KR870009717A - 신규 경구용 약제 - Google Patents
신규 경구용 약제 Download PDFInfo
- Publication number
- KR870009717A KR870009717A KR870004132A KR870004132A KR870009717A KR 870009717 A KR870009717 A KR 870009717A KR 870004132 A KR870004132 A KR 870004132A KR 870004132 A KR870004132 A KR 870004132A KR 870009717 A KR870009717 A KR 870009717A
- Authority
- KR
- South Korea
- Prior art keywords
- alkaline
- omeprazole
- compound
- formulation
- core
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (13)
- 알칼리성 반응 화합물과 함게 오페프라졸을 함유하거나 임의로 알카리성 반응 화합물과 함께 오메프라졸의 알칼리성 염을 함유한 코어 물질이 되고, 이 코어 물질 상에서 물 중에서 용해되거나 신속히 분해되는 정제 부형제 또는 폴리머성, 수용성, 필름 형성 화합물로 되는 1개 이상의 불활성 반응 내피층이 알칼리성 반응 코어와 외피층 사이에서 장용피인 pH-완충, 알칼리성 화합물을 임의로 함유하는 것을 특징으로 하는 유효성분으로 오메프라졸을 함유하는 경구용 약제.
- 제1항에 있어서, 내피층이 1개 이상의 산화마그네숨, 수산화마그네슘 또는 혼성물질 [Al2O3·6MgO·CO2·12H2O 또는 MgO·Al2O3·nH2O](여기에서, n은 정수가 아닌 2미만의 숫자임)로 되는 제제물.
- 제1항에 있어서, 내피가 2개 이상의 내피층으로 된 제제물.
- 제3항에 있어서, 내피가 히드록시프로필 메틸셀물로오스, 히드록시프로필 세룰로오스 또는 플리비닐피롤리돈으로 된 제제물.
- 제1항에 있어서, 알칼리성 코어가 오메프라졸 및 오메프라졸의 미세환경(micro-environment) pH7-12로 되게 하는 pH-완충 알칼리성 화합물로 되는 제제물.
- 제5항에 있어서, 알칼리성 화합물이 1개 이상의 산화, 수산화 또는 탄산마그네슘, 수산화 알루미늄, 탄산, 인산 또는 시트르산알루미늄, 칼슘, 나트륨 또는 칼륨, 알루미늄/마그네슘 혼성 화합물 Al2O3·6MgO·CO2·12H2O또는 MgO·Al|2O3·nH2O](여기에서, n은 정수가 아닌 2미만의 숫자임)로 되는 제제물.
- 제1항에 있어서, 알칼리성 코어가 나트륨, 칼륨, 마그네숨, 칼슘 또는 암모늄염과 같은 오메프라졸의 알칼리성염으로 되는 제제물.
- 제7항에 있어서, 알칼리성 코어가 불활성, 알칼리성 화합물과 혼합된 오메프라졸의 알칼리성염으로 되는 제제물.
- 제1항에 있어서, 장용피가 히드록시프로필 메틸셀룰로오스 프탈레이트, 셀룰로오스 아세테이트 프탈레이트, 공중합체 메타크릴산/메틸에스테르 도는 폴리비닐 아세테이트로 되고, 임의로 가소제를 함유한 약제.
- 제1항에 있어서, 오메프라졸을 함유한 최종 복용형태의 수분 함량의 1.5중량%를 초과하지 않는 제제물.
- 알칼리성 반응 화합물과 혼합된 오메프라졸 또는 알칼리성 반응 화합물과 임의로 혼합된 오메프라졸의 알칼리성 염을 함유한 코어를 1개 이상의 불활성 반내피층으로 피복시키고, 이어서 내피 피복 코어를 장용피로 추가 피복시킨 오메프라졸을 함유하는 경구용 약제의 제조방법.
- 제1항에 의한 제제물을 치료하고자 하는 숙주에게 치료학적으로 유효한 양을 투여하는 것을 특징으로 하는 위장관 질병의 치료 방법.
- 위장관 질병을 치료하기 위한 제1항에 의한 제제물의 의약품 제조 용도※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08610572A GB2189698A (en) | 1986-04-30 | 1986-04-30 | Coated omeprazole tablets |
GB8610572 | 1986-04-30 | ||
SG154294A SG154294G (en) | 1986-04-30 | 1994-10-21 | New pharmaceutical preparation for oral use |
Publications (2)
Publication Number | Publication Date |
---|---|
KR870009717A true KR870009717A (ko) | 1987-11-30 |
KR910004579B1 KR910004579B1 (ko) | 1991-07-06 |
Family
ID=26290693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870004132A KR910004579B1 (ko) | 1986-04-30 | 1987-04-29 | 오메프라졸 경구 제형의 제조 방법 |
Country Status (35)
Country | Link |
---|---|
US (1) | US4786505A (ko) |
EP (3) | EP0496437B1 (ko) |
JP (2) | JPS62258320A (ko) |
KR (1) | KR910004579B1 (ko) |
CN (1) | CN1020852C (ko) |
AR (1) | AR240250A1 (ko) |
AT (3) | ATE184482T1 (ko) |
CA (1) | CA1292693C (ko) |
CY (1) | CY1810A (ko) |
DD (1) | DD273197A5 (ko) |
DE (3) | DE3783394T2 (ko) |
DK (1) | DK169988B1 (ko) |
DZ (1) | DZ1077A1 (ko) |
ES (3) | ES2135443T3 (ko) |
FI (1) | FI90393C (ko) |
GB (1) | GB2189698A (ko) |
GR (4) | GR890300058T1 (ko) |
HK (2) | HK135294A (ko) |
HR (1) | HRP920854B1 (ko) |
HU (1) | HU196708B (ko) |
IE (1) | IE61416B1 (ko) |
IL (1) | IL82911A (ko) |
IS (1) | IS1917B (ko) |
LT (1) | LT3699B (ko) |
LV (2) | LV10357B (ko) |
NO (1) | NO174239C (ko) |
NZ (1) | NZ220096A (ko) |
PH (1) | PH25701A (ko) |
PL (1) | PL151631B1 (ko) |
PT (1) | PT84785B (ko) |
RU (2) | RU1820837C (ko) |
SG (1) | SG154294G (ko) |
SI (1) | SI8710681A8 (ko) |
YU (1) | YU46192B (ko) |
ZA (1) | ZA872378B (ko) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100254021B1 (ko) * | 1991-06-17 | 2000-05-01 | 서키 허버트, 울프 울리히 | 판토프라졸 함유 약제의 경구 투여 형태 |
WO2019004770A3 (ko) * | 2017-06-30 | 2019-04-18 | 롯데정밀화학 주식회사 | 프로톤 펌프 저해제를 포함하는 경구용 고형제제 조성물, 이를 포함하는 경구용 고형제제 및 그 제조방법 |
Families Citing this family (354)
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US5540945A (en) * | 1989-05-11 | 1996-07-30 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical preparations for oral administration that are adapted to release the drug at appropriate sites in the intestines |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
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US5316772A (en) * | 1990-12-19 | 1994-05-31 | Solvay & Cie, S.A. (Societe Anonyme) | Bilayered oral pharmaceutical composition with pH dependent release |
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US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
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PT621032E (pt) * | 1993-04-23 | 2001-01-31 | Novartis Ag | Dispositivo de distribuicao de libertacao controlada de farmaco |
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EE03378B1 (et) * | 1994-07-08 | 2001-04-16 | Astra Aktiebolag | Omeprasooli magneesiumisoola sisaldav peroraalne ravimvorm |
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- 1987-04-16 DE DE198787850127T patent/DE247983T1/de active Pending
- 1987-04-16 ES ES93201611T patent/ES2135443T3/es not_active Expired - Lifetime
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- 1987-04-30 JP JP62108762A patent/JPS62258320A/ja active Granted
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1989
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1991
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1992
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1993
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1994
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1995
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1996
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1997
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1999
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100254021B1 (ko) * | 1991-06-17 | 2000-05-01 | 서키 허버트, 울프 울리히 | 판토프라졸 함유 약제의 경구 투여 형태 |
WO2019004770A3 (ko) * | 2017-06-30 | 2019-04-18 | 롯데정밀화학 주식회사 | 프로톤 펌프 저해제를 포함하는 경구용 고형제제 조성물, 이를 포함하는 경구용 고형제제 및 그 제조방법 |
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