 | 2022-06-14 | Eisai R&D Management Co., Ltd. | Drug combinations for reducing cell viability and/or cell proliferation |
| CN107541495B (zh) * | 2016-06-28 | 2022-04-26 | 上海市东方医院 | 一种fgf19过表达的人肝癌细胞系及其应用 |
| WO2018055503A1 (en) | 2016-09-20 | 2018-03-29 | Novartis Ag | Combination comprising a pd-1 antagonist and an fgfr4 inhibitor |
| EP3534902B1 (en) | 2016-11-02 | 2022-11-23 | Novartis AG | Combinations of fgfr4 inhibitors and bile acid sequestrants |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| SG11202010882XA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Salts of an fgfr inhibitor |
| DK3788047T3 (da) | 2018-05-04 | 2024-09-16 | Incyte Corp | Faste former af en FGFR-inhibitor og fremgangsmåder til fremstilling deraf |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| MX2022004513A (es) | 2019-10-14 | 2022-07-19 | Incyte Corp | Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr). |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
| JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US20230172867A1 (en) * | 2020-05-15 | 2023-06-08 | Eisai R&D Management Co., Ltd. | A method for treating cancer with an oral dosage form of an fgfr4 inhibitor |
| EP4323405A1 (en) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101155799A (zh) | 2005-03-16 | 2008-04-02 | 塔格根公司 | 嘧啶化合物和使用方法 |
| WO2007056075A2 (en) | 2005-11-02 | 2007-05-18 | Targegen, Inc. | Six membered heteroaromatic inhibitors targeting resistant kinase mutations |
| US8030487B2 (en) | 2006-07-07 | 2011-10-04 | Targegen, Inc. | 2-amino—5-substituted pyrimidine inhibitors |
| US9464077B2 (en) * | 2012-02-28 | 2016-10-11 | Astellas Pharma Inc. | Nitrogen-containing aromatic heterocyclic compound |
| ES2702305T3 (es) * | 2012-03-08 | 2019-02-28 | Astellas Pharma Inc | Nuevo producto de fusión de FGFR3 |
-
2014
- 2014-08-26 TW TW103129371A patent/TW201605452A/zh unknown
- 2014-08-26 AR ARP140103193A patent/AR097455A1/es unknown
- 2014-08-27 JP JP2015534246A patent/JPWO2015030021A1/ja active Pending
- 2014-08-27 EP EP14840047.6A patent/EP3040072A4/en not_active Withdrawn
- 2014-08-27 MX MX2016002589A patent/MX2016002589A/es unknown
- 2014-08-27 RU RU2016106774A patent/RU2016106774A/ru not_active Application Discontinuation
- 2014-08-27 CA CA2922352A patent/CA2922352A1/en not_active Abandoned
- 2014-08-27 SG SG11201601461RA patent/SG11201601461RA/en unknown
- 2014-08-27 CN CN201480047119.2A patent/CN105492009A/zh active Pending
- 2014-08-27 WO PCT/JP2014/072349 patent/WO2015030021A1/ja active Application Filing
- 2014-08-27 KR KR1020167007640A patent/KR20160040719A/ko not_active Application Discontinuation
- 2014-08-27 US US14/914,955 patent/US20160199371A1/en not_active Abandoned
- 2014-08-27 AU AU2014312919A patent/AU2014312919A1/en not_active Abandoned
-
2016
- 2016-02-21 IL IL244206A patent/IL244206A0/en unknown
- 2016-02-24 PH PH12016500372A patent/PH12016500372A1/en unknown
- 2016-06-29 HK HK16107576.9A patent/HK1219432A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN105492009A (zh) | 2016-04-13 |
| EP3040072A1 (en) | 2016-07-06 |
| WO2015030021A1 (ja) | 2015-03-05 |
| AR097455A1 (es) | 2016-03-16 |
| SG11201601461RA (en) | 2016-03-30 |
| IL244206A0 (en) | 2016-04-21 |
| MX2016002589A (es) | 2016-06-14 |
| JPWO2015030021A1 (ja) | 2017-03-02 |
| US20160199371A1 (en) | 2016-07-14 |
| TW201605452A (zh) | 2016-02-16 |
| EP3040072A4 (en) | 2017-03-29 |
| RU2016106774A (ru) | 2017-10-03 |
| KR20160040719A (ko) | 2016-04-14 |
| AU2014312919A1 (en) | 2016-03-10 |
| PH12016500372A1 (en) | 2016-05-02 |
| CA2922352A1 (en) | 2015-03-05 |
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