HUP1800250A2 - Substituted (aza)indole derivatives - Google Patents

Substituted (aza)indole derivatives

Info

Publication number
HUP1800250A2
HUP1800250A2 HU1800250A HUP1800250A HUP1800250A2 HU P1800250 A2 HUP1800250 A2 HU P1800250A2 HU 1800250 A HU1800250 A HU 1800250A HU P1800250 A HUP1800250 A HU P1800250A HU P1800250 A2 HUP1800250 A2 HU P1800250A2
Authority
HU
Hungary
Prior art keywords
aza
substituted
indole derivatives
indole
derivatives
Prior art date
Application number
HU1800250A
Other languages
Hungarian (hu)
Inventor
Istvan Dr Ledneczki
Janos Dr Eles
Pal Dr Tapolcsanyi
Anita Dr Horvath
Zsolt Dr Nemethy
Gyoergy Istvan Dr Levay
Janos Dr Galambos
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to HUP1800250A priority Critical patent/HU231478B1/en
Priority to TW108122551A priority patent/TW202017904A/en
Priority to ARP190101993A priority patent/AR115228A1/en
Priority to PCT/IB2019/055950 priority patent/WO2020012424A1/en
Publication of HUP1800250A2 publication Critical patent/HUP1800250A2/en
Publication of HU231478B1 publication Critical patent/HU231478B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
HUP1800250A 2018-07-13 2018-07-13 Substituted (aza)indole derivatives HU231478B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
HUP1800250A HU231478B1 (en) 2018-07-13 2018-07-13 Substituted (aza)indole derivatives
TW108122551A TW202017904A (en) 2018-07-13 2019-06-27 Substituted (aza)indole derivatives
ARP190101993A AR115228A1 (en) 2018-07-13 2019-07-12 SUBSTITUTE (AZA) INDOLE DERIVATIVES, A METHOD FOR ITS PREPARATION, INTERMEDIARIES FOR THEIR SYNTHESIS, COMPOSITION AND PHARMACEUTICAL COMBINATION THAT INCLUDE THEM AND THE USE OF THE SAME IN THE TREATMENT OF DISEASES ASSOCIATED WITH THE NICOTINN ACETILCHINE 7 RECEPTOR
PCT/IB2019/055950 WO2020012424A1 (en) 2018-07-13 2019-07-12 Substituted (aza)indole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUP1800250A HU231478B1 (en) 2018-07-13 2018-07-13 Substituted (aza)indole derivatives

Publications (2)

Publication Number Publication Date
HUP1800250A2 true HUP1800250A2 (en) 2020-01-28
HU231478B1 HU231478B1 (en) 2024-02-28

Family

ID=89985025

Family Applications (1)

Application Number Title Priority Date Filing Date
HUP1800250A HU231478B1 (en) 2018-07-13 2018-07-13 Substituted (aza)indole derivatives

Country Status (4)

Country Link
AR (1) AR115228A1 (en)
HU (1) HU231478B1 (en)
TW (1) TW202017904A (en)
WO (1) WO2020012424A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202202495A (en) 2020-03-26 2022-01-16 匈牙利商羅特格登公司 Naphthyridine and pyrido〔3,4-c〕pyridazine derivatives as gamma-aminobutyric acid a receptor subunit alpha 5 receptor modulators
HUP2100338A1 (en) 2021-09-29 2023-04-28 Richter Gedeon Nyrt Bicyclic amine derivatives as gabaa alfa5 receptor modulators
AR127972A1 (en) 2021-12-17 2024-03-13 Pi Industries Ltd NOVEL FUSED SUBSTITUTED BICYCLIC CARBOXAMIDE PYRIDINE COMPOUNDS TO COMBAT PHYTOPATHOGENIC FUNGI

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1782811A4 (en) 2004-08-09 2010-09-01 Eisai R&D Man Co Ltd Novel antimalaria agent containing heterocyclic compound
EA015034B1 (en) 2005-09-13 2011-04-29 Янссен Фармацевтика Н.В. 2-aniline-4-aryl substituted thiazole derivatives
WO2009043784A1 (en) 2007-10-04 2009-04-09 F. Hoffmann-La Roche Ag Cyclopropyl aryl amide derivatives and uses thereof
CN101821246B (en) 2007-10-04 2013-05-01 弗·哈夫曼-拉罗切有限公司 Tetrazole-substituted aryl amide derivatives and uses thereof
JP2011511800A (en) 2008-02-07 2011-04-14 アボット・ラボラトリーズ Amide derivatives as positive allosteric modifiers and methods for their use
MY152486A (en) 2008-03-19 2014-10-15 Janssen Pharmaceutica Nv Trisubstituted 1,2,4 - triazoles as nicotinic acetylcholine receptor modulators
MX2010011358A (en) 2008-04-17 2010-11-10 Glaxo Group Ltd Indoles as modulators of nicotinic acetylcholin receptor subtype alpha-71.
WO2009135944A1 (en) 2008-05-09 2009-11-12 Janssen Pharmaceutica Nv Trisubstituted pyrazoles as acetylcholine receptor modulators
AU2009260519A1 (en) 2008-05-30 2009-12-23 Merck Sharp & Dohme Corp. Novel substituted azabenzoxazoles
WO2012042915A1 (en) 2010-10-01 2012-04-05 Raqualia Pharma Inc. Sulfamoyl benzoic acid heterobicyclic derivatives as trpm8 antagonists
US20120252853A1 (en) 2011-04-01 2012-10-04 H. Lundbeck A/S Positive allosteric modulators of nicotinic acetylcholine receptor
WO2014049133A1 (en) * 2012-09-28 2014-04-03 H. Lundbeck A/S New positive allosteric modulators of nicotinic acetylcholine receptor
AU2014229300A1 (en) 2013-03-13 2015-06-11 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
GB201421088D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
MY195948A (en) 2016-03-22 2023-02-27 Merck Sharp & Dohme Allosteric Modulators of Nicotinic Acetylcholine Receptors
US10870630B2 (en) 2016-11-01 2020-12-22 Merck Sharp & Dohme Corp. Substituted bicyclic heteroaryl allosteric modulators of nicotinic acetylcholine receptors

Also Published As

Publication number Publication date
WO2020012424A1 (en) 2020-01-16
AR115228A1 (en) 2020-12-09
TW202017904A (en) 2020-05-16
HU231478B1 (en) 2024-02-28

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